Details of the Target

General Information of Target

Target ID LDTP13203
Target Name STE20/SPS1-related proline-alanine-rich protein kinase (STK39)
Gene Name STK39
Gene ID 27347
Synonyms
PASK; SPAK; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; EC 2.7.11.1; DCHT; Serine/threonine-protein kinase 39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRNKKILKEDELLSETQQAAFHQIAMEPFEINVPKPKRRNGVNFSLAVVVIYLILLTAGA
GLLVVQVLNLQARLRVLEMYFLNDTLAAEDSPSFSLLQSAHPGEHLAQGASRLQVLQAQL
TWVRVSHEHLLQRVDNFTQNPGMFRIKGEQGAPGLQGHKGAMGMPGAPGPPGPPAEKGAK
GAMGRDGATGPSGPQGPPGVKGEAGLQGPQGAPGKQGATGTPGPQGEKGSKGDGGLIGPK
GETGTKGEKGDLGLPGSKGDRGMKGDAGVMGPPGAQGSKGDFGRPGPPGLAGFPGAKGDQ
GQPGLQGVPGPPGAVGHPGAKGEPGSAGSPGRAGLPGSPGSPGATGLKGSKGDTGLQGQQ
GRKGESGVPGPAGVKGEQGSPGLAGPKGAPGQAGQKGDQGVKGSSGEQGVKGEKGERGEN
SVSVRIVGSSNRGRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKGRALYKVGAGTGQ
IWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVECSV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Cytoplasm
Function
Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure. Specifically recognizes and binds proteins with a RFXV motif. Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity. Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases. Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux. Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities. Phosphorylates RELT.
TTD ID
T67837
Uniprot ID
Q9UEW8
DrugMap ID
TTYQTIU
Ensemble ID
ENST00000355999.5
HGNC ID
HGNC:17717
ChEMBL ID
CHEMBL1163108

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.Q115Ter DBIA    Probe Info 
HCT15 SNV: p.G307D DBIA    Probe Info 
OZ SNV: p.Q402R DBIA    Probe Info 
TE11 SNV: p.Q402R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K349(10.00); K515(0.07)  LDD0277  [2]
BTD
 Probe Info  		C99(0.62)  LDD2092  [3]
HPAP
 Probe Info  		4.44  LDD0062  [4]
DBIA
 Probe Info  		C237(0.98); C99(0.93); C525(0.87)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C99(0.00); C82(0.00); C450(0.00); C317(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C99(0.00); C82(0.00); C450(0.00); C317(0.00)  LDD0036  [6]
IPIAA_L
 Probe Info  		C450(0.00); C525(0.00)  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C82(0.00); C450(0.00); C525(0.00); C317(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [8]
NAIA_4
 Probe Info  		C82(0.00); C237(0.00); C450(0.00); C525(0.00)  LDD2226  [9]
WYneN
 Probe Info  		C99(0.00); C525(0.00)  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		C450(0.00); C525(0.00)  LDD2216  [11]
IPM
 Probe Info  		C317(0.00); C237(0.00); C99(0.00); C450(0.00)  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		C525(0.00); C317(0.00); C450(0.00)  LDD0236  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C99(0.28)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C99(0.92)  LDD2117  [3]
 LDCM0214  AC1 HCT 116 C237(0.98); C317(0.99); C450(1.13); C525(1.17)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C237(1.18); C317(1.03); C450(1.37); C525(1.03)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C237(0.95); C317(1.29); C450(0.92); C525(0.73)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C237(0.97); C317(1.16); C450(1.07); C525(0.88)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C237(0.93); C317(1.17); C450(1.09); C525(0.81)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C237(1.12); C317(1.20); C450(1.31); C525(0.94)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C237(0.93); C317(1.16); C450(1.02); C525(0.77)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C237(1.05); C317(1.23); C450(1.19); C525(0.98)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C237(1.09); C317(1.38); C450(1.19); C525(0.93)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C237(0.99); C317(1.19); C450(0.95); C525(0.99)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C237(0.86); C317(1.25); C450(1.08); C525(0.83)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C237(0.79); C317(1.18); C450(1.18); C525(0.81)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C237(1.15); C317(0.98); C450(1.31); C525(1.05)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C237(0.85); C317(1.25); C450(1.43); C525(0.76)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C237(0.90); C317(1.26); C450(1.02); C525(0.83)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C237(0.95); C317(1.38); C450(1.11); C525(0.93)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C116(0.89); C237(1.07); C317(1.06); C450(1.15)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C116(0.98); C237(1.15); C317(0.95); C450(1.03)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C116(1.21); C237(1.27); C317(1.01); C450(1.10)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C116(1.48); C237(1.25); C317(0.98); C450(1.52)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C116(1.02); C237(1.16); C317(1.03); C450(1.33)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C116(0.91); C237(1.11); C317(0.96); C450(1.12)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C116(1.09); C237(1.14); C317(0.96); C450(1.19)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C237(1.08); C317(1.18); C450(1.15); C525(0.86)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C116(1.00); C237(1.08); C317(0.89); C450(1.14)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C116(0.92); C237(1.11); C317(1.08); C450(1.20)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C116(1.09); C237(1.10); C317(1.05); C450(1.05)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C116(0.84); C237(1.11); C317(1.11); C450(1.02)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C116(0.87); C237(1.07); C317(1.05); C450(1.19)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C116(1.16); C237(1.07); C317(0.93); C450(1.08)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C116(0.85); C237(1.27); C317(0.96); C450(1.11)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