Details of the Target

General Information of Target

Target ID LDTP07522
Target Name Centrosomal protein of 85 kDa (CEP85)
Gene Name CEP85
Gene ID 64793
Synonyms
CCDC21; Centrosomal protein of 85 kDa; Cep85; Coiled-coil domain-containing protein 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAI
GTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPL
SGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFD
IPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGP
HSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQM
QLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRE
SELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE
VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE
RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR
EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL
EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS
PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL
QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ
Target Bioclass
Other
Family
CEP85 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility. Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity.
Uniprot ID
Q6P2H3
Ensemble ID
ENST00000252992.8
HGNC ID
HGNC:25309

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.14  LDD0403  [1]
DA-P3
 Probe Info  		6.55  LDD0179  [2]
HPAP
 Probe Info  		3.12  LDD0062  [3]
DBIA
 Probe Info  		C281(1.29); C286(1.29); C49(1.20); C64(1.20)  LDD0078  [4]
W1
 Probe Info  		C380(1.11)  LDD0239  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
IPM
 Probe Info  		C380(0.00); C281(0.00)  LDD0147  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		14.70  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C281(0.56); C380(0.86)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C286(1.03); C281(1.03); C380(1.08)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C286(0.67); C281(0.67); C380(0.97)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C286(0.72); C281(0.72); C380(0.92)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C286(0.79); C281(0.79); C380(0.87)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C286(0.88); C281(0.88); C380(1.05)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C286(0.89); C281(0.89); C380(0.92)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C286(0.69); C281(0.69); C380(1.02)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C286(0.83); C281(0.83); C380(1.13)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C286(0.69); C281(0.69); C380(1.03)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C286(0.82); C281(0.82); C380(1.05)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C286(0.92); C281(0.92); C380(0.91)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C286(1.18); C281(1.18); C380(1.32)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C286(0.76); C281(0.76); C380(0.89)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C286(0.68); C281(0.68); C380(0.87)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C286(0.97); C281(0.97); C380(0.92)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C286(0.80); C281(0.90); C380(0.98)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C286(0.99); C281(0.94); C380(1.00)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C286(0.92); C281(0.85); C380(0.99)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C286(1.07); C281(1.02); C380(1.03)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C286(0.98); C281(1.06); C380(0.99)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C286(1.00); C281(0.98); C380(1.00)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C286(1.09); C281(1.30); C380(1.12)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C286(1.15); C281(1.15); C380(1.17)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C286(1.07); C281(1.12); C380(1.07)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C286(0.95); C281(0.91); C380(0.82)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C286(0.97); C281(1.03); C380(1.17)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C286(0.87); C281(0.94); C380(0.94)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C286(0.95); C281(0.93); C380(0.88)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C286(0.96); C281(0.99); C380(0.92)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C286(0.92); C281(0.89); C380(1.01)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C286(1.13); C281(1.09); C380(0.92)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C286(0.94); C281(0.97); C380(1.01)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C286(0.99); C281(0.95); C380(1.25)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C286(1.03); C281(1.10); C380(1.20)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C286(1.13); C281(1.04); C380(1.15)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C286(1.15); C281(1.52); C380(1.30)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C286(1.14); C281(1.00); C380(1.14)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C286(1.35); C281(1.47); C380(1.13)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C286(1.12); C281(0.98); C380(1.26)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C286(1.04); C281(1.05); C380(1.22)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C286(1.33); C281(1.15); C380(1.31)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C286(1.20); C281(1.12); C380(1.24)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C286(1.38); C281(1.07); C380(1.35)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C286(1.17); C281(1.17); C380(0.94)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C286(1.18); C281(1.19); C380(1.54)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C286(1.21); C281(1.13); C380(1.41)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C286(0.92); C281(0.93); C380(1.17)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C286(1.05); C281(1.01); C380(1.09)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C281(0.84); C286(0.86); C380(1.14)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C286(0.89); C281(0.92); C380(0.95)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C281(0.90); C286(1.02); C380(1.21)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C281(0.91); C380(0.94); C286(0.97)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C286(0.90); C281(0.95); C380(1.33)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C281(0.99); C286(1.12); C380(1.26)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C286(0.91); C281(0.91); C380(1.02)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C380(0.92); C281(1.18); C286(1.44)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C281(0.88); C286(0.98); C380(1.22)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C380(0.85); C281(0.88); C286(0.98)