Details of the Target

General Information of Target

Target ID LDTP07598
Target Name BRCA1-associated ATM activator 1 (BRAT1)
Gene Name BRAT1
Gene ID 221927
Synonyms
BAAT1; C7orf27; BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPECAQLLPALCAVLVDPRQPVADDTCLEKLLDWFKTVTEGESSVVLLQEHPCLVELLS
HVLKVQDLSSGVLSFSLRLAGTFAAQENCFQYLQQGELLPGLFGEPGPLGRATWAVPTVR
SGWIQGLRSLAQHPSALRFLADHGAVDTIFSLQGDSSLFVASAASQLLVHVLALSMRGGA
EGQPCLPGGDWPACAQKIMDHVEESLCSAATPKVTQALNVLTTTFGRCQSPWTEALWVRL
SPRVACLLERDPIPAAHSFVDLLLCVARSPVFSSSDGSLWETVARALSCLGPTHMGPLAL
GILKLEHCPQALRTQAFQVLLQPLACVLKATVQAPGPPGLLDGTADDATTVDTLLASKSS
CAGLLCRTLAHLEELQPLPQRPSPWPQASLLGATVTVLRLCDGSAAPASSVGGHLCGTLA
GCVRVQRAALDFLGTLSQGTGPQELVTQALAVLLECLESPGSSPTVLKKAFQATLRWLLS
SPKTPGCSDLGPLIPQFLRELFPVLQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCA
LLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEARQSLFLELLHIL
SVDSEGFPRRAVMQVFTEWLRDGHADAAQDTEQFVATVLQAASRDLDWEVRAQGLELALV
FLGQTLGPPRTHCPYAVALPEVAPAQPLTEALRALCHVGLFDFAFCALFDCDRPVAQKSC
DLLLFLRDKIASYSSLREARGSPNTASAEATLPRWRAGEQAQPPGDQEPEAVLAMLRSLD
LEGLRSTLAESSDHVEKSPQSLLQDMLATGGFLQGDEADCY
Target Bioclass
Other
Subcellular location
Nucleus
Function
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.
Uniprot ID
Q6PJG6
Ensemble ID
ENST00000340611.9
HGNC ID
HGNC:21701

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.V169L .
HCT15 SNV: p.A563V .
HT SNV: p.D645A .
HT3 SNV: p.P212A DBIA    Probe Info 
JHH6 SNV: p.E458K .
KMS27 SNV: p.G363D .
LN229 SNV: p.L137V .
LNCaP clone FGC SNV: p.A586V DBIA    Probe Info 
MOLT4 SNV: p.L450F IA-alkyne    Probe Info 
NALM6 SNV: p.A406T DBIA    Probe Info 
NB1 SNV: p.L723F DBIA    Probe Info 
NCIH1155 SNV: p.M775I DBIA    Probe Info 
SNU1 SNV: p.A774T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.71  LDD0402  [1]
CHEMBL5175495
 Probe Info  		5.62  LDD0196  [2]
STPyne
 Probe Info  		K507(8.01)  LDD0277  [3]
P11
 Probe Info  		1.11  LDD0210  [4]
Curcusone 37
 Probe Info  		13.63  LDD0188  [5]
DA-P3
 Probe Info  		12.31  LDD0179  [6]
AHL-Pu-1
 Probe Info  		C308(20.00); C246(2.32); C289(4.98)  LDD0168  [7]
HPAP
 Probe Info  		3.54  LDD0063  [8]
EA-probe
 Probe Info  		C673(1.48)  LDD2210  [9]
DBIA
 Probe Info  		C513(1.17); C246(1.12); C487(1.12); C228(1.08)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C539(0.00); C265(0.00); C720(0.00); C487(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C289(0.00); C539(0.00); C228(0.00); C308(0.00)  LDD0037  [11]
BTD
 Probe Info  		N.A.  LDD0004  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		C228(0.00); C326(0.00); C487(0.00); C539(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		C720(0.00); C246(0.00); C487(0.00)  LDD0021  [13]
aHNE
 Probe Info  		N.A.  LDD0001  [13]
Compound 10
 Probe Info  		C228(0.00); C246(0.00); C487(0.00); C673(0.00)  LDD2216  [16]
Compound 11
 Probe Info  		C228(0.00); C326(0.00); C487(0.00); C673(0.00)  LDD2213  [16]
ENE
 Probe Info  		C28(0.00); C513(0.00); C246(0.00)  LDD0006  [13]
IPM
 Probe Info  		C487(0.00); C308(0.00); C673(0.00)  LDD0005  [13]
VSF
 Probe Info  		C673(0.00); C194(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Methacrolein
 Probe Info  		C513(0.00); C308(0.00)  LDD0218  [18]
W1
 Probe Info  		C487(0.00); C720(0.00)  LDD0236  [19]
AOyne
 Probe Info  		6.30  LDD0443  [20]
NAIA_5
 Probe Info  		C289(0.00); C539(0.00); C265(0.00); C207(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		21.11  LDD1816  [21]
C159
 Probe Info  		7.89  LDD1839  [21]
C160
 Probe Info  		7.31  LDD1840  [21]
C161
 Probe Info  		9.78  LDD1841  [21]
C218
 Probe Info  		17.15  LDD1892  [21]
C220
 Probe Info  		12.13  LDD1894  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		5.92  LDD0478  [22]
OEA-DA
 Probe Info  		20.00  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C308(1.07)  LDD2142  [24]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C308(1.00)  LDD2112  [24]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C308(0.71)  LDD2095  [24]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C246(1.61)  LDD2117  [24]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C308(1.39)  LDD2152  [24]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C308(0.91)  LDD2103  [24]
