Details of the Target

General Information of Target

Target ID LDTP00293
Target Name Cytochrome c oxidase subunit NDUFA4 (NDUFA4)
Gene Name NDUFA4
Gene ID 4697
Synonyms
Cytochrome c oxidase subunit NDUFA4; Complex I-MLRQ; CI-MLRQ; NADH-ubiquinone oxidoreductase MLRQ subunit
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPND
QYKFYSVNVDYSKLKKERPDF
Target Bioclass
Enzyme
Family
Complex IV NDUFA4 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
Uniprot ID
O00483
Ensemble ID
ENST00000339600.6
HGNC ID
HGNC:7687
ChEMBL ID
CHEMBL2317

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.68  LDD0402  [1]
TH211
 Probe Info  		Y65(20.00)  LDD0260  [2]
TH216
 Probe Info  		Y65(6.90)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
Probe 1
 Probe Info  		Y62(110.24); Y65(10.10); Y71(22.35)  LDD3495  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
HPAP
 Probe Info  		3.08  LDD0064  [6]
EA-probe
 Probe Info  		C44(1.06); C44(1.15)  LDD2210  [7]
DBIA
 Probe Info  		C44(1.62)  LDD0080  [8]
ATP probe
 Probe Info  		K55(0.00); K73(0.00); K75(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		K73(0.00); K55(0.00)  LDD0010  [15]
SF
 Probe Info  		N.A.  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		K63(0.00); K55(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C235
 Probe Info  		17.27  LDD1908  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C44(1.09)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C44(1.05)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C44(0.91)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C44(0.92)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C44(0.80)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C44(0.78)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C44(0.81)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C44(0.81)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C44(0.82)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C44(0.82)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C44(1.01)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C44(0.83)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C44(1.06)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C44(0.87)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C44(0.90)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C44(0.82)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C44(1.05)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C44(1.04)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C44(1.08)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C44(0.98)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C44(1.07)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C44(1.12)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C44(1.12)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C44(1.14)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C44(1.41)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C44(0.98)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C44(1.12)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C44(1.04)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C44(0.99)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C44(1.15)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C44(0.96)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C44(1.09)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C44(0.89)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C44(1.17)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C44(0.98)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C44(1.01)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C44(1.29)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C44(1.09)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C44(1.09)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C44(1.08)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C44(1.16)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C44(1.29)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C44(1.21)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C44(1.20)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C44(1.06)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C44(1.27)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C44(1.19)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C44(1.28)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C44(1.05)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C44(0.84)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C44(0.97)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C44(0.84)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C44(0.85)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C44(0.79)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C44(0.81)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C44(1.05)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C44(0.97)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C44(1.19)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C44(0.82)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C44(0.76)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C44(0.90)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C44(0.87)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C44(0.92)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C44(1.01)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C44(1.22)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C44(1.07)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C44(1.09)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C44(1.09)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C44(1.12)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C44(1.15)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C44(1.19)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C44(1.18)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C44(1.15)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C44(1.09)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C44(1.11)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C44(1.14)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C44(1.41)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C44(1.22)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C44(1.14)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C44(1.19)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C44(1.12)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C44(1.21)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C44(1.04)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C44(1.05)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C44(1.12)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C44(1.17)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C44(1.03)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C44(1.18)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C44(1.04)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C44(1.04)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C44(0.84)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C44(0.96)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C44(0.99)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C44(1.02)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C44(0.95)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C44(0.82)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C44(1.11)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C44(1.16)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C44(1.24)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C44(0.95)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C44(1.12)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C44(0.94)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C44(1.38)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C44(1.09)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C44(0.97)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C44(1.03)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C44(0.96)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C44(0.99)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C44(0.94)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C44(0.95)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C44(0.90)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C44(1.01)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C44(1.02)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C44(1.03)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C44(0.88)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C44(0.99)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C44(0.96)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C44(1.21)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C44(1.26)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C44(1.02)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C44(0.89)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C44(0.87)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C44(1.04)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C44(0.76)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C44(0.93)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C44(0.82)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C44(0.82)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C44(0.85)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C44(0.89)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C44(0.86)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C44(0.89)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C44(1.04)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C44(1.02)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C44(1.04)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C44(0.90)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C44(1.04)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C44(0.99)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C44(0.86)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C44(0.90)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C44(1.13)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C44(1.10)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C44(1.09)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C44(1.04)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C44(0.94)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C44(1.24)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C44(0.85)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C44(0.95)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C44(1.12)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C44(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C44(1.10)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C44(0.99)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C44(0.99)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C44(0.73)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C44(0.93)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C44(1.12)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C44(1.01)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C44(0.88)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.21  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C44(1.12)  LDD2171  [8]
