Details of the Target

General Information of Target

Target ID LDTP07456
Target Name Molybdate-anion transporter (MFSD5)
Gene Name MFSD5
Gene ID 84975
Synonyms
Molybdate-anion transporter; Major facilitator superfamily domain-containing protein 5; Molybdate transporter 2 homolog; hsMOT2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVTAYLAFVGLLASCLGLELSRCRAKPPGRACSNPSFLRFQLDFYQVYFLALAADWLQA
PYLYKLYQHYYFLEGQIAILYVCGLASTVLFGLVASSLVDWLGRKNSCVLFSLTYSLCCL
TKLSQDYFVLLVGRALGGLSTALLFSAFEAWYIHEHVERHDFPAEWIPATFARAAFWNHV
LAVVAGVAAEAVASWIGLGPVAPFVAAIPLLALAGALALRNWGENYDRQRAFSRTCAGGL
RCLLSDRRVLLLGTIQALFESVIFIFVFLWTPVLDPHGAPLGIIFSSFMAASLLGSSLYR
IATSKRYHLQPMHLLSLAVLIVVFSLFMLTFSTSPGQESPVESFIAFLLIELACGLYFPS
MSFLRRKVIPETEQAGVLNWFRVPLHSLACLGLLVLHDSDRKTGTRNMFSICSAVMVMAL
LAVVGLFTVVRHDAELRVPSPTEEPYAPEL
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Cell membrane
Function Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
Uniprot ID
Q6N075
Ensemble ID
ENST00000329548.5
HGNC ID
HGNC:28156

