Details of the Target

General Information of Target

Target ID LDTP00598
Target Name Serine palmitoyltransferase 2 (SPTLC2)
Gene Name SPTLC2
Gene ID 9517
Synonyms
KIAA0526; LCB2; Serine palmitoyltransferase 2; EC 2.3.1.50; Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
Target Bioclass
Enzyme
Family
Class-II pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Crucial for adipogenesis.
Uniprot ID
O15270
Ensemble ID
ENST00000216484.7
HGNC ID
HGNC:11278
ChEMBL ID
CHEMBL1250344

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.82  LDD0402  [1]
DA-P2
 Probe Info  		22.78  LDD0348  [2]
HRP
 Probe Info  		23.13  LDD0347  [2]
STPyne
 Probe Info  		K293(2.48)  LDD0277  [3]
BTD
 Probe Info  		C99(1.15); C511(1.00)  LDD2092  [4]
Sulforaphane-probe2
 Probe Info  		2.42  LDD0042  [5]
AHL-Pu-1
 Probe Info  		C19(5.60)  LDD0171  [6]
Alkyne-RA190
 Probe Info  		2.44  LDD0303  [7]
DBIA
 Probe Info  		C188(1.17)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C254(0.00); C188(0.00); C99(0.00); C425(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C511(0.00); C99(0.00); C425(0.00); C188(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C425(0.00); C139(0.00); C204(0.00); C99(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
WYneO
 Probe Info  		C188(0.00); C99(0.00)  LDD0022  [12]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C8(0.00); C10(0.00)  LDD0005  [12]
NPM
 Probe Info  		N.A.  LDD0016  [12]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		N.A.  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Acrolein
 Probe Info  		C188(0.00); C438(0.00); C511(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		14.50  LDD0443  [17]
NAIA_5
 Probe Info  		C19(0.00); C511(0.00); C99(0.00); C139(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C355
 Probe Info  		22.47  LDD2016  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		11.48  LDD0463  [19]
FFF probe3
 Probe Info  		11.77  LDD0465  [19]
OEA-DA
 Probe Info  		15.57  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C511(0.74)  LDD2142  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C99(1.19); C188(0.95)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C99(1.78); C511(1.58); C188(1.49)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C511(0.58)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C511(0.99)  LDD2131  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C19(5.60)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C188(1.30); C19(0.86); C8(0.97); C9(0.97)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C99(1.01); C10(1.10); C188(1.11); C19(1.04)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C99(0.92); C10(1.39); C188(0.89); C19(1.05)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C99(1.05); C10(0.76); C188(0.90); C19(1.16)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C99(0.99); C10(1.03); C188(0.95); C19(1.22)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C99(1.44); C10(1.96); C188(0.81); C19(1.28)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C99(1.23); C10(0.93); C188(0.93); C19(1.02)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C99(1.24); C10(1.39); C188(0.86); C19(1.52)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C99(1.42); C10(1.16); C188(0.90); C19(1.38)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C99(1.15); C10(1.08); C188(0.94); C19(1.16)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C99(1.05); C10(1.18); C188(0.86); C19(1.13)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C99(0.97); C10(1.26); C188(1.09); C19(1.04)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C99(1.84); C10(1.15); C188(1.03); C19(1.11)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C99(0.86); C10(1.32); C188(0.83); C19(1.41)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C99(1.09); C10(1.44); C188(0.80); C19(1.38)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C99(0.94); C10(0.97); C188(0.78); C19(1.14)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C99(0.95); C10(1.37); C188(1.25); C19(0.99)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C99(0.83); C10(0.89); C188(1.08); C19(1.15)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C99(0.87); C10(1.56); C188(1.18); C19(1.04)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C99(0.95); C10(1.20); C188(1.01); C19(0.98)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C99(1.05); C10(1.28); C188(1.07); C19(0.81)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C99(0.99); C10(1.35); C188(0.98); C19(1.17)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C99(0.91); C10(1.11); C188(1.08); C19(0.99)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C99(1.00); C10(0.90); C188(1.21); C19(0.96)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C99(1.20); C10(1.48); C188(0.93); C19(1.06)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C99(0.86); C10(1.62); C188(1.17); C19(0.89)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C99(0.84); C10(1.20); C188(0.98); C19(1.11)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C99(0.83); C10(1.01); C188(1.43); C19(0.92)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C99(0.92); C10(0.97); C188(1.02); C19(1.15)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C99(1.05); C10(1.25); C188(0.92); C19(1.01)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C99(0.99); C10(1.22); C188(1.04); C19(1.33)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C99(0.87); C10(1.04); C188(0.98); C19(1.10)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C99(1.47); C10(0.41); C188(1.42); C8(0.41)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C99(0.94); C10(0.49); C188(1.35); C8(0.49)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C99(1.50