Details of the Target

General Information of Target

Target ID LDTP07323
Target Name Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2)
Gene Name MBLAC2
Gene ID 153364
Synonyms
Acyl-coenzyme A thioesterase MBLAC2; Acyl-CoA thioesterase MBLAC2; EC 3.1.2.2; Beta-lactamase MBLAC2; EC 3.5.2.6; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSS
GLLQDREAKEDAARRPLLAVATHVHFDHSGGLYQFDRVAVHHAEAEALARGDNFETVTWL
SDSEVVRTPSPGWRARQFRVQAVQPTLILQDGDVINLGDRQLTVMHMPGHSRGSICLHDK
DRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERL
FRLASNYISKAGICHKVSTFAMRSLASLALRVTNSRTSP
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, Glyoxalase II family
Subcellular location
Endoplasmic reticulum membrane
Function
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
Uniprot ID
Q68D91
Ensemble ID
ENST00000316610.7
HGNC ID
HGNC:33711

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.R182Ter .
HGC27 Deletion: p.S60del .
RKO SNV: p.V140L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K256(5.56)  LDD0277  [1]
BTD
 Probe Info  		C254(1.06)  LDD2107  [2]
Curcusone 37
 Probe Info  		3.88  LDD0188  [3]
Alkyne-RA190
 Probe Info  		3.61  LDD0303  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
DBIA
 Probe Info  		C176(0.97)  LDD1508  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
1c-yne
 Probe Info  		K226(0.00); K10(0.00)  LDD0228  [11]
AOyne
 Probe Info  		11.30  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C388
 Probe Info  		39.12  LDD2047  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C176(0.97)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C176(0.99)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C176(1.03)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C176(0.87)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C176(0.90)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C176(0.96)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C176(1.01)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C176(0.90)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C176(1.01)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C176(0.96)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C176(1.01)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C176(1.01)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C176(0.95)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C176(1.00)  LDD1528  [6]
 LDCM0291  AC30 HEK-293T C176(1.06)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C176(1.05)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C176(0.96)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C176(1.03)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C176(0.96)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C176(1.01)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C176(0.99)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C176(0.98)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C176(1.01)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C176(0.96)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C176(0.96)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C176(0.91)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C176(0.99)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C176(0.95)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C176(0.93)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C176(0.92)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C176(1.00)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C176(1.00)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C176(0.93)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C176(1.00)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C176(0.98)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C176(0.91)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C176(0.95)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C176(0.94)  LDD1560  [6]
 LDCM0323  AC6 HEK-293T C176(1.02)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C176(0.92)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C176(0.91)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C176(0.96)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C176(0.89)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C176(0.92)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C176(0.91)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C176(1.05)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C176(0.95)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C176(0.96)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C176(1.04)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C176(1.09)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C176(0.99); C212(0.97)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C176(1.03)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C176(0.96)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C176(1.04); C212(1.05)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C176(0.88); C212(1.01)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C176(0.99)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C176(0.98)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C176(0.93); C212(0.97)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C176(0.88); C212(1.06)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C176(0.96)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C176(0.95)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C176(1.02)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C176(0.97); C212(1.13)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C176(1.07); C212(1.01)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C176(1.08)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C176(1.04)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C176(0.98); C212(1.07)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C176(1.07); C212(0.97)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C176(1.06)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C176(0.95)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C176(1.06); C212(1.16)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C176(1.13)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C176(1.04); C212(1.07)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C176(0.93)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C176(1.01)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C176(0.98); C212(1.08)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C176(0.96); C212(1.06)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C176(0.90)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C176(0.93)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C176(1.02); C212(1.12)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C176(0.91); C212(1.04)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C176(0.94)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C176(1.07)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C176(1.12); C212(1.30)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C176(1.03); C212(0.96)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C176(0.97)  LDD1609  [6]
 LDCM0407  CL2 HEK-293T C176(1.08)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C176(0.97)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C176(0.98)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C176(0.98)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C176(0.95)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C176(1.13)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C176(0.93)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C176(0.93)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C176(0.97); C212(0.94)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C176(0.90); C212(0.98)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C176(1.14); C212(1.20)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C176(1.10)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C176(1.03)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C176(1.11)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C176(0.92)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C176(1.00)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C176(1.03)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C176(1.00)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C176(1.02); C212(0.98)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C176(1.07); C212(1.10)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C176(0.92); C212(1.12)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C176(0.90)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C176(1.03)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C176(1.00)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C176(1.07)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C176(0.98)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C176(1.01)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C176(0.97)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C176(0.98)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C176(1.02); C212(1.07)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C176(0.97)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C176(0.92)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C176(1.08)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C176(0.99)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C176(1.00)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C176(1.02)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C176(1.04)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C176(0.95)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C176(1.01)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C176(0.97); C212(1.19)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C176(0.94); C212(1.08)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C176(1.02)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C176(0.90)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C176(1.00)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C176(0.94)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C176(0.93)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C176(0.96)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C176(0.99)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C176(1.01)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C176(1.01); C212(1.06)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C176(0.96)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C176(0.90)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C176(1.03)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C176(1.01)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C176(0.97)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C176(0.96)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C176(0.95)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C176(0.94)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C176(0.91)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C176(0.92); C212(1.04)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C176(0.91); C212(1.04)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C176(0.94)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C176(0.88)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C176(0.89)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C176(0.95)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C176(0.94)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C176(0.82)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C176(0.89)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C176(0.99)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C176(0.94)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C176(0.98); C212(1.02)  LDD1697  [6]
 LDCM0033  Curcusone1d MCF-7 3.88  LDD0188  [3]
 LDCM0495  E2913 HEK-293T C176(0.91); C212(0.93)  LDD1698  [6]
 LDCM0625  F8 Ramos C212(0.95)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C212(0.56)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C212(3.96)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C212(0.52)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C212(0.85)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C212(0.96)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C212(0.45)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C212(0.77)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C212(0.85)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C212(1.19)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C212(0.95)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C212(1.03)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C212(1.21)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C212(0.54)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C176(1.03); C212(1.04)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C212(0.69)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C212(0.74)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C176(1.11)  LDD1631  [6]
 LDCM0610  Fragment52 Ramos C212(0.90)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C212(1.81)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C212(0.76)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C212(0.55)  LDD2188  [15]
 LDCM0022  KB02 Ramos C212(0.70)  LDD2182  [15]
 LDCM0023  KB03 Ramos C212(0.64)  LDD2183  [15]
 LDCM0024  KB05 Ramos C212(0.50)  LDD2185  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C254(1.06)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C254(0.92)  LDD2109  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C254(1.04)  LDD2137  [2]
 LDCM0131  RA190 SK-MEL-5 3.61  LDD0303  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD027578