Details of the Target

General Information of Target

Target ID LDTP12057
Target Name ATPase PAAT (PAAT)
Gene Name PAAT
Gene ID 80007
Synonyms
C10orf88; ATPase PAAT; EC 3.6.1.-; Protein associated with ABC transporters; PAAT
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFTVIYNEQMASKKRELFS
NLQEFAGPSGKLSLLEVGCGTGANFKFYPPGCRVTCIDPNPNFEKFLIKSIAENRHLQFE
RFVVAAGENMHQVADGSVDVVVCTLVLCSVKNQERILREVCRVLRPGGAFYFMEHVAAEC
STWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFSKLKLQHIQAPLSWELVRPHIYG
YAVK
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.
Uniprot ID
Q9H8K7
Ensemble ID
ENST00000481909.2
HGNC ID
HGNC:25822

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [1]
AHL-Pu-1
 Probe Info  		C375(5.53)  LDD0168  [2]
Alkyne-RA190
 Probe Info  		2.10  LDD0303  [3]
DBIA
 Probe Info  		C353(5.01)  LDD0209  [4]
IA-alkyne
 Probe Info  		C117(0.00); C144(0.00)  LDD0165  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [7]
Compound 10
 Probe Info  		C218(0.00); C353(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C218(0.00); C353(0.00)  LDD2213  [8]
IPM
 Probe Info  		C218(0.00); C375(0.00)  LDD2156  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.92  LDD1838  [12]
C278
 Probe Info  		48.50  LDD1948  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C375(5.53)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C375(5.01)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C108(0.95); C73(0.75)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C73(0.81)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C108(0.88); C73(1.01)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C108(1.06); C73(0.87)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C108(1.02); C73(0.87)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C108(1.01); C73(0.96)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C108(0.90); C73(1.06)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C108(1.02); C73(1.05)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C108(0.84); C73(1.00)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C108(0.84); C73(0.93)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C108(0.95); C73(0.90)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C108(0.89); C73(1.14)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C73(0.81)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C108(0.93); C73(0.87)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C108(0.91); C73(1.00)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C108(0.90); C73(0.86)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C108(1.11); C73(1.03)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C108(1.09); C73(0.96)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C108(1.07); C73(0.86)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C108(0.97); C73(1.01)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C108(1.01); C73(1.19)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C108(1.30); C73(1.01)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C108(1.06); C73(1.47)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C73(0.99)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C108(1.19); C73(1.12)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C108(1.01); C73(1.80)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C108(1.15); C73(0.98)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C108(1.04); C73(0.92)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C108(0.89); C73(1.50)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C108(1.15); C73(1.09)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C108(1.06); C73(0.96)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C108(1.26); C73(1.15)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C73(1.30)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C73(0.98)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C73(0.84)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C73(0.88)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C73(0.68)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C73(0.85)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C73(0.76)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C73(0.83)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C73(0.68)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C73(0.76)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C73(0.80)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C73(0.63)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C73(0.82)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C73(0.69)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C73(0.77)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C73(0.75)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C73(1.10)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C73(0.69)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C73(0.87)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C73(0.60)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C73(0.82)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C73(0.77)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C73(0.58)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C73(0.87)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C73(0.80)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C73(0.87)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C73(0.73)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C73(0.53)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C73(0.76)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C73(0.72)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C73(1.47)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C73(1.21)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C108(0.75); C73(0.86)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C108(0.63); C73(0.72)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C108(0.78); C73(0.83)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C73(0.84); C108(0.98)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C108(0.66); C73(0.78)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C108(0.76); C73(0.85)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C73(0.84); C108(0.86)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C108(0.62); C73(0.79)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C108(0.80); C73(0.91)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C108(0.80); C73(0.99); C353(1.04)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C73(0.83); C108(0.86); C353(1.22)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C108(0.70); C73(0.96); C353(1.39)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C108(0.81); C73(1.05); C353(1.16)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C108(0.75); C73(0.80); C353(1.63)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C73(0.97); C108(1.13)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C73(0.74); C108(0.78); C353(1.65)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C108(0.83); C73(0.89); C353(1.38)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C108(0.66); C73(0.71); C353(1.56)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C73(0.88); C108(0.96); C353(1.32)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C108(0.77); C73(0.85); C353(1.10)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C353(0.96); C73(1.17)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C73(0.92); C353(1.16)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C353(0.85); C73(1.03)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C73(1.01); C353(1.20)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C73(0.95); C353(0.96)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C73(1.06); C108(1.17)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C73(0.97); C353(1.00)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C73(0.85); C353(1.04)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C73(0.90); C353(1.24)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C73(0.78); C353(1.11)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C353(0.87); C73(1.03)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C353(0.85); C73(0.95)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C73(0.81)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C73(1.06)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C73(0.65)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C73(0.96)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C73(0.94); C108(1.09)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C73(0.94)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C73(1.09)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C73(0.92)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C73(0.93)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C73(0.86)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C73(1.20)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C73(0.94)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C108(0.80); C73(0.85)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C73(0.82); C108(0.87)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C73(0.71); C108(0.88)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C73(0.75)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C73(0.70); C108(0.73)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C108(0.65); C73(0.67)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C73(0.71); C108(0.75)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C108(0.74); C73(0.76)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C73(0.76); C108(0.92)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C73(0.68); C108(0.98)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C73(0.75); C108(0.88)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C73(0.56); C108(0.66)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C73(0.88); C108(1.05)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C73(1.06); C108(1.07)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C73(0.80)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C73(0.90); C108(1.00)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C108(1.03); C73(1.31)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C73(0.94); C108(0.95)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C108(0.81); C73(0.88)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C108(0.85); C73(1.06)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C73(0.85); C108(1.09)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C108(1.07); C73(1.22)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C108(1.01); C73(1.05)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C73(0.87); C108(0