C116(1.02); C237(1.22); C317(1.01); C450(1.30)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C237(1.21); C317(1.30); C450(1.32); C525(1.48)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C237(1.00); C317(0.91); C450(0.90); C525(1.27)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C237(1.16); C317(1.07); C450(1.11); C525(1.56)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C237(1.03); C317(0.88); C450(1.06); C525(1.30)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C237(1.07); C317(0.96); C450(1.01); C525(1.39)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C237(1.08); C317(1.04); C450(1.06); C525(1.49)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C237(1.25); C317(1.03); C450(1.13); C525(1.72)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C237(1.20); C317(1.10); C450(1.02); C525(1.39)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C237(1.14); C317(1.07); C450(1.12); C525(1.23)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C237(1.07); C317(1.03); C450(0.98); C525(1.21)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C237(1.23); C317(1.08); C450(1.24); C525(1.25)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C237(1.25); C317(0.98); C450(1.14); C525(1.65)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C237(1.10); C317(0.89); C450(1.28); C525(1.07)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C237(1.34); C317(1.00); C450(1.22); C525(1.71)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C237(1.27); C317(0.93); C450(1.17); C525(1.68)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C237(1.01); C317(1.01); C450(0.96); C525(1.63)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C450(0.96); C99(0.99); C317(1.11); C525(1.14)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C317(0.62); C237(1.26); C450(1.26); C99(1.32)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C317(0.80); C450(0.95); C237(1.16); C525(1.17)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C317(0.88); C450(0.98); C99(1.16); C237(1.26)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C317(0.87); C450(1.17); C99(1.21); C525(1.27)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C317(0.88); C99(1.22); C450(1.42); C237(1.74)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C317(0.86); C450(1.17); C99(1.22); C237(1.39)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C99(0.93); C317(0.96); C237(1.14); C525(1.14)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C317(0.90); C450(1.04); C525(1.08); C237(1.19)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C317(0.89); C237(1.10); C525(1.22); C99(1.36)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C317(1.08); C99(1.17); C525(1.20); C237(1.32)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C317(1.16); C99(1.54); C450(1.59); C525(1.82)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C237(1.22); C317(0.86); C450(1.12); C525(1.21)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C237(1.24); C317(0.98); C450(1.08); C525(1.17)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C237(1.06); C317(0.84); C450(1.02); C525(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C237(1.04); C317(0.80); C450(0.95); C525(1.15)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C525(1.01); C237(1.06); C317(1.07); C99(1.12)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C525(0.90); C99(1.01); C317(1.02); C237(1.09)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C317(0.99); C525(1.05); C237(1.07); C99(1.08)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C317(0.95); C99(0.96); C237(1.04); C450(1.06)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C525(1.03); C99(1.03); C317(1.06); C237(1.09)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C525(0.92); C237(1.00); C317(1.07); C99(1.10)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C525(0.99); C450(1.02); C237(1.04); C317(1.10)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C525(0.98); C99(0.98); C317(1.00); C237(1.02)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C525(0.98); C317(0.99); C237(1.03); C99(1.05)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C317(0.97); C237(1.05); C525(1.06); C450(1.08)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C317(0.96); C237(1.11); C99(1.14); C525(1.15)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C317(0.88); C99(1.04); C525(1.08); C237(1.17)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C317(0.90); C99(1.06); C525(1.07); C237(1.16)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C317(0.92); C99(1.08); C237(1.15); C525(1.21)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C99(0.91); C317(0.96); C237(0.98); C450(1.09)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C317(0.94); C525(1.12); C99(1.16); C237(1.21)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C317(0.90); C99(1.13); C450(1.18); C237(1.20)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C317(0.98); C99(1.18); C525(1.19); C237(1.40)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C99(0.87); C317(0.96); C237(1.23); C525(1.24)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C317(0.97); C99(0.98); C525(1.11); C237(1.35)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C450(0.86); C525(0.89); C237(0.91); C99(0.99)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C237(0.92); C450(0.99); C525(1.00); C99(1.01)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C450(0.82); C237(0.89); C525(0.89); C99(0.98)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C450(0.79); C237(0.93); C317(0.94); C99(0.96)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C525(0.95); C237(1.04); C99(1.04); C450(1.05)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C99(0.95); C317(0.98); C237(1.08); C450(1.14)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C525(0.93); C99(0.93); C237(1.04); C450(1.17)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