Details of the Target

General Information of Target

Target ID LDTP12911
Target Name Adenosine deaminase 2 (ADA2)
Gene Name ADA2
Gene ID 51816
Synonyms
ADGF; CECR1; IDGFL; Adenosine deaminase 2; EC 3.5.4.4; Cat eye syndrome critical region protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG
GAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWF
KVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family, ADGF subfamily
Subcellular location
Secreted
Function
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.
Uniprot ID
Q9NZK5
Ensemble ID
ENST00000262607.3
HGNC ID
HGNC:1839

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R294I .
HT115 SNV: p.K275N .
KMCH1 SNV: p.Y290D .
KMRC1 SNV: p.Y453H .
LS123 SNV: p.H332Q .
MEWO SNV: p.M465I .
ONS76 SNV: p.F14L .
SW620 SNV: p.Y220S .
TF1 SNV: p.V175I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C408(2.15)  LDD3338  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0202  EV-93 T cell C408(20.00)  LDD0527  [4]
 LDCM0625  F8 Ramos C408(1.12)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C408(1.35)  LDD2189  [5]
 LDCM0574  Fragment12 Ramos C408(1.94)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C408(1.89)  LDD2192  [5]
 LDCM0579  Fragment20 Ramos C408(1.21)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C408(1.71)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C408(0.66)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C408(0.90)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C408(0.79)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C408(1.49)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C408(1.06)  LDD2200  [5]
 LDCM0468  Fragment33 Ramos C408(2.28)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C408(1.04)  LDD2203  [5]
 LDCM0614  Fragment56 Ramos C408(0.82)  LDD2205  [5]
 LDCM0022  KB02 T cell C408(20.00)  LDD1707  [4]
 LDCM0023  KB03 K052 C408(2.07)  LDD2844  [1]
 LDCM0024  KB05 MV4-11 C408(2.15)  LDD3338  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578