General Information of Target

Target ID LDTP16142
Target Name BET1-like protein (BET1L)
Gene Name BET1L
Gene ID 51272
Synonyms
GS15; BET1-like protein; Golgi SNARE with a size of 15 kDa; GOS-15; GS15; Vesicle transport protein GOS15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLRPSLLPLHLLLLLLLSAAVCRAEAGLETESPVRTLQVETLVEPPEPCAEPAAFGDTL
HIHYTGSLVDGRIIDTSLTRDPLVIELGQKQVIPGLEQSLLDMCVGEKRRAIIPSHLAYG
KRGFPPSVPADAVVQYDVELIALIRANYWLKLVKGILPLVGMAMVPALLGLIGYHLYRKA
NRPKVSKKKLKEEKRNKSKKK
Target Bioclass
Other
Subcellular location
Golgi apparatus membrane
Function Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex.
Uniprot ID
Q9NYM9
Ensemble ID
ENST00000382762.8
HGNC ID
HGNC:19348

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info 
K31(6.60); K36(5.46)  LDD0277  [1]
Alkyne-RA190
 Probe Info 
2.65  LDD0303  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0131  RA190 SK-MEL-5 2.65  LDD0303  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.