Details of the Target

General Information of Target

Target ID LDTP11953
Target Name Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)
Gene Name SUV39H2
Gene ID 79723
Synonyms
KMT1B; Histone-lysine N-methyltransferase SUV39H2; EC 2.1.1.355; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEREALPWGLEPQDVQSSDEMRSPEGYLRGNMSENEEEEISQQEGSGDYEVEEIPFGLEP
QSPGFEPQSPEFEPQSPRFEPESPGFESRSPGLVPPSPEFAPRSPESDSQSPEFESQSPR
YEPQSPGYEPRSPGYEPRSPGYESESSRYESQNTELKTQSPEFEAQSSKFQEGAEMLLNP
EEKSPLNISVGVHPLDSFTQGFGEQPTGDLPIGPPFEMPTGALLSTPQFEMLQNPLGLTG
ALRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQ
SSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYL
LRHQRTHSHERPYSCTECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHA
RSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHT
GERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Uniprot ID
Q9H5I1
Ensemble ID
ENST00000313519.9
HGNC ID
HGNC:17287
ChEMBL ID
CHEMBL1795177

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.G378V .
MOLT4 SNV: p.P15S .
RKO SNV: p.Y126C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C405(0.81)  LDD1702  [1]
DBIA
 Probe Info  		C400(1.51); C405(1.51)  LDD0080  [2]
IA-alkyne
 Probe Info  		C253(0.00); C333(0.00); C86(0.00)  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C53(1.04)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C53(1.05)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C233(0.79); C239(0.79); C53(0.53); C86(0.99)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C233(0.97); C239(0.97); C53(0.54); C86(1.10)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C233(0.84); C239(0.84); C53(0.47); C86(1.03)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C233(0.42); C239(0.42); C53(0.54); C86(0.98)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C233(0.51); C239(0.51); C53(0.48); C86(1.02)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C233(0.57); C239(0.57); C53(0.48); C86(1.03)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C233(0.68); C239(0.68); C53(0.56); C86(1.03)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C233(0.95); C239(0.82); C53(0.69); C86(1.13)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C233(0.52); C239(0.72); C53(0.38); C86(0.97)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C233(0.57); C239(0.58); C53(0.44); C86(1.02)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C53(0.88)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C233(0.90); C239(0.52); C53(0.40); C86(1.07)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C233(0.68); C239(0.58); C53(0.44); C86(1.07)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C233(0.74); C239(0.74); C53(0.58); C86(1.11)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C191(0.93); C196(1.11); C201(1.04); C202(1.04)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C191(1.14); C196(1.06); C201(1.14); C202(1.14)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C191(0.96); C196(1.05); C201(1.00); C202(1.00)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C191(1.01); C196(1.00); C201(1.03); C202(1.03)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C191(1.15); C196(1.19); C201(1.12); C202(1.12)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C191(0.97); C196(1.21); C201(1.13); C202(1.13)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C191(1.11); C196(1.12); C201(1.02); C202(1.02)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C53(0.75)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C191(1.00); C196(1.07); C201(1.17); C202(1.17)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C191(1.36); C196(1.15); C201(1.05); C202(1.05)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C191(1.38); C196(1.22); C201(1.17); C202(1.17)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C191(1.24); C196(1.16); C201(1.11); C202(1.11)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C191(1.41); C196(1.09); C201(1.09); C202(1.09)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C191(1.19); C196(1.16); C201(1.28); C202(1.28)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C191(1.69); C196(1.40); C201(1.34); C202(1.34)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C191(1.79); C196(1.57); C201(1.44); C202(1.44)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C191(0.89); C235(0.94)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C191(1.32); C235(1.25)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C191(1.29); C235(1.32)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C191(1.22); C235(1.21)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C191(1.17); C235(1.18)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C191(1.22); C235(1.53)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C191(1.45); C235(1.60)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C191(1.52); C235(1.49)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C191(1.41); C235(1.47)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C191(1.25); C235(1.86)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C191(1.59); C235(2.25)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C191(1.68); C235(1.99)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C53(0.97)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C191(1.26); C235(1.66)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C191(1.57); C235(1.95)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C191(1.45); C235(1.66)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C53(0.76); C400(0.88); C405(0.88); C86(1.05)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C235(0.60); C53(0.65); C233(0.68); C239(0.68)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C400(0.77); C405(0.77); C235(0.78); C53(0.78)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C235(0.80); C53(0.82); C400(0.86); C405(0.86)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C235(0.60); C53(0.67); C233(0.68); C239(0.68)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C233(0.50); C239(0.50); C235(0.52); C53(0.74)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C235(0.57); C233(0.61); C239(0.61); C53(0.67)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C53(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C400(0.67); C405(0.67); C53(0.86); C235(0.98)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C53(0.75); C233(0.93); C239(0.93); C235(1.02)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C235(0.53); C233(0.53); C239(0.53); C400(0.57)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C233(0.59); C239(0.59); C235(0.60); C53(0.70)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C233(0.65); C235(0.62); C239(0.65); C400(0.74)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C233(0.75); C235(0.72); C239(0.75); C400(0.89)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