Details of the Target

General Information of Target

Target ID LDTP06962
Target Name RILP-like protein 1 (RILPL1)
Gene Name RILPL1
Gene ID 353116
Synonyms
RLP1; RILP-like protein 1; Rab-interacting lysosomal-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEERGSALAAESALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRV
LEILEVLVSRHHVAPELDELRLELDRLRLERMDRIEKERKHQKELELVEDVWRGEAQDLL
SQIAQLQEENKQLMTNLSHKDVNFSEEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAK
DRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEM
GSLRAELGKLRERLQGEHSQNGEEEPETEPVGEESISDAEKVAMDLKDPNRPRFTLQELR
DVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQPESGIKRLFSFF
SRDKKRLANTQRNVHIQESFGQWANTHRDDGYTEQGQEALQHL
Target Bioclass
Other
Family
RILPL family
Subcellular location
Cytoplasm, cytosol
Function
Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis.
Uniprot ID
Q5EBL4
Ensemble ID
ENST00000376874.9
HGNC ID
HGNC:26814

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.V60I .
HUPT4 SNV: p.E3V .
JURKAT SNV: p.R160Ter; p.Q371E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K167(6.67)  LDD0277  [1]
BTD
 Probe Info  		C47(0.74)  LDD2107  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
DBIA
 Probe Info  		C47(1.13)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C47(0.55)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C47(0.81)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C47(1.39)  LDD1094  [4]
 LDCM0216  AC100 HCT 116 C47(1.60)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C47(1.06)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C47(1.03)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C47(1.32)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C47(1.07)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C47(1.19)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C47(1.61)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C47(1.09)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C47(1.16)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C47(1.10)  LDD0542  [4]
 LDCM0226  AC11 PaTu 8988t C47(1.33)  LDD1105  [4]
 LDCM0227  AC110 HCT 116 C47(1.55)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C47(1.30)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C47(1.25)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C47(0.88)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C47(0.79)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C47(0.96)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C47(1.10)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C47(0.91)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C47(0.95)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C47(0.86)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C47(1.59)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C47(0.96)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C47(0.66)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C47(0.94)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C47(0.71)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C47(0.83)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C47(0.91)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C47(0.95)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C47(0.78)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C47(1.05)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C47(1.24)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C47(1.34)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C47(1.23)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C47(1.33)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C47(1.46)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C47(1.12)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C47(1.49)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C47(1.25)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C47(1.23)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C47(1.15)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C47(1.36)  LDD0856  [4]
 LDCM0259  AC14 PaTu 8988t C47(1.02)  LDD1138  [4]
 LDCM0260  AC140 HEK-293T C47(1.19)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C47(1.37)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C47(1.36)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C47(0.83)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C47(0.54)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C47(0.54)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C47(0.78)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C47(0.68)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C47(0.80)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C47(0.79)  LDD0586  [4]
 LDCM0270  AC15 PaTu 8988t C47(1.40)  LDD1149  [4]
 LDCM0271  AC150 HCT 116 C47(1.25)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C47(1.01)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C47(1.01)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C47(0.66)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C47(0.96)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C47(0.98)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C47(0.67)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C47(0.85)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C47(0.94)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C47(1.03)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C47(1.04)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C47(0.99)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C47(0.99)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C47(1.03)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C47(1.06)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C47(1.20)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C47(1.04)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C47(1.12)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C47(1.44)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C47(1.40)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C47(1.56)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C47(1.49)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C47(1.03)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C47(1.29)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C47(1.30)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C47(1.84)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C47(1.05)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C47(0.90)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C47(0.91)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C47(0.95)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C47(0.89)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C47(1.06)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C47(0.97)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C47(0.99)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C47(0.93)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C47(0.96)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C47(0.97)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C47(0.95)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C47(0.91)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C47(0.88)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C47(0.93)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C47(0.97)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C47(0.93)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C47(1.12)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C47(1.00)  LDD0629  [4]
 LDCM0316  AC53 HEK-293T C47(1.07)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C47(0.98)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C47(1.00)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C47(1.02)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C47(1.21)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C47(1.15)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C47(1.01)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C47(1.15)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C47(0.98)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C47(1.13)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C47(1.24)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C47(1.01)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C47(1.03)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C47(1.17)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C47(0.88)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C47(1.08)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C47(0.99)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C47(0.83)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C47(1.16)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C47(1.00)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C47(0.95)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C47(1.11)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C47(1.07)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C47(1.00)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C47(1.16)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C47(0.92)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C47(1.23)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C47(1.09)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C47(0.99)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C47(1.06)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C47(1.03)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C47(1.02)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C47(1.11)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C47(0.87)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C47(0.95)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C47(1.00)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C47(1.00)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C47(0.99)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C47(0.91)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C47(0.93)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C47(1.14)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C47(0.93)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C47(0.94)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C47(0.86)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C47(0.78)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C47(1.06)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C47(0.85)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C47(0.88)  LDD1243  [4]
