Details of the Target

General Information of Target

Target ID LDTP03450
Target Name Retinoic acid receptor RXR-beta (RXRB)
Gene Name RXRB
Gene ID 6257
Synonyms
NR2B2; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
Target Type
Successful
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR2 subfamily
Subcellular location
Nucleus
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
TTD ID
T60077
Uniprot ID
P28702
DrugMap ID
TTKLV96
Ensemble ID
ENST00000374680.4
HGNC ID
HGNC:10478
ChEMBL ID
CHEMBL1870

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.A528T DBIA    Probe Info 
TCCSUP SNV: p.E505Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K235(10.00); K427(0.41)  LDD0277  [2]
DBIA
 Probe Info  		C208(110.50)  LDD0209  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C503(0.00); C247(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C503(0.00); C241(0.00); C19(0.00); C440(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C475(0.00); C503(0.00); C191(0.00)  LDD0037  [5]
TFBX
 Probe Info  		C19(0.00); C340(0.00); C191(0.00)  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C19(2.36)  LDD0372  [11]
 LDCM0214  AC1 HEK-293T C340(1.01); C503(0.89); C30(1.07); C440(0.97)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C503(0.80); C30(0.95); C265(1.07); C225(0.95)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C191(0.97); C503(0.93); C30(0.99); C440(1.05)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C191(0.98); C340(0.96); C503(0.98); C30(1.01)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C191(1.02); C340(0.99); C503(1.12); C30(1.06)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C340(1.13); C503(1.13); C30(0.96); C265(1.14)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C340(1.04); C503(0.97); C30(0.97); C440(0.91)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C503(1.12); C30(1.04); C265(1.04); C225(0.95)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C191(1.20); C503(0.82); C30(1.66); C440(1.07)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C503(1.01); C30(0.92); C265(0.97); C225(1.04)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C191(0.96); C340(1.19); C503(1.05); C30(1.02)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C503(1.03); C30(0.91); C265(1.00)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C191(0.92); C340(0.93); C503(1.05); C30(1.11)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C340(1.14); C503(1.11); C30(0.88); C265(1.07)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C503(1.00); C30(1.03); C247(1.15); C225(1.07)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C340(1.02); C503(0.87); C30(1.11); C440(0.79)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C503(0.78); C30(0.95); C265(0.99); C225(1.06)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C191(0.93); C503(0.96); C30(0.98); C440(1.08)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C191(0.98); C340(0.94); C503(1.06); C30(1.00)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C503(1.12); C30(0.96); C265(0.99)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C191(0.98); C503(1.02); C30(0.99); C440(1.02)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C191(1.10); C340(1.15); C503(1.04); C30(1.05)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C340(1.05); C503(1.09); C30(0.94); C265(1.06)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C503(0.99); C30(0.96); C247(1.12); C225(0.91)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C340(1.06); C503(0.90); C30(1.13); C440(0.87)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C503(0.74); C30(0.96); C265(0.99); C225(1.01)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C191(0.92); C503(0.91); C30(1.02); C440(1.12)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C191(1.01); C340(1.12); C503(1.14); C30(1.04)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C503(1.07); C30(0.90); C265(1.10)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C191(0.93); C340(1.16); C503(1.06); C30(1.03)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C340(1.04); C503(1.13); C30(0.97); C265(1.14)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C191(1.00); C340(0.98); C503(0.97); C30(1.03)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C503(1.01); C30(1.03); C247(1.14); C225(1.01)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C340(1.08); C503(0.89); C30(0.95); C440(0.90)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C503(0.77); C30(1.02); C265(1.04); C225(1.04)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C191(0.92); C503(0.99); C30(1.04); C440(1.03)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C191(1.05); C340(0.94); C503(1.05); C30(1.13)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C503(1.00); C30(1.02); C265(1.08)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C191(1.00); C340(0.94); C503(1.11); C30(1.06)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C340(1.20); C503(1.06); C30(0.95); C265(1.10)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C503(1.05); C30(0.99); C247(1.21); C225(1.00)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C340(1.02); C503(0.95); C30(0.92); C440(0.86)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C503(1.07); C30(0.97); C265(1.04)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C503(0.91); C30(0.96); C265(1.02); C225(0.98)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C191(0.92); C503(1.02); C30(0.98); C440(1.03)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C191(1.00); C340(1.07); C503(0.98