Details of the Target

General Information of Target

Target ID LDTP10077
Target Name Patatin-like phospholipase domain-containing protein 2 (PNPLA2)
Gene Name PNPLA2
Gene ID 57104
Synonyms
ATGL; Patatin-like phospholipase domain-containing protein 2; EC 3.1.1.3; Adipose triglyceride lipase; Calcium-independent phospholipase A2-zeta; iPLA2-zeta; EC 3.1.1.4; Desnutrin; Pigment epithelium-derived factor receptor; PEDF-R; TTS2.2; Transport-secretion protein 2; TTS2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQITARIL
EAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDAST
GDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRA
KDQNESLDEEMFYKLTSGWV
Target Bioclass
Enzyme
Subcellular location
Lipid droplet
Function
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets . Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade. Also possesses acylglycerol transacylase and phospholipase A2 activities. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes.
Uniprot ID
Q96AD5
Ensemble ID
ENST00000336615.9
HGNC ID
HGNC:30802
ChEMBL ID
CHEMBL3822353

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.L84CfsTer8 .
JURLMK1 SNV: p.E368Q .
LS180 SNV: p.K384E .
NCIH446 SNV: p.E437K .
OVCAR5 SNV: p.A495V .
TE4 SNV: p.S391C .
VCAP SNV: p.G483W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
STPyne
 Probe Info  		K224(10.00)  LDD0277  [3]
Curcusone 37
 Probe Info  		2.16  LDD0188  [4]
HPAP
 Probe Info  		3.67  LDD0062  [5]
Alkyne-RA190
 Probe Info  		2.29  LDD0299  [6]
DBIA
 Probe Info  		C439(6.43)  LDD0209  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		C194(0.00); C312(0.00); C412(0.00); C439(0.00)  LDD2226  [10]
NAIA_5
 Probe Info  		N.A.  LDD2225  [10]
TFBX
 Probe Info  		C412(0.00); C374(0.00)  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0476  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe3
 Probe Info  		20.00  LDD0465  [14]
A-DA
 Probe Info  		2.17  LDD0142  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C144(0.94); C152(0.94)  LDD1093  [17]
 LDCM0215  AC10 PaTu 8988t C144(1.26); C152(1.26)  LDD1094  [17]
 LDCM0216  AC100 HCT 116 C144(0.35); C152(0.35); C374(0.77); C412(0.80)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C144(0.45); C152(0.45); C374(0.88); C412(1.06)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C144(0.43); C152(0.43); C374(0.78); C412(1.01)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C144(0.48); C152(0.48); C374(1.18); C412(1.08)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C144(0.35); C152(0.35); C374(0.81); C412(1.17)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C144(0.37); C152(0.37); C374(0.79); C412(0.98)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C144(0.50); C152(0.50); C374(0.68); C412(0.98)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C144(0.45); C152(0.47); C374(0.60); C412(1.23)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C144(0.35); C152(0.46); C374(0.98); C412(0.93)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C144(0.49); C152(0.37); C374(0.65); C412(1.01)  LDD0542  [17]
 LDCM0226  AC11 PaTu 8988t C144(0.99); C152(0.99)  LDD1105  [17]
 LDCM0227  AC110 HCT 116 C144(0.35); C152(0.49); C374(0.67); C412(1.05)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C144(0.50); C152(0.44); C374(0.86); C412(1.13)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C144(0.36); C152(0.42); C374(0.87); C412(1.14)  LDD0546  [17]
 LDCM0230  AC113 HEK-293T C412(1.33)  LDD0828  [17]
 LDCM0231  AC114 HEK-293T C412(0.84)  LDD0829  [17]
 LDCM0232  AC115 HEK-293T C412(0.79)  LDD0830  [17]
 LDCM0233  AC116 HEK-293T C412(0.90)  LDD0831  [17]
 LDCM0234  AC117 HEK-293T C412(1.10)  LDD0832  [17]
 LDCM0235  AC118 HEK-293T C412(0.96)  LDD0833  [17]
 LDCM0236  AC119 HEK-293T C412(1.12)  LDD0834  [17]
 LDCM0237  AC12 PaTu 8988t C144(0.82); C152(0.82)  LDD1116  [17]
 LDCM0238  AC120 HEK-293T C412(1.03)  LDD0836  [17]
 LDCM0239  AC121 HEK-293T C412(1.35)  LDD0837  [17]
 LDCM0240  AC122 HEK-293T C412(1.24)  LDD0838  [17]
 LDCM0241  AC123 HEK-293T C412(1.93)  LDD0839  [17]
 LDCM0242  AC124 HEK-293T C412(1.48)  LDD0840  [17]
 LDCM0243  AC125 HEK-293T C412(1.50)  LDD0841  [17]
 LDCM0244  AC126 HEK-293T C412(1.29)  LDD0842  [17]
 LDCM0245  AC127 HEK-293T C412(2.04)  LDD0843  [17]
 LDCM0246  AC128 PaTu 8988t C144(0.81); C152(0.81)  LDD1125  [17]
 LDCM0247  AC129 PaTu 8988t C144(0.77); C152(0.77)  LDD1126  [17]
