General Information of Experiment

Probe Name IPM  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Hoch_cp18  Competitor Info 
Competitor Concentration 3 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cell lysate (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) C56 6.7
 LDTP01268  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) C106 5.0
 LDTP11248  Probable ATP-dependent RNA helicase DDX23 (DDX23) C692 3.5
 LDTP11243  Glucose-6-phosphatase 3 (G6PC3) C269 2.5
 LDTP09216  Serine palmitoyltransferase small subunit B (SPTSSB) C68 2.4
 LDTP09053  Xyloside xylosyltransferase 1 (XXYLT1) C10 2.2
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C412 4.5
 LDTP03546  Translocator protein (TSPO) C19 3.3
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13269  Cysteine and histidine-rich domain-containing protein 1 (CHORDC1) C86 4.0

References

1 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.