C450(0.93); C99(0.99); C237(1.00); C525(1.05)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C99(0.91); C525(0.99); C450(1.00); C237(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C450(0.84); C99(0.96); C525(1.10); C237(1.14)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C450(0.82); C525(0.84); C99(0.95); C237(1.07)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C525(0.87); C99(0.93); C450(1.02); C237(1.11)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C237(1.02); C317(1.04); C99(1.07); C525(1.07)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C450(1.02); C237(1.04); C525(1.06); C99(1.10)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C450(0.94); C237(1.06); C317(1.18); C525(1.22)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C99(1.23); C525(1.25); C317(1.28); C237(1.30)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C99(0.93); C317(0.96); C237(1.10); C525(1.19)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C99(1.21); C317(1.23); C525(1.24); C237(1.25)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C450(0.83); C237(0.94); C99(0.95); C317(1.05)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C450(0.96); C237(1.05); C99(1.06); C317(1.21)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C525(0.96); C450(0.98); C99(1.00); C317(1.12)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C99(1.03); C450(1.09); C525(1.11); C237(1.12)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C450(1.11); C99(1.11); C237(1.27); C317(1.30)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C99(1.26); C525(1.42); C450(1.44); C237(1.45)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C116(0.79); C99(0.86); C317(1.05); C525(1.13)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C99(0.78); C317(1.05); C525(1.24); C237(1.34)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C99(0.96); C317(1.06); C525(1.12); C116(1.29)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C99(0.96); C317(1.02); C237(1.16); C525(1.19)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C99(0.91); C116(0.98); C317(1.02); C525(1.09)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C99(0.94); C317(1.07); C237(1.20); C116(1.23)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C116(0.86); C99(0.92); C317(1.08); C525(1.44)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C116(0.80); C99(0.84); C317(1.08); C450(1.20)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C116(0.68); C99(0.90); C317(1.11); C525(1.21)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C99(0.91); C317(1.13); C116(1.34); C525(1.38)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C99(0.86); C116(0.88); C317(1.10); C525(1.23)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C116(0.74); C99(1.01); C317(1.21); C525(1.46)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C99(0.87); C525(0.89); C450(0.95); C317(1.06)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C525(0.87); C99(0.99); C450(1.01); C317(1.04)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C99(0.92); C525(0.96); C317(0.99); C450(1.09)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C317(0.93); C525(0.98); C99(1.05); C450(1.08)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C525(0.82); C450(0.83); C99(0.88); C317(0.93)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C317(0.95); C99(0.97); C525(1.01); C450(1.12)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C525(1.02); C99(1.05); C317(1.14); C450(1.46)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C525(0.90); C99(0.94); C317(1.04); C450(1.28)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C99(1.05); C525(1.09); C317(1.18); C450(1.64)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C525(0.97); C99(0.97); C317(1.06); C450(1.22)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C525(0.90); C99(0.99); C317(1.03); C450(1.25)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C525(0.94); C99(0.95); C450(0.98); C317(1.05)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C99(0.97); C317(0.98); C450(0.99); C525(1.03)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C317(0.95); C99(0.96); C525(0.98); C237(1.13)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C525(0.98); C99(0.98); C317(1.04); C237(1.20)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C317(0.87); C450(0.91); C525(0.97); C99(0.99)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C525(0.99); C99(0.99); C317(1.04); C450(1.52)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C317(1.01); C99(1.02); C525(1.20); C116(1.26)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C99(1.04); C317(1.05); C237(1.22); C116(1.24)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C116(0.91); C99(1.03); C317(1.04); C237(1.19)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C317(1.06); C99(1.06); C116(1.10); C525(1.14)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C525(0.94); C237(1.07); C450(1.09); C99(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C116(0.99); C525(1.00); C237(1.02); C99(1.07)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C116(1.02); C317(1.07); C525(1.13); C237(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C116(0.96); C99(1.13); C450(1.13); C237(1.18)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C116(0.79); C317(1.08); C99(1.17); C525(1.22)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C116(0.84); C99(1.07); C525(1.16); C317(1.23)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C116(0.87); C525(0.88); C99(1.00); C237(1.04)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C116(0.94); C99(1.01); C237(1.05); C317(1.14)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C116(0.88); C99(0.99); C317(1.07); C525(1.08)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C116(0.68); C99(1.07); C317(1.09); C525(1.13)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C116(0.82); C525(1.02); C317(1.05); C99(1.13)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C99(0.91); C317(1.19); C237(1.22); C525(1.22)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C99(0.76); C525(0.78); C237(0.94); C317(1.15)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C99(0.50)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C237(1.05); C317(1.14); C450(1.16); C525(0.94)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C317(0.89); C99(0.90); C525(0.94); C237(1.13)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C317(0.96); C99(1.04); C525(1.38); C237(1.46)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.32  