Details of the Target

General Information of Target

Target ID LDTP00555
Target Name BET1 homolog (BET1)
Gene Name BET1
Gene ID 10282
Synonyms
BET1 homolog; hBET1; Golgi vesicular membrane-trafficking protein p18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVTAIKSLSIEIGHEVKTQ
NKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMMLFSLFVFFIIYWIIKLR
Target Bioclass
Other
Family
BET1 family
Subcellular location
Endoplasmic reticulum membrane
Function Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane.
Uniprot ID
O15155
Ensemble ID
ENST00000222547.8
HGNC ID
HGNC:14562

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.V43A; p.Q60H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K84(0.44)  LDD0277  [2]
IA-alkyne
 Probe Info  		C28(1.42)  LDD0304  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
HPAP
 Probe Info  		3.08  LDD0062  [5]
DBIA
 Probe Info  		C28(1.73)  LDD0080  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Acrolein
 Probe Info  		C28(0.00); H55(0.00)  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		51.98  LDD1948  [11]
C293
 Probe Info  		17.51  LDD1963  [11]
C296
 Probe Info  		11.96  LDD1966  [11]
C388
 Probe Info  		35.75  LDD2047  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C28(1.12)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C28(1.15)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C28(1.13)  LDD1509  [12]
 LDCM0230  AC113 PaTu 8988t C28(0.67)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C28(0.80)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C28(0.95)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C28(0.95)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C28(0.73)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C28(0.74)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C28(0.96)  LDD1115  [6]
 LDCM0237  AC12 HEK-293T C28(1.11)  LDD1510  [12]
 LDCM0238  AC120 PaTu 8988t C28(1.00)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C28(0.79)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C28(0.78)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C28(0.93)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C28(0.90)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C28(1.07)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C28(1.03)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C28(0.89)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C28(0.97)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C28(1.11)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C28(1.20)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C28(0.88)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C28(0.95)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C28(1.05)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C28(1.07)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C28(1.10)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C28(1.09)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C28(0.89)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C28(0.98)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C28(1.21)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C28(0.98)  LDD1512  [12]
 LDCM0260  AC140 PaTu 8988t C28(1.34)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C28(1.02)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C28(1.36)  LDD1141  [6]
 LDCM0270  AC15 HEK-293T C28(0.87)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C28(1.02)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C28(0.97)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C28(1.29)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C28(0.98)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C28(1.14)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C28(1.05)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C28(1.13)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C28(1.11)  LDD1522  [12]
 LDCM0285  AC25 HEK-293T C28(1.16)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C28(1.01)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C28(1.00)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C28(1.27)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C28(0.99)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C28(0.91)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C28(1.03)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C28(0.90)  LDD1531  [12]
 LDCM0294  AC33 HEK-293T C28(0.90)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C28(0.91)  LDD1534  [12]
 LDCM0296  AC35 PaTu 8988t C28(1.26)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C28(1.30)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C28(1.11)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C28(1.27)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C28(1.17)  LDD1179  [6]
 LDCM0301  AC4 HEK-293T C28(1.09)  LDD1540  [12]
 LDCM0302  AC40 PaTu 8988t C28(1.46)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C28(1.02)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C28(1.14)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C28(1.20)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C28(1.16)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C28(1.19)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C28(1.16)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C28(1.08)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C28(1.12)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C28(1.18)  LDD1190  [6]
 LDCM0312  AC5 HEK-293T C28(1.02)  LDD1551  [12]
 LDCM0313  AC50 PaTu 8988t C28(1.44)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C28(1.11)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C28(1.36)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C28(1.36)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C28(1.46)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C28(1.19)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C28(1.51)  LDD1198  [6]
 LDCM0320  AC57 HEK-293T C28(0.96)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C28(1.14)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C28(1.03)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C28(0.92)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C28(1.07)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C28(1.09)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C28(1.02)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C28(0.88)  LDD1566  [12]
 LDCM0334  AC7 HEK-293T C28(0.87)  LDD1568  [12]
 LDCM0248  AKOS034007472 HEK-293T C28(1.11)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C28(1.06)  LDD1570  [12]
 LDCM0156  Aniline NCI-H1299 14.80  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 PaTu 8988t C28(0.83)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C28(1.13)  LDD1247  [6]
 LDCM0369  CL100 HEK-293T C28(0.99)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C28(1.13)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C28(1.09)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C28(1.09)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C28(1.01)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C28(1.27)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C28(1.03)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C28(1.04)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C28(1.07)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C28(1.39)  LDD1582  [12]
 LDCM0379  CL11 PaTu 8988t C28(0.89)  LDD1258  [6]
 LDCM0380  CL110 HEK-293T C28(1.13)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C28(1.14)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C28(1.01)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C28(1.06)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C28(1.04)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C28(1.07)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C28(1.01)  LDD1590  [12]
 LDCM0387  CL117 PaTu 8988t C28(1.31)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C28(1.08)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C28(1.25)  LDD1268  [6]
 LDCM0390  CL12 PaTu 8988t C28(0.97)  LDD1269  [6]
 LDCM0391  CL120 PaTu 8988t C28(1.37)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C28(1.07)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C28(1.30)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C28(1.33)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C28(1.39)  LDD1274  [6]
