Details of the Target

General Information of Target

Target ID LDTP00464
Target Name Glutathione S-transferase 3, mitochondrial (MGST3)
Gene Name MGST3
Gene ID 4259
Synonyms
Glutathione S-transferase 3, mitochondrial; GST-3; EC 2.5.1.-; Glutathione peroxidase MGST3; EC 1.11.1.-; LTC4 synthase MGST3; EC 4.4.1.20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Target Bioclass
Enzyme
Family
MAPEG family
Subcellular location
Endoplasmic reticulum membrane
Function
Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites. Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response. Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides.
Uniprot ID
O14880
Ensemble ID
ENST00000367884.6
HGNC ID
HGNC:7064
ChEMBL ID
CHEMBL1743186

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.59  LDD0402  [1]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0381  [2]
HDSF-alk
 Probe Info  		1.75  LDD0197  [3]
CHEMBL5175495
 Probe Info  		5.57  LDD0196  [4]
TH211
 Probe Info  		Y40(12.31)  LDD0260  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K149(10.00)  LDD0277  [7]
ONAyne
 Probe Info  		K149(10.00)  LDD0275  [7]
BTD
 Probe Info  		C56(1.24)  LDD2093  [8]
Curcusone 37
 Probe Info  		2.39  LDD0188  [9]
AHL-Pu-1
 Probe Info  		C56(2.02)  LDD0173  [10]
HPAP
 Probe Info  		3.49  LDD0062  [11]
HHS-482
 Probe Info  		Y100(1.30); Y40(0.62)  LDD0285  [12]
DBIA
 Probe Info  		C56(5.52)  LDD0080  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C56(0.00); C131(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
JW-RF-010
 Probe Info  		C150(0.00); C56(0.00)  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C150(0.00); C151(0.00)  LDD0027  [17]
IPM
 Probe Info  		N.A.  LDD0005  [19]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [21]
Crotonaldehyde
 Probe Info  		C56(0.00); H52(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		28.84  LDD1785  [23]
C158
 Probe Info  		9.58  LDD1838  [23]
C218
 Probe Info  		11.16  LDD1892  [23]
C220
 Probe Info  		13.45  LDD1894  [23]
C235
 Probe Info  		18.64  LDD1908  [23]
C285
 Probe Info  		19.16  LDD1955  [23]
C349
 Probe Info  		11.08  LDD2010  [23]
FFF probe11
 Probe Info  		16.63  LDD0471  [24]
FFF probe13
 Probe Info  		18.29  LDD0475  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
FFF probe6
 Probe Info  		6.00  LDD0467  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
STS-1
 Probe Info  		N.A.  LDD0136  [25]
BD-F
 Probe Info  		S132(0.00); V130(0.00)  LDD0024  [26]
OEA-DA
 Probe Info  		3.37  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C56(0.95)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C56(0.95)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C56(0.45)  LDD2117  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C56(2.02)  LDD0173  [10]
 LDCM0214  AC1 HCT 116 C56(0.98)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C131(1.37); C56(0.87)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C56(0.86)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C56(1.27)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C56(1.09)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C56(1.07)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C56(1.25)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C56(0.94)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C56(1.22)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C56(0.83)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C56(0.96)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C56(1.12)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C131(1.42); C56(1.00)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C56(0.99)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C56(1.12)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C56(0.98)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C56(1.12)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C56(0.88)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C56(1.19)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C56(0.91)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C56(0.86)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C56(0.95)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C56(1.02)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C131(1.47); C56(0.80)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C56(0.86)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C56(0.84)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C56(0.76)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C56(0.99)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C56(0.81)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C56(0.81)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C56(0.91)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C56(0.96)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C131(0.81); C56(1.01)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C131(1.15); C56(0.83)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C131(0.71); C56(0.86)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C131(1.13); C56(1.06)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C131(0.91); C56(0.98)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C131(0.81); C56(0.76)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C131(0.89); C56(0.99)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C131(0.91); C56(1.03)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C131(1.05); C56(0.90)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C131(1.24); C56(1.00)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C131(0.83); C56(2.59)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C131(0.92); C56(1.00)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C131(0.92); C56(0.88)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C131(0.90); C56(1.44)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C131(0.96); C56(1.31)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C131(0.98); C56(0.92)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C56(1.30)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C56(0.73)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C56(0.91)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C56(0.84)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C56(0.88)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C56(1.05)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C56(0.99)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C56(1.01); C131(1.36)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C56(0.75)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C56(0.72)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C56(0.88)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C56(1.29)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C56(1.16)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C56(0.94)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C56(0.69)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C56(0.86)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C56(0.73)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C56(0.97)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C56(0.76)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C56(0.96)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C56(1.01)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C56(1.05)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C56(0.82)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C56(1.46)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C56(0.96)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C56(0.77)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C56(0.64)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C56(0.73)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C56(1.02)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C56(0.89)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C56(0.86)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C56(0.95)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C56(0.86)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C56(0.76)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C56(0.87)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C56(1.20)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C56(0.99)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C56(0.93)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C56(1.00)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C56(0.98)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C56(0.79)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C56(0.98)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C56(1.27)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C56(1.17)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C56(1.33)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C56(0.94)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C56(1.00)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C56(1.34)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C56(1.02)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C56(0.81)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C56(0.92)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C56(1.17)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C56(0.86)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C56(1.03)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