); C10(0.49); C188(1.42); C8(0.49)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C99(1.12); C10(0.94); C188(1.20); C8(0.94)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C99(1.11); C10(0.55); C188(1.19); C8(0.55)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C99(1.20); C10(0.46); C188(1.40); C8(0.46)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C99(1.65); C10(0.51); C188(1.07); C8(0.51)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C99(1.79); C10(0.52); C188(1.17); C8(0.52)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C99(1.29); C10(0.46); C188(1.19); C8(0.46)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C99(1.03); C10(0.63); C188(1.13); C8(0.63)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C99(1.36); C10(0.31); C188(0.97); C8(0.31)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C99(1.29); C10(0.46); C188(0.99); C8(0.46)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C99(1.37); C10(1.31); C188(1.12); C19(0.85)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C99(1.48); C10(0.53); C188(0.88); C8(0.53)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C99(1.18); C10(0.49); C188(0.85); C8(0.49)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C99(0.94); C10(0.39); C188(1.01); C8(0.39)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C99(1.37); C188(0.98); C9(1.14); C19(1.17)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C8(0.74); C9(0.97); C188(1.09); C10(1.31)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C8(0.72); C10(0.86); C9(1.00); C19(1.05)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C8(1.04); C10(1.09); C188(1.18); C9(1.26)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C9(0.88); C8(0.94); C188(1.01); C10(1.08)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C8(0.81); C10(1.04); C188(1.07); C9(1.09)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C9(0.93); C8(0.93); C10(1.04); C188(1.21)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C19(0.92); C425(1.11); C8(1.24); C188(1.25)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C8(0.82); C9(1.02); C10(1.07); C188(1.08)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C10(0.79); C8(0.99); C188(1.15); C9(1.16)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C9(0.94); C8(0.99); C10(1.00); C188(1.04)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C8(0.88); C10(1.07); C188(1.17); C9(1.24)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C99(5.57); C10(0.93); C188(1.20); C19(1.46)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C99(2.17); C10(1.17); C188(1.30); C19(1.76)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C99(1.63); C10(0.92); C188(1.17); C19(1.40)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C99(1.74); C10(1.24); C188(1.04); C19(1.46)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C8(0.48); C10(0.54); C9(0.54); C19(0.87)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C8(0.60); C10(0.65); C9(0.65); C19(0.91)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C8(0.57); C10(0.64); C9(0.64); C19(0.83)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C19(0.92); C188(0.94); C8(1.01); C9(1.01)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C8(0.22); C10(0.43); C9(0.43); C438(0.94)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C8(0.25); C10(0.45); C9(0.45); C19(0.81)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C8(0.62); C10(0.68); C9(0.68); C19(0.72)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C8(0.59); C10(0.65); C9(0.65); C19(0.90)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C10(0.70); C9(0.70); C8(0.72); C19(0.87)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C19(0.84); C188(1.00)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C188(0.95); C19(1.14)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C188(0.96); C19(1.22)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C188(0.98); C19(1.05)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C188(0.84); C19(1.12)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C19(0.90); C188(1.05); C8(1.10); C9(1.10)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C188(0.86); C19(1.20)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C188(1.02); C19(1.12)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C188(0.88); C19(1.23)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C188(0.81); C19(1.33)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C188(0.78); C19(1.05)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C19(0.66); C188(0.97); C10(1.08); C9(1.08)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C19(0.87); C188(0.89); C10(0.89); C9(0.89)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C10(0.81); C9(0.81); C188(1.03); C19(1.10)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C188(0.87); C10(0.87); C9(0.87); C19(1.24)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C188(0.84); C10(1.10); C9(1.10); C19(1.23)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C19(0.93); C188(1.21); C8(1.24); C9(1.24)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C10(0.73); C9(0.73); C188(0.82); C19(0.99)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C10(0.50); C9(0.50); C19(0.77); C188(0.81)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C10(0.65); C9(0.65); C188(0.78); C19(1.02)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C10(0.49); C9(0.49); C188(0.76); C19(1.07)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C10(0.44); C9(0.44); C188(0.87); C19(0.89)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C10(0.46); C9(0.46); C188(0.87); C19(0.97)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C188(0.87); C438(1.01)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C188(0.94); C438(1.08)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C188(0.88); C438(1.03)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C188(0.89); C438(0.95)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C19(0.79); C8(1.14); C9(1.14); C188(1.20)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C188(0.92); C438(0.98)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C188(0.79); C438(0.95)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C188(0.83); C438(0.94)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C188(0.94); C438(1.00)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C188(0.89); C438(1.00)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C188(0.96); C438(1.11)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C188(0.76); C438(1.05)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C10(0.73); C8(0.73); C9(0.73); C19(1.06)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C10(0.81); C8(0.81); C9(0.81); C19(1.03)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C19(1.22); C99(1.36); C10(1.38); C8(1.38)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C188(0.88); C19(0.97); C10(0.98); C9(0.98)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C10(1.05); C8(1.05); C9(1.05); C19(1.08)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C19(0.94); C10(0.97); C8(0.97); C9(0.97)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C19(0.86); C10(1.06); C8(1.06); C9(1.06)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C10(1.01); C8(1.01); C9(1.01); C19(1.14)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C19(1.20); C10(1.29); C8(1.29); C9(1.29)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C10(0.85); C8(0.85); C9(0.85); C19(1.02)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C10(0.74); C8(0.74); C9(0.74); C19(0.94)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C10(0.81); C8(0.81); C9(0.81); C19(1.09)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C188(0.77); C99(1.22); C8(1.24); C9(1.24)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C188(0.79); C99(1.04); C8(1.07); C9(1.07)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C19(0.83); C10(0.94); C9(0.94); C425(1.05)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C188(0.69); C8(1.35); C9(1.35); C10(1.58)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C188(0.80); C8(1.17); C9(1.17); C99(1.20)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C188(0.68); C99(1.04); C8(1.74); C9(1.74)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C99(1.66); C188(0.73); C8(1.52); C9(1.52)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C188(0.89); C8(1.37); C9(1.37); C10(1.53)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C188(0.73); C99(1.63); C8(1.70); C9(1.70)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C188(0.84); C8(1.11); C9(1.11); C99(1.22)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C188(0.72); C8(1.26); C9(1.26); C99(1.52)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C188(0.75); C99(1.04); C8(1.26); C9(1.26)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C188(0.63); C99(1.06); C8(1.52); C9(1.52)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C10(0.83); C9(0.83); C8(0.86); C19(0.89)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C188(0.91); C99(0.97); C8(1.28); C9(1.28)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C188(0.68); C99(0.82); C8(1.16); C9(1.16)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C188(0.80); C8(1.20); C9(1.20); C19(1.50)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C19(1.08); C188(1.17); C10(1.41); C9(1.41)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C19(0.85); C188(1.08); C10(1.15); C9(1.15)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C10(0.69); C9(0.69); C8(0.82); C19(0.83)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C19(0.94); C188(0.95); C99(1.36); C10(1.59)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C10(0.84); C9(0.84); C188(0.97); C19(0.97)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C19(0.89); C188(0.95); C99(1.02); C10(1.17)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C19(0.73); C188(0.90); C99(1.26); C10(1.38)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C99(0.86); C19(0.93); C188(0.94); C10(1.30)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C19(0.71); C188(1.14); C99(1.92); C10(2.40)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C19(0.92); C188(1.16); C10(1.19); C9(1.19)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C19(0.70); C10(0.84); C9(0.84); C188(0.96)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C19(0.84); C99(1.06); C10(1.23); C9(1.23)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C19(0.76); C188(0.85); C99(1.15); C10(1.61)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C19(0.85); C10(1.08); C9(1.08); C188(1.11)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C19(0.82); C188(0.97); C99(1.49); C10(1.51)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C188(0.84); C438(0.92); C10(1.10); C8(1.10)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C99(0.75); C188(0.78); C438(1.00); C19(1.28)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C511(0.88)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C99(1.07); C10(0.83); C188(1.07); C19(0.94)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C10(0.98); C9(0.98); C19(1.06); C425(1.06)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C8(0.93); C425(1.00); C19(1.03); C188(1.08)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C188(1.17)  LDD0078  [8]
