Details of the Target

General Information of Target

Target ID LDTP05958
Target Name Ras-related protein Rab-32 (RAB32)
Gene Name RAB32
Gene ID 10981
Synonyms
Ras-related protein Rab-32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGGAGDPGLGAAAAPAPETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGV
DFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKW
KSDLDSKVHLPNGSPIPAVLLANKCDQNKDSSQSPSQVDQFCKEHGFAGWFETSAKDNIN
IEEAARFLVEKILVNHQSFPNEENDVDKIKLDQETLRAENKSQCC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Mitochondrion
Function
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Uniprot ID
Q13637
Ensemble ID
ENST00000367495.4
HGNC ID
HGNC:9772

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.39  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C145(1.10)  LDD2092  [3]
HPAP
 Probe Info  		3.19  LDD0064  [4]
DBIA
 Probe Info  		C162(0.86)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		19.16  LDD1799  [11]
C246
 Probe Info  		13.93  LDD1919  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C162(0.58)  LDD1093  [5]
 LDCM0215  AC10 HEK-293T C162(0.81)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C162(1.02)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C162(0.85)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C162(1.09)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C162(1.01)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C162(1.19)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C162(0.96)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C162(0.91)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C162(1.14)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C162(1.06)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C162(1.14)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C162(0.81)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C162(1.43)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C162(1.59)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C162(1.65)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C162(0.72)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C162(1.12)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C162(0.89)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C162(1.04)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C162(0.93)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C162(0.86)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C162(1.08)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C162(1.16)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C162(1.07)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C162(0.89)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C162(0.95)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C162(0.97)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C162(0.98)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C162(0.88)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C162(1.08)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C162(1.06)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C162(0.69)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C162(0.81)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C162(0.77)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C162(0.79)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C162(0.72)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C162(0.96)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C162(1.27)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C162(0.77)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C162(0.82)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C162(1.02)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C162(0.89)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C162(1.00)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C162(1.18)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C162(0.90)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C162(0.98)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C162(0.96)  LDD0860  [5]
 LDCM0263  AC143 PaTu 8988t C162(1.06)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C162(1.16)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C162(1.04)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C162(0.91)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C162(0.95)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C162(1.06)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C162(1.19)  LDD1148  [5]
 LDCM0270  AC15 HEK-293T C162(1.01)  LDD0868  [5]
 LDCM0271  AC150 PaTu 8988t C162(0.96)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C162(0.94)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C162(0.96)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C162(1.03)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C162(0.99)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C162(1.02)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C162(0.99)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C162(1.29)  LDD2169  [5]
 LDCM0276  AC17 PaTu 8988t C162(1.12)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C162(0.94)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C162(1.00)  LDD1157  [5]
 LDCM0279  AC2 PaTu 8988t C162(0.45)  LDD1158  [5]
 LDCM0280  AC20 PaTu 8988t C162(0.88)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C162(1.05)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C162(0.87)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C162(0.86)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C162(0.78)  LDD1163  [5]
 LDCM0285  AC25 HEK-293T C162(1.34)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C162(1.39)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C162(1.41)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C162(1.40)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C162(1.65)  LDD0887  [5]
 LDCM0290  AC3 PaTu 8988t C162(0.47)  LDD1169  [5]
 LDCM0291  AC30 HEK-293T C162(1.72)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C162(1.97)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C162(1.81)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C162(1.90)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C162(1.96)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C162(0.86)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C162(0.64)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C162(0.89)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C162(0.82)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C162(0.89)  LDD0898  [5]
 LDCM0301  AC4 PaTu 8988t C162(0.44)  LDD1180  [5]
 LDCM0302  AC40 HEK-293T C162(0.67)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C162(0.40)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C162(0.50)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C162(0.71)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C162(0.39)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C162(0.66)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C162(0.16)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C162(0.23)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C162(1.10)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C162(0.46)  LDD0909  [5]
 LDCM0312  AC5 PaTu 8988t C162(0.48)  LDD1191  [5]
 LDCM0313  AC50 HEK-293T C162(1.09)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C162(1.04)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C162(0.82)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C162(0.73)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C162(1.02)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C162(1.43)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C162(0.86)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C162(1.04)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C162(0.88)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C162(1.11)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C162(0.97)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C162(0.77)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C162(0.75)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C162(0.77)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C162(0.88)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C162(0.77)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C162(0.84)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C162(0.98)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C162(0.78)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C162(1.01)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C162(1.27)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C162(0.53)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C162(1.04)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C162(1.14)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C162(1.26)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C162(0.93)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C162(1.13)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C162(1.28)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C162(1.33)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C162(1.11)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C162(1.27)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C162(1.42)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C162(0.63)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C162(1.37)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C162(1.17)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C162(1.87)  LDD0946  [5]