 LDCM0249  AC130 PaTu 8988t C144(0.84); C152(0.84)  LDD1128  [17]
 LDCM0250  AC131 PaTu 8988t C144(0.69); C152(0.69)  LDD1129  [17]
 LDCM0251  AC132 PaTu 8988t C144(0.77); C152(0.77)  LDD1130  [17]
 LDCM0252  AC133 PaTu 8988t C144(0.82); C152(0.82)  LDD1131  [17]
 LDCM0253  AC134 PaTu 8988t C144(0.66); C152(0.66)  LDD1132  [17]
 LDCM0254  AC135 PaTu 8988t C144(0.94); C152(0.94)  LDD1133  [17]
 LDCM0255  AC136 PaTu 8988t C144(0.86); C152(0.86)  LDD1134  [17]
 LDCM0256  AC137 PaTu 8988t C144(1.23); C152(1.23)  LDD1135  [17]
 LDCM0257  AC138 PaTu 8988t C144(0.97); C152(0.97)  LDD1136  [17]
 LDCM0258  AC139 PaTu 8988t C144(0.84); C152(0.84)  LDD1137  [17]
 LDCM0259  AC14 PaTu 8988t C144(0.89); C152(0.89)  LDD1138  [17]
 LDCM0260  AC140 PaTu 8988t C144(1.06); C152(1.06)  LDD1139  [17]
 LDCM0261  AC141 PaTu 8988t C144(0.75); C152(0.75)  LDD1140  [17]
 LDCM0262  AC142 PaTu 8988t C144(0.90); C152(0.90)  LDD1141  [17]
 LDCM0263  AC143 HCT 116 C144(0.79); C152(0.79); C374(0.91)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C144(0.77); C152(0.77); C374(1.36)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C374(0.86); C144(1.23); C152(1.23)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C144(0.75); C152(0.75); C374(1.21)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C144(0.78); C152(0.78); C374(1.68)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C144(1.02); C152(1.02); C374(1.61)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C144(0.74); C152(0.74); C374(1.21)  LDD0586  [17]
 LDCM0270  AC15 PaTu 8988t C144(0.82); C152(0.82)  LDD1149  [17]
 LDCM0271  AC150 HCT 116 C144(0.77); C152(0.77); C374(1.15)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C144(0.67); C152(0.67); C374(1.24)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C144(0.92); C152(0.92); C374(1.22)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C144(0.96); C152(0.96); C374(1.48)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C144(0.73); C152(0.73); C374(1.77)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C144(0.95); C152(0.95); C374(1.76)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C144(0.79); C152(0.79); C374(1.26)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C144(1.07); C152(1.07); C374(1.18)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C144(1.08); C152(1.08)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C144(0.72); C152(0.72)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C144(1.04); C152(1.04)  LDD0595  [17]
 LDCM0279  AC2 PaTu 8988t C144(1.00); C152(1.00)  LDD1158  [17]
 LDCM0280  AC20 HCT 116 C144(1.08); C152(1.08)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C144(0.90); C152(0.90)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C144(1.13); C152(1.13)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C144(1.05); C152(1.05)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C144(1.40); C152(1.40)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C144(0.98); C152(0.98)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C144(0.89); C152(0.89)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C144(0.96); C152(0.96)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C144(0.94); C152(0.94)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C144(0.64); C152(0.64)  LDD0606  [17]
 LDCM0290  AC3 PaTu 8988t C144(0.98); C152(0.98)  LDD1169  [17]
 LDCM0291  AC30 HCT 116 C144(0.79); C152(0.79)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C144(0.74); C152(0.74)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C144(0.73); C152(0.73)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C144(0.86); C152(0.86)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C144(0.77); C152(0.77)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C412(1.51)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C412(1.50)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C412(1.34)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C412(1.83)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C412(1.59)  LDD0617  [17]
 LDCM0301  AC4 PaTu 8988t C144(1.10); C152(1.10)  LDD1180  [17]
 LDCM0302  AC40 HCT 116 C412(1.66)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C412(1.27)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C412(1.29)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C412(1.47)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C412(1.44)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C412(1.40)  LDD0624  [17]