.96)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C73(0.96); C108(0.98)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C73(0.76)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C108(1.11); C73(1.26)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C73(0.96); C108(1.14)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C73(0.93); C108(1.08)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C73(0.62)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C73(0.60)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C73(0.54)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C73(0.93)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C73(0.85)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C73(0.95)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C73(0.91)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C73(1.88)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C73(0.84)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C73(0.82)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C73(0.80)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C73(0.72)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C73(0.57)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C73(0.70)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C73(0.86)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C73(0.70); C108(0.77)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C73(0.78); C108(0.99)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C73(0.84)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C73(0.82)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C73(0.67)  LDD0592  [13]
 LDCM0367  CL1 HCT 116 C73(0.81)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C73(0.73)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C73(0.90); C108(1.12)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C73(0.78)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C73(0.83)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C73(0.85)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C73(0.84)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C108(0.64); C73(0.72)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C108(0.49); C73(0.70)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C108(0.65); C73(0.71)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C108(0.73); C73(0.99)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C73(0.61); C108(0.64)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C73(0.88)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C108(0.66); C73(0.92)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C73(0.58); C108(0.70)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C108(0.81); C73(1.03); C353(1.25)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C108(0.77); C73(0.88); C353(1.57)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C73(0.65); C108(0.68); C353(1.36)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C73(0.86); C108(0.99); C353(1.38)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C108(0.80); C73(0.92); C353(1.06)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C73(0.91); C353(1.08)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C73(0.91); C353(1.04)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C73(0.91); C353(1.17)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C73(0.84)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C73(0.93); C353(1.20)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C73(0.98)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C73(0.80)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C73(0.87)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C73(0.88)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C73(0.76); C108(1.13)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C73(0.76); C108(1.14)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C73(0.73); C108(0.98)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C73(0.85); C108(0.91)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C73(1.03)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C73(0.96)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C73(0.99)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C73(0.76)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C73(0.54)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C73(0.39)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C73(0.48)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C73(0.84)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C73(0.79)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C73(0.57)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C73(0.58)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C73(0.91)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C73(0.65)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C73(0.64)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C73(0.73)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C73(0.69)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C73(0.58)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C73(0.58)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C73(0.86)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C73(0.68)  LDD0736  [13]
 LDCM0420  CL31 HEK-293T C73(1.02)  LDD1018  [13]
 LDCM0421  CL32 HCT 116 C73(0.75)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C73(0.90)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C73(0.95)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C73(0.81)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C73(1.40)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C73(0.99)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C73(0.91)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C73(0.86)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C73(0.98)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C73(1.07)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C73(1.26)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C73(0.97)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C73(0.96)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C73(0.97)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C353(1.08); C73(0.79)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C353(1.01); C73(0.86)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C353(0.89); C73(0.79)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C353(0.90); C73(1.09)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C73(1.03)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C353(0.91); C73(0.82)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C353(1.03); C73(0.96)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C353(1.01); C73(0.70)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C353(0.95); C73(0.86)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C353(0.84); C73(0.87)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C353(0.86); C73(1.04)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C353(0.79); C73(1.01)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C353(0.86); C73(1.06)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C353(0.98); C73(0.94)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C353(0.85); C73(1.01)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C73(0.80)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C353(0.84); C73(0.79)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C353(0.99)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C353(0.83)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C353(0.75)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C353(0.95)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C353(0.92)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C353(0.82)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C353(1.18)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C353(0.64)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C353(0.81)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C73(0.96)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C353(0.92)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C353(0.78)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C353(1.16)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C353(0.86)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C353(0.85)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C73(1.25)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C73(1.17)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C73(0.89)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C73(1.28)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C73(0.98)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C73(1.04)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C73(1.46)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C73(1.84)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C73(1.40)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C73(1.14)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C73(1.11)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C73(1.12)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C73(1.98)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C73(1.95)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C73(1.14)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C73(0.99)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C73(1.31)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C108(0.89); C73(1.02)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C108(0.87); C73(0.89)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C108(0.91); C73(0.95)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C108(1.02); C73(0.93)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C108(0.85); C73(0.88)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C108(0.89); C73(0.94)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C108(0.92); C73(0.93)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C108(0.83); C73(0.88)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C108(1.02); C73(0.90)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C156(1.03)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C353(0.78)  LDD0785  [13]
 LDCM0427  Fragment51 HCT 116 C73(1.13)  LDD0744  [13]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [1]
 LDCM0022  KB02 42-MG-BA C156(1.97)  LDD2244  [15]
 LDCM0023  KB03 Jurkat C353(5.01)  LDD0209  [4]
 LDCM0024  KB05 MSTO-211H C353(4.99)  LDD3337  [15]
 LDCM0131  RA190 SK-MEL-5 2.10  LDD0303  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396
Heat shock factor 2-binding protein (HSF2BP) . O75031
Ligand of Numb protein X 2 (LNX2) . Q8N448

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840