C233(0.87); C235(0.72); C239(0.87); C400(0.95)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C233(1.03); C235(0.84); C239(1.03); C400(0.81)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C53(0.95)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C53(0.83)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C53(0.91)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C53(1.07)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C53(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C53(0.71)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C53(0.81)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C53(0.83)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C53(0.99)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C86(0.94); C405(0.95); C53(1.01); C233(1.14)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C53(0.88); C86(0.90); C233(0.99); C239(0.99)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C86(0.95); C53(0.98); C233(0.99); C239(0.99)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C233(0.74); C239(0.74); C86(0.90); C405(1.14)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C53(0.93); C233(0.95); C239(0.95); C405(1.11)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C53(1.09)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C233(0.83); C239(0.83); C53(0.98); C86(1.13)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C233(0.88); C239(0.88); C405(0.90); C53(1.00)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C53(0.81); C233(0.87); C239(0.87); C86(1.18)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C233(0.87); C239(0.87); C53(1.01); C86(1.03)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C233(0.81); C239(0.81); C53(0.87); C86(1.02)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C53(0.88); C233(1.27); C239(1.27)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C53(0.97); C233(1.15); C239(1.15)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C53(0.90); C233(1.10); C239(1.10)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C233(1.14); C239(1.14); C53(1.49)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C53(1.17); C233(1.38); C239(1.38)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C53(0.99)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C53(1.27); C233(1.53); C239(1.53)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C53(0.75); C233(1.51); C239(1.51)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C53(0.82); C233(1.27); C239(1.27)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C53(0.78); C233(1.14); C239(1.14)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C53(0.93); C233(1.51); C239(1.51)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C53(0.79); C233(1.21); C239(1.21)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C86(0.96); C53(1.00); C233(1.33); C235(1.33)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C86(0.90); C53(0.93); C233(1.03); C235(1.03)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C86(0.73); C53(1.22); C233(2.29); C235(2.29)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C239(0.44); C233(0.58); C235(0.58); C53(0.95)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C53(1.08)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C239(0.47); C233(0.54); C235(0.54); C53(0.75)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C86(0.87); C53(0.92); C233(1.18); C235(1.18)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C86(0.70); C53(0.82); C233(0.94); C235(0.94)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C239(0.68); C233(0.69); C235(0.69); C53(0.80)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C239(0.55); C233(0.59); C235(0.59); C86(0.86)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C239(0.52); C233(0.68); C235(0.68); C53(0.81)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C239(0.59); C233(0.68); C235(0.68); C86(0.81)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C235(0.60); C233(0.74); C239(0.74); C53(0.92)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C235(0.65); C233(0.85); C239(0.85); C53(0.96)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C235(0.42); C233(0.54); C239(0.54); C53(1.03)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C53(1.00)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C235(0.86); C233(1.01); C239(1.01); C53(1.05)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C53(1.16); C233(1.92); C239(1.92); C235(1.96)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C235(0.42); C233(0.47); C239(0.47); C53(1.01)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C235(0.93); C233(1.03); C239(1.03); C53(1.19)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C235(0.41); C233(0.52); C239(0.52); C53(0.94)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C235(0.57); C233(0.86); C239(0.86); C53(1.20)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C235(0.73); C233(1.01); C239(1.01); C53(1.24)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C235(0.31); C233(0.46); C239(0.46); C53(0.92)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C233(0.88); C239(0.88); C235(0.91); C53(0.96)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C235(0.56); C233(0.61); C239(0.61); C53(0.91)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C53(0.98)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C53(0.65); C233(0.90); C239(0.90); C235(0.97)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C400(0.92); C405(0.92); C53(1.13); C233(1.50)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C235(0.53); C233(0.58); C239(0.58); C53(0.88)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C235(0.40); C233(0.50); C239(0.50); C53(1.02)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C235(0.42); C233(0.48); C239(0.48); C400(0.92)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C235(0.41); C233(0.49); C239(0.49); C53(1.07)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C235(0.39); C233(0.49); C239(0.49); C53(0.83)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C235(0.48); C233(0.55); C239(0.55); C53(0.84)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C235(0.96); C233(1.21); C239(1.21); C400(1.24)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C235(0.75); C233(0.84); C239(0.84); C53(0.90)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C53(0.89)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C235(0.52); C233(0.57); C239(0.57); C53(0.83)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C235(0.67); C233(0.69); C239(0.69); C400(0.82)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C235(0.51); C233(0.52); C239(0.52); C53(1.20)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C235(0.27); C233(0.29); C239(0.29)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C235(0.28); C233(0.30); C239(0.30)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C235(0.61); C233(0.95); C239(0.95)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C235(0.69); C233(0.90); C239(0.90)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C235(0.74); C233(2.04); C239(2.04)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C235(0.70); C233(0.83); C239(0.83)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C233(0.48); C239(0.48); C235(0.49)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C235(1.20); C233(1.38); C239(1.38)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C235(0.19); C233(0.26); C239(0.26)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C235(0.23); C233(0.30); C239(0.30)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C235(0.54); C233(0.59); C239(0.59)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C235(0.63); C233(0.94); C239(0.94)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C235(1.17); C233(2.04); C239(2.04)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C235(0.60); C233(0.74); C239(0.74)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C235(0.25); C233(0.36); C239(0.36)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C233(0.33); C239(0.33); C53(0.46); C86(1.11)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C53(0.51); C233(0.85); C239(0.85); C86(0.97)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C53(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C53(0.91)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C53(0.95)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C400(1.25); C405(1.25)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C53(0.79); C233(0.91); C239(0.91)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C233(0.50); C239(0.50); C53(0.97)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C53(1.18)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C53(0.90)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C53(0.98)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C53(0.96)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C53(0.93)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C53(0.88)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C53(0.83)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C53(0.84)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C53(0.97)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C53(0.81)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C233(0.43); C239(0.43); C53(0.99)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C53(0.77)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C53(0.85)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C405(0.78); C233(0.87); C239(0.87); C86(1.01)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C233(0.85); C239(0.85); C53(0.92); C405(1.05)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C53(0.86); C233(0.95); C239(0.95); C86(1.10)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C233(0.83); C239(0.83); C53(0.99); C86(1.10)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C86(0.94); C53(1.05); C405(1.18); C233(1.21)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C233(1.37); C239(1.37); C53(1.76)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C53(0.78); C233(1.35); C239(1.35)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C53(0.79); C233(1.07); C239(1.07)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C233(0.48); C239(0.48); C53(1.08)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C53(0.82); C233(1.69); C239(1.69)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C86(0.88); C53(1.01); C233(1.49); C235(1.49)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C86(0.69); C53(0.91); C233(0.99); C235(0.99)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C239(0.50); C233(0.59); C235(0.59); C53(0.75)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C239(0.48); C233(0.59); C235(0.59); C53(0.81)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C53(1.02); C233(1.17); C239(1.17); C235(1.33)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C233(0.98); C239(0.98); C53(1.04); C235(1.05)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C53(0.97); C235(1.19); C233(1.28); C239(1.28)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C235(0.48); C233(0.60); C239(0.60); C53(0.92)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C233(0.72); C239(0.72); C53(1.01)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C53(0.84); C233(1.01); C239(1.01)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C233(0.95); C239(0.95); C53(0.97)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C233(0.62); C239(0.62); C235(0.64); C53(0.91)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C233(0.90); C239(0.90); C53(0.93); C86(0.97)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C86(1.04); C53(1.06); C233(1.16); C239(1.16)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C233(0.81); C239(0.81); C235(0.85); C86(1.05)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C53(0.92); C233(1.22); C239(1.22)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C235(0.41); C233(0.46); C239(0.46); C53(0.78)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C235(0.29); C233(0.35); C239(0.35); C53(0.85)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C235(0.30); C233(0.32); C239(0.32); C86(1.05)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C235(0.39); C233(0.42); C239(0.42); C53(0.93)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C233(0.26); C235(0.24); C239(0.26); C53(0.80)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C233(0.31); C235(0.27); C239(0.31); C53(0.94)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C233(0.47); C235(0.47); C239(0.47); C53(0.85)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C233(0.76); C235(0.66); C239(0.76); C53(0.94)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C233(0.46); C235(0.47); C239(0.46); C53(0.87)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C233(0.52); C235(0.45); C239(0.52); C53(0.97)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C233(0.90); C239(0.90); C53(0.95)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C233(0.85); C235(0.87); C239(0.85); C53(0.90)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C233(0.67); C235(0.87); C239(0.67); C53(1.06)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C233(0.94); C235(1.21); C239(0.94); C400(0.97)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C233(1.02); C235(1.02); C239(1.02); C400(0.86)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C233(0.45); C235(0.59); C239(0.45); C400(1.38)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C233(0.46); C235(0.52); C239(0.46); C400(1.19)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C233(0.48); C235(0.55); C239(0.48); C400(0.94)