 LDCM0309  AC47 HEK-293T C449(1.24); C412(1.19)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C449(1.07); C152(1.17)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C449(1.06); C312(0.98)  LDD1550  [18]
 LDCM0312  AC5 PaTu 8988t C144(1.05); C152(1.05)  LDD1191  [17]
 LDCM0313  AC50 HEK-293T C412(0.97)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C449(1.13); C412(1.01); C152(1.01)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C449(0.80); C152(0.88)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C449(1.01)  LDD1555  [18]
 LDCM0318  AC55 HEK-293T C449(1.00); C412(0.93)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C449(0.95); C152(1.11)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C412(0.83)  LDD0918  [17]
 LDCM0321  AC58 HEK-293T C412(0.79)  LDD0919  [17]
 LDCM0322  AC59 HEK-293T C412(0.75)  LDD0920  [17]
 LDCM0323  AC6 PaTu 8988t C144(0.61); C152(0.61)  LDD1202  [17]
 LDCM0324  AC60 HEK-293T C412(0.76)  LDD0922  [17]
 LDCM0325  AC61 HEK-293T C412(1.07)  LDD0923  [17]
 LDCM0326  AC62 HEK-293T C412(1.08)  LDD0924  [17]
 LDCM0327  AC63 HEK-293T C412(0.78)  LDD0925  [17]
 LDCM0328  AC64 HEK-293T C412(1.06)  LDD0926  [17]
 LDCM0329  AC65 HEK-293T C412(1.17)  LDD0927  [17]
 LDCM0330  AC66 HEK-293T C412(0.96)  LDD0928  [17]
 LDCM0331  AC67 HEK-293T C412(0.97)  LDD0929  [17]
 LDCM0332  AC68 HCT 116 C374(1.12)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C374(1.01)  LDD0650  [17]
 LDCM0334  AC7 PaTu 8988t C144(1.08); C152(1.08)  LDD1213  [17]
 LDCM0335  AC70 HCT 116 C374(0.97)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C374(0.89)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C374(0.86)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C374(1.03)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C374(1.17)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C374(1.08)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C374(0.99)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C374(0.95)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C374(1.12)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C374(1.03)  LDD0661  [17]
 LDCM0345  AC8 PaTu 8988t C144(1.25); C152(1.25)  LDD1224  [17]
 LDCM0346  AC80 HCT 116 C374(1.22)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C374(0.97)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C374(0.97)  LDD0665  [17]
 LDCM0365  AC98 HCT 116 C144(0.36); C152(0.36); C374(0.82); C412(1.01)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C144(0.40); C152(0.40); C412(0.82); C374(0.99)  LDD0683  [17]
 LDCM0248  AKOS034007472 PaTu 8988t C144(0.88); C152(0.88)  LDD1127  [17]
 LDCM0356  AKOS034007680 PaTu 8988t C144(1.22); C152(1.22)  LDD1235  [17]
 LDCM0275  AKOS034007705 PaTu 8988t C144(0.93); C152(0.93)  LDD1154  [17]
 LDCM0156  Aniline NCI-H1299 12.35  LDD0403  [1]
 LDCM0083  Avasimibe A-549 8.08  LDD0143  [15]
 LDCM0630  CCW28-3 231MFP C312(2.15)  LDD2214  [19]
 LDCM0367  CL1 HCT 116 C144(0.94); C152(0.94)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C144(1.63); C152(1.63)  LDD0685  [17]
 LDCM0369  CL100 PaTu 8988t C144(0.94); C152(0.94)  LDD1248  [17]
 LDCM0370  CL101 PaTu 8988t C144(1.06); C152(1.06)  LDD1249  [17]
 LDCM0371  CL102 PaTu 8988t C144(0.74); C152(0.74)  LDD1250  [17]
 LDCM0372  CL103 PaTu 8988t C144(0.90); C152(0.90)  LDD1251  [17]
 LDCM0373  CL104 PaTu 8988t C144(1.00); C152(1.00)  LDD1252  [17]
 LDCM0374  CL105 HCT 116 C144(0.93); C152(0.93)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C144(0.83); C152(0.83)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C144(0.93); C152(0.93)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C144(0.97); C152(0.97)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C144(0.91); C152(0.91)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C144(0.95); C152(0.95)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C144(1.01); C152(1.01)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C144(1.02); C152(1.02)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C144(0.82); C152(0.82)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C144(0.98); C152(0.98)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C144(0.64); C152(0.64)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C144(1.10); C152(1.10)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C144(0.90); C152(0.90)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C412(1.73)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C412(1.04)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C412(1.00)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C144(0.80); C152(0.80)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C412(1.18)  LDD0708  [17]