 LDCM0630  CCW28-3 231MFP C44(1.82)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C44(1.04); C44(0.89); C44(0.53)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C44(1.13)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C44(1.02)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C44(1.05)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C44(0.94)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C44(1.04)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C44(1.04)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C44(1.01)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C44(1.01)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C44(0.96)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C44(1.01)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C44(0.95)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C44(1.08)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C44(1.04)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C44(1.08)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C44(1.20)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C44(1.10)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C44(1.16)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C44(1.20)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C44(1.22)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C44(1.18)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C44(0.81)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C44(0.99)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C44(0.88)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C44(0.93)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C44(1.04)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C44(0.86)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C44(1.02)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C44(1.07)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C44(0.92)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C44(1.09)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C44(1.09)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C44(1.06)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C44(0.91)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C44(1.00)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C44(1.15)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C44(0.97)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C44(0.96)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C44(1.15)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C44(1.01)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C44(0.94)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C44(1.13)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C44(0.86)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C44(0.82)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C44(0.85)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C44(0.98)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C44(0.84)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C44(0.92)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C44(0.96)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C44(0.99)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C44(1.00)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C44(0.95)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C44(1.12)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C44(1.14)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C44(1.01)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C44(1.09)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C44(0.97)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C44(0.80)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C44(0.79)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C44(0.83)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C44(0.75)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C44(0.84)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C44(1.04)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C44(0.95)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C44(0.86)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C44(0.84)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C44(0.80)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C44(0.90)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C44(0.92)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C44(1.11)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C44(1.17)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C44(1.06)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C44(1.03)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C44(1.11)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C44(1.10)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C44(1.07)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C44(1.09)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C44(1.01)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C44(1.19)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C44(1.05)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C44(0.99)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C44(1.02)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C44(1.14)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C44(1.18)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C44(0.90)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C44(1.15)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C44(1.05)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C44(1.04)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C44(0.99)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C44(0.87)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C44(1.01)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C44(0.77)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C44(0.83)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C44(0.90)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C44(1.01)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C44(0.88)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C44(1.08)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C44(1.01)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C44(1.09)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C44(1.01)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C44(0.94)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C44(0.91)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C44(0.92)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C44(0.94)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C44(0.78)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C44(0.91)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C44(0.96)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C44(0.97)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C44(0.78)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C44(0.80)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C44(0.77)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C44(1.10)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C44(1.21)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C44(0.98)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C44(0.83)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C44(0.95)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C44(1.08)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C44(1.25)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C44(1.02)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C44(1.05)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C44(1.07)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C44(0.93)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C44(1.00)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C44(1.09)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C44(1.05)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C44(1.09)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C44(0.97)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C44(1.08)  LDD1698  [25]
 LDCM0175  Ethacrynic acid HeLa C44(1.06); C44(1.15)  LDD2210  [7]
 LDCM0625  F8 Ramos C44(0.77)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C44(3.28)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C44(0.31)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C44(4.10)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C44(0.89)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C44(4.45)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C44(8.95)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C44(0.81)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C44(0.86)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C44(0.72)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C44(0.72)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C44(0.97)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C44(0.86)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C44(3.48)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C44(0.90)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C44(1.44)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C44(1.51)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C44(0.84)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C44(1.29)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C44(0.72)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C44(2.69)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C44(6.69)  LDD2188  [26]
 LDCM0149  GA MCF-7 C44(2.27)  LDD0379  [27]
 LDCM0015  HNE MDA-MB-231 C44(1.21)  LDD0346  [26]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C44(1.62)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C44(1.99)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C44(3.85)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [20]
 LDCM0627  NUDT7-COV-1 HEK-293T C44(1.43); C44(1.25); C44(0.80); C44(0.46)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C44(2.39); C44(1.12); C44(0.72); C44(0.70)  LDD2207  [28]
 LDCM0014  Panhematin hPBMC 3.08  LDD0064  [6]
 LDCM0131  RA190 MM1.R C44(3.26)  LDD0304  [29]
 LDCM0021  THZ1 HCT 116 C44(1.12)  LDD2173  [8]
 LDCM0110  W12 Hep-G2 C44(0.96)  LDD0237  [21]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.