Details of the Target

General Information of Target

Target ID LDTP11243
Target Name Glucose-6-phosphatase 3 (G6PC3)
Gene Name G6PC3
Gene ID 92579
Synonyms
UGRP; Glucose-6-phosphatase 3; G-6-Pase 3; G6Pase 3; EC 3.1.3.9; Glucose-6-phosphatase beta; G6Pase-beta; Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQP
ATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPG
EPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGE
GSAKRSQPEPGVADEDQTA
Target Bioclass
Enzyme
Family
Glucose-6-phosphatase family
Subcellular location
Endoplasmic reticulum membrane
Function
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Uniprot ID
Q9BUM1
Ensemble ID
ENST00000269097.9
HGNC ID
HGNC:24861

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
DBIA
 Probe Info  		C269(1.01)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
NAIA_5
 Probe Info  		C269(0.00); C235(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		Q272(0.00); P268(0.00); S267(0.00); V273(0.00)  LDD0024  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C269(0.87)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C269(0.64)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C269(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C269(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C269(0.90)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C269(0.69)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C269(1.00)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C269(0.81)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C269(0.71)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C269(0.94)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C269(0.93)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C269(0.78)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C269(0.77)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C269(0.85)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C269(0.81)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C269(0.76)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C269(0.79)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C269(0.80)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C269(0.88)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C269(0.86)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C269(0.77)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C269(0.76)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C269(0.90)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C269(0.70)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C269(0.81)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C269(0.78)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C269(0.83)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C269(0.92)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C269(1.12)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C269(0.78)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C269(0.79)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C269(0.87)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C269(0.92)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C269(0.91)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C269(1.05)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C269(1.09)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C269(1.03)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C269(0.92)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C269(1.08)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C269(0.95)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C269(0.95)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C269(1.07)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C269(1.03)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C269(1.08)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C269(0.65)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C269(0.96)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C269(0.94)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C269(1.28)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C269(1.55)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C269(1.44)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C269(1.42)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C269(1.48)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C269(1.38)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C269(1.68)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C269(1.11)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C269(0.78)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C269(1.27)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C269(1.39)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C269(1.28)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C269(1.10)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C269(0.99)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C269(1.09)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C269(1.78)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C269(1.55)  LDD2165  [3]
 LDCM0276  AC17 PaTu 8988t C269(1.11)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C269(1.13)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C269(1.13)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C269(0.91)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C269(1.12)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C269(1.20)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C269(1.11)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C269(1.30)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C269(1.00)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C269(1.37)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C269(1.43)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C269(1.69)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C269(1.54)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C269(1.60)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C269(0.92)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C269(1.53)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C269(1.22)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C269(1.35)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C269(1.45)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C269(1.20)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C269(1.15)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C269(0.95)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C269(1.13)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C269(1.00)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C269(1.18)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C269(1.00)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C269(1.16)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C269(1.02)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C269(1.09)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C269(0.97)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C269(1.09)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C269(1.20)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C269(0.95)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C269(0.97)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C269(1.19)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C269(0.78)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C269(1.09)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C269(0.94)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C269(0.82)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C269(0.87)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C269(0.99)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C269(0.98)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C269(1.12)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C269(0.64)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C269(0.99)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C269(0.96)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C269(1.06)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C269(0.75)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C269(1.09)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C269(1.10)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C269(1.05)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C269(1.20)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C269(1.10)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C269(1.05)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C269(1.04)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C269(1.09)  LDD0929  [3]
 LDCM0332  AC68 PaTu 8988t C269(1.27)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C269(0.95)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C269(0.99)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C269(1.31)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C269(0.99)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C269(1.13)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C269(1.34)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C269(1.23)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C269(1.27)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C269(1.19)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C269(1.14)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C269(1.23)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C269(1.11)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C269(0.76)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C269(1.79)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C269(1.14)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C269(1.25)  LDD1227  [3]