 LDCM0393  CL122 HEK-293T C374(1.06); C449(0.96); C152(0.95)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C449(0.98); C152(1.12)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C449(0.93)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C412(0.71)  LDD0994  [17]
 LDCM0397  CL126 HEK-293T C412(0.66)  LDD0995  [17]
 LDCM0398  CL127 HEK-293T C412(0.75)  LDD0996  [17]
 LDCM0399  CL128 HEK-293T C412(0.68)  LDD0997  [17]
 LDCM0400  CL13 HCT 116 C144(0.71); C152(0.71)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C144(0.97); C152(0.97)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C144(0.81); C152(0.81)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C144(0.78); C152(0.78); C374(0.95); C412(1.27)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C144(0.77); C152(0.77); C374(0.85)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C144(0.61); C152(0.61); C374(0.86)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C374(0.87); C144(1.20); C152(1.20)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C144(0.65); C152(0.65)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C374(0.80); C144(0.97); C152(0.97)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C374(0.87); C144(0.90); C152(0.90)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C374(0.90); C144(0.99); C152(0.99)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C144(0.96); C152(0.96); C374(1.06)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C144(0.91); C152(0.91); C374(0.98)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C144(1.18); C152(1.18); C374(0.81)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C144(0.78); C152(0.78); C374(1.00)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C144(1.07); C152(1.07); C374(1.05)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C144(1.28); C152(1.28); C374(1.10)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C144(0.90); C152(0.90); C374(0.99)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C144(2.57); C152(2.57)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C144(0.75); C152(0.75); C374(1.04)  LDD0736  [17]
 LDCM0420  CL31 HEK-293T C152(1.08)  LDD1018  [17]
 LDCM0421  CL32 HCT 116 C412(1.06)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C412(1.68)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C412(1.09)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C412(0.83)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C412(1.27)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C412(0.89)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C412(1.12)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C144(1.62); C152(1.62)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C412(1.02)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C412(1.05)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C412(0.88)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C412(1.13)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C412(0.86)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C412(0.81)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C144(1.32); C152(1.32)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C144(1.11); C152(1.11)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C144(1.49); C152(1.49)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C144(1.50); C152(1.50)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C144(0.75); C152(0.75)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C144(1.23); C152(1.23)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C144(1.36); C152(1.36)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C144(1.38); C152(1.38)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C144(1.23); C152(1.23)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C144(1.93); C152(1.93)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C144(1.33); C152(1.33)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C144(1.01); C152(1.01)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C144(1.09); C152(1.09)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C144(1.25); C152(1.25)