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C237(0.98); C99(0.93); C525(0.87)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C317(2.93); C237(1.37); C99(1.34); C317(1.14)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C450(0.83); C525(0.83); C237(0.90); C317(0.91)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C99(1.00); C317(1.08); C237(1.14); C525(1.25)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C317(0.97); C99(0.97); C237(1.03); C525(1.20)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C99(0.91); C317(0.92); C237(1.11); C525(1.17)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C99(0.88); C237(0.99); C317(1.00); C525(1.02)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C317(0.87); C99(0.94); C237(1.02); C450(1.19)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C99(0.93); C317(1.04); C237(1.05); C525(1.09)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C99(1.00); C317(1.02); C525(1.08); C237(1.10)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C99(1.09); C525(1.14); C317(1.17); C237(1.31)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C317(1.10); C525(1.18); C99(1.19); C237(1.31)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C317(1.05); C525(1.10); C99(1.27); C237(1.37)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C317(0.92); C525(1.03); C237(1.08); C99(1.14)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C99(0.92); C525(1.11); C237(1.14); C450(1.31)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C317(1.03); C525(1.06); C237(1.09); C99(1.12)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C525(1.01); C317(1.03); C99(1.09); C237(1.12)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C317(0.91); C99(1.01); C450(1.06); C525(1.08)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C99(1.02); C317(1.04); C525(1.10); C237(1.28)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C99(0.88); C317(0.92); C525(1.10); C237(1.11)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C99(0.88); C317(0.90); C525(1.09); C237(1.28)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C99(0.92); C317(0.96); C525(1.10); C237(1.16)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C99(0.93); C525(1.04); C450(1.06); C237(1.29)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C525(0.98); C99(1.02); C450(1.05); C237(1.07)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C237(1.01); C99(1.07); C525(1.11); C317(1.17)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C99(1.02); C450(1.18); C317(1.23); C237(1.35)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C450(0.87); C237(1.01); C99(1.02); C317(1.07)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C237(0.70); C99(0.93); C525(0.95); C450(1.06)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C99(0.95); C450(0.95); C237(1.13); C525(1.14)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C525(1.01); C450(1.02); C99(1.06); C317(1.11)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C317(1.16); C99(1.22); C525(1.23); C237(1.25)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C99(0.90); C317(1.02); C525(1.05); C116(1.07)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C99(0.72); C525(0.98); C317(1.00); C237(1.02)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C116(0.79); C99(0.82); C317(1.01); C237(1.07)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C99(0.87); C116(0.92); C317(1.02); C525(1.15)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C99(0.91); C237(1.05); C525(1.06); C317(1.12)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C99(0.91); C317(0.96); C450(0.99); C237(1.03)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C99(0.89); C317(1.08); C450(1.09); C237(1.09)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C237(0.94); C99(0.95); C525(1.04); C450(1.34)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C116(0.88); C237(0.96); C99(1.00); C525(1.08)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C116(0.94); C99(0.98); C237(1.05); C525(1.22)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C116(0.80); C99(0.99); C237(1.01); C525(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C237(0.97); C317(0.99); C450(1.01); C99(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C99(0.99); C116(1.04); C237(1.13); C525(1.33)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C116(0.85); C99(0.87); C237(1.14); C450(1.24)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C99(0.90); C237(1.37); C116(1.49); C525(1.67)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C99(0.96); C116(1.00); C237(1.08); C525(1.11)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C116(0.91); C237(1.11); C450(1.43); C525(1.36)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C116(0.90); C237(1.14); C450(1.56); C525(1.45)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C116(0.94); C237(1.04); C450(1.76); C525(1.15)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C116(0.81); C237(1.10); C450(1.61); C525(1.27)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C116(1.01); C237(1.06); C450(1.54); C525(1.26)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C116(1.34); C237(1.15); C450(1.48); C525(1.31)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C237(0.97); C317(1.03); C450(0.90); C