 LDCM0025  4SU-RNA HEK-293T C308(20.00); C246(2.32); C289(4.98)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C308(12.76); C265(3.04); C246(6.22); C510(2.17)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C513(1.22); C510(1.11); C185(0.97); C194(1.01)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C513(1.22); C510(1.20); C185(1.12); C194(1.06)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C513(0.90); C510(0.76); C673(0.71); C185(0.92)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C513(1.05); C510(0.79); C673(1.19); C185(0.88)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C513(0.89); C510(0.73); C673(0.97); C185(0.88)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C513(1.38); C510(0.92); C673(0.87); C185(0.98)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C513(1.17); C510(0.78); C673(0.84); C185(0.98)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C513(1.07); C510(0.70); C673(0.83); C185(0.91)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C513(1.05); C510(0.79); C673(0.76); C185(0.97)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C513(1.22); C510(0.79); C673(0.63); C185(0.92)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C513(0.73); C510(0.74); C673(0.69); C185(0.85)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C513(0.84); C510(0.79); C673(0.79); C185(0.85)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C513(1.13); C510(1.04); C185(1.21); C194(1.09)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C513(0.81); C510(0.73); C673(0.67); C185(0.90)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C513(1.01); C510(0.72); C673(0.92); C185(0.86)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C513(1.17); C510(0.86); C673(0.81); C185(0.94)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C513(1.03); C510(1.04); C673(0.97); C185(0.99)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C513(1.00); C510(0.95); C673(0.73); C185(0.98)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C513(1.33); C510(0.97); C673(0.89); C185(1.09)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C513(1.44); C510(1.14); C673(1.08); C185(1.12)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C513(1.14); C510(1.05); C673(0.77); C185(1.04)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C513(0.89); C510(0.95); C673(0.76); C185(0.99)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C513(1.05); C510(0.92); C673(0.83); C185(1.07)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C513(0.99); C510(0.98); C185(0.96); C194(1.01)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C513(1.20); C510(0.93); C673(1.03); C185(1.01)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C513(1.02); C510(1.04); C673(0.89); C185(1.08)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C513(0.99); C510(0.85); C673(0.84); C185(1.04)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C513(0.92); C510(0.95); C673(0.79); C185(0.98)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C513(0.95); C510(1.00); C673(0.68); C185(0.92)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C513(1.02); C510(0.90); C673(0.78); C185(0.94)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C513(1.21); C510(0.92); C673(0.75); C185(1.09)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C513(1.33); C510(1.07); C673(0.72); C185(1.06)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C513(1.18); C185(1.11); C194(1.15); C228(1.52)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C513(0.83); C185(0.99); C194(1.01); C228(1.15)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C513(1.03); C185(1.13); C194(1.19); C228(1.47)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C513(0.82); C185(1.03); C194(1.04); C228(1.18)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C513(0.92); C185(0.92); C194(0.96); C228(1.35)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C513(0.93); C185(0.98); C194(1.02); C228(1.50)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C513(1.08); C185(1.06); C194(1.07); C228(1.56)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C513(1.17); C185(0.92); C194(0.95); C228(1.71)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C513(1.21); C185(0.98); C194(0.96); C228(1.35)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C513(0.89); C185(0.92); C194(0.96); C228(1.24)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C513(1.07); C185(1.08); C194(1.11); C228(1.62)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C513(1.12); C185(1.00); C194(1.01); C228(1.58)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C513(0.98); C510(0.95); C185(1.02); C194(0.99)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C513(1.19); C185(1.01); C194(1.03); C228(1.73)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C513(1.18); C185(1.08); C194(1.10); C228(1.59)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C513(0.85); C185(0.88); C194(0.93); C228(1.34)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C513(1.14); C510(0.90); C673(1.19); C185(0.97)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C28(0.96); C510(1.02); C228(1.03); C361(1.07)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C246(0.87); C510(0.90); C185(0.96); C28(1.00)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C361(0.81); C28(0.82); C185(0.98); C510(1.05)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