Details of the Target

General Information of Target

Target ID LDTP18863
Target Name Uncharacterized protein C15orf61 (C15orf61)
Gene Name C15orf61
Gene ID 145853
Synonyms
Uncharacterized protein C15orf61
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVKGPSGRSFCCESEGQFKSCLKRHTPSLLLPSSWKGNSGSCLMAEALHRTSPTPNSCP
LPLPLCRMSGVLCSRNLFTFKFSLFQLDSGASGEPGHSLGLTLGFSYCGNCQTAVVSAQP
EGMASNGAYPVLGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLST
FPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGG
VVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGP
WPQGAHGESSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFL
IPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQKSQ
WMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARR
PPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEK
QREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDF
LALSQDLEQEEGLTLAQLVEKRLPPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDV
PDPQQGVGMETCPPQMTARDSQGRGRAHTGMARSEDSVVLLGCQDSPGLRAAWPTSPPQD
HRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSP
VPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPYPGPGL
RVSGEQSLTWGLGGPSQSQKRKGDPLVSRKEKKQHCSQ
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
A6NNL5
Ensemble ID
ENST00000342683.6
HGNC ID
HGNC:34453

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkyne-RA190
 Probe Info  		2.47  LDD0303  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C84(1.19)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		C84(0.00); C17(0.00)  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C84(1.19)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C84(1.18)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C84(0.86)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C84(1.01)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C84(1.24)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C84(1.22)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C84(1.32)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C84(1.30)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C84(1.31)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C84(0.89)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C84(1.39)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C84(1.30)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C84(1.26)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C84(1.21)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C84(1.74)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C84(1.06)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C84(0.78)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C84(0.71)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C84(0.64)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C84(0.75)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C84(0.99)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C84(0.63)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C84(0.76)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C84(0.61)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C84(1.02)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C84(1.20)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C84(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C84(0.79)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C84(0.73)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C84(0.97)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C84(1.03)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C84(1.22)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C84(0.66)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C84(0.70)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C84(0.81)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C84(0.72)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C84(0.75)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C84(0.65)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C84(0.80)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C84(0.81)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C84(0.98)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C84(0.87)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C84(0.99)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C84(0.94)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C84(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C84(0.82)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C84(0.76)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C84(0.95)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C84(0.77)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C84(0.85)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C84(0.92)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C84(1.43)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C84(0.80)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C84(1.01)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C84(0.74)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C84(0.93)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C84(0.67)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C84(0.66)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C84(0.70)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C84(0.82)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C84(1.03)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C84(0.64)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C84(1.10)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C84(0.97)  LDD0662  [3]
 LDCM0248  AKOS034007472 HCT 116 C84(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C84(0.87)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C84(1.05)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C84(0.86)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C84(0.79)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C84(0.82)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C84(1.15)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C84(1.38)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C84(1.47)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C84(1.10)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C84(1.33)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C84(1.39)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C84(1.04)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C84(1.31)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C84(1.09)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C84(0.93)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C84(1.31)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C84(1.06)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C84(0.91)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C84(0.80)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C84(0.96)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C84(1.07)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C84(0.92)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C84(0.75)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C84(0.86)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C84(0.83)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C84(0.87)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C84(0.68)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C84(0.76)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C84(1.03)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C84(0.81)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C84(0.79)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C84(0.84)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C84(1.07)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C84(0.98)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C84(0.95)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C84(1.02)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C84(0.96)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C84(1.10)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C84(0.74)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C84(1.16)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C84(0.84)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C84(0.97)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C84(0.87)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C84(0.89)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C84(1.70)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C84(1.42)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C84(0.80)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C84(0.68)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C84(0.66)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C84(0.79)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C84(0.82)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C84(0.67)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C84(0.75)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C84(0.98)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C84(0.76)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C84(0.74)  LDD1624  [6]
 LDCM0421  CL32 HCT 116 C84(0.65)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C84(0.71)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C84(1.30)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C84(0.75)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C84(1.66)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C84(0.94)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C84(0.69)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C84(1.08)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C84(0.67)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C84(0.98)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C84(1.25)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C84(0.86)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C84(1.00)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C84(0.83)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C84(0.81)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C84(0.89)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C84(0.97)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C84(1.04)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C84(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C84(1.13)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C84(1.16)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C84(0.89)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C84(1.09)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C84(0.99)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C84(0.95)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C84(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C84(1.08)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C84(0.98)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C84(1.16)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C84(0.94)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C84(0.98)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C84(1.02)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C84(0.97)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C84(0.90)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C84(1.07)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C84(0.90)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C84(0.85)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C84(0.75)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C84(0.74)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C84(0.79)  LDD1664  [6]
 LDCM0462  CL7 HCT 116 C84(0.86)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C84(0.66)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C84(0.66)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C84(0.71)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C84(1.12)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C84(0.99)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C84(0.95)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C84(1.07)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C84(0.86)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C84(0.81)  LDD1675  [6]
 LDCM0473  CL8 HCT 116 C84(1.08)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C84(0.78)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C84(0.78)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C84(0.64)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C84(0.69)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C84(0.80)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C84(1.12)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C84(1.08)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C84(1.11)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C84(1.00)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C84(0.97)  LDD1686  [6]
 LDCM0484  CL9 HCT 116 C84(0.86)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C84(1.54)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C84(1.18)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C84(1.29)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C84(1.16)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C84(0.92)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C84(1.34)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C84(1.09)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C84(1.04)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C84(0.87)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C84(0.96)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C84(0.90)  LDD1698  [6]
 LDCM0625  F8 Ramos C84(0.70); C17(1.49)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C84(2.78); C17(0.32)  LDD2190  [7]
 LDCM0575  Fragment13 Ramos C17(0.92)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C84(1.87); C17(4.53)  LDD2193  [7]
 LDCM0580  Fragment21 Ramos C84(1.01); C17(0.85)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C84(0.86); C17(0.59)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C84(0.86); C17(0.64)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C17(0.90)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C84(1.02); C17(0.79)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C17(0.81)  LDD2200  [7]
 LDCM0468  Fragment33 HEK-293T C84(0.94)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C17(0.95)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C17(3.57)  LDD2184  [7]
 LDCM0427  Fragment51 HCT 116 C84(0.93)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C17(0.51)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C84(2.47); C17(0.64)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C17(2.31)  LDD2186  [7]
 LDCM0022  KB02 HEK-293T C84(0.96)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C84(0.94)  LDD1497  [6]
 LDCM0024  KB05 OAW-28 C84(3.69)  LDD3368  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C84(1.00)  LDD2206  [9]
 LDCM0131  RA190 SK-MEL-5 2.47  LDD0303  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.