Details of the Target

General Information of Target

Target ID LDTP03818
Target Name Phosphoglucomutase-1 (PGM1)
Gene Name PGM1
Gene ID 5236
Synonyms
Phosphoglucomutase-1; PGM 1; EC 5.4.2.2; Glucose phosphomutase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVG
GDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNP
GGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENK
FKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEE
LGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKH
GFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWK
FFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKY
GRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPV
DGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYIDSYEKDVAKINQDPQVMLAPLI
SIALKVSQLQERTGRTAPTVIT
Target Bioclass
Enzyme
Family
Phosphohexose mutase family
Subcellular location
Cytoplasm
Function This enzyme participates in both the breakdown and synthesis of glucose.
Uniprot ID
P36871
Ensemble ID
ENST00000371083.4
HGNC ID
HGNC:8905

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.G363WfsTer22 .
COLO792 SNV: p.H416Y DBIA    Probe Info 
MFE296 SNV: p.G289R DBIA    Probe Info 
NCIH23 SNV: p.G92Ter DBIA    Probe Info 
SKNSH SNV: p.R76S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K16(9.39); K172(10.00); K234(7.69); K3(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y476(16.23)  LDD3495  [4]
m-APA
 Probe Info  		15.00  LDD0403  [5]
DBIA
 Probe Info  		C119(1.19); C178(0.96)  LDD3310  [6]
JZ128-DTB
 Probe Info  		C101(0.00); C160(0.00)  LDD0462  [7]
BTD
 Probe Info  		C374(0.86)  LDD1700  [8]
D5yne
 Probe Info  		1.90  LDD0055  [9]
HHS-482
 Probe Info  		Y12(2.99)  LDD0285  [10]
HHS-475
 Probe Info  		Y232(0.72)  LDD0264  [11]
IPM
 Probe Info  		C374(2.66)  LDD1701  [8]
ATP probe
 Probe Info  		K16(0.00); K172(0.00); K443(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C374(0.00); C101(0.00); C160(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C251(0.00); C238(0.00); C374(0.00); C101(0.00)  LDD0036  [13]
IPIAA_L
 Probe Info  		C374(0.00); C160(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C374(0.00); C101(0.00); C160(0.00); C251(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K8(0.00); K27(0.00)  LDD0035  [15]
NAIA_4
 Probe Info  		C101(0.00); C374(0.00)  LDD2226  [16]
NHS
 Probe Info  		K457(0.00); K523(0.00); K172(0.00)  LDD0010  [17]
PF-06672131
 Probe Info  		N.A.  LDD0152  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
1c-yne
 Probe Info  		K457(0.00); K27(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C374(0.00); C160(0.00)  LDD0217  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C364
 Probe Info  		18.25  LDD2025  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [23]
STS-1
 Probe Info  		N.A.  LDD0137  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [24]
DA-2
 Probe Info  		N.A.  LDD0071  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C374(0.67)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C160(1.28)  LDD2117  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C374(1.06)  LDD2103  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C160(1.14)  LDD2131  [8]
 LDCM0214  AC1 HEK-293T C101(0.89); C374(1.03); C238(1.03)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C101(1.09); C374(1.22); C251(0.90)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C101(0.88); C160(1.00); C238(0.97)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C101(0.96); C160(0.97)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C101(1.06); C160(1.08)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C101(1.11)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C101(0.97); C374(0.87); C238(1.01)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C101(0.90); C374(1.13); C251(1.33)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C101(0.89); C160(1.00); C238(0.84)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C101(1.02); C374(1.24); C251(1.16)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C101(1.01); C160(0.98)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C101(1.01); C374(0.87); C238(0.99)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C101(1.10); C160(1.02)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C101(1.08)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C101(1.06); C160(0.98); C251(1.04)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C101(0.88); C374(0.93); C238(0.97)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C101(1.00); C374(1.13); C251(1.05)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C101(0.96); C160(1.07); C238(1.07)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C101(1.00); C160(0.90)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C101(0.82); C374(0.94); C238(1.13)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C101(1.08); C160(1.07); C238(0.96)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C101(1.01); C160(1.05)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C101(0.95)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C101(1.03); C160(0.97); C251(0.96)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C101(0.95); C374(1.01); C238(0.96)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C101(1.06); C374(1.21); C251(1.11)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C101(1.04); C160(0.94); C238(0.95)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C101(1.12); C160(1.00)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C101(0.93); C374(1.11); C238(1.11)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C101(1.04); C160(1.04)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C101(0.97)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C101(1.06); C160(0.99)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C101(0.97); C160(0.92); C251(0.97)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C101(1.10); C374(0.92); C238(0.95)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C101(1.01); C374(1.20); C251(0.76)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C101(0.88); C160(0.99); C238(0.88)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C101(1.00); C160(0.94)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C101(0.90); C374(1.07); C238(1.14)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C101(1.06); C160(1.07)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C101(1.13)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C101(1.00); C160(1.05); C251(0.88)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C101(0.96); C374(0.93); C238(0.88)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C101(0.89); C374(1.06); C238(1.26)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C101(0.98); C374(1.02); C251(0.73)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C101(0.99); C160(1.06); C238(0.94)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C101(1.01); C160(0.98)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C101(0.90); C374(0.96); C238(1.06)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C101(1.02); C160(1.03)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C101(0.96)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C101(0.91); C160(1.00); C251(0.85)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C101(1.04); C374(0.90); C238(0.99)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C101(1.09); C374(1.24); C251(1.01)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C101(0.94); C160(1.02); C238(0.91)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C101(1.03); C160(1.10)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C101(1.05); C160(0.93)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C101(0.83); C374(0.88); C238(1.01)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C101(0.96); C160(0.95)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C101(1.00)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C101(0.89); C160(1.04); C251(0.99)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C101(1.06)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C101(0.88); C160(1.08); C251(0.95)  LDD1569  [26]