C510(0.93); C308(1.06); C28(1.07); C185(1.10)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C308(0.84); C28(0.85); C361(0.86); C510(1.10)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C28(0.80); C361(0.81); C308(0.95); C510(1.06)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C308(0.80); C510(0.92); C28(0.95); C246(0.96)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C28(0.81); C361(0.87); C228(0.94); C185(0.97)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C246(0.93); C361(0.93); C308(0.96); C366(0.97)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C28(0.84); C361(0.91); C308(0.91); C246(1.00)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C28(0.74); C361(0.79); C308(1.06); C246(1.35)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C513(1.19); C510(1.01); C673(1.44); C185(1.04)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C513(1.16); C510(1.00); C673(1.21); C185(1.20)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C513(1.06); C510(1.05); C673(1.20); C185(0.99)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C513(1.04); C510(1.02); C673(1.28); C185(1.28)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C366(0.86); C89(0.94); C510(0.94); C673(0.94)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C89(0.44); C246(0.96); C308(1.00); C228(1.00)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C366(0.85); C228(0.88); C510(0.91); C513(0.96)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C89(0.81); C308(0.84); C185(0.95); C510(0.97)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C673(0.70); C366(0.90); C510(0.94); C513(0.98)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C366(0.87); C89(0.89); C246(0.91); C673(0.92)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C673(0.86); C366(0.86); C510(0.91); C246(0.92)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C673(0.81); C246(0.88); C366(0.92); C28(1.05)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C366(0.76); C246(0.88); C89(0.96); C228(0.96)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C308(0.89); C510(0.90); C513(0.95); C228(1.00)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C185(1.02); C510(1.02); C308(1.03); C513(1.04)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C510(0.87); C513(0.87); C308(1.01); C228(1.06)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C308(1.09); C228(1.12); C513(1.14); C510(1.21)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C185(1.04); C308(1.12); C194(1.14); C510(1.16)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C308(0.82); C185(0.93); C366(0.96); C361(0.96)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C361(0.99); C366(1.08); C185(1.08); C510(1.11)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C308(1.00); C513(1.03); C510(1.04); C185(1.07)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C510(0.99); C513(1.04); C185(1.13); C308(1.15)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C308(0.96); C510(1.02); C513(1.06); C228(1.10)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C308(0.86); C228(0.99); C513(1.04); C510(1.04)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C366(0.86); C361(0.86); C487(0.87); C228(0.90)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C194(0.86); C487(0.89); C361(0.92); C308(0.94)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C361(0.73); C194(0.86); C308(0.91); C487(0.91)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C194(0.93); C487(0.96); C510(0.98); C720(1.01)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C361(0.86); C308(0.92); C194(0.96); C228(0.97)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C308(0.93); C185(0.94); C361(1.01); C28(1.02)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C366(0.94); C246(0.98); C361(0.99); C194(1.02)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C246(0.98); C194(0.99); C487(0.99); C185(1.01)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C246(0.97); C185(1.03); C308(1.03); C194(1.04)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C228(0.93); C308(0.96); C720(1.00); C185(1.03)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C308(0.94); C246(0.97); C194(0.98); C185(0.98)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C308(0.89); C246(0.98); C487(1.03); C361(1.05)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C361(0.98); C720(1.00); C228(1.02); C366(1.03)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C366(0.93); C185(0.96); C194(0.98); C228(1.01)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C361(0.93); C720(0.98); C194(0.99); C366(1.01)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C361(0.81); C366(0.98); C228(1.10); C185(1.18)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C308(0.78); C185(