Details of the Target

General Information of Target

Target ID LDTP08389
Target Name Syntaxin-12 (STX12)
Gene Name STX12
Gene ID 23673
Synonyms
Syntaxin-12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQ
ENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDFSAALNNFQAV
QRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLEL
IKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRA
AYYQKKSRKKMCILVLVLSVIILILGLIIWLVYKTK
Target Bioclass
Other
Family
Syntaxin family
Subcellular location
Endosome membrane
Function
SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Uniprot ID
Q86Y82
Ensemble ID
ENST00000373943.9
HGNC ID
HGNC:11430

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.13  LDD0318  [1]
FBP2
 Probe Info  		2.18  LDD0317  [1]
Probe 1
 Probe Info  		Y242(56.67); Y243(111.25)  LDD3495  [2]
BTD
 Probe Info  		C29(0.44)  LDD2112  [3]
D5yne
 Probe Info  		2.26  LDD0055  [4]
DBIA
 Probe Info  		C29(1.02)  LDD1492  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NHS
 Probe Info  		N.A.  LDD0010  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
1c-yne
 Probe Info  		K44(0.00); K82(0.00)  LDD0228  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		9.06  LDD1850  [12]
C231
 Probe Info  		12.04  LDD1904  [12]
C310
 Probe Info  		11.55  LDD1977  [12]
C362
 Probe Info  		26.54  LDD2023  [12]
FFF probe11
 Probe Info  		18.79  LDD0471  [13]
FFF probe12
 Probe Info  		13.85  LDD0473  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe2
 Probe Info  		15.69  LDD0463  [13]
FFF probe3
 Probe Info  		17.80  LDD0464  [13]
JN0003
 Probe Info  		20.00  LDD0469  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.34)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.44)  LDD2112  [3]
 LDCM0214  AC1 HEK-293T C29(0.90)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C29(0.87)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C29(0.82)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C29(0.96)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C29(0.91)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C29(0.91)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C29(0.92)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C29(0.89)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C29(0.81)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C29(0.98)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C29(1.02)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C29(1.11)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C29(0.95)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C29(0.85)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C29(0.89)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C29(0.96)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C29(0.82)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C29(0.84)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C29(0.84)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C29(0.92)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C29(0.82)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C29(0.91)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C29(0.96)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C29(0.87)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C29(0.98)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C29(0.86)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C29(0.94)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C29(0.99)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C29(0.97)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C29(0.96)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C29(0.93)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C29(0.86)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C29(1.06)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C29(0.89)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C29(0.82)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C29(0.93)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C29(0.97)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C29(1.03)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C29(0.98)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C29(0.91)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C29(0.98)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C29(0.85)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C29(1.03)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C29(0.87)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C29(0.92)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C29(1.01)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C29(1.02)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C29(1.04)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C29(0.93)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C29(0.99)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C29(0.83)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C29(0.83)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C29(0.86)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C29(0.82)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C29(0.88)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C29(0.86)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C29(0.89)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C29(0.80)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C29(0.78)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C29(0.84)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C29(0.85)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C29(1.09)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C29(0.88)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C29(0.93)  LDD1514  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C29(0.94)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C29(0.76)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C29(0.87)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C29(0.95)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C29(0.80)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C29(1.00)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C29(0.86)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C29(0.90)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C29(0.89)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C29(0.93)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C29(0.95)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C29(0.85)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C29(0.87)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C29(0.80)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C29(0.80)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C29(0.97)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C29(0.94)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C29(0.81)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C29(0.89)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C29(0.99)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C29(0.96)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C29(0.85)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C29(0.90)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C29(1.21)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C29(0.95)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C29(0.97)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C29(0.89)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C29(0.86)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C29(0.89)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C29(0.85)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C29(0.92)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C29(0.89)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C29(0.89)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C29(1.02)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C29(0.86)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C29(0.91)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C29(0.89)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C29(0.83)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C29(0.93)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C29(0.99)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C29(0.99)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C29(1.01)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C29(0.94)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C29(1.26)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C29(0.94)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C29(1.13)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C29(0.89)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C29(1.13)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C29(0.91)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C29(0.90)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C29(0.97)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C29(0.86)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C29(1.00)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C29(0.93)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C29(0.97)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C29(0.88)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C29(1.00)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C29(0.81)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C29(0.88)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C29(0.99)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C29(0.90)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C29(0.93)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C29(0.99)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C29(0.83)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C29(1.01)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C29(0.95)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C29(0.95)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C29(1.00)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C29(0.86)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C29(0.96)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C29(0.99)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C29(0.97)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C29(0.92)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C29(1.02)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C29(0.92)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C29(0.92)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C29(0.85)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C29(0.91)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C29(0.95)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C29(0.89)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C29(0.91)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C29(0.97)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C29(0.89)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C29(1.17)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C29(0.98)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C29(0.98)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C29(0.94)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C29(0.88)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C29(0.88)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C29(0.99)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C29(0.91)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C29(0.98)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C29(1.02)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C29(0.94)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C29(0.90)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C29(0.87)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C29(1.11)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C29(0.90)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C29(0.90)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C29(0.95)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C29(0.71)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C29(0.88)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C29(1.15)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C29(0.54)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C29(1.00)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C29(1.20)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C29(0.96)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C29(0.90)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C29(0.84)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C29(1.00)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C29(0.85)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C29(0.82)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C29(0.83)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C29(0.89)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C29(0.97)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C29(0.83)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C29(0.93)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C29(0.95)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C29(1.02)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C29(0.96)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C29(0.84)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C29(0.94)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C29(0.84)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C29(0.84)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C29(0.91)  LDD1697  [5]
 LDCM0095  DC-LC3IN-D5 HeLa 2.26  LDD0055  [4]
 LDCM0495  E2913 HEK-293T C29(1.01)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C29(0.94)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C29(0.98)  LDD1631  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C29(1.02)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C29(0.98)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C29(0.97)  LDD1502  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid-transporting ATPase ABCA1 (ABCA1) ABCA family O95477
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein kish-B (TMEM167B) KISH family Q9NRX6
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
Synaptosomal-associated protein 47 (SNAP47) SVAP1 family Q5SQN1
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Syntaxin-binding protein 5-like (STXBP5L) WD repeat L(2)GL family Q9Y2K9
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein KASH5 (KASH5) . Q8N6L0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.