C56(1.15)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C56(0.96)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C56(1.07)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C56(1.03)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C56(1.00)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C56(1.10)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C56(0.95)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C56(1.37)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C56(1.26)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C131(1.02); C56(1.04)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C56(1.18)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C56(0.93)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C56(0.95)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C56(1.23)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C56(1.05)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C56(1.06)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C56(1.24)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C56(1.23)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C131(0.92); C56(0.96)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C131(0.86); C56(1.16)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C56(0.95); C131(1.41)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C131(0.82); C56(0.87)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C131(0.93); C56(0.93)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C56(0.88); C131(1.11)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C131(0.88); C56(1.31)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C131(0.70); C56(1.35)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C131(0.78); C56(1.16)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C56(0.90); C131(1.16)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C131(1.04); C56(1.24)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C131(0.70); C56(0.87)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C56(0.92); C131(1.15)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C56(0.84); C131(1.46)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C56(0.82); C131(1.24)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C131(1.11); C56(1.15)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C131(0.89); C56(0.99)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C56(1.49)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C56(1.38)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C56(0.75)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C56(1.46)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C56(0.83)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C56(1.67)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C56(1.00)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C56(1.14)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C56(1.01)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C56(1.07)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C56(0.99)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C56(1.28)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C56(0.95)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C56(0.87)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C56(1.19)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C56(0.54)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C56(1.14)  LDD0683  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C56(0.70)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C131(1.57); C56(0.66)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C56(0.98); C131(1.14)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C56(1.00); C131(1.18)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0199  BPK-21 T cell C56(7.29)  LDD0530  [28]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C131(1.14)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C131(0.63)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C56(0.87)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C56(0.97); C131(1.47)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C56(1.67); C131(1.82)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C56(0.86); C131(1.32)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C56(0.89); C131(1.06)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C56(0.95)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C56(1.47)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C56(0.86)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C56(0.79)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C56(1.31)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C131(0.68)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C56(0.97)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C56(0.81)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C56(0.87)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C56(0.91)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C56(1.15)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C56(1.00)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C56(1.07)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C56(1.32)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C56(1.25)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C56(1.19)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C131(0.69)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C56(1.08)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C56(1.10)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C56(1.49)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C56(1.46)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C56(1.18)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C56(0.99)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C56(1.23)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C56(1.05)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C56(1.01)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C131(0.59)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C131(0.83)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C131(0.69)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C131(0.66); C56(0.88)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C131(0.60); C56(1.37)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C131(0.47); C56(0.86)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C131(0.51); C56(1.22)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C131(0.99)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C131(0.50); C56(1.27)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C131(0.62); C56(2.60)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C131(0.58); C56(1.22)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C131(0.71); C56(1.84)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C131(0.70); C56(1.20)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C131(0.64); C56(1.20)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C131(0.70); C56(1.25)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C131(0.57); C56(0.98)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C131(0.56); C56(1.12)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C131(0.67); C56(1.13)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C131(0.79)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C131(0.71); C56(1.65)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C56(1.25)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C56(1.95)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C56(1.39)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C56(1.35)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C56(1.51)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C56(1.82)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C56(1.42)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C56(1.39)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C131(0.81)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C56(1.98)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C56(1.48)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C56(1.82)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C56(1.72)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C56(1.55)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C56(1.69)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C131(1.24); C56(0.70)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C131(1.04); C56(0.88)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C131(1.04); C56(1.07)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C131(1.18); C56(0.94)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C131(0.78)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C131(0.96); C56(1.08)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C131(0.96); C56(0.75)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C131(1.10); C56(0.81)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C131(1.02); C56(1.57)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C131(1.23); C56(1.45)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C131(1.02); C56(0.85)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C131(1.05); C56(1.11)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C131(0.96); C56(1.29)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C131(1.14); C56(1.17)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C131(1.09); C56(0.84)