525(0.92)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C116(1.45); C237(0.99); C450(1.46); C525(1.12)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C116(1.13); C237(1.08); C317(0.97); C450(1.01)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C116(0.92); C237(1.10); C317(1.13); C450(1.12)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C116(0.76); C237(1.11); C317(0.98); C450(1.17)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C116(1.09); C237(1.26); C317(1.13); C450(1.37)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C116(1.51); C237(1.23); C317(1.15); C450(1.38)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C116(1.05); C237(1.23); C317(1.23); C450(1.29)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C116(1.30); C237(1.36); C317(1.18); C450(1.46)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C116(1.04); C237(1.38); C317(1.24); C450(1.35)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C237(0.93); C317(0.98); C450(1.27); C525(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C116(1.15); C237(1.26); C317(1.15); C450(1.32)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C116(1.21); C237(1.25); C317(1.10); C450(1.25)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C116(1.75); C237(1.58); C317(1.60); C450(1.83)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C116(1.16); C237(1.40); C317(1.35); C450(1.50)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C116(0.96); C237(1.22); C317(1.20); C450(1.23)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C116(0.82); C237(1.34); C317(1.33); C450(1.43)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C116(0.53); C237(0.96); C317(1.06); C450(0.97)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C116(0.67); C237(0.97); C317(1.33); C450(0.94)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C116(0.62); C237(0.82); C317(1.18); C450(0.91)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C116(0.57); C237(0.95); C317(1.11); C450(1.06)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C237(1.00); C317(1.04); C450(0.95); C525(1.05)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C116(0.51); C237(0.93); C317(1.03); C450(0.75)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C116(0.55); C237(0.96); C317(1.17); C450(0.97)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C116(0.56); C237(1.02); C317(1.14); C450(1.11)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C116(0.96); C237(0.94); C317(0.99); C450(0.81)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C116(0.56); C237(0.94); C317(0.92); C450(0.90)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C116(0.59); C237(0.95); C317(1.15); C450(0.94)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C116(0.59); C237(0.97); C317(1.17); C450(0.86)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C116(1.29); C237(0.93); C317(1.13); C450(0.83)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C116(0.54); C237(0.92); C317(0.98); C450(0.97)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C116(0.58); C237(0.96); C317(1.04); C450(0.95)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C237(0.99); C317(1.04); C450(0.92); C525(0.88)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C116(0.49); C237(0.97); C317(1.11); C450(1.04)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C237(1.14); C317(0.94); C450(0.95); C525(0.96)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C237(1.22); C317(0.97); C450(1.02); C525(1.09)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C237(1.21); C317(0.95); C450(1.00); C525(1.08)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C237(1.27); C317(0.87); C450(1.08); C525(1.14)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C237(1.17); C317(0.97); C450(1.06); C525(0.97)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C237(1.26); C317(1.16); C450(1.33); C525(1.16)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C237(1.20); C317(1.02); C450(1.16); C525(0.88)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C237(1.19); C317(0.99); C450(1.04); C525(0.99)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C237(1.08); C317(0.92); C450(0.94); C525(0.99)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C237(1.18); C317(1.12); C450(1.31); C525(1.38)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C237(1.18); C317(1.06); C450(1.04); C525(1.09)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C237(1.14); C317(1.07); C450(1.04); C525(1.15)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C237(1.11); C317(1.02); C450(1.00); C525(0.94)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C237(1.15); C317(0.89); C450(1.06); C525(0.98)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C237(1.18); C317(0.96); C450(1.03); C525(1.03)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C237(1.07); C317(0.96); C450(1.08); C525(1.10)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C237(0.93); C317(0.89); C450(0.98); C525(0.93)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C237(1.09); C317(0.99); C450(1.17); C525(1.13)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C237(1.28); C317(1.00); C450(1.28); C525(1.11)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C237(1.25); C317(1.15); C450(1.25); C525(1.69)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C237(0.98); C317(0.99); C450(1.04); C525(1.01)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C237(1.17); C317(0.92); C450(1.10); C525(1.06)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C237(1.33); C317(1.13); C450(1.48); C525(1.23)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C237(1.36); C317(1.08); C450(1.51); C525(1.24)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C237(1.56); C317(1.21); C450(1.77); C525(1.38)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C237(1.15); C317(0.99); C450(1.16); C525(1.14)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C237