Details of the Target

General Information of Target

Target ID LDTP08902
Target Name CDGSH iron-sulfur domain-containing protein 2 (CISD2)
Gene Name CISD2
Gene ID 493856
Synonyms
CDGSH2; ERIS; ZCD2; CDGSH iron-sulfur domain-containing protein 2; Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFL
PKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNEL
TGDNVGPLILKKKEV
Target Bioclass
Other
Family
CISD protein family, CISD2 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Uniprot ID
Q8N5K1
Ensemble ID
ENST00000273986.10
HGNC ID
HGNC:24212
ChEMBL ID
CHEMBL4523399

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		1.97  LDD0197  [2]
DA-P2
 Probe Info  		8.99  LDD0348  [3]
HRP
 Probe Info  		9.90  LDD0347  [3]
CHEMBL5175495
 Probe Info  		8.10  LDD0196  [4]
SAA-alkyne
 Probe Info  		1.07  LDD0252  [5]
FBP2
 Probe Info  		2.92  LDD0317  [6]
THZ1-DTB
 Probe Info  		C92(1.08)  LDD0460  [7]
AHL-Pu-1
 Probe Info  		C110(2.28)  LDD0169  [8]
Alkyne-RA190
 Probe Info  		2.34  LDD0303  [9]
EA-probe
 Probe Info  		C92(0.91)  LDD2210  [10]
DBIA
 Probe Info  		C92(1.71)  LDD0080  [11]
ATP probe
 Probe Info  		K19(0.00); K74(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C92(0.00); C110(0.00)  LDD0037  [13]
BTD
 Probe Info  		N.A.  LDD0004  [15]
IPM
 Probe Info  		N.A.  LDD0025  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
TFBX
 Probe Info  		C92(0.00); C110(0.00)  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
DA-P3
 Probe Info  		N.A.  LDD0178  [3]
aHNE
 Probe Info  		N.A.  LDD0001  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [15]
NHS
 Probe Info  		K74(0.00); K11(0.00); K19(0.00)  LDD0010  [15]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
STPyne
 Probe Info  		K81(0.00); K11(0.00)  LDD0009  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C92(0.00); C101(0.00)  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Methacrolein
 Probe Info  		C92(0.00); C110(0.00)  LDD0218  [21]
W1
 Probe Info  		C92(0.00); C110(0.00)  LDD0236  [22]
AOyne
 Probe Info  		14.20  LDD0443  [23]
NAIA_5
 Probe Info  		C92(0.00); C110(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		5.03  LDD1945  [24]
C388
 Probe Info  		51.27  LDD2047  [24]
FFF probe11
 Probe Info  		17.74  LDD0471  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
OEA-DA
 Probe Info  		4.62  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C92(1.01)  LDD2112  [27]
 LDCM0026  4SU-RNA+native RNA HEK-293T C110(2.28)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C110(0.85); C92(1.33)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C110(1.01); C92(1.10)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C110(0.92); C92(0.85)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C110(0.91); C92(0.91)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C110(0.96); C92(0.95)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C110(1.07); C92(1.20)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C110(0.96); C92(1.04)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C110(1.01); C92(1.13)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C110(1.04); C92(1.07)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C110(0.70); C92(0.91)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C110(0.76); C92(0.79)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C110(0.80); C92(0.82)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C110(1.00); C92(1.17)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C110(0.74); C92(0.80)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C110(0.72); C92(0.81)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C110(0.73); C92(0.91)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C110(0.90); C92(0.99)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C110(0.91); C92(1.07)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C110(0.99); C92(1.14)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C110(0.87); C92(1.22)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C110(0.93); C92(1.05)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C110(0.79); C92(1.04)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C110(0.88); C92(1.13)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C110(0.95); C92(1.05)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C110(0.69); C92(1.10)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C110(0.98); C92(0.98)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C110(0.78); C92(1.09)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C110(0.92); C92(0.96)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C110(0.86); C92(0.96)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C110(0.89); C92(0.96)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C110(0.83); C92(1.14)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C110(0.74); C92(1.08)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C110(0.84); C92(1.32)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C110(0.68); C92(0.85)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C110(0.83); C92(1.15)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C110(0.75); C92(0.86)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C110(0.70); C92(0.90)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C110(0.79); C92(1.09)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C110(0.81); C92(1.16)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C110(0.72); C92(1.11)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C110(0.72); C92(1.05)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C110(0.76); C92(0.97)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C110(0.68); C92(1.03)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C110(0.74); C92(1.03)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C110(0.98); C92(1.04)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C110(0.77); C92(1.12)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C110(0.67); C92(1.06)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C110(0.64); C92(0.90)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C92(1.31)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C92(1.27)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C92(1.30)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C92(1.26)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C92(1.05)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C92(2.65)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C92(2.03)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C110(1.02); C92(1.04)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C92(1.20)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C92(1.15)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C92(1.20)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C92(2.30)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C92(1.17)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C92(1.39)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C92(1.23)