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C286(0.89); C281(0.98); C380(1.23)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C286(0.81); C281(0.90); C380(0.92)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C286(1.00); C281(0.96); C380(1.26)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C286(1.09); C281(1.03); C380(1.02)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C286(0.76); C281(0.83); C380(0.92)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C286(0.94); C380(1.10); C281(1.16)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C286(1.01); C380(1.07); C281(1.16)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C286(0.98); C380(1.12); C281(1.18)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C281(0.88); C380(1.18)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C286(0.88); C281(1.00); C380(1.15)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C286(0.93); C281(1.01); C380(1.11)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C286(0.77); C281(1.07); C380(1.34)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C286(1.13); C281(1.29); C380(1.47)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C286(0.68); C380(1.08); C281(1.16)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C380(1.13); C286(1.23); C281(1.23)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C286(1.25); C281(1.25); C380(1.42)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C286(1.14); C281(1.14); C380(1.40)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C286(0.98); C281(0.98); C380(1.37)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C286(1.07); C281(1.07); C380(1.34)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C281(0.73); C380(1.07)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C286(1.11); C281(1.11); C380(1.60)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C286(1.27); C281(1.27); C380(1.65)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C286(1.12); C281(1.12); C380(1.61)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C380(1.12); C286(1.19); C281(1.19)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C380(0.91); C286(1.08); C281(1.08)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C281(0.89); C380(1.44)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C281(1.02); C380(1.42)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C281(0.70); C380(1.40)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C281(1.08); C380(1.19)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C281(1.06); C380(1.25)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C281(0.67); C380(1.18)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C380(1.25); C281(1.38)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C380(1.29); C281(1.39)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C380(1.13); C281(1.28)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C380(1.10); C281(1.38)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C281(0.96); C380(1.30)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C281(1.00); C380(1.31)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C286(1.18); C281(1.18); C380(1.47)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C286(0.86); C281(0.86); C380(1.10)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C286(0.84); C281(0.84); C380(1.16)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C286(1.03); C281(1.03); C380(1.39)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C281(0.68); C380(1.12)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C286(0.91); C281(0.91); C380(1.34)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C286(0.83); C281(0.83); C380(1.37)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C286(0.78); C281(0.78); C380(1.19)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C286(0.91); C281(0.91); C380(1.10)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C286(0.74); C281(0.74); C380(1.03)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C286(1.04); C281(1.04); C380(1.15)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C286(0.89); C281(0.89); C380(1.13)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C286(0.95); C281(0.98); C380(1.40)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C286(0.90); C281(0.99); C380(1.48)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C281(1.00); C286(1.14); C380(1.51)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C286(1.11); C281(1.11); C380(1.11)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C281(1.17); C286(1.39); C380(1.40)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C281(0.79); C286(1.00); C380(1.24)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C281(0.96); C286(1.21); C380(2.14)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C281(1.04); C380(1.35); C286(1.54)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C281(0.93); C286(1.34); C380(1.61)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C281(0.94); C286(1.20); C380(1.31)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C281(0.85); C286(1.15); C380(1.38)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C281(1.02); C380(1.46); C286(1.49)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C380(0.72); C286(0.98); C281(0.98)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C380(0.79); C286(0.91); C281(0.91)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C286(1.11); C281(1.11); C380(1.17)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C286(1.14); C281(1.14); C380(1.53)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C286(0.75); C281(0.75); C380(0.86)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C286(1.09); C281(1.09); C380(1.34)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C286(1.17); C281(1.17); C380(1.39)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C286(0.80); C281(0.80); C380(1.00)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C380(1.09); C286(1.18); C281(1.18)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C286(0.93); C281(0.93); C380(0.97)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C380(0.78); C286(1.16); C281(1.16)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C380(0.76); C286(0.99); C281(0.99)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C380(1.08); C286(1.10); C281(1.10)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C286(1.03); C281(1.03); C380(1.14)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C286(0.84); C281(0.84); C380(0.92)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C286(1.06); C281(1.06); C380(1.07)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C380(0.98); C286(0.99); C281(0.99)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C286(1.23); C281(1.23); C380(1.26)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C286(1.20); C281(