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L211M .
HDQP1 SNV: p.I263T .
IM95 SNV: p.W166R .
MOLT4 SNV: p.R173Ter .
NCIH1155 SNV: p.T114I .
NCIH2286 SNV: p.G278V .
RPMI8226 Deletion: p.V430AfsTer2 .
SUPT1 Insertion: p.V129CfsTer27 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K367(10.00)  LDD0277  [1]
BTD
 Probe Info  		C33(1.24)  LDD2105  [2]
AHL-Pu-1
 Probe Info  		C33(2.47)  LDD0171  [3]
DBIA
 Probe Info  		C33(267.50)  LDD0209  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
AOyne
 Probe Info  		14.90  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C393
 Probe Info  		4.92  LDD2052  [9]
FFF probe13
 Probe Info  		8.41  LDD0475  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C236(0.94)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C33(2.47)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C33(0.96)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C33(0.94)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C33(0.97)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C33(0.98)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C33(0.92); C242(0.91)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C33(0.99); C242(0.95)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C33(0.96)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C33(0.92)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C33(1.16)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C33(0.91)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C33(0.93)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C33(0.97)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C33(0.86); C242(0.89)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C33(1.04); C242(0.93)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C33(0.89)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C33(1.01)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C33(0.98)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C33(1.02)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C33(1.06)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C33(0.93)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C33(0.96)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C33(0.83); C242(0.95)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C33(0.96); C242(0.90)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C33(0.94)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C33(1.00)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C33(0.94)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C33(0.98)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C33(1.03)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C33(0.91)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C33(0.78); C242(1.03)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C33(1.04); C242(0.90)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C33(0.91)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C33(0.99)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C33(0.96)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C33(0.97)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C33(1.01)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C33(0.89)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C33(0.93)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C33(0.87); C242(0.98)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C33(0.97); C242(0.94)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C33(0.93)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C33(0.90)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C33(0.89)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C33(0.98)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C33(1.00)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C33(0.94)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C33(0.87)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C33(0.87); C242(1.13)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C33(1.01); C242(1.02)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C33(0.93)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C33(0.98)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C33(1.00)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C33(1.02)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C33(0.93); C242(1.07)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C33(1.06)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C33(0.98)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C33(0.89); C242(1.20)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C33(1.03); C242(1.02)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C33(0.92)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C33(0.99); C242(0.98)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C33(0.96)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C33(0.95)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C33(1.01)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C33(1.02)  LDD1514  [12]
 LDCM0367  CL1 HEK-293T C33(1.21); C390(0.96)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C33(1.75); C242(1.00)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C33(0.98)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C33(1.11); C390(0.95)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C33(1.30)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C33(1.03)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C33(1.01)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C33(0.99); C390(0.87)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C33(1.07)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C33(0.91)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C33(0.91)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C33(1.06); C390(0.91)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C33(1.38); C242(0.73)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C33(1.41)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C33(1.24)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C33(1.08)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C33(0.95); C390(1.02)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C33(1.29)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C33(0.99)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C33(0.96)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C33(1.03); C390(0.98)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C33(0.97)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C33(0.91)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C33(1.45)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C33(0.98)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C33(0.97); C390(0.92)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C33(1.02)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C33(1.28)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C33(1.07)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C33(1.07); C390(1.02)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C33(1.18)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C33(1.08)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C33(1.04)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C33(1.13); C390(1.01)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C33(1.03)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C33(1.68)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C33(0.91)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C33(1.47)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C33(1.03)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C33(1.14)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C33(1.03)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C33(1.01)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C33(1.49)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C33(1.07); C242(0.65)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C33(1.12); C242(0.65)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C33(1.37)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C33(1.37); C390(1.08)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C33(0.99)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C33(0.97)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C33(1.03)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C33(0.96)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C33(1.18)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C33(1.02)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C33(1.11)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C33(1.08)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C33(2.44)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C33(1.19); C242(0.65)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C33(1.34); C242(0.63)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C33(1.33)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C33(1.15); C390(1.09)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C33(1.03)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C33(1.06)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C33(0.90)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C33(1.08)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C33(0.98)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C33(1.13)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C33(1.04)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C33(1.26)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C33(1.33); C242(0.67)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C33(1.35); C242(0.69)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C33(1.21)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C33(1.06); C390(1.11)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C33(1.06)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C33(1.22)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C33(0.90)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C33(1.36)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C33(1.12)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C33(1.05)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C33(1.19)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C33(1.36)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C33(1.13); C242(0.76)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C33(1.35); C242(0.74)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C33(1.23)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C33(1.54)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C33(1.00); C390(1.14)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C33(1.00)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C33(0.91)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C33(1.29)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C33(0.96)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C33(1.03)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C33(1.00)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C33(1.13)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C33(1.20)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C33(1.12)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C33(1.11); C242(0.65)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C33(1.23); C242(0.77)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C33(1.28)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C33(1.23); C390(0.98)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C33(1.00)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C33(0.92)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C33(1.42)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C33(0.95)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C33(1.01)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C33(2.21)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C33(0.93)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C33(1.05)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C33(0.96); C242(0.75)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C33(1.34); C242(0.75)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C33(1.64)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C33(1.06); C390(1.29)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C33(1.15)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C33(1.03)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C33(0.99)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C33(1.00)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C33(1.26)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C33(1.40)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C33(1.03)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C33(1.12)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C33(1.30)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C33(0.96); C242(0.84)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C33(1.74); C242(1.15)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C33(1.54)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C33(1.09); C390(1.02)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C33(1.06)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C33(1.02)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C33(1.04)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C242(4.38); C236(2.60)  LDD1702  [2]
 LDCM0202  EV-93 T cell C33(4.43)  LDD0514  [13]
 LDCM0203  EV-96 T cell C33(4.22)  LDD0523  [13]
 LDCM0204  EV-97 T cell C33(5.04)  LDD0525  [13]
 LDCM0625  F8 Ramos C236(1.58)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C390(7.99)  LDD2190  [14]
 LDCM0575  Fragment13 Ramos C236(1.47)  LDD2192  [14]
 LDCM0580  Fragment21 Ramos C236(1.59)  LDD2195  [14]
 LDCM0578  Fragment27 Ramos C236(1.82)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C236(0.75)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C236(3.40)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C236(3.32)  LDD2200  [14]
 LDCM0468  Fragment33 HEK-293T C33(0.98)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C33(0.89)  LDD1631  [12]
 LDCM0614  Fragment56 Ramos C236(2.98)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C390(0.18)  LDD2186  [14]
 LDCM0022  KB02 HEK-293T C33(0.82)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C33(267.50)  LDD0209  [4]
 LDCM0024  KB05 G361 C33(4.78)  LDD3311  [15]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C33(1.24)  LDD2105  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C236(1.01)  LDD2111  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C33(1.65); C236(1.28)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C33(1.13); C236(1.22)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C236(1.01)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C33(2.71); C236(1.53)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C33(1.35)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
E3 ubiquitin-protein ligase RNF144A (RNF144A) RBR family P50876
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bestrophin-2 (BEST2) Anion channel-forming bestrophin family Q8NFU1
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Clarin-1 (CLRN1) Clarin family P58418
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-5 protein (GJA5) Connexin family P36382
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Statherin (STATH) Histatin/statherin family P02808
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Synaptic vesicular amine transporter (SLC18A2) Vesicular transporter family Q05940
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Cardiac phospholamban (PLN) Phospholamban family P26678
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Transmembrane protein 203 (TMEM203) . Q969S6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Adhesion G protein-coupled receptor E2 (ADGRE2) G-protein coupled receptor 2 family Q9UHX3
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Interleukin-27 receptor subunit alpha (IL27RA) Type I cytokine receptor family Q6UWB1
Tumor necrosis factor receptor superfamily member 5 (CD40) . P25942
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Bladder cancer-associated protein (BLCAP) BLCAP family P62952
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Protein KASH5 (KASH5) . Q8N6L0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 130 (TMEM130) . Q8N3G9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840