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C92(1.36)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C110(1.01); C92(1.06)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C110(1.16); C92(1.27)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C110(0.96); C92(1.11)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C110(0.82); C92(1.28)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C110(0.94); C92(1.03)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C110(0.98); C92(1.06)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C110(0.95); C92(1.00)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C110(0.86); C92(1.09)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C110(0.92); C92(0.94)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C110(1.01); C92(1.07)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C110(1.02); C92(1.19)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C110(1.04); C92(1.20)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C110(0.98); C92(1.24)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C110(1.01); C92(1.28)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C110(0.83); C92(1.22)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C110(1.00); C92(1.35)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C110(1.06); C92(1.22)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C110(1.06); C92(1.51)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C110(1.02); C92(1.26)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C110(1.10); C92(1.40)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C92(0.88); C110(1.00)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C92(0.80); C110(0.89)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C92(0.83); C110(0.97)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C92(0.91); C110(1.04)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C92(1.08); C110(1.14)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C110(0.90); C92(1.28)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C110(1.10); C92(1.11)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C92(0.91); C110(1.12)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C92(0.99); C110(0.99)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C92(0.98); C110(1.09)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C92(1.00); C110(1.09)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C92(1.15); C110(1.18)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C110(0.92); C92(1.08)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C92(1.04); C110(1.08)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C110(0.94); C92(1.15)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C110(0.69); C92(1.38)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C110(0.90); C92(1.37)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C110(0.85); C92(1.26)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C110(0.77); C92(0.89)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C110(0.71); C92(0.98)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C110(0.63); C92(1.14)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C110(0.86); C92(1.14)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C110(1.04); C92(1.25)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C110(0.77); C92(1.47)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C110(1.20); C92(1.27)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C110(1.08); C92(1.31)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C110(1.28); C92(1.32)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C110(1.12); C92(1.16)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C92(1.23); C110(1.34)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C92(1.22); C110(1.22)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C110(1.30); C92(1.31)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C92(1.16); C110(1.29)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C110(1.35); C92(1.40)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C110(1.08); C92(1.54)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C110(1.14); C92(1.47)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C110(1.05); C92(1.65)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C92(0.98); C110(1.35)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C92(0.94); C110(1.39)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C110(0.96); C92(1.09)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C92(1.03); C110(1.58)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C92(0.84); C110(1.49)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C92(0.99); C110(1.19)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C92(1.08); C110(1.23)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C92(0.87); C110(1.15)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C92(1.02); C110(1.37)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C92(0.91); C110(1.35)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C92(1.06); C110(1.19)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C92(0.95); C110(1.11)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C110(1.04); C92(1.08)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C110(1.09); C92(1.13)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C92(0.91); C110(1.14)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C92(0.95); C110(1.12)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C92(0.99); C110(1.00)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C92(1.45)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C92(1.54)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C92(1.28)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C92(1.15)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C92(0.94)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C92(1.00)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C92(1.26)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C92(0.89)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C92(1.47)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C92(1.44)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C92(1.06)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C92(1.12)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C92(1.04)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C92(1.25)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C92(1.28)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C110(1.17); C92(1.39)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C110(0.84); C92(0.93)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C110(0.97); C92(1.02)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C110(1.06); C92(1.10)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C110(1.23); C92(1.48)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C110(1.15)  LDD2171  [11]
 LDCM0630  CCW28-3 231MFP C92(2.24)  LDD2214  [28]
