Details of the Target
General Information of Target
Target ID | LDTP05415 | |||||
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Target Name | AT-rich interactive domain-containing protein 5A (ARID5A) | |||||
Gene Name | ARID5A | |||||
Gene ID | 10865 | |||||
Synonyms |
MRF1; AT-rich interactive domain-containing protein 5A; ARID domain-containing protein 5A; Modulator recognition factor 1; MRF-1 |
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3D Structure | ||||||
Sequence |
MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQA
FLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGG SPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPK KAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYK RLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQS PKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPR DFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSP MAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAG SGLVSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLA TAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL |
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Target Bioclass |
Transcription factor
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Subcellular location |
Nucleus
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Function |
Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention. Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock. Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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IA-alkyne Probe Info |
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C130(4.43) | LDD0523 | [1] | |
DBIA Probe Info |
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C248(1.10) | LDD1509 | [2] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0226 | AC11 | HEK-293T | C248(1.10) | LDD1509 | [2] |
LDCM0259 | AC14 | HEK-293T | C416(0.81) | LDD1512 | [2] |
LDCM0270 | AC15 | HEK-293T | C248(0.93) | LDD1513 | [2] |
LDCM0278 | AC19 | HEK-293T | C248(1.10) | LDD1517 | [2] |
LDCM0282 | AC22 | HEK-293T | C416(0.80) | LDD1521 | [2] |
LDCM0283 | AC23 | HEK-293T | C248(1.09) | LDD1522 | [2] |
LDCM0287 | AC27 | HEK-293T | C248(1.25) | LDD1526 | [2] |
LDCM0290 | AC3 | HEK-293T | C248(1.11) | LDD1529 | [2] |
LDCM0291 | AC30 | HEK-293T | C416(0.83) | LDD1530 | [2] |
LDCM0292 | AC31 | HEK-293T | C248(1.04) | LDD1531 | [2] |
LDCM0296 | AC35 | HEK-293T | C248(1.18) | LDD1535 | [2] |
LDCM0299 | AC38 | HEK-293T | C416(0.65) | LDD1538 | [2] |
LDCM0300 | AC39 | HEK-293T | C248(0.75) | LDD1539 | [2] |
LDCM0305 | AC43 | HEK-293T | C248(1.26) | LDD1544 | [2] |
LDCM0308 | AC46 | HEK-293T | C416(0.70) | LDD1547 | [2] |
LDCM0309 | AC47 | HEK-293T | C248(0.77) | LDD1548 | [2] |
LDCM0314 | AC51 | HEK-293T | C248(1.23) | LDD1553 | [2] |
LDCM0317 | AC54 | HEK-293T | C416(0.69) | LDD1556 | [2] |
LDCM0318 | AC55 | HEK-293T | C248(0.95) | LDD1557 | [2] |
LDCM0322 | AC59 | HEK-293T | C248(1.08) | LDD1561 | [2] |
LDCM0323 | AC6 | HEK-293T | C416(0.81) | LDD1562 | [2] |
LDCM0326 | AC62 | HEK-293T | C416(0.73) | LDD1565 | [2] |
LDCM0327 | AC63 | HEK-293T | C248(1.04) | LDD1566 | [2] |
LDCM0334 | AC7 | HEK-293T | C248(0.87) | LDD1568 | [2] |
LDCM0368 | CL10 | HEK-293T | C416(0.87) | LDD1572 | [2] |
LDCM0369 | CL100 | HEK-293T | C248(1.06) | LDD1573 | [2] |
LDCM0372 | CL103 | HEK-293T | C248(1.12) | LDD1576 | [2] |
LDCM0373 | CL104 | HEK-293T | C248(1.28) | LDD1577 | [2] |