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C144(1.52); C152(1.52)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C144(0.69); C152(0.69)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C144(1.31); C152(1.31)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C144(0.84); C152(0.84)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C144(0.68); C152(0.68)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C144(0.68); C152(0.68)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C144(0.77); C152(0.77)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C144(0.62); C152(0.62)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C144(1.23); C152(1.23)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C144(0.64); C152(0.64)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C144(0.72); C152(0.72)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C144(0.80); C152(0.80)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C144(0.77); C152(0.77)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C144(0.83); C152(0.83)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C144(0.79); C152(0.79)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C144(0.89); C152(0.89)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C144(0.81); C152(0.81)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C144(0.78); C152(0.78)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C144(0.93); C152(0.93); C412(1.05)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C144(0.89); C152(0.89); C412(0.85)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C144(0.88); C152(0.88); C412(1.07)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C144(1.10); C152(1.10); C412(0.82)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C144(1.41); C152(1.41)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C144(0.74); C152(0.74); C412(0.90)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C144(0.96); C152(0.96); C412(0.88)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C144(1.22); C152(1.22); C412(0.88)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C144(1.10); C152(1.10); C412(0.99)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C144(1.13); C152(1.13); C412(1.27)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C144(0.93); C152(0.93); C412(1.14)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C144(0.80); C152(0.80); C412(0.98)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C144(1.57); C152(1.57); C412(0.92)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C144(1.02); C152(1.02); C412(0.85)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C144(1.06); C152(1.06); C412(0.87)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C144(1.87); C152(1.87)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C144(3.18); C152(3.18); C412(1.32)  LDD0802  [17]
 LDCM0486  CL91 PaTu 8988t C144(0.85); C152(0.85)  LDD1365  [17]
 LDCM0487  CL92 PaTu 8988t C144(1.12); C152(1.12)  LDD1366  [17]
 LDCM0488  CL93 PaTu 8988t C144(1.12); C152(1.12)  LDD1367  [17]
 LDCM0489  CL94 PaTu 8988t C144(1.03); C152(1.03)  LDD1368  [17]
 LDCM0490  CL95 PaTu 8988t C144(1.21); C152(1.21)  LDD1369  [17]
 LDCM0491  CL96 PaTu 8988t C144(0.98); C152(0.98)  LDD1370  [17]
 LDCM0492  CL97 PaTu 8988t C144(0.94); C152(0.94)  LDD1371  [17]
 LDCM0493  CL98 PaTu 8988t C144(0.97); C152(0.97)  LDD1372  [17]
 LDCM0494  CL99 PaTu 8988t C144(0.93); C152(0.93)  LDD1373  [17]
 LDCM0033  Curcusone1d MCF-7 2.16  LDD0188  [4]
 LDCM0495  E2913 HEK-293T C449(0.84); C152(1.02)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C412(0.98)  LDD1702  [20]
 LDCM0203  EV-96 T cell C412(4.86)  LDD0523  [21]
 LDCM0082  FK866 A-549 2.17  LDD0142  [15]
 LDCM0468  Fragment33 HCT 116 C144(0.68); C152(0.68)  LDD0785  [17]
 LDCM0427  Fragment51 HCT 116 C412(0.97)  LDD0744  [17]
 LDCM0149  GA MCF-7 C412(2.43)  LDD0379  [22]
 LDCM0022  KB02 T cell C412(5.42)  LDD1703  [21]
 LDCM0023  KB03 Jurkat C439(6.43)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C88(3.06)  LDD3310  [23]
 LDCM0014  Panhematin HEK-293T 3.67  LDD0062  [5]
 LDCM0131  RA190 MM1.R 2.29  LDD0299  [6]
 LDCM0084  Ro 48-8071 A-549 2.00  LDD0144  [15]

References

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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD039908 , PXD029761
21 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
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Mass spectrometry data entry: PXD047840