); C30(1.02)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C503(1.03); C30(0.98); C265(1.04)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C191(0.93); C340(1.21); C503(1.06); C30(1.04)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C340(1.23); C503(1.10); C30(1.01); C265(1.13)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C503(1.05); C30(0.92); C247(1.04); C225(1.04)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C340(1.03); C503(0.86); C30(1.05); C440(1.05)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C503(0.64); C30(1.02); C265(1.00); C225(0.95)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C191(0.95); C503(1.01); C30(1.01); C440(1.09)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C191(1.03); C340(1.00); C503(0.97); C30(1.00)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C191(0.94); C340(1.22); C503(1.03); C30(1.05)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C503(1.01); C30(0.98); C265(0.99)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C191(1.04); C340(1.07); C503(0.99); C30(1.04)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C340(1.14); C503(1.07); C30(1.00); C265(1.11)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C503(1.13); C30(1.01); C247(1.36); C225(0.99)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C340(1.10); C503(1.18); C30(0.97); C265(1.10)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C503(0.97); C30(1.01); C247(1.10); C225(0.98)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C503(1.04); C30(0.96); C265(1.06)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C340(1.01); C503(0.91); C30(1.23); C440(0.90)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C503(1.00); C30(1.00); C247(1.11); C225(0.96)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 11.54  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C191(0.87); C340(1.16); C503(0.91); C30(1.00)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C191(0.94); C340(1.37); C503(0.93); C30(1.04)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C191(0.96); C340(0.92); C503(1.01); C30(0.98)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C191(0.88); C340(1.03); C503(0.96); C30(0.99)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C191(0.96); C340(1.40); C503(1.09); C30(1.07)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C191(1.06); C340(0.83); C30(1.45); C440(0.91)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C191(1.02); C340(1.21); C503(1.12); C30(0.97)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C191(0.82); C340(1.08); C503(1.05); C30(1.01)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C191(0.90); C340(1.13); C503(0.98); C30(1.01)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C191(0.90); C340(0.88); C30(1.00); C440(0.85)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C191(0.90); C340(1.01); C503(1.18); C30(0.98)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C191(0.93); C340(1.37); C503(1.03); C30(0.94)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C340(1.44); C503(1.01); C30(0.96); C265(1.42)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C191(0.87); C340(1.47); C503(0.98); C30(0.98)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C191(0.88); C340(1.00); C30(1.13); C440(0.90)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C191(1.03); C340(1.05); C503(1.06); C30(1.09)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C191(0.89); C340(1.15); C503(1.02); C30(1.13)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C191(0.88); C340(1.16); C503(0.96); C30(1.02)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C191(0.92); C340(0.90); C30(1.06); C440(0.90)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C191(0.93); C340(0.99); C503(1.10); C30(1.03)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C191(1.07); C340(1.07); C503(0.93); C30(1.01)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C191(1.10); C340(1.14); C503(0.94); C30(1.10)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C191(0.85); C340(0.84); C30(1.14); C440(0.90)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C503(1.05); C30(0.94); C247(0.66); C225(1.02)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C191(1.01); C340(1.11); C503(1.14); C30(1.04)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C191(1.08); C340(1.03); C503(0.94); C30(0.98)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C191(1.02); C340(1.18); C503(0.93); C30(1.05)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C191(0.77); C340(1.33); C30(0.85); C440(0.92)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C191(0.93); C340(1.12); C503(1.13); C30(1.03)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C191(0.76); C340(0.91); C503(0.96); C30(0.99)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C191(1.00); C340(1.04); C503(0.85); C30(1.00)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C191(0.92); C340(0.95); C30(1.15); C440(1.04)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C191(0.89); C340(1.05); C503(1.06); C30(1.03)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C191(1.03); C340(1.10); C503(0.81); C30(1.09)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C191(1.10); C340(1.14); C503(0.88); C30(0.96)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C191(0.83); C340(1.20); C30(1.00); C440(0.91)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C191(0.98); C340(0.95); C503(1.10); C30(0.93)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C340(1.56); C503(0.75); C30(1.43); C440(0.90)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