0.94); C326(1.01); C28(1.02)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C366(1.04); C361(1.08); C228(1.10); C185(1.14)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C194(0.87); C228(0.89); C720(0.94); C185(0.95)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C361(1.01); C185(1.01); C194(1.06); C720(1.07)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C361(0.87); C366(0.98); C228(1.08); C185(1.10)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C228(0.90); C361(0.92); C366(1.02); C194(1.04)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C246(1.04); C185(1.11); C194(1.14); C366(1.16)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C361(0.99); C366(1.17); C228(1.22); C28(1.25)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C487(0.66); C194(1.00); C185(1.02); C228(1.02)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C487(0.62); C308(0.84); C194(1.01); C185(1.06)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C487(0.61); C308(0.84); C510(1.10); C361(1.11)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C194(1.02); C246(1.03); C308(1.03); C366(1.04)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C487(0.60); C361(0.99); C185(1.10); C308(1.11)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C487(0.72); C308(0.83); C361(0.91); C185(0.95)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C487(0.61); C308(0.91); C361(1.00); C246(1.02)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C487(0.61); C361(0.95); C308(0.98); C194(1.09)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C487(0.54); C246(0.80); C361(0.97); C194(1.10)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C487(0.84); C361(0.97); C194(1.08); C185(1.09)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C487(0.77); C246(0.86); C308(0.98); C361(1.02)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C487(0.43); C308(0.96); C361(1.04); C510(1.20)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C513(0.90); C673(0.95); C361(0.99); C720(1.02)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C673(0.85); C366(0.85); C513(0.90); C361(1.02)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C308(0.87); C246(0.99); C185(1.02); C194(1.03)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C673(0.97); C361(1.01); C366(1.03); C720(1.06)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C513(0.87); C366(0.87); C308(0.92); C673(0.93)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C366(0.94); C361(1.04); C185(1.07); C673(1.08)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C366(0.94); C673(0.98); C361(1.03); C510(1.11)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C366(0.96); C673(0.98); C361(0.98); C513(0.98)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C513(0.92); C673(0.94); C366(1.02); C510(1.03)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C513(0.89); C366(0.99); C308(1.00); C510(1.01)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C361(0.92); C673(0.99); C366(1.00); C513(1.13)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C720(0.91); C366(0.96); C513(0.97); C185(1.04)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C366(0.90); C513(0.97); C720(1.00); C673(1.01)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C308(0.88); C720(0.95); C510(1.01); C246(1.01)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C366(0.91); C513(0.94); C673(0.96); C361(0.99)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C366(0.89); C228(0.93); C361(0.94); C673(0.98)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C673(1.06); C308(1.14); C366(1.19); C361(1.23)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C673(0.42); C308(1.01); C510(1.07); C228(1.07)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C673(0.52); C28(0.99); C510(1.04); C308(1.06)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C673(0.46); C308(1.02); C28(1.03); C510(1.06)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C673(0.40); C510(1.04); C246(1.10); C28(1.11)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C673(0.36); C510(1.03); C308(1.03); C513(1.06)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C673(0.54); C510(1.05); C308(1.06); C228(1.06)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C673(0.41); C246(1.04); C510(1.04); C28(1.05)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C673(0.40); C28(0.97); C401(0.99); C416(0.99)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C673(0.33); C308(0.92); C401(0.97); C416(0.97)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C673(0.35); C246(0.94); C401(0.96); C416(0.96)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C673(0.49); C401(0.93); C416(0.93); C422(0.93)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C673(0.35); C246(0.95); C401(0.96); C416(0.96)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C673(0.46); C401(0.82); C416(0.82); C422(0.82)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C673(0.34); C401(0.97); C416(0.97); C422(0.97)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C673(0.48); C308(1.05); C28(1.10); C401(1.10)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C673(0.67); C401(0.90); C416(0.90); C422(0.90)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C510(0.80); C673(0.81); C28(0.85); C228(0.86)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C308(0.40)  LDD2138  [24]