 LDCM0520  AKOS000195272 MDA-MB-231 C374(0.59)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C101(0.92); C374(0.98); C238(1.18)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C101(0.98); C374(0.96); C238(1.02)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C101(0.96); C160(1.03); C251(0.91)  LDD1514  [26]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [5]
 LDCM0498  BS-3668 MDA-MB-231 C374(0.81)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C374(0.00); C160(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C101(0.99); C160(0.93)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C101(1.07); C160(0.95)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C101(1.10); C374(1.33)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C101(0.86); C160(0.91)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C101(0.90)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C101(0.89); C160(0.95)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C101(1.00); C374(1.20)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C101(1.04); C160(0.91)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C101(0.93)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C101(0.99); C160(0.81)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C101(0.97); C374(1.26)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C101(0.88); C160(0.97)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C101(0.94)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C101(0.93)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C101(1.24); C160(0.87)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C101(1.08); C374(1.24)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C101(0.94); C160(0.81)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C101(0.93)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C101(0.95); C160(0.88)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C101(0.92); C374(1.29)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C101(0.90); C160(0.82)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C101(1.05)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C101(1.05); C160(0.88)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C101(0.99); C160(1.00); C251(1.01)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C101(1.01); C374(1.36)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C101(0.83); C160(0.90)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C101(0.94)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C101(1.02); C160(0.96)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C101(0.95); C374(1.38)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C101(0.97); C160(0.95)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C101(1.12)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C101(1.13); C160(0.88)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C101(1.04); C374(1.20)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C101(1.07); C160(0.95)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C101(0.89)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C101(1.03); C160(0.86)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C101(0.99); C374(1.34)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C101(1.06); C374(0.96); C238(0.99)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C101(1.12); C374(1.08); C251(0.94)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C101(0.99); C160(1.00); C238(1.06)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C101(1.08)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C101(0.99); C160(1.21)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C101(0.87); C374(0.97); C238(0.83)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C101(0.95); C160(1.00)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C101(1.03)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C101(1.14); C160(1.00); C251(1.07)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C101(0.86); C160(0.86)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C101(0.84)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C101(1.02); C160(0.86)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C101(0.99); C374(1.50)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C101(0.94); C374(0.96); C238(1.16)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C101(0.94); C160(0.94)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C101(1.01); C374(1.19); C251(1.27)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C101(1.10); C160(1.02); C238(0.97)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C101(1.04); C160(1.08)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C101(0.84); C374(0.94); C238(1.03)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C101(0.87); C160(0.95)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C101(0.99)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C101(0.97); C160(1.07); C251(0.92)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C101(0.93); C160(0.91)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C101(0.96); C160(0.98)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C101(1.01); C374(1.38)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C101(1.04); C374(1.42)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C101(1.02); C374(0.73); C238(1.10)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C101(1.10); C374(1.08); C251(0.87)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C101(1.00); C160(0.92); C238(0.94)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C101(0.95); C160(1.08)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C101(0.82); C374(1.17); C238(1.11)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C101(1.06); C160(0.95)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C101(0.97)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C101(0.90); C160(0.96); C251(0.95)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C101(1.04); C160(0.95)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C101(0.97); C374(0.94); C238(1.23)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C101(1.15)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C101(0.95); C374(1.29)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C101(1.02); C374(0.92); C238(0.95)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C101(1.18); C374(1.16); C251(0.56)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C101(0.98); C160(1.09); C238(1.04)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C101(0.97); C160(1.10)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C101(0.89); C374(0.98); C238(0.89)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C101(1.03); C160(0.90)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C101(1.12)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C101(1.00); C374(1.17); C251(0.92)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C101(1.06); C160(1.06); C251(0.82)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C101(0.99); C160(0.90)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C101(0.98)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C101(1.12); C160(0.93)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C101(0.92); C374(1.24)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C101(0.97); C374(1.05); C238(1.09)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C101(1.02); C374(1.14); C251(0.96)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C101(1.01); C160(1.03); C238(1.08)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C101(1.04); C160(0.93)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C101(0.96); C374(0.94); C238(1.00)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C101(1.09); C160(1.06); C238(1.13)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C101(1.07); C160(0.94)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C101(1.06)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C101(1.02); C160(0.99); C251(0.82)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C101(1.03); C160(0.84)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