 LDCM0087  Capsaicin HEK-293T 108.41  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa C188(0.00); C204(0.00); C438(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C188(0.58); C99(0.31)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C188(0.84); C425(0.89); C19(1.10); C10(1.23)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C425(0.69); C19(0.83); C188(1.05); C10(1.48)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C19(0.99); C188(1.23); C8(1.24); C9(1.24)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C19(0.90); C188(0.93); C425(1.10); C99(1.13)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C19(0.93); C188(0.94); C425(1.10); C99(1.24)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C19(0.93); C99(1.07); C8(1.21); C188(1.23)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C19(0.85); C8(1.05); C188(1.13); C10(1.17)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C8(0.38); C10(0.54); C9(0.54); C19(0.69)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C8(0.65); C19(0.75); C10(0.78); C9(0.78)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C8(0.51); C10(0.70); C9(0.70); C19(0.81)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C8(0.60); C10(0.71); C9(0.71); C19(0.86)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C8(0.60); C10(0.66); C9(0.66); C425(0.91)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C425(0.82); C188(0.94); C19(0.95); C10(1.18)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C10(0.63); C9(0.63); C8(0.66); C19(0.77)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C8(0.56); C10(0.75); C9(0.75); C19(0.76)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C188(0.91); C19(1.24)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C188(0.79); C19(1.09)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C188(0.71); C19(1.02)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C188(0.75); C19(1.19)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C188(0.85); C19(1.00)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C10(0.73); C9(0.73); C188(0.75); C19(0.82)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C19(0.54); C10(0.87); C9(0.87); C188(0.93)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C19(0.61); C10(0.88); C9(0.88); C188(0.94)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C19(0.71); C425(0.93); C188(0.99); C10(1.50)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C10(0.65); C9(0.65); C19(0.80); C188(0.85)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C188(0.89); C438(0.91)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C188(0.86); C438(0.94)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C188(0.69); C438(1.04)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C188(0.76); C438(1.05)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C99(1.01); C19(1.02); C10(1.04); C8(1.04)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C10(1.01); C8(1.01); C9(1.01); C19(1.02)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C10(0.90); C8(0.90); C9(0.90); C19(0.97)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C10(0.65); C8(0.65); C9(0.65); C19(1.11)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C19(0.87); C188(0.88); C425(0.89); C10(1.88)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C19(0.85); C425(0.99); C188(1.00); C10(1.65)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C19(0.80); C188(0.89); C425(0.97); C10(2.09)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C188(0.81); C19(1.05); C425(1.07); C10(1.22)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C19(0.75); C425(0.90); C8(0.96); C188(1.02)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C425(0.81); C19(1.00); C188(1.03); C8(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C425(0.96); C19(1.03); C188(1.31); C8(1.39)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C19(0.72); C188(0.98); C425(1.03); C10(1.33)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C188(0.88); C425(1.01); C19(1.28); C10(1.61)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C425(0.99); C19(1.06); C188(1.07); C8(1.74)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C425(0.75); C188(1.01); C19(1.15); C10(1.48)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C188(0.88); C425(0.94); C19(1.14); C10(1.17)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C10(1.12); C188(0.99); C19(1.25); C425(1.00)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C10(1.02); C188(0.85); C19(0.83); C425(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C10(1.84); C188(0.98); C19(1.16); C425(1.00)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C10(1.31); C188(0.85); C19(0.97); C425(1.09)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C10(1.74); C188(1.06); C19(0.76); C425(0.88)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C10(1.41); C188(1.03); C19(0.88); C425(1.32)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C10(1.35); C188(1.28); C19(0.99); C425(0.97)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C10(1.35); C188(0.98); C19(0.94); C425(1.09)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C99(1.09); C188(0.93); C19(0.96)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C99(0.78); C10(1.24); C188(0.90); C19(1.07)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C99(0.94); C10(0.83); C188(0.91); C19(0.82)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C99(7.64); C10(1.97); C188(0.89); C19(0.69)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C99(1.16); C10(1.69); C188(0.83); C19(0.82)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C99(0.98); C10(1.75); C188(0.71); C19(0.80)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C99(1.20); C10(1.33); C188(0.84); C19(0.87)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C99(0.98); C10(0.93); C188(0.79); C19(0.73)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C10(1.35); C188(0.99); C19(1.05); C425(0.99)