 LDCM0108  Chloroacetamide HeLa C92(0.00); C110(0.00); H114(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C92(5.16); C92(1.18)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C110(0.66); C92(0.97)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C110(0.70); C92(1.32)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C110(0.84); C92(1.36)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C110(0.93); C92(1.18)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C110(0.79); C92(0.96)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C110(0.81); C92(1.01)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C110(0.91); C92(1.03)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C110(1.06); C92(1.22)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C110(1.10); C92(1.42)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C110(1.13); C92(1.31)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C110(1.16); C92(1.35)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C110(0.96); C92(1.19)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C110(1.19); C92(1.39)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C110(0.96); C92(1.24)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C110(0.92); C92(1.16)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C92(1.08); C110(1.08)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C110(1.07); C92(1.37)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C110(0.95); C92(1.24)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C110(0.99); C92(1.19)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C110(1.02); C92(1.16)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C110(1.26); C92(1.50)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C92(1.00); C110(1.08)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C92(1.12); C110(1.22)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C110(1.10); C92(1.37)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C110(0.89); C92(0.96)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C110(0.84); C92(1.21)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C110(0.86); C92(1.13)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C110(0.50); C92(1.28)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C110(0.77); C92(1.29)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C110(1.00); C92(1.09)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C110(0.93); C92(1.02)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C92(0.98); C110(1.06)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C110(1.24); C92(1.32)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C110(1.19); C92(1.30)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C110(0.74); C92(1.05)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C110(0.74); C92(1.27)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C110(0.92)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C110(0.80); C92(0.98)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C110(0.82); C92(1.35)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C110(0.90); C92(1.09)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C110(0.66); C92(0.98)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C110(0.79); C92(1.67)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C110(0.56); C92(1.35)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C110(0.72); C92(0.91)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C110(0.77); C92(1.43)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C110(0.81); C92(1.09)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C110(0.62); C92(1.11)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C110(0.83); C92(1.33)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C110(0.78); C92(1.29)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C110(0.76); C92(1.15)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C110(0.66); C92(1.48)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C110(0.76); C92(1.07)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C110(0.71); C92(1.16)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C110(0.91); C92(1.06)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C110(1.09); C92(1.15)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C110(1.01); C92(1.13)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C110(1.28); C92(1.30)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C110(1.08); C92(1.25)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C110(1.16); C92(1.21)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C110(1.50); C92(1.22)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C110(1.33); C92(1.18)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C110(0.76); C92(1.10)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C110(0.84); C92(1.18)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C110(1.37); C92(1.12)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C110(1.11); C92(1.51)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C110(1.19); C92(1.26)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C110(1.33); C92(1.19)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C110(1.07); C92(1.36)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C110(0.91); C92(0.96)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C110(0.86); C92(0.96)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C110(0.83); C92(0.88)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C110(0.88); C92(0.99)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C110(0.92); C92(1.02)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C110(0.81); C92(0.91)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C110(0.84); C92(0.98)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C110(0.79); C92(0.96)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C110(0.75); C92(0.92)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C110(0.67); C92(0.92)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C110(0.81); C92(0.94)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C110(0.84); C92(1.09)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C110(0.75); C92(0.88)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C110(0.81); C92(0.94)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C110(0.82); C92(0.96)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C110(0.82); C92(1.21)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C110(0.82); C92(0.96)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C110(1.19); C92(1.02)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C110(1.13); C92(1.08)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C110(0.99); C92(1.18)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C110(0.80); C92(1.17)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C110(0.80); C92(1.10)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C110(1.01); C92(1.51)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C110(0.92); C92(1.16)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C110(0.86); C92(1.22)