C101(0.91)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C101(0.89); C374(1.30)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C101(0.91); C374(0.88); C238(1.04)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C101(0.97); C374(1.14); C251(0.97)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C101(0.97); C160(1.02); C238(1.01)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C101(0.93); C160(1.08)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C101(1.12); C160(1.37)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C101(0.86); C374(1.03); C238(1.05)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C101(1.03); C160(0.99)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C101(1.06)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C101(0.77); C160(0.99); C251(1.00)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C101(0.98); C160(0.97)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C101(0.92)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C101(1.14); C160(0.83)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C101(1.06); C374(1.38)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C101(0.93); C374(0.89); C238(0.85)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C101(1.08); C374(1.07); C238(1.14)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C101(0.90); C374(1.19); C251(0.79)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C101(0.97); C160(1.06); C238(1.05)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C101(1.00); C160(1.11)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C101(0.83); C374(0.97); C238(0.97)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C101(1.02); C160(1.02)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C101(1.01)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C101(1.00); C160(0.99); C251(0.91)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C101(0.83); C160(0.84)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C101(1.01)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C101(0.97); C160(1.02)  LDD1697  [26]
 LDCM0095  DC-LC3IN-D5 HeLa 1.90  LDD0055  [9]
 LDCM0495  E2913 HEK-293T C101(0.86); C160(0.90)  LDD1698  [26]
 LDCM0625  F8 Ramos C101(0.53); C160(0.56)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C101(0.53); C160(0.66)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C101(2.30); C160(1.16)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C101(0.53); C160(0.81)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C101(1.09); C160(1.33)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C101(0.82); C160(1.22)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C101(0.45); C160(0.75)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C101(0.76); C160(1.11)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C101(1.59); C160(1.53)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C101(1.16); C160(1.18)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C101(1.50)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C101(1.12); C160(1.27)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C101(1.29); C160(1.41)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C101(0.46); C160(0.80)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C101(1.02); C160(0.95)  LDD1671  [26]
 LDCM0596  Fragment38 Ramos C101(0.98); C160(0.94)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C101(0.60); C160(0.51)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C101(1.03)  LDD1631  [26]
 LDCM0610  Fragment52 Ramos C101(1.32); C160(1.60)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C101(1.04); C160(1.39)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C101(0.75); C160(0.60)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C101(0.49); C160(0.58)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y232(0.72)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y232(1.00)  LDD0265  [11]
 LDCM0119  HHS-0401 DM93 Y232(1.21)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y232(0.98)  LDD0268  [11]
 LDCM0107  IAA HeLa C374(0.00); C160(0.00)  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y12(2.99)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y12(0.89)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y12(1.72)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y12(18.86)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y12(5.86)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y12(4.63)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y12(1.25)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y12(2.00)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 C101(0.00); C160(0.00)  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C101(1.04); C160(1.03)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C101(1.02); C160(1.02)  LDD1497  [26]
 LDCM0024  KB05 COLO792 C119(1.19); C178(0.96)  LDD3310  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C374(1.07)  LDD2102  [8]
 LDCM0109  NEM HeLa C374(0.00); C160(0.00)  LDD0223  [21]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C374(1.25)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C374(1.22)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C374(1.62)  LDD2093  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C374(0.06)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C374(0.90)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C374(0.63)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C374(1.57)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C160(0.87)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C374(0.77)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C374(0.33)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C374(1.25)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C374(1.29); C160(1.21)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C374(0.48)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C374(0.87); C160(1.16)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C374(0.40)  LDD2110  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C374(0.48)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C374(0.38)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C374(0.38)  LDD2116  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C374(1.68)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C374(0.66); C160(1.18)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C160(1.47)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C374(1.16); C160(1.25)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C374(1.49)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C374(0.83)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C374(1.21)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C374(0.47)  LDD2133  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C374(2.70)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C374(1.07); C160(1.49)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C160(1.11)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C374(0.86)  LDD1700  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C374(0.59)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C374(0.75)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C374(2.21)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C374(1.33)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C374(2.00)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C374(0.45)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C160(0.83)  LDD2150  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C374(2.86)  LDD2153  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Human Calcitonin . DB06773
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-d-glucose 16-bisphosphate . DB02835
Alpha-d-glucose-1-phosphate-6-vanadate . DB04397

References

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2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD029255
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD041587
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25 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578