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C99(2.60); C10(1.01); C188(0.68); C19(0.83)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C99(0.85); C10(1.96); C188(0.96); C19(0.92)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C99(1.15); C10(0.87); C188(0.82); C19(0.66)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C99(0.76); C10(1.53); C188(0.81); C19(0.79)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C99(1.11); C10(1.64); C188(0.92); C19(0.77)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C99(0.80); C10(1.58); C188(0.77); C19(0.73)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C99(0.84); C188(0.98); C19(1.16); C8(0.96)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C99(0.73); C188(0.95); C19(0.93); C8(1.20)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C99(0.73); C188(1.05); C19(1.07); C8(1.29)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C99(0.73); C188(1.25); C19(1.12); C8(0.98)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C10(1.71); C188(1.06); C19(0.76); C425(1.05)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C99(0.87); C188(0.99); C19(1.15); C8(1.31)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C99(0.74); C188(1.03); C19(1.00); C8(0.94)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C99(1.08); C188(0.99); C19(1.11); C8(1.09)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C99(1.43); C188(0.84); C19(0.93); C8(2.17)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C99(0.69); C188(0.90); C19(0.97); C8(1.60)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C99(0.71); C188(0.94); C19(1.00); C8(0.83)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C99(0.77); C188(0.98); C19(0.94); C8(1.14)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C99(0.93); C188(1.03); C19(0.99); C8(1.63)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C99(0.66); C188(1.04); C19(1.02); C8(1.21)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C99(0.66); C188(1.04); C19(1.18); C8(1.95)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C10(1.87); C188(0.93); C19(0.79); C425(0.96)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C99(0.73); C188(1.12); C19(1.09); C8(1.55)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C99(1.36); C10(0.99); C188(1.04); C19(0.95)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C99(1.52); C10(1.19); C188(1.16); C19(1.16)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C99(1.27); C10(1.17); C188(0.97); C19(0.90)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C99(1.15); C10(1.04); C188(0.98); C19(0.82)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C99(1.56); C10(1.26); C188(1.11); C19(1.03)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C99(1.33); C10(1.16); C188(1.09); C19(1.09)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C99(1.09); C10(0.80); C188(1.06); C19(1.06)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C99(1.78); C10(0.76); C188(0.86); C19(0.87)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C99(1.24); C10(0.90); C188(0.90); C19(1.03)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C10(1.79); C188(1.07); C19(0.78); C425(0.96)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C99(1.45); C10(0.87); C188(0.98); C19(1.10)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C99(1.36); C10(0.99); C188(0.98); C19(0.96)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C99(2.64); C10(0.91); C188(0.83); C19(0.93)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C99(1.68); C10(0.78); C188(0.97); C19(0.74)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C99(1.34); C10(1.31); C188(0.92); C19(1.18)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C99(1.08); C188(0.94); C19(0.99)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C99(1.15); C188(1.06); C19(0.99)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C99(1.08); C188(0.96); C19(1.00)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C99(1.31); C188(0.95); C19(1.00)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C10(1.02); C188(0.75); C19(2.83); C425(0.76)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C99(1.15); C188(1.07); C19(1.06)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C99(1.23); C188(1.28); C19(1.48)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C99(1.60); C188(1.43); C19(1.05)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C99(1.47); C188(1.22); C19(0.96)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C99(3.17); C188(0.94); C19(1.37)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C99(1.09); C188(0.93); C19(1.06)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C99(1.14); C188(1.07); C19(1.04)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C99(1.50); C188(1.14); C19(0.94)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C99(1.46); C188(1.28); C19(0.95)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C99(1.82); C188(1.12); C19(1.01)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C10(1.06); C188(1.06); C19(0.93); C425(0.96)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C99(3.64); C188(1.04); C19(0.69)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C188(0.86); C19(1.09); C8(1.15); C9(1.15)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C188(0.84); C19(0.95); C8(1.02); C9(1.02)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C188(0.98); C19(0.75); C8(0.99); C9(0.99)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C188(1.04); C19(0.96); C8(1.22); C9(1.22)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C188(0.80); C19(1.12); C8(1.05); C9(1.05)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C188(0.85); C19(0.93); C8(1.07); C9(1.07)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C188(0.88); C19(0.94); C8(1.23); C9(1.23)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C188(1.03); C19(0.84); C8(1.08); C9(1.08)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C188(1.06); C19(0.92); C8(1.11); C9(1.11)  LDD0811  [8]