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C110(0.88); C92(1.03)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C110(1.21); C92(1.31)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C110(0.79); C92(1.15)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C110(0.76); C92(1.26)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C110(0.80); C92(1.01)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C110(0.75); C92(1.12)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C110(0.77); C92(1.20)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C110(1.27); C92(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C110(0.92); C92(0.94)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C110(1.06); C92(1.04)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C110(1.26); C92(1.16)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C110(0.92); C92(1.57)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C110(1.16); C92(1.05)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C110(1.29); C92(1.06)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C110(1.56); C92(1.39)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C110(1.27); C92(1.28)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C110(1.51); C92(1.40)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C110(1.14); C92(1.16)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C110(1.06); C92(0.99)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C110(1.33); C92(1.19)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C110(1.27); C92(1.30)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C110(1.84); C92(1.68)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C110(1.07); C92(1.27)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C110(0.63); C92(0.99)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C110(1.02); C92(1.11)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C110(0.91); C92(1.03)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C110(0.87); C92(0.96)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C110(1.00); C92(1.10)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C110(0.89); C92(1.24)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C110(0.98); C92(1.14)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C110(0.73); C92(1.35)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C110(0.83); C92(1.29)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C110(0.94); C92(1.39)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C92(0.44)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C110(0.91); C92(0.90)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(1.30)  LDD1702  [27]
 LDCM0175  Ethacrynic acid HeLa C92(0.91)  LDD2210  [10]
 LDCM0625  F8 Ramos C92(0.76)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C92(1.51)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C92(0.11)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C92(1.05)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C92(1.14)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C92(0.70)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C92(1.04)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C92(1.60)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C92(1.27)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C92(1.19)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C92(1.17)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C92(0.79)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C92(1.00)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C92(1.18)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C110(0.75); C92(1.18)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C92(0.67)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C92(0.84)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C110(1.44); C92(1.56)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C92(0.68)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C92(0.69)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C92(1.09)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C92(1.04)  LDD2188  [30]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C92(1.71)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C92(1.34)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C92(1.44)  LDD0082  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [21]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C92(0.73)  LDD2104  [27]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C92(0.65)  LDD2106  [27]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C92(0.67)  LDD2108  [27]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C92(1.39)  LDD2110  [27]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C92(0.74)  LDD2114  [27]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C92(0.87)  LDD2141  [27]
 LDCM0627  NUDT7-COV-1 HEK-293T C92(0.59)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C92(0.55)  LDD2207  [31]
 LDCM0131  RA190 SK-MEL-5 2.34  LDD0303  [9]
 LDCM0021  THZ1 HeLa S3 C92(1.08)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Epididymis-specific alpha-mannosidase (MAN2B2) Glycosyl hydrolase 38 family Q9Y2E5
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) Glycosyltransferase 13 family Q8WZA1
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) Glycosyltransferase 2 family Q8N3T1
Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL) Membrane-bound acyltransferase family Q9HCP6
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) VKOR family Q8N0U8
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis regulator Bcl-2 (BCL2) Bcl-2 family P10415
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Aquaporin-10 (AQP10) MIP/aquaporin (TC 1.A.8) family Q96PS8
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) SLC13A/DASS transporter family Q8WWT9
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Transmembrane protein 187 (TMEM187) . Q14656
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L2 (APOL2) Apolipoprotein L family Q9BQE5
BET1 homolog (BET1) BET1 family O15155
Claudin-10 (CLDN10) Claudin family P78369
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Gastrin (GAST) Gastrin/cholecystokinin family P01350
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Low-density lipoprotein receptor-related protein 10 (LRP10) LDLR family Q7Z4F1
Pro-neuregulin-4, membrane-bound isoform (NRG4) Neuregulin family Q8WWG1
Neuronal vesicle trafficking-associated protein 1 (NSG1) NSG family P42857
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Syntaxin-7 (STX7) Syntaxin family O15400
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Acrosomal protein SP-10 (ACRV1) . P26436
Alpha-tocopherol transfer protein (TTPA) . P49638
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
Emerin (EMD) . P50402
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Protein SNORC (SNORC) . Q6UX34
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
28 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.