Details of the Target
General Information of Target
| Target ID | LDTP03599 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) | |||||
| Gene Name | FMO4 | |||||
| Gene ID | 2329 | |||||
| Synonyms |
FMO2; Dimethylaniline monooxygenase [N-oxide-forming] 4; EC 1.14.13.8; Dimethylaniline oxidase 4; Hepatic flavin-containing monooxygenase 4; FMO 4 |
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| 3D Structure | ||||||
| Sequence |
MAKKVAVIGAGVSGLSSIKCCVDEDLEPTCFERSDDIGGLWKFTESSKDGMTRVYKSLVT
NVCKEMSCYSDFPFHEDYPNFMNHEKFWDYLQEFAEHFDLLKYIQFKTTVCSITKRPDFS ETGQWDVVTETEGKQNRAVFDAVMVCTGHFLNPHLPLEAFPGIHKFKGQILHSQEYKIPE GFQGKRVLVIGLGNTGGDIAVELSRTAAQVLLSTRTGTWVLGRSSDWGYPYNMMVTRRCC SFIAQVLPSRFLNWIQERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKT SVIEFTETSAVFEDGTVEENIDVVIFTTGYTFSFPFFEEPLKSLCTKKIFLYKQVFPLNL ERATLAIIGLIGLKGSILSGTELQARWVTRVFKGLCKIPPSQKLMMEATEKEQLIKRGVF KDTSKDKFDYIAYMDDIAACIGTKPSIPLLFLKDPRLAWEVFFGPCTPYQYRLMGPGKWD GARNAILTQWDRTLKPLKTRIVPDSSKPASMSHYLKAWGAPVLLASLLLICKSSLFLKLV RDKLQDRMSPYLVSLWRG |
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| Target Bioclass |
Enzyme
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| Family |
FMO family
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| Subcellular location |
Microsome membrane
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| Function | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C63(2.04) | LDD3325 | [1] | |
|
Alkyne-RA190 Probe Info |
 |
2.15 | LDD0302 | [2] | |
|
NAIA_4 Probe Info |
 |
N.A. | LDD2226 | [3] | |
Competitor(s) Related to This Target
References