LDCM0376 | CL107 | HEK-293T | C248(1.15) | LDD1580 | [2] |
LDCM0377 | CL108 | HEK-293T | C248(1.26) | LDD1581 | [2] |
LDCM0379 | CL11 | HEK-293T | C248(1.15) | LDD1583 | [2] |
LDCM0381 | CL111 | HEK-293T | C248(1.15) | LDD1585 | [2] |
LDCM0382 | CL112 | HEK-293T | C248(0.98) | LDD1586 | [2] |
LDCM0385 | CL115 | HEK-293T | C248(1.14) | LDD1589 | [2] |
LDCM0386 | CL116 | HEK-293T | C248(1.04) | LDD1590 | [2] |
LDCM0389 | CL119 | HEK-293T | C248(0.97) | LDD1593 | [2] |
LDCM0391 | CL120 | HEK-293T | C248(1.15) | LDD1595 | [2] |
LDCM0394 | CL123 | HEK-293T | C248(0.86) | LDD1598 | [2] |
LDCM0395 | CL124 | HEK-293T | C248(1.05) | LDD1599 | [2] |
LDCM0398 | CL127 | HEK-293T | C248(1.11) | LDD1602 | [2] |
LDCM0399 | CL128 | HEK-293T | C248(1.11) | LDD1603 | [2] |
LDCM0402 | CL15 | HEK-293T | C248(1.06) | LDD1606 | [2] |
LDCM0403 | CL16 | HEK-293T | C248(1.11) | LDD1607 | [2] |
LDCM0406 | CL19 | HEK-293T | C248(1.13) | LDD1610 | [2] |
LDCM0410 | CL22 | HEK-293T | C416(0.79) | LDD1614 | [2] |
LDCM0411 | CL23 | HEK-293T | C248(1.03) | LDD1615 | [2] |
LDCM0415 | CL27 | HEK-293T | C248(0.92) | LDD1619 | [2] |
LDCM0416 | CL28 | HEK-293T | C248(1.04) | LDD1620 | [2] |
LDCM0418 | CL3 | HEK-293T | C248(1.25) | LDD1622 | [2] |
LDCM0420 | CL31 | HEK-293T | C248(1.06) | LDD1624 | [2] |
LDCM0423 | CL34 | HEK-293T | C416(0.80) | LDD1627 | [2] |
LDCM0424 | CL35 | HEK-293T | C248(0.88) | LDD1628 | [2] |
LDCM0428 | CL39 | HEK-293T | C248(1.08) | LDD1632 | [2] |
LDCM0429 | CL4 | HEK-293T | C248(1.07) | LDD1633 | [2] |
LDCM0430 | CL40 | HEK-293T | C248(1.19) | LDD1634 | [2] |
LDCM0433 | CL43 | HEK-293T | C248(0.89) | LDD1637 | [2] |
LDCM0436 | CL46 | HEK-293T | C416(0.73) | LDD1640 | [2] |
LDCM0437 | CL47 | HEK-293T | C248(1.01) | LDD1641 | [2] |
LDCM0443 | CL52 | HEK-293T | C248(1.17) | LDD1646 | [2] |
LDCM0446 | CL55 | HEK-293T | C248(1.01) | LDD1649 | [2] |
LDCM0449 | CL58 | HEK-293T | C416(0.80) | LDD1652 | [2] |
LDCM0450 | CL59 | HEK-293T | C248(0.91) | LDD1653 | [2] |
LDCM0455 | CL63 | HEK-293T | C248(1.17) | LDD1658 | [2] |
LDCM0456 | CL64 | HEK-293T | C248(1.23) | LDD1659 | [2] |
LDCM0459 | CL67 | HEK-293T | C248(1.36) | LDD1662 | [2] |
LDCM0462 | CL7 | HEK-293T | C248(0.95) | LDD1665 | [2] |
LDCM0463 | CL70 | HEK-293T | C416(0.69) | LDD1666 | [2] |
LDCM0464 | CL71 | HEK-293T | C248(0.97) | LDD1667 | [2] |
LDCM0469 | CL76 | HEK-293T | C248(0.95) | LDD1672 | [2] |
LDCM0472 | CL79 | HEK-293T | C248(1.11) | LDD1675 | [2] |
LDCM0476 | CL82 | HEK-293T | C416(0.67) | LDD1679 | [2] |
LDCM0477 | CL83 | HEK-293T | C248(0.97) | LDD1680 | [2] |
LDCM0481 | CL87 | HEK-293T | C248(1.05) | LDD1684 | [2] |
LDCM0482 | CL88 | HEK-293T | C248(0.93) | LDD1685 | [2] |
LDCM0486 | CL91 | HEK-293T | C248(1.07) | LDD1689 | [2] |
LDCM0489 | CL94 | HEK-293T | C416(0.78) | LDD1692 | [2] |
LDCM0490 | CL95 | HEK-293T | C248(1.24) | LDD1693 | [2] |
LDCM0494 | CL99 | HEK-293T | C248(1.08) | LDD1697 | [2] |
LDCM0495 | E2913 | HEK-293T | C248(1.32) | LDD1698 | [2] |
LDCM0203 | EV-96 | T cell | C130(4.43) | LDD0523 | [1] |
LDCM0468 | Fragment33 | HEK-293T | C248(1.13) | LDD1671 | [2] |
LDCM0022 | KB02 | T cell-activated | C507(20.00); C248(11.20); C334(13.11); C235(7.58) | LDD1704 | [1] |
LDCM0024 | KB05 | T cell-activated | C416(14.69); C507(11.28); C248(20.00); C334(20.00) | LDD1706 | [1] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
Transcription factor
Other
References