 LDCM0248  AKOS034007472 HCT 116 C513(0.97); C510(0.94); C185(0.99); C194(0.99)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C28(0.98); C366(0.98); C194(1.00); C308(1.02)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C246(0.90); C308(0.93); C28(1.05); C228(1.15)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 C487(0.00); C673(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C513(1.17); C246(1.12); C487(1.12); C228(1.08)  LDD0078  [10]
 LDCM0089  C30 HEK-293T 1.11  LDD0210  [4]
 LDCM0088  C45 HEK-293T 1.02  LDD0211  [4]
 LDCM0087  Capsaicin HEK-293T 4.39  LDD0185  [6]
 LDCM0630  CCW28-3 231MFP C487(2.40); C673(1.18)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa C289(0.00); C207(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C720(1.93); C228(1.59); C207(0.92); C289(0.90)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C246(0.98); C487(1.13); C308(1.13); C720(1.17)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C361(1.01); C308(1.22); C366(1.23); C228(1.38)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C89(0.67); C308(0.83); C28(0.90); C361(0.98)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C246(0.74); C308(0.91); C228(1.00); C510(1.12)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C246(1.01); C89(1.02); C487(1.07); C308(1.09)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C246(0.83); C308(0.84); C366(0.97); C361(1.03)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C510(0.86); C308(0.87); C246(0.92); C720(0.99)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C673(0.82); C366(0.92); C89(0.98); C308(1.01)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C673(0.79); C89(0.85); C366(0.99); C246(1.04)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C673(0.72); C89(0.83); C366(0.93); C510(1.00)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C673(0.84); C366(0.96); C89(1.10); C308(1.13)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C673(0.95); C308(1.02); C366(1.05); C89(1.07)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C720(0.89); C308(1.11); C361(1.31); C366(1.32)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C89(0.82); C366(1.06); C308(1.06); C673(1.08)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C366(0.85); C720(1.02); C246(1.03); C673(1.08)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C308(0.91); C228(1.01); C361(1.03); C185(1.09)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C308(1.07); C510(1.09); C228(1.10); C361(1.12)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C361(1.15); C308(1.18); C185(1.24); C510(1.27)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C185(1.06); C228(1.10); C361(1.13); C510(1.15)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C510(0.92); C513(0.97); C308(0.97); C185(0.97)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C308(0.96); C246(1.01); C366(1.07); C228(1.09)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C361(0.82); C308(0.92); C194(0.98); C487(1.01)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C487(0.93); C361(0.96); C510(1.00); C246(1.01)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C361(1.02); C246(1.04); C308(1.22); C720(1.23)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C487(0.96); C185(1.00); C194(1.00); C308(1.02)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C228(0.78); C194(0.90); C720(0.90); C361(0.92)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C185(1.11); C194(1.12); C228(1.18); C28(1.20)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C366(1.11); C361(1.15); C308(1.17); C228(1.27)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C361(0.85); C366(1.05); C246(1.12); C228(1.22)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C246(0.88); C361(0.90); C308(0.93); C228(0.96)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C487(0.85); C185(1.03); C194(1.05); C308(1.08)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C228(0.86); C487(0.86); C308(0.92); C185(0.95)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C487(0.68); C308(0.82); C673(0.95); C361(1.00)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C308(0.97); C361(1.03); C366(1.09); C194(1.13)