 LDCM0028  Dobutamine HEK-293T 17.99  LDD0180  [2]
 LDCM0495  E2913 HEK-293T C99(1.27); C188(1.02); C19(0.93); C438(0.98)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C99(9.63); C139(3.19); C188(1.46)  LDD1702  [4]
 LDCM0625  F8 Ramos C188(1.18); C19(1.12); C139(1.10); C511(0.58)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C188(1.24); C19(1.87); C139(1.24); C511(0.85)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C188(3.75); C19(0.29); C139(0.45); C511(1.07)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C188(0.93); C19(1.37); C139(0.72); C511(1.14)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C188(0.89); C19(0.74); C139(0.74); 0.62  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C188(1.00); C19(2.90); C139(1.22); C99(1.02)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C188(0.99); C19(2.05); C139(0.78); C511(0.90)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C188(0.94); C19(0.83); C139(0.73); C511(0.86)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C188(0.54); C19(0.69); C139(0.96); C511(0.97)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C188(0.97); C19(0.67); C139(1.11); C511(0.61)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C188(0.68); C19(0.95); C139(0.90); C99(0.67)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C188(1.53); C19(0.93); C139(0.85); C511(1.81)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C188(0.83); C19(0.87); C139(0.81); C511(0.91)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C188(1.13); C19(1.57); C139(0.69); C511(1.14)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C99(1.27); C10(0.89); C188(1.02); C19(1.07)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C188(0.79); C19(1.00); C139(1.86); C511(0.80)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C188(0.94); C19(1.54); C139(1.10); C99(1.85)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C99(3.47); C10(1.23); C188(0.60); C19(0.92)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C188(1.18); C19(1.06); C139(0.72)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C188(1.44); C19(1.25); C139(0.74); 0.54  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C188(1.14); C19(1.77); C139(1.23); C99(1.69)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C188(1.28); C19(2.26); C139(0.75); C511(0.80)  LDD2188  [22]
 LDCM0022  KB02 HEK-293T C188(0.93); C19(1.04); C438(0.95); C139(0.93)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C188(1.16); C19(0.96); C438(0.98); C139(1.01)  LDD1497  [21]
 LDCM0024  KB05 G361 C19(2.64); C438(1.93); C188(1.99); C204(2.01)  LDD3311  [23]
 LDCM0030  Luteolin HEK-293T 56.56  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0226  [15]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C99(1.15); C511(1.00)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C188(0.79)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C99(1.02)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C511(0.57)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C511(1.49)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C99(1.11); C188(0.85)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C511(1.20)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C99(0.89); C511(0.87)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C188(0.92)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C511(0.98)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C99(1.07); C188(0.90)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C511(1.86); C188(1.09); C139(0.99)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C511(0.64)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C511(1.50)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C511(1.06)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C511(2.81)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C99(0.88); C511(1.01); C188(1.31); C139(0.83)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C511(1.15); C188(1.01); C139(0.94)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C99(1.40); C188(1.03); C139(0.93)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C99(0.74)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C511(1.03)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C511(2.46)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C99(1.12); C188(1.10)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C99(1.05); C511(1.07); C188(0.85); C139(0.94)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C99(1.08); C511(2.11); C188(0.67)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C99(0.63); C188(0.88)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C511(1.71)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C99(0.38)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C99(0.91); C511(1.74)  LDD2146  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C511(1.15)  LDD2151  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C19(0.86)  LDD2206  [24]
 LDCM0029  Quercetin HEK-293T 48.49  LDD0181  [2]
 LDCM0131  RA190 SK-MEL-5 2.44  LDD0303  [7]
 LDCM0003  Sulforaphane MCF-7 2.42  LDD0042  [5]
 LDCM0021  THZ1 HCT 116 C19(1.30); C10(1.16); C8(1.16); C9(1.16)  LDD2173  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyridoxal Phosphate Small molecular drug DB00114
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Serine Small molecular drug DB00133

References

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2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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