1.20); C380(1.21)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C380(1.28); C286(1.32); C281(1.32)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C380(1.19); C286(1.33); C281(1.33)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C286(1.11); C281(1.11); C380(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C380(1.17); C286(1.27); C281(1.27)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C380(1.23); C286(1.32); C281(1.32)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C380(1.26); C286(1.30); C281(1.30)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C286(1.38); C281(1.38); C380(1.47)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C286(1.35); C281(1.35); C380(1.50)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C380(1.12); C286(1.32); C281(1.32)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C286(1.42); C281(1.42); C380(1.43)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C380(1.29); C286(1.32); C281(1.32)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C286(1.23); C281(1.23); C380(1.35)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C380(1.38); C286(1.57); C281(1.57)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C286(0.78); C281(0.78); C380(1.24)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C286(0.74); C281(0.74); C380(0.91)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C286(1.04); C281(1.04); C380(1.02)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C380(1.27); C286(1.40); C281(1.40)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C286(1.04); C281(1.04); C380(1.18)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 12.14  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C281(1.29); C286(1.29); C49(1.20); C64(1.20)  LDD0078  [4]
 LDCM0087  Capsaicin HEK-293T 82.62  LDD0185  [2]
 LDCM0367  CL1 HCT 116 C281(1.69); C380(2.07); C286(2.88)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C281(1.10); C286(1.32); C380(1.42)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C281(0.61); C380(1.36)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C380(1.34); C286(1.68); C281(1.68)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C380(1.39); C286(2.72); C281(2.72)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C286(1.04); C281(1.04); C380(1.18)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C380(1.17); C286(1.52); C281(1.52)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C286(1.30); C380(1.31); C281(1.38)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C286(1.22); C380(1.22); C281(1.61)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C286(0.97); C380(1.03); C281(1.23)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C286(1.24); C281(1.39); C380(1.76)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C281(1.63); C286(1.70); C380(2.00)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C380(1.70); C281(1.72); C286(2.72)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C380(2.05); C286(2.39); C281(2.49)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C286(1.73); C380(1.85); C281(2.08)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C380(1.33); C286(1.35); C281(1.35)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C286(1.14); C281(1.14); C380(1.46)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C380(1.24); C286(1.70); C281(1.70)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C380(1.28); C286(1.55); C281(1.55)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C380(1.10); C286(1.21); C281(1.21)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C380(1.41); C281(1.83)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C281(1.26); C380(2.30)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C281(0.74); C380(1.63)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C281(1.04); C286(1.32); C380(1.41)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C380(1.51); C281(2.04)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C380(1.33); C286(1.40); C281(1.40)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C286(1.06); C281(1.06); C380(1.11)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C380(2.23); C286(2.91); C281(2.91)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C286(1.41); C281(1.41); C380(1.53)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C281(1.19); C286(1.28); C380(1.46)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C281(1.35); C286(1.69); C380(2.36)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C281(1.13); C286(1.19); C380(1.33)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C286(0.84); C281(0.85); C380(1.53)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C286(0.62); C281(0.87); C380(1.16)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C281(1.28); C380(1.42); C286(1.87)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C380(1.97); C281(2.30); C286(2.45)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C380(1.13); C286(1.45); C281(1.45)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C380(1.64); C286(1.65); C281(1.65)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C286(0.96); C281(0.96); C380(1.09)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C380(1.04); C286(1.25); C281(1.25)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C281(1.40); C380(1.56); C286(2.09)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C286(0.72); C281(0.72); C380(1.29)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C380(1.51); C286(2.47); C281(2.47)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C380(1.31); C286(2.33); C281(2.33)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C380(0.96); C286(1.07); C281(1.07)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C286(0.88); C281(0.88); C380(1.25)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C286(1.10); C281(1.10); C380(1.65)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C286(1.01); C281(1.01); C380(1.04)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C286(1.30); C281(1.30); C380(1.43)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C286(1.60); C281(1.60); C380(1.90)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C286(0.79); C281(0.79); C380(1.30)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C286(1.42); C281(1.04); C380(1.41)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C286(0.93); C281(0.93); C380(1.34)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C281(0.94); C380(1.77)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C286(0.89); C281(0.65); C380(1.43)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C286(3.40); C281(2.17); C380(1.39)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C286(1.47); C281(1.28); C380(1.16)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C286(1.05); C281(1.16); C380(1.23)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C286(0.91); C281(0.78); C380(1.36)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C286(0.79); C281(0.76); C380(1.20)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C286(1.15); C281(0.94); C380(1.21)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C286(1.31); C281(1.96); C380(3.01)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C286(1.46); C281(1.61); C380(1.