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C246(1.02); C361(1.12); C308(1.15); C366(1.16)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C720(1.09); C308(1.21); C361(1.35); C366(1.47)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C326(0.79); C228(0.91); C28(0.93); C366(0.98)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C366(1.16); C361(1.21); C487(1.21); C228(1.24)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C194(0.91); C28(0.91); C510(0.93); C487(0.99)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C510(0.95); C228(0.96); C28(0.99); C513(1.00)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C246(0.82); C487(0.91); C194(0.95); C366(0.98)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C510(0.90); C326(1.02); C28(1.06); C308(1.08)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C361(1.18); C366(1.18); C308(1.23); C326(1.40)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C361(0.94); C308(1.00); C366(1.04); C510(1.11)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C673(0.89); C228(0.96); C326(0.97); C510(1.02)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C361(0.93); C366(0.98); C510(0.99); C326(1.02)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C513(1.62); C510(1.20); C673(1.99); C185(1.59)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C513(1.07); C510(0.98); C673(1.39); C185(1.18)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C513(1.13); C510(1.05); C673(1.15); C185(1.06)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C513(1.33); C510(1.12); C673(1.59); C185(1.36)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C513(1.18); C510(0.93); C673(1.47); C185(1.18)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C513(1.06); C510(1.13); C185(1.10); C194(1.08)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C513(1.07); C510(1.08); C673(0.91); C185(1.09)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C513(2.03); C510(2.13); C185(1.20); C194(1.29)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C513(1.34); C510(1.16); C185(1.02); C194(1.07)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C513(4.53); C510(4.97); C185(3.10); C194(2.94)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C513(1.83); C510(1.41); C185(1.47); C194(1.43)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C513(1.40); C510(1.10); C185(1.22); C194(1.22)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C513(1.64); C510(1.34); C185(1.30); C194(1.35)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C513(1.38); C510(1.01); C185(1.24); C194(1.27)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C513(2.92); C510(2.11); C185(1.57); C194(1.54)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C513(1.09); C510(1.16); C185(2.08); C194(1.99)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C513(3.41); C510(3.73); C185(1.47); C194(1.50)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C513(1.47); C510(1.11); C185(1.12); C194(1.19)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C513(2.00); C510(1.35); C185(1.88); C194(1.85)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C513(1.63); C510(1.25); C185(1.21); C194(1.32)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C513(2.00); C510(1.59); C185(1.33); C194(1.30)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C513(2.71); C510(2.38); C185(1.67); C194(1.65)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C513(1.21); C510(1.62); C673(0.93); C185(1.21)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C513(1.23); C510(1.20); C673(1.09); C185(1.07)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C513(0.97); C510(1.06); C673(1.10); C185(0.98)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C513(1.00); C510(0.93); C673(1.26); C185(1.11)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C513(1.01); C510(1.06); C185(1.02); C194(1.03)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C513(0.92); C510(0.86); C673(1.18); C185(1.01)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C513(0.97); C510(0.95); C673(0.94); C185(1.05)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C513(0.96); C510(1.03); C673(1.16); C185(1.06)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C513(0.96); C510(0.92); C673(2.26); C185(1.08)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C513(1.09); C510(1.18); C673(1.90); C185(1.20)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C513(0.87); C510(1.01); C673(0.96); C185(1.02)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C513(1.29); C510(1.26); C673(1.28); C185(1.03)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C513(1.77); C510(1.75); C673(2.23); C185(1.13)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C513(1.00); C510(1.23); C673(0.89); C185(1.10)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