C503(0.66); C30(0.93); C265(1.08); C225(1.02)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C191(1.06); C503(0.95); C30(0.97); C440(1.25)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C191(1.08); C340(1.20); C503(1.14); C30(1.09)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C191(1.00); C340(1.01); C503(1.05); C30(1.01)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C503(1.06); C30(0.92); C265(1.10)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C191(1.07); C340(1.17); C503(0.99); C30(0.93)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C340(1.31); C503(1.06); C30(0.89); C265(1.22)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C503(0.95); C30(0.86); C247(0.44); C225(1.05)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C191(0.83); C340(1.03); C503(0.97); C30(0.95)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C191(0.89); C340(1.20); C503(1.13); C30(0.97)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C191(1.00); C340(0.94); C30(1.39); C440(0.87)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C191(1.01); C340(1.07); C503(0.93); C30(0.96)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C340(0.90); C503(0.93); C30(0.83); C440(0.94)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C191(0.77); C340(0.98); C30(0.98); C440(1.03)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C503(0.89); C30(0.97); C265(1.07); C225(0.92)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C191(1.01); C503(1.10); C30(0.94); C440(1.11)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C191(1.03); C340(1.17); C503(1.09); C30(0.98)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C503(1.00); C30(0.96); C265(1.06)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C191(1.02); C340(1.25); C503(1.05); C30(0.96)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C340(1.45); C503(1.07); C30(0.93); C265(1.20)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C503(0.93); C30(0.92); C247(0.41); C225(0.92)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C191(0.99); C340(1.30); C503(1.03); C30(0.90)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C191(0.86); C340(0.90); C30(1.28); C440(0.95)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C191(0.94); C340(1.21); C503(1.12); C30(0.88)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C191(0.96); C340(1.04); C503(1.07); C30(0.95)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C340(1.22); C503(0.75); C30(0.98); C440(1.06)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C503(0.77); C30(0.97); C265(0.97); C225(1.01)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C191(0.98); C503(1.11); C30(0.94); C440(1.05)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C191(1.02); C340(1.22); C503(0.96); C30(1.04)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C503(0.90); C30(0.95); C265(1.08)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C191(1.08); C340(1.07); C503(1.01); C30(0.98)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C340(1.31); C503(0.99); C30(0.96); C265(1.09)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C503(0.93); C30(0.95); C247(0.37); C225(1.01)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C191(0.83); C340(1.07); C503(1.03); C30(0.92)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C340(1.04); C503(0.84); C30(0.96); C440(1.06)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C191(1.04); C340(1.17); C503(1.01); C30(1.06)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C191(1.00); C340(1.00); C503(1.08); C30(1.01)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C340(1.48); C503(0.85); C30(1.04); C440(0.96)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C503(0.92); C30(0.88); C265(1.17); C225(0.93)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C191(0.99); C503(0.97); C30(0.96); C440(1.09)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C191(1.01); C340(0.95); C503(0.94); C30(0.96)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C503(0.97); C30(1.08); C265(1.06)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C191(0.99); C340(1.23); C503(1.00); C30(0.98)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C340(1.30); C503(1.05); C30(0.93); C265(1.26)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C503(0.79); C30(0.94); C265(1.33); C225(0.93)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C503(0.96); C30(1.01); C247(0.41); C225(1.16)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C191(0.88); C340(0.94); C503(1.01); C30(0.97)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C191(0.93); C340(1.25); C503(1.01); C30(1.09)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C191(0.92); C340(0.93); C30(0.99); C440(1.00)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C191(1.01); C340(1.16); C503(0.99); C30(1.05)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C340(1.03); C503(0.89); C30(0.80); C440(0.94)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C503(0.93); C30(0.94); C265(0.99); C225(1.00)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C191(0.93); C503(0.95); C30(0.98); C440(1.17)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C191(0.98); C340(1.15); C503(1.10); C30(0.98)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C503(1.04); C30(0.89); C265(1.04)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C191(1.01); C503(0.97); C30(0.87); C440(1.27)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C191(1.04); C340(1.50); C503(1.00); C30(0.97)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C