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C286(1.20); C281(0.99); C380(1.10)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C286(0.67); C281(0.85); C380(1.11)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C286(0.79); C281(0.96); C380(1.10)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C286(0.87); C281(0.74); C380(1.33)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C286(0.68); C281(1.15); C380(1.83)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C286(2.32); C281(2.32); C380(1.92)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C286(1.11); C281(1.11); C380(1.73)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C286(1.47); C281(1.47); C380(1.63)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C286(1.08); C281(1.08); C380(1.26)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C286(0.88); C281(0.66); C380(1.11)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C286(1.18); C281(1.18); C380(1.27)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C286(1.38); C281(1.38); C380(1.85)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C286(2.30); C281(2.30); C380(1.50)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C286(1.00); C281(1.00); C380(1.08)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C286(1.79); C281(1.79); C380(1.81)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C286(2.04); C281(2.04); C380(1.54)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C286(0.85); C281(0.85); C380(1.10)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C286(1.38); C281(1.38); C380(1.72)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C286(2.23); C281(2.23); C380(1.44)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C286(0.94); C281(0.94); C380(1.06)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C286(1.98); C281(1.27); C380(1.86)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C286(1.13); C281(1.13); C380(1.64)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C286(1.32); C281(1.67); C380(1.29)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C286(1.42); C281(1.52); C380(1.66)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C286(1.65); C281(1.76); C380(1.91)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C286(1.19); C281(1.28); C380(1.88)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C286(1.58); C281(1.93); C380(1.26)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C286(1.08); C281(1.06); C380(2.40)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C286(1.62); C281(1.84); C380(1.50)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C286(1.04); C281(1.05); C380(1.85)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C286(1.99); C281(1.93); C380(1.70)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C286(0.88); C281(0.84); C380(1.49)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C286(1.53); C281(1.55); C380(1.29)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C286(1.26); C281(1.28); C380(1.96)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C286(1.44); C281(1.45); C380(1.24)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C286(1.20); C281(1.41); C380(1.70)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C286(1.72); C281(1.66); C380(1.62)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C286(1.01); C281(1.10); C380(0.98)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C286(1.48); C281(1.25); C380(1.01)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C286(1.70); C281(1.59); C380(1.18)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C286(0.89); C281(0.94); C380(0.87)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C286(5.46); C281(3.11); C380(1.65)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C286(0.86); C281(0.83); C380(0.94)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C286(1.02); C281(0.86); C380(1.03)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C286(0.71); C281(0.76); C380(0.87)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C286(1.24); C281(1.19); C380(0.96)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C286(1.48); C281(1.23); C380(1.29)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C286(0.98); C281(0.95); C380(1.00)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C286(0.78); C281(0.86); C380(0.89)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C286(1.19); C281(1.17); C380(1.32)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C286(0.96); C281(0.88); C380(0.98)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C286(0.97); C281(0.86); C380(1.01)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C286(1.13); C281(1.07); C380(1.70)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C286(3.54); C281(3.54); C380(2.01)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C281(0.92); C380(1.29)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C281(0.98); C380(1.59)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C281(0.76); C380(1.15)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C281(0.63); C380(1.54)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C281(1.95); C380(1.41)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C281(0.76); C380(1.14)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C281(0.83); C380(1.48)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C281(0.96); C380(1.46)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C281(0.77); C380(1.22)  LDD0811  [4]
 LDCM0028  Dobutamine HEK-293T 31.23  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 6.55  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C527(1.04); C281(1.35)  LDD1698  [13]
 LDCM0203  EV-96 T cell C281, C286(5.88)  LDD0523  [14]
 LDCM0204  EV-97 T cell C281, C286(20.00)  LDD0525  [14]
 LDCM0468  Fragment33 HCT 116 C286(1.38); C281(1.33); C380(1.96)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C286(0.96); C281(0.96); C380(1.81)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C527(1.17)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C527(1.02)  LDD1497  [13]
 LDCM0024  KB05 IGR39 C527(0.58)  LDD3315  [15]
 LDCM0030  Luteolin HEK-293T 79.89  LDD0182  [2]
 LDCM0014  Panhematin HEK-293T 3.12  LDD0062  [3]
 LDCM0029  Quercetin HEK-293T 47.38  LDD0181  [2]
 LDCM0021  THZ1 HCT 116 C49(1.09); C64(1.09); C380(0.86)  LDD2173  [4]
 LDCM0112  W16 Hep-G2 C380(1.11)  LDD0239  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840