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C131(0.89)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C131(0.91); C56(0.96)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C56(1.01)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C56(1.09)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C56(1.62)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C56(1.20)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C56(1.15)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C56(1.11)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C56(1.15)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C56(1.24)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C56(1.14)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C131(1.07)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C56(1.27)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C56(1.10)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C56(1.40)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C56(2.31)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C56(1.50)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C56(1.17)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C56(3.10)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C56(1.11)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C56(1.22)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C131(1.29)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C56(1.34)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C56(0.99)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C56(1.36)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C56(1.43)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C56(1.38)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C56(1.16)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C56(1.17)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C56(1.27)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C56(2.00)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C56(1.51)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C131(0.93)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C56(2.04)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C56(0.86)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C56(0.96)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C56(1.21)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C56(0.89)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C56(0.98)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C56(1.04)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C56(1.08)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C56(0.82)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C56(0.87)  LDD0811  [13]
 LDCM0033  Curcusone1d MCF-7 2.39  LDD0188  [9]
 LDCM0495  E2913 HEK-293T C56(0.96)  LDD1698  [29]
 LDCM0202  EV-93 T cell C56(11.27)  LDD0527  [28]
 LDCM0625  F8 Ramos C56(1.38)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C56(1.46)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C56(1.48)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C56(1.11)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C56(0.52)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C56(1.13)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C56(0.83)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C56(0.82)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C56(0.97)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C56(0.75)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C56(1.41)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C56(0.60)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C56(0.92)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C56(0.77)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C56(1.30)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C56(2.19)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C56(2.20)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C56(2.58)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C56(1.99)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C56(0.66)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C56(1.19)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C56(0.72)  LDD2188  [30]
 LDCM0149  GA MCF-7 C56(5.32)  LDD0379  [31]
 LDCM0150  Hoch_cp18 MCF-7 C56(6.69)  LDD0380  [31]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y100(1.30); Y40(0.62)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y100(0.77); Y40(0.27)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y100(3.25); Y40(1.79)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y100(2.72); Y40(3.74)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y100(5.93); Y40(5.32)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y100(1.29); Y40(0.67)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y100(0.72); Y40(0.14)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y100(1.44); Y40(0.65)  LDD0292  [12]
 LDCM0022  KB02 HCT 116 C56(5.52)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C56(20.00)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C56(20.00)  LDD0082  [13]
 LDCM0109  NEM HeLa N.A.  LDD0224  [21]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C56(1.24)  LDD2093  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C56(0.79)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C56(1.25)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C56(0.47)  LDD2100  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C56(0.55)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C56(0.92)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C56(1.32)  LDD2109  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C56(0.42)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C56(2.15)  LDD2119  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C56(1.17)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C56(0.92)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C56(1.23)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C56(0.53)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C56(0.44)  LDD2134  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C56(1.38)  LDD2136  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C56(2.44)  LDD2145  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C56(0.28)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C56(1.06); C131(0.77)  LDD2207  [32]
 LDCM0014  Panhematin HEK-293T 3.49  LDD0062  [11]
 LDCM0131  RA190 MM1.R C56(2.42)  LDD0304  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sialidase-1 (NEU1) Glycosyl hydrolase 33 family Q99519
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Transporter and channel
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Clarin-1 (CLRN1) Clarin family P58418
Excitatory amino acid transporter 1 (SLC1A3) Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family P43003
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) Sugar transporter (TC 2.A.1.1) family P22732
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Aquaporin-10 (AQP10) MIP/aquaporin (TC 1.A.8) family Q96PS8
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Cardiac phospholamban (PLN) Phospholamban family P26678
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) PMP-22/EMP/MP20 family Q06432
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-3 (STX3) Syntaxin family Q13277
Tetraspanin-12 (TSPAN12) Tetraspanin (TM4SF) family O95859
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Proteolipid protein 2 (PLP2) . Q04941
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 60 (TMEM60) . Q9H2L4
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) . Q9BVC6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Transcription factor A, mitochondrial (TFAM) . Q00059
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Other
Click To Hide/Show 38 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L2 (APOL2) Apolipoprotein L family Q9BQE5
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) ARL6IP6 family Q8N6S5
BET1 homolog (BET1) BET1 family O15155
Apolipoprotein D (APOD) Lipocalin family P05090
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Cyclin-C (CCNC) Cyclin family P24863
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
P antigen family member 1 (PAGE1) GAGE family O75459
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Low-density lipoprotein receptor-related protein 10 (LRP10) LDLR family Q7Z4F1
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Neuronal vesicle trafficking-associated protein 1 (NSG1) NSG family P42857
Nurim (NRM) Nurim family Q8IXM6
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Synaptosomal-associated protein 47 (SNAP47) SVAP1 family Q5SQN1
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Protein SYS1 homolog (SYS1) SYS1 family Q8N2H4
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Protein YIF1A (YIF1A) YIF1 family O95070
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
LEM domain-containing protein 1 (LEMD1) . Q68G75
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Protein SNORC (SNORC) . Q6UX34
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane protein 107 (TMEM107) . Q6UX40
Transmembrane protein 140 (TMEM140) . Q9NV12
Uncharacterized protein C11orf24 (C11orf24) . Q96F05

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutathione Small molecular drug DB00143

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.