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C233(0.48); C235(0.57); C239(0.48); C400(1.04)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C233(0.40); C235(0.52); C239(0.40); C400(0.94)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C233(0.93); C239(0.93); C53(0.94)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C233(0.47); C235(0.60); C239(0.47); C400(1.17)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C233(0.56); C235(0.65); C239(0.56); C400(1.01)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C233(0.47); C235(0.52); C239(0.47); C400(0.81)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C233(0.39); C235(0.46); C239(0.39); C400(0.94)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C233(0.56); C235(0.63); C239(0.56); C400(1.43)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C233(0.46); C235(0.61); C239(0.46); C400(1.33)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C233(1.07); C235(1.07); C239(1.07); C400(0.69)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C233(1.09); C235(1.09); C239(1.09); C400(0.96)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C233(1.20); C235(1.20); C239(1.20); C400(0.93)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C233(0.81); C235(0.81); C239(0.81); C400(0.82)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C233(0.90); C239(0.90); C53(1.07)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C233(0.99); C235(0.99); C239(0.99); C400(0.77)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C233(1.07); C235(1.07); C239(1.07); C400(1.09)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C233(1.38); C235(1.38); C239(1.38); C400(0.79)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C233(1.07); C235(1.07); C239(1.07); C400(0.81)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C233(1.16); C235(1.16); C239(1.16); C400(0.84)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C233(1.30); C235(1.30); C239(1.30); C400(0.80)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C233(0.80); C235(0.80); C239(0.80); C400(0.65)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C233(1.31); C235(1.31); C239(1.31); C400(0.81)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C233(1.12); C235(1.12); C239(1.12); C400(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C233(0.94); C235(0.94); C239(0.94); C400(0.98)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C233(0.91); C239(0.91); C53(1.02)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C233(0.83); C235(0.83); C239(0.83); C400(1.07)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C400(1.04); C405(1.04)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C400(1.08); C405(1.08)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C400(0.95); C405(0.95)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C400(1.11); C405(1.11)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C400(1.13); C405(1.13)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C400(1.22); C405(1.22)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C400(1.27); C405(1.27)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C400(1.20); C405(1.20)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C400(1.30); C405(1.30)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C233(0.55); C239(0.55); C53(1.16)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C400(1.11); C405(1.11)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C400(1.20); C405(1.20)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C400(0.89); C405(0.89)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C400(1.12); C405(1.12)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C400(1.20); C405(1.20)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C233(1.27); C235(1.32); C239(1.27); C400(1.00)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C233(0.77); C235(0.78); C239(0.77); C400(0.80)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C233(0.79); C235(0.84); C239(0.79); C400(1.01)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C233(0.56); C235(0.60); C239(0.56); C400(1.14)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C233(0.43); C239(0.43); C53(0.93)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C233(0.98); C235(1.06); C239(0.98); C400(1.32)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C233(0.81); C235(0.81); C239(0.81); C400(0.92)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C233(0.37); C235(0.39); C239(0.37); C400(0.81)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C233(0.43); C235(0.42); C239(0.43); C400(1.29)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C233(0.39); C235(0.41); C239(0.39); C400(0.95)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C233(0.88); C235(0.84); C239(0.88); C400(1.04)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C233(0.99); C235(1.02); C239(0.99); C400(0.89)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C233(0.86); C235(0.94); C239(0.86); C400(1.12)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C233(0.48); C235(0.56); C239(0.48); C400(1.05)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C233(0.44); C235(0.49); C239(0.44); C400(1.16)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C233(0.58); C239(0.58); C53(0.98)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C233(0.91); C235(0.74); C239(0.91); C400(0.77)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C53(0.97)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C53(1.07)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C53(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C53(0.99)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C53(1.09)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C53(1.11)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C53(0.95)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C53(0.98)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C53(1.00)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C405(0.81)  LDD1702  [1]
 LDCM0203  EV-96 T cell C201, C202(4.16)  LDD0523  [4]
 LDCM0468  Fragment33 HCT 116 C400(1.06); C405(1.06)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C233(0.42); C235(0.55); C239(0.42); C400(0.82)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C400(1.51); C405(1.51)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C400(1.83); C405(1.83)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C400(1.38); C405(1.38)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C400(1.25); C405(1.25)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 212 (ZNF212) Krueppel C2H2-type zinc-finger protein family Q9UDV6
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
DCC-interacting protein 13-beta (APPL2) . Q8NEU8
Kelch domain-containing protein 4 (KLHDC4) . Q8TBB5
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.