 LDCM0349  AC83 HEK-293T C269(0.96)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C269(1.13)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C269(0.99)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C269(1.04)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C269(0.93)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C269(1.03)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C269(1.10)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C269(1.07)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C269(0.99)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C269(1.08)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C269(0.94)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C269(1.07)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C269(0.95)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C269(0.95)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C269(0.90)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C269(0.90)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C269(0.80)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C269(0.71)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C269(0.92)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C269(0.77)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C269(1.01)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C269(1.18)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C269(3.94)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C269(0.87)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C269(1.26)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C269(1.86)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C269(1.05)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C269(1.97)  LDD0690  [3]
 LDCM0374  CL105 PaTu 8988t C269(2.08)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C269(3.96)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C269(1.01)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C269(1.20)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C269(3.03)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C269(3.54)  LDD0977  [3]
 LDCM0380  CL110 PaTu 8988t C269(3.36)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C269(1.64)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C269(1.45)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C269(1.36)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C269(2.02)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C269(1.63)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C269(1.84)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C269(0.99)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C269(0.99)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C269(1.32)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C269(1.24)  LDD0988  [3]
 LDCM0391  CL120 PaTu 8988t C269(1.12)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C269(0.91)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C269(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C269(1.41)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C269(1.10)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C269(1.05)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C269(1.06)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C269(0.94)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C269(1.08)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C269(1.41)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C269(1.50)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C269(2.49)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C269(1.25)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C269(0.91)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C269(1.29)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C269(1.02)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C269(1.30)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C269(1.07)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C269(1.37)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C269(1.09)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C269(1.33)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C269(1.08)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C269(1.02)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C269(1.14)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C269(1.07)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C269(1.07)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C269(0.88)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C269(1.86)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C269(1.00)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C269(1.17)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C269(0.76)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C269(1.91)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C269(1.57)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C269(1.16)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C269(1.61)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C269(1.21)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C269(0.97)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C269(1.66)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C269(1.86)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C269(1.15)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C269(1.33)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C269(0.90)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C269(0.86)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C269(1.35)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C269(0.91)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C269(0.91)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C269(0.95)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C269(0.99)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C269(1.54)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C269(1.16)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C269(1.30)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C269(1.05)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C269(1.03)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C269(1.10)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C269(0.79)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C269(0.90)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C269(0.88)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C269(0.89)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C269(0.97)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C269(1.41)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C269(0.90)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C269(0.95)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C269(1.09)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C269(3.54)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C269(1.30)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C269(1.10)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C269(0.88)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C269(1.01)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C269(2.21)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C269(2.01)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C269(2.20)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C269(1.60)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C269(1.63)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C269(1.11)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C269(1.20)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C269(1.45)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C269(1.14)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C269(3.32)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C269(1.00)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C269(0.86)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C269(0.80)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C269(1.02)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C269(1.41)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C269(0.99)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C269(3.59)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C269(5.15)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C269(0.83)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C269(0.90)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C269(1.04)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C269(0.88)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C269(1.05)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C269(1.14)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C269(9.51)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C269(1.07)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C269(1.22)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C269(1.07)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C269(1.19)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C269(2.05)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C269(1.08)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C269(1.38)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C269(0.99)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C269(0.88)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C269(1.13)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C269(0.89)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C269(4.58)  LDD0744  [3]
 LDCM0149  GA MCF-7 C269(2.78)  LDD0379  [12]
 LDCM0150  Hoch_cp18 MCF-7 C269(2.45)  LDD0380  [12]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [1]
 LDCM0022  KB02 A2058 C269(3.75)  LDD2253  [13]
 LDCM0023  KB03 MDA-MB-231 C269(2.06)  LDD1701  [14]
 LDCM0024  KB05 UACC257 C269(3.08)  LDD3325  [13]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C269(0.20); C269(0.07)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C269(0.18)  LDD2207  [15]
 LDCM0131  RA190 MM1.R C269(4.49)  LDD0304  [16]

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.