 LDCM0396  CL125 HEK-293T C28(1.39)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C28(0.90)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C28(1.26)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C28(1.01)  LDD1603  [12]
 LDCM0400  CL13 PaTu 8988t C28(1.59)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C28(1.39)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C28(0.99)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C28(1.11)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C28(1.23)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C28(1.62)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C28(1.21)  LDD1610  [12]
 LDCM0407  CL2 PaTu 8988t C28(0.91)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C28(1.28)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C28(1.13)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C28(1.15)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C28(1.15)  LDD1615  [12]
 LDCM0413  CL25 HEK-293T C28(1.12)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C28(0.92)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C28(1.08)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C28(0.87)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C28(1.14)  LDD1621  [12]
 LDCM0418  CL3 PaTu 8988t C28(0.98)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C28(1.24)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C28(1.09)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C28(1.33)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C28(0.79)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C28(0.90)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C28(1.03)  LDD1628  [12]
 LDCM0426  CL37 HEK-293T C28(1.18)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C28(1.00)  LDD1632  [12]
 LDCM0429  CL4 PaTu 8988t C28(0.98)  LDD1308  [6]
 LDCM0430  CL40 HEK-293T C28(1.02)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C28(1.23)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C28(1.20)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C28(1.00)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C28(1.28)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C28(1.36)  LDD1639  [12]
 LDCM0436  CL46 PaTu 8988t C28(1.35)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C28(1.00)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C28(1.34)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C28(1.11)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C28(1.10)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C28(1.27)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C28(1.29)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C28(1.27)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C28(1.01)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C28(1.29)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C28(1.44)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C28(1.21)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C28(1.13)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C28(1.38)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C28(1.01)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C28(1.20)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C28(1.14)  LDD1331  [6]
 LDCM0453  CL61 HEK-293T C28(1.69)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C28(0.93)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C28(1.08)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C28(0.91)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C28(0.88)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C28(0.81)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C28(0.90)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C28(1.34)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C28(1.17)  LDD1664  [12]
 LDCM0462  CL7 PaTu 8988t C28(1.24)  LDD1341  [6]
 LDCM0463  CL70 HEK-293T C28(1.13)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C28(0.86)  LDD1667  [12]
 LDCM0466  CL73 HEK-293T C28(1.43)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C28(1.11)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C28(0.89)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C28(0.94)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C28(0.94)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C28(1.24)  LDD1675  [12]
 LDCM0473  CL8 PaTu 8988t C28(0.94)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C28(1.01)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C28(1.00)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C28(0.86)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C28(0.92)  LDD1680  [12]
 LDCM0479  CL85 HEK-293T C28(1.26)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C28(0.89)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C28(1.10)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C28(0.84)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C28(1.08)  LDD1686  [12]
 LDCM0484  CL9 PaTu 8988t C28(1.14)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C28(0.95)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C28(0.91)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C28(1.01)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C28(1.10)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C28(1.00)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C28(0.99)  LDD1693  [12]
 LDCM0492  CL97 HEK-293T C28(1.33)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C28(1.22)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C28(1.13)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C28(0.92)  LDD1698  [12]
 LDCM0625  F8 Ramos C28(1.59)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C28(0.40)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C28(1.03)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C28(0.38)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C28(0.99)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C28(0.75)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C28(0.58)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C28(1.13)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C28(0.35)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C28(0.50)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C28(0.56)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C28(0.94)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C28(2.47)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C28(1.16)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C28(0.70)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C28(0.44)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C28(0.87)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C28(0.93)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C28(0.39)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C28(0.36)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C28(0.48)  LDD2188  [13]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C28(1.73)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C28(1.44)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C28(1.73)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0224  [9]
 LDCM0014  Panhematin HEK-293T 3.08  LDD0062  [5]
 LDCM0131  RA190 MM1.R C28(1.42)  LDD0304  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Prostaglandin E synthase (PTGES) MAPEG family O14684
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Claudin-7 (CLDN7) Claudin family O95471
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenosine receptor A2a (ADORA2A) G-protein coupled receptor 1 family P29274
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Syntaxin-1B (STX1B) Syntaxin family P61266
Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A) TMCO5 family Q8N6Q1
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (ASZ1) . Q8WWH4
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9
Cell growth regulator with RING finger domain protein 1 (CGRRF1) . Q99675
Ly6/PLAUR domain-containing protein 5 (LYPD5) . Q6UWN5
Melanoma-associated antigen 6 (MAGEA6) . P43360
Protein KASH5 (KASH5) . Q8N6L0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 52B (TMEM52B) . Q4KMG9
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578