Details of the Target

General Information of Target

Target ID LDTP11281
Target Name Voltage-gated monoatomic cation channel TMEM109 (TMEM109)
Gene Name TMEM109
Gene ID 79073
Synonyms
Voltage-gated monoatomic cation channel TMEM109; Mitsugumin-23; Mg23; Transmembrane protein 109
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
Target Bioclass
Transporter and channel
Subcellular location
Nucleus outer membrane
Function Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium. Plays a role in the cellular response to DNA damage.
Uniprot ID
Q9BVC6
Ensemble ID
ENST00000227525.8
HGNC ID
HGNC:28771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.16  LDD0066  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
OPA-S-S-alkyne
 Probe Info  		K46(3.24); K215(3.67)  LDD3494  [3]
HPAP
 Probe Info  		4.70  LDD0062  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [5]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		11.39  LDD1740  [6]
C056
 Probe Info  		16.22  LDD1753  [6]
C094
 Probe Info  		32.67  LDD1785  [6]
C112
 Probe Info  		20.25  LDD1799  [6]
C218
 Probe Info  		11.47  LDD1892  [6]
C228
 Probe Info  		15.24  LDD1901  [6]
C231
 Probe Info  		37.27  LDD1904  [6]
C232
 Probe Info  		35.75  LDD1905  [6]
C235
 Probe Info  		39.67  LDD1908  [6]
C289
 Probe Info  		32.22  LDD1959  [6]
C349
 Probe Info  		9.71  LDD2010  [6]
C350
 Probe Info  		35.02  LDD2011  [6]
C362
 Probe Info  		31.12  LDD2023  [6]
OEA-DA
 Probe Info  		5.94  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0014  Panhematin HEK-293T 4.70  LDD0062  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Synaptic vesicular amine transporter (SLC18A2) Vesicular transporter family Q05940
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-9 (AQP9) MIP/aquaporin (TC 1.A.8) family O43315
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Transmembrane protein 52B (TMEM52B) . Q4KMG9
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570