(1.09); C317(0.99); C450(1.07); C525(1.00)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C237(1.18); C317(0.96); C450(1.19); C525(1.11)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C237(1.19); C317(1.10); C450(1.34); C525(1.23)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C237(1.62); C317(1.36); C450(2.02); C525(1.39)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C237(1.06); C317(1.08); C450(1.14); C525(1.18)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C237(0.90); C317(1.01); C450(0.78); C525(0.87)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C237(0.98); C317(0.96); C450(1.11); C525(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C237(0.97); C317(0.94); C450(1.02); C525(1.02)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C237(0.91); C317(0.96); C450(0.97); C525(1.04)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C237(0.99); C317(0.83); C450(1.04); C525(1.02)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C237(0.98); C317(0.93); C450(1.06); C525(1.12)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C237(0.97); C317(1.01); C450(1.09); C525(1.11)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C237(1.00); C317(1.01); C450(1.20); C525(1.10)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C237(1.07); C317(0.92); C450(1.19); C525(1.12)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C237(1.02); C317(0.95); C450(1.20); C525(1.15)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C525(1.06)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C525(1.00); C450(0.95); C99(0.94); C237(1.25)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C317(5.35)  LDD1702  [3]
 LDCM0625  F8 Ramos C525(1.26); C237(1.29); C317(0.87); C99(1.05)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C525(0.87); C237(3.75); C317(0.71); C99(1.48)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C525(0.46); C237(0.62); C317(0.31); C99(0.38)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C525(1.15); C237(2.16); C317(1.28); C99(2.05)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C525(0.94); C237(0.84); C317(0.86); C99(1.02)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C525(1.58); C237(1.80); C317(3.15); C99(1.37)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C525(1.10); C237(3.37); C99(2.50); C450(2.78)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C525(0.95); C237(0.98); C317(0.93); C99(0.99)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C525(0.80); C237(1.32); C99(1.24); C450(1.81)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C525(0.87); C237(1.07); C317(1.00); C99(0.80)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C525(0.81); C237(0.87); C317(0.68); C99(0.80)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C525(1.03); C237(1.43); C317(0.66); C99(1.25)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C525(1.00); C237(1.20); C317(0.79); C99(1.08)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C525(1.18); C237(1.53); C317(0.62); C99(1.42)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C237(1.15); C317(0.97); C450(1.03); C525(0.98)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C525(1.05); C237(1.73); C317(0.69); C99(0.87)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C525(1.15); C237(1.27); C317(1.36); C99(1.26)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C116(1.80); C237(1.42); C317(1.39); C450(1.80)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C525(1.14); C237(1.52); C317(1.14); C99(1.24)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C525(1.31); C237(0.96); C317(0.84); C99(1.12)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C525(1.21); C237(1.68); C317(1.17); C99(1.77)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C525(1.35); C237(3.37); C99(2.66); C450(1.51)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C317(1.23); C450(1.48); C237(1.35); C525(1.13)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C317(1.89); C450(1.52); C237(1.68); C525(1.21)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C317(4.65); C450(2.78); C237(1.70); C525(1.27)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0226  [13]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C99(0.62)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C99(1.20)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C99(1.17)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C99(0.65)  LDD2098  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C99(0.66)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C99(0.81)  LDD2107  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C99(1.04)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C99(1.43)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C99(1.22)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C99(1.00)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C99(0.74)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C317(1.05)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C99(1.01)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C99(1.00)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C99(1.19)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C99(1.22); C317(1.00)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C317(0.89)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C99(0.84)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C99(0.50)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C99(0.86)  LDD2146  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C99(0.95)  LDD2153  [3]
 LDCM0014  Panhematin HEK-293T 4.44  LDD0062  [4]
 LDCM0131  RA190 MM1.R C450(1.17); C525(1.13)  LDD0304  [19]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [16]
 LDCM0021  THZ1 HCT 116 C450(1.39); C237(1.05); C317(0.92); C525(0.95)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding protein 39 (CAB39) Mo25 family Q9Y376

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.