 LDCM0365  AC98 HCT 116 C47(1.74)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C47(1.42)  LDD0683  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C47(1.19)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C47(1.70)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C47(1.61)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C47(1.13)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C47(1.02)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C47(0.79)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C47(0.93)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C47(1.26)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C47(1.56)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C47(1.57)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C47(1.35)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C47(1.15)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C47(0.94)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C47(0.96)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C47(0.91)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C47(1.15)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C47(1.00)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C47(1.01)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C47(1.14)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C47(1.15)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C47(1.57)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C47(1.28)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C47(1.13)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C47(1.05)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C47(0.95)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C47(1.02)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C47(0.96)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C47(0.80)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C47(0.97)  LDD0708  [4]
 LDCM0396  CL125 HCT 116 C47(1.30)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C47(0.95)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C47(0.97)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C47(1.18)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C47(0.94)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C47(1.21)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C47(0.89)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C47(0.97)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C47(1.02)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C47(0.73)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C47(0.78)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C47(0.93)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C47(0.72)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C47(0.66)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C47(0.51)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C47(1.22)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C47(0.57)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C47(0.88)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C47(0.84)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C47(0.62)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C47(0.42)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C47(0.56)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C47(1.10)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C47(0.41)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C47(0.87)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C47(1.24)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C47(1.20)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C47(1.20)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C47(1.59)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C47(1.25)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C47(1.51)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C47(1.25)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C47(0.95)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C47(1.27)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C47(1.28)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C47(0.99)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C47(1.19)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C47(1.50)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C47(1.43)  LDD0752  [4]
 LDCM0436  CL46 PaTu 8988t C47(1.21)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C47(1.15)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C47(1.16)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C47(1.27)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C47(0.79)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C47(1.20)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C47(1.19)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C47(1.47)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C47(1.43)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C47(1.18)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C47(1.62)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C47(1.31)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C47(1.24)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C47(1.17)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C47(1.03)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C47(1.14)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C47(1.18)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C47(1.00)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C47(1.02)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C47(1.00)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C47(0.88)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C47(1.08)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C47(0.99)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C47(1.10)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C47(0.94)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C47(0.94)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C47(0.95)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C47(0.99)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C47(0.93)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C47(0.96)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C47(0.99)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C47(1.15)  LDD1065  [4]
 LDCM0469  CL76 HCT 116 C47(0.96)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C47(1.07)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C47(0.96)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C47(1.04)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C47(1.41)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C47(1.07)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C47(1.02)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C47(0.96)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C47(1.04)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C47(1.01)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C47(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C47(0.86)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C47(0.98)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C47(0.93)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C47(0.89)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C47(1.14)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C47(1.21)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C47(0.95)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C47(0.93)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C47(1.05)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C47(0.84)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C47(1.07)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C47(1.06)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C47(1.07)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C47(1.03)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C47(1.07)  LDD0811  [4]
 LDCM0203  EV-96 T cell C47(4.19)  LDD0523  [12]
 LDCM0468  Fragment33 HEK-293T C47(0.86)  LDD1066  [4]
 LDCM0427  Fragment51 HCT 116 C47(1.57)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C47(0.88)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C47(0.96)  LDD1497  [11]
 LDCM0024  KB05 MKN-1 C47(6.60)  LDD3331  [13]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C47(0.74)  LDD2107  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ras-related protein Rab-8A (RAB8A) Rab family P61006
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) . Q86T03
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Motile sperm domain-containing protein 3 (MOSPD3) . O75425
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840