C513(0.94); C510(0.91); C673(1.20); C185(0.95)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C513(1.31); C510(1.36); C185(1.24); C194(1.19)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C513(1.09); C510(0.99); C673(1.41); C185(1.01)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C513(1.31); C510(1.07); C185(0.97); C194(1.00)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C513(1.32); C510(1.19); C185(0.95); C194(1.02)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C513(1.55); C510(1.19); C185(1.05); C194(1.08)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C513(1.07); C510(0.91); C185(1.24); C194(1.24)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C513(1.05); C510(0.97); C185(0.98); C194(0.95)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C513(1.62); C510(1.32); C185(1.27); C194(1.27)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C513(0.95); C510(0.83); C185(1.03); C194(1.12)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C513(1.39); C510(1.43); C185(1.11); C194(1.15)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C513(1.40); C510(1.29); C185(1.05); C194(1.11)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C513(1.11); C510(1.10); C185(1.16); C194(1.12)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C513(1.16); C510(1.04); C185(1.12); C194(1.20)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C513(1.21); C510(1.05); C185(1.10); C194(1.13)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C513(1.10); C510(1.00); C185(0.92); C194(0.95)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C513(1.56); C510(1.59); C185(1.21); C194(1.19)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C513(1.19); C510(1.00); C185(0.97); C194(0.97)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C513(1.12); C510(1.09); C185(0.99); C194(0.97)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C513(1.67); C510(1.70); C185(1.13); C194(1.11)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C513(1.28); C510(1.29); C185(1.09); C194(1.07)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C513(1.34); C510(1.14); C185(1.11); C194(1.13)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C513(11.68); C510(5.45); C185(2.43); C194(2.43)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C513(1.10); C510(1.09); C185(0.88); C194(0.94)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C513(1.23); C510(1.12); C185(0.99); C194(1.00)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C513(1.66); C510(1.46); C185(1.33); C194(1.30)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C513(1.81); C510(1.60); C185(1.36); C194(1.33)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C513(2.17); C510(1.94); C185(1.67); C194(1.59)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C513(1.29); C510(1.11); C185(1.01); C194(1.02)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C513(1.39); C510(1.35); C185(0.99); C194(1.00)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C513(1.70); C510(1.61); C185(1.13); C194(1.15)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C513(1.37); C510(1.29); C185(1.20); C194(1.16)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C513(1.92); C510(1.69); C185(1.54); C194(1.45)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C513(1.29); C510(1.50); C185(1.32); C194(1.30)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C513(6.40); C510(8.27); C185(2.47); C194(2.30)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C513(1.42); C510(1.27); C185(1.02); C194(1.07)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C513(1.89); C510(1.58); C185(1.29); C194(1.42)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C513(1.32); C510(1.21); C185(1.01); C194(1.07)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C513(2.13); C510(1.76); C185(1.26); C194(1.39)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C513(2.41); C510(1.88); C185(1.45); C194(1.47)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C513(1.35); C510(1.18); C185(1.13); C194(1.12)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C513(1.30); C510(1.21); C185(1.22); C194(1.24)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C513(1.52); C510(1.22); C185(1.09); C194(1.30)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C513(1.85); C510(1.61); C185(0.96); C194(0.99)  LDD0811  [10]
 LDCM0033  Curcusone1d MCF-7 13.63  LDD0188  [5]
 LDCM0634  CY-0357 Hep-G2 C228(0.59)  LDD2228  [15]
 LDCM0027  Dopamine HEK-293T 12.31  LDD0179  [6]
 LDCM0495  E2913 HEK-293T C246(1.02); C207(0.99); C720(1.05); C289(0.80)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C246(14.60)  LDD1702  [24]
 LDCM0175  Ethacrynic acid HeLa C673(1.48)  LDD2210  [9]
 LDCM0202  EV-93 T cell C673(6.07)  LDD0514  [27]
 LDCM0203  EV-96 T cell C513(4.80)  LDD0523  [27]
