Details of the Target

General Information of Target

Target ID LDTP02747
Target Name Interleukin-2 receptor subunit beta (IL2RB)
Gene Name IL2RB
Gene ID 3560
Synonyms
IL15RB; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75; p75; CD antigen CD122
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQ
VHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMA
IQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEE
APLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
IPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDV
QKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFT
NQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCT
FPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVP
DLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQ
ELQGQDPTHLV
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 4 subfamily
Subcellular location
Cell membrane
Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
TTD ID
T19579
Uniprot ID
P14784
DrugMap ID
TT9721Y
Ensemble ID
ENST00000216223.10
HGNC ID
HGNC:6009
ChEMBL ID
CHEMBL3276

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(0.94)  LDD2412  [1]
IA-alkyne
 Probe Info  		C280(5.70)  LDD0523  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0203  EV-96 T cell C280(5.70)  LDD0523  [2]
 LDCM0022  KB02 T cell-activated C280(6.79)  LDD1704  [2]
 LDCM0023  KB03 Karpas-299 C194(1.02)  LDD2829  [1]
 LDCM0024  KB05 Karpas-299 C194(0.93)  LDD3246  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-15 (IL15) IL-15/IL-21 family P40933
Interleukin-2 (IL2) IL-2 family P60568

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aldesleukin BiotechDrug DB00041
Denileukin Diftitox BiotechDrug DB00004
Basiliximab Monoclonal antibody DB00074
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nktr-214 Recombinant protein D5ISZ1
Nktr 214 . D02QQE
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aftvac Vaccine D05YFL
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Leukocyte Interleukin . D0U0RJ
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Daclizumab Monoclonal antibody DB00111
Dab-486-il-2 . D06KWH

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.