340(1.24); C503(1.10); C30(1.02); C265(1.13)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C503(0.94); C30(0.99); C247(0.46); C225(1.09)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C191(0.80); C340(1.23); C503(1.03); C30(0.94)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C191(1.04); C340(1.16); C503(1.01); C30(0.99)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C191(0.97); C340(1.05); C503(1.12); C30(1.00)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C340(1.14); C503(0.90); C30(1.03); C440(0.88)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C503(0.81); C30(1.01); C265(1.02); C225(1.03)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C191(1.01); C503(0.96); C30(1.03); C440(1.10)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C191(0.73); C340(1.77); C503(1.28); C30(1.02)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C191(1.03); C340(1.33); C503(1.09); C30(0.97)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C503(1.12); C30(0.91); C265(1.11)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C191(1.01); C340(1.04); C503(1.03); C30(0.98)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C340(1.54); C503(1.06); C30(0.89); C265(1.16)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C503(0.92); C30(0.88); C247(0.49); C225(0.88)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C191(0.94); C340(0.98); C503(0.96); C30(0.97)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C191(0.90); C340(1.12); C503(0.93); C30(0.97)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C191(0.88); C340(0.81); C30(1.00); C440(1.06)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C191(0.90); C340(0.98); C503(1.14); C30(0.94)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C340(1.00); C503(0.92); C30(0.91); C440(1.02)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C503(1.02); C30(0.89); C265(1.11)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C503(0.81); C30(0.95); C265(1.39); C225(0.87)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C191(0.99); C503(0.92); C30(0.97); C440(1.05)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C191(0.96); C340(1.43); C503(1.00); C30(0.96)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C503(1.09); C30(0.92); C265(1.05)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C191(1.06); C340(1.30); C503(1.00); C30(1.02)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C340(2.17); C503(0.93); C30(1.04); C265(1.45)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C503(0.90); C30(0.89); C247(0.69); C225(0.96)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C191(0.95); C340(1.26); C503(0.92); C30(1.08)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C191(0.89); C340(1.13); C503(1.21); C30(1.08)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C191(0.91); C340(0.72); C30(1.06); C440(1.13)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C191(1.07); C340(0.94); C30(0.94); C440(0.91)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C191(1.27)  LDD1702  [13]
 LDCM0202  EV-93 T cell C340(4.51)  LDD0527  [14]
 LDCM0625  F8 Ramos C503(0.90)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C503(15.56)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C503(0.86)  LDD2193  [15]
 LDCM0468  Fragment33 HEK-293T C191(0.82); C340(1.02); C30(1.17); C440(0.95)  LDD1671  [12]
 LDCM0566  Fragment4 Ramos C503(1.11)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C191(0.96); C340(1.10); C503(0.87); C30(1.03)  LDD1631  [12]
 LDCM0569  Fragment7 Ramos C503(1.22)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C30(1.09); C191(0.92); C241(0.91); C265(1.02)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C208(110.50)  LDD0209  [3]
 LDCM0024  KB05 G361 C507(4.87); C444(2.64)  LDD3311  [16]
 LDCM0131  RA190 MM1.R C340(18.15)  LDD0304  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Transcriptional adapter 3 (TADA3) NGG1 family O75528
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Speckle-type POZ protein-like (SPOPL) Tdpoz family Q6IQ16
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) Calcium channel alpha-1 subunit family Q00975
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Peroxisome proliferator-activated receptor gamma (PPARG) Nuclear hormone receptor family P37231
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Retinoic acid receptor gamma (RARG) Nuclear hormone receptor family P13631
Glucocorticoid receptor (NR3C1) Nuclear hormone receptor family P04150
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Ubiquitin-like protein 7 (UBL7) . Q96S82

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acitretin Small molecular drug DB00459
Adapalene Small molecular drug DB00210
Alitretinoin Small molecular drug D0G3PI
Bexarotene Small molecular drug DB00307
Bezafibrate Small molecular drug DB01393
Doconexent Small molecular drug DB03756
Rosiglitazone Small molecular drug DB00412
Tazarotene Small molecular drug DB00799
Tretinoin Small molecular drug DB00755
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Agn-34 Small molecular drug D0GR9O
Lg-100268 Small molecular drug DB01941
Lg100754 Small molecular drug D0Q9FZ
Phthalic Acid Small molecular drug DB02746
To-901317 Small molecular drug DB07080
(2e4e)-11-methoxy-3711-trimethyldodeca-24-dienoic Acid . DB08175
N-(Tert-butyl)-35-dimethyl-n'-[(5-methyl-23-dihydro-14-benzodioxin-6-yl)Carbonyl]Benzohydrazide . DB07929
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Etretinate Small molecular drug DB00926

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.