 LDCM0349  AC83 PaTu 8988t C162(0.83)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C162(0.98)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C162(0.99)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C162(0.89)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C162(1.09)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C162(0.95)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C162(0.86)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C162(1.37)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C162(1.00)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C162(0.85)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C162(1.09)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C162(0.96)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C162(0.89)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C162(1.21)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C162(0.95)  LDD1243  [5]
 LDCM0365  AC98 HEK-293T C162(0.79)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C162(1.15)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C162(0.68)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C162(1.09)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C162(1.25)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 13.36  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C162(0.86)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C162(0.83)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C162(0.82)  LDD0966  [5]
 LDCM0369  CL100 PaTu 8988t C162(0.52)  LDD1248  [5]
 LDCM0370  CL101 HEK-293T C162(0.79)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C162(1.18)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C162(1.43)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C162(0.47)  LDD0971  [5]
 LDCM0374  CL105 PaTu 8988t C162(0.98)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C162(1.05)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C162(1.14)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C162(0.95)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C162(0.89)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C162(0.92)  LDD0977  [5]
 LDCM0380  CL110 PaTu 8988t C162(0.91)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C162(0.85)  LDD1260  [5]
 LDCM0382  CL112 HEK-293T C162(1.80)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C162(1.67)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C162(1.74)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C162(1.91)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C162(1.96)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C162(0.73)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C162(0.85)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C162(0.78)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C162(1.00)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C162(0.62)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C162(1.16)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C162(1.03)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C162(0.93)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C162(0.60)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C162(0.98)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C162(0.64)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C162(0.79)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C162(0.92)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C162(0.97)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C162(0.91)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C162(0.79)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C162(2.01)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C162(1.37)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C162(1.43)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C162(1.12)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C162(1.20)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C162(1.12)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C162(1.12)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C162(1.21)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C162(0.95)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C162(1.39)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C162(1.06)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C162(1.03)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C162(0.95)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C162(0.91)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C162(1.03)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C162(0.86)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C162(1.13)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C162(1.03)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C162(0.89)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C162(1.26)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C162(0.77)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C162(0.71)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C162(0.80)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C162(0.62)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C162(1.78)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C162(1.07)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C162(0.64)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C162(1.12)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C162(0.87)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C162(0.84)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C162(1.02)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C162(1.25)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C162(1.45)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C162(1.15)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C162(1.45)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C162(0.95)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C162(1.12)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C162(1.07)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C162(0.99)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C162(0.96)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C162(0.85)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C162(0.94)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C162(1.10)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C162(0.99)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C162(0.88)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C162(0.81)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C162(1.06)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C162(1.09)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C162(1.13)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C162(1.10)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C162(1.31)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C162(1.14)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C162(1.33)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C162(1.26)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C162(0.98)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C162(1.39)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C162(1.39)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C162(0.95)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C162(1.07)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C162(1.12)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C162(1.38)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C162(1.14)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C162(1.30)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C162(1.25)  LDD1065  [5]
 LDCM0469  CL76 PaTu 8988t C162(1.00)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C162(1.07)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C162(0.96)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C162(0.79)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C162(1.10)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C162(0.88)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C162(0.84)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C162(1.07)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C162(1.19)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C162(1.06)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C162(0.88)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C162(1.04)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C162(0.96)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C162(1.01)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C162(0.74)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C162(1.20)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C162(1.14)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C162(0.54)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C162(0.47)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C162(0.52)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C162(0.47)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C162(0.55)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C162(0.50)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C162(0.44)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C162(0.52)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C162(0.48)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C162(0.90)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C162(1.18)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C162(0.69)  LDD1025  [5]
 LDCM0107  IAA HeLa H165(0.00); C162(0.00)  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C162(1.58)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C162(1.75)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C162(2.53)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C145(1.07)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C145(1.10)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C145(1.23)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C145(0.95)  LDD2098  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C145(1.32)  LDD2105  [3]
 LDCM0014  Panhematin hPBMC 3.19  LDD0064  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402