 LDCM0204  EV-97 T cell C28(8.05)  LDD0524  [27]
 LDCM0625  F8 Ramos C720(0.78); C673(1.28)  LDD2187  [28]
 LDCM0573  Fragment11 Ramos C720(11.24); C228(0.16)  LDD2190  [28]
 LDCM0575  Fragment13 Ramos C326(0.72); C673(1.75)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C720(1.04); C673(2.91)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C720(2.14)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C673(1.55)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C720(0.47); C228(1.99); C326(0.27); C673(0.61)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C720(0.60); C228(0.73); C326(0.55); C673(0.91)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C720(0.67); C228(0.87); C326(0.20); C673(1.76)  LDD2198  [28]
 LDCM0587  Fragment29 Ramos C673(4.57)  LDD1476  [29]
 LDCM0588  Fragment30 Ramos C720(0.53); C326(0.64); C673(1.87)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C673(20.00)  LDD1478  [29]
 LDCM0590  Fragment32 Ramos C326(0.59)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C513(1.20); C510(1.08); C185(1.02); C194(1.02)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C720(2.61); C228(0.80); C673(1.32)  LDD2203  [28]
 LDCM0427  Fragment51 HCT 116 C513(1.64); C510(1.27); C185(2.33); C194(3.98)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C720(1.26); C673(1.36)  LDD2204  [28]
 LDCM0614  Fragment56 MDA-MB-231 C673(0.87)  LDD1484  [29]
 LDCM0022  KB02 HCT 116 C185(8.99); C194(8.99); C513(5.08); C228(7.20)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C185(20.00); C194(20.00); C513(9.63); C228(7.74)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C185(13.03); C194(13.03); C513(10.95); C228(6.21)  LDD0082  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C308(0.75)  LDD2089  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C308(1.16)  LDD2090  [24]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C308(0.97)  LDD2092  [24]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C308(0.96)  LDD2094  [24]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C308(1.07)  LDD2098  [24]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C308(0.91)  LDD2099  [24]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C308(1.81)  LDD2100  [24]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C308(0.95)  LDD2104  [24]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C308(1.16)  LDD2105  [24]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C308(0.98)  LDD2106  [24]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C308(0.92); C246(1.78)  LDD2107  [24]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C308(0.89)  LDD2108  [24]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C308(1.07)  LDD2109  [24]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C246(0.86)  LDD2111  [24]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C308(1.03)  LDD2114  [24]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C308(1.53)  LDD2119  [24]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C308(0.85); C246(1.12)  LDD2123  [24]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C308(0.75)  LDD2125  [24]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C308(1.37)  LDD2127  [24]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C308(1.54)  LDD2129  [24]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C308(1.08)  LDD2135  [24]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C308(1.31)  LDD2136  [24]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C308(0.95); C246(0.93)  LDD2137  [24]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C308(1.25)  LDD1700  [24]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C308(0.69)  LDD2140  [24]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C308(0.88)  LDD2141  [24]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C308(2.55)  LDD2144  [24]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C308(0.91); C246(1.33)  LDD2146  [24]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C246(0.90)  LDD2148  [24]
 LDCM0627  NUDT7-COV-1 HEK-293T C228(0.19); C720(0.14); C673(0.07)  LDD2206  [30]
 LDCM0032  Oleacein HEK-293T 6.21  LDD0184  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C207(1.30); C228(0.91); C720(0.69); C673(0.30)  LDD2207  [30]
 LDCM0014  Panhematin K562 3.54  LDD0063  [8]
 LDCM0029  Quercetin HEK-293T 7.97  LDD0181  [6]
 LDCM0021  THZ1 HCT 116 C228(1.09); C246(1.05); C487(1.04); C185(1.04)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Mesogenin-1 (MSGN1) . A6NI15
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
N-myc-interactor (NMI) NMI family Q13287
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2

References

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2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.