Details of the Target

General Information of Target

Target ID LDTP01206
Target Name Vesicle-trafficking protein SEC22b (SEC22B)
Gene Name SEC22B
Gene ID 9554
Synonyms
SEC22L1; Vesicle-trafficking protein SEC22b; ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMT
FHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQ
KTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKY
RQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL
Target Bioclass
Other
Family
Synaptobrevin family
Subcellular location
Endoplasmic reticulum membrane
Function SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Uniprot ID
O75396
Ensemble ID
ENST00000578049.4
HGNC ID
HGNC:10700
ChEMBL ID
CHEMBL4295679

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
C-Sul
 Probe Info  		3.02  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [4]
AZ-9
 Probe Info  		E141(10.00); D167(10.00)  LDD2208  [5]
ONAyne
 Probe Info  		K38(0.00); K43(0.00)  LDD0273  [6]
HPAP
 Probe Info  		3.11  LDD0064  [7]
DBIA
 Probe Info  		C52(1.04)  LDD1511  [8]
AMP probe
 Probe Info  		N.A.  LDD0200  [9]
ATP probe
 Probe Info  		K38(0.00); K169(0.00); K43(0.00)  LDD0199  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		K43(0.00); Y110(0.00)  LDD0028  [11]
STPyne
 Probe Info  		K178(0.00); K169(0.00); K38(0.00)  LDD0009  [10]
W1
 Probe Info  		N.A.  LDD0236  [12]
MPP-AC
 Probe Info  		N.A.  LDD0428  [13]
NAIA_5
 Probe Info  		C52(0.00); C75(0.00); C70(0.00)  LDD2223  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [13]
TPP-AC
 Probe Info  		N.A.  LDD0427  [13]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		23.92  LDD1785  [15]
C134
 Probe Info  		20.11  LDD1816  [15]
C187
 Probe Info  		20.68  LDD1865  [15]
C191
 Probe Info  		16.00  LDD1868  [15]
C193
 Probe Info  		7.31  LDD1869  [15]
C289
 Probe Info  		27.86  LDD1959  [15]
C350
 Probe Info  		24.08  LDD2011  [15]
C388
 Probe Info  		35.75  LDD2047  [15]
FFF probe11
 Probe Info  		16.78  LDD0472  [16]
FFF probe13
 Probe Info  		9.22  LDD0476  [16]
FFF probe3
 Probe Info  		11.54  LDD0465  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
DA-2
 Probe Info  		N.A.  LDD0071  [18]
STS-1
 Probe Info  		N.A.  LDD0068  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C52(0.95)  LDD1512  [8]
 LDCM0281  AC21 HEK-293T C52(0.86)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C52(0.80)  LDD1521  [8]
 LDCM0289  AC29 HEK-293T C52(0.90)  LDD1528  [8]
 LDCM0291  AC30 HEK-293T C52(0.67)  LDD1530  [8]
 LDCM0298  AC37 HEK-293T C52(1.11)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C52(0.76)  LDD1538  [8]
 LDCM0307  AC45 HEK-293T C52(1.07)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C52(0.78)  LDD1547  [8]
 LDCM0312  AC5 HEK-293T C52(0.85)  LDD1551  [8]
 LDCM0316  AC53 HEK-293T C52(0.91)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C52(0.74)  LDD1556  [8]
 LDCM0323  AC6 HEK-293T C52(0.71)  LDD1562  [8]
 LDCM0325  AC61 HEK-293T C52(1.08)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C52(0.87)  LDD1565  [8]
 LDCM0248  AKOS034007472 HEK-293T C52(1.04)  LDD1511  [8]
 LDCM0367  CL1 HEK-293T C52(0.88)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C52(0.97)  LDD1572  [8]
 LDCM0370  CL101 HEK-293T C52(0.98)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C52(0.92)  LDD1576  [8]
 LDCM0374  CL105 HEK-293T C52(0.85)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C52(0.97)  LDD1580  [8]
 LDCM0378  CL109 HEK-293T C52(0.90)  LDD1582  [8]
 LDCM0381  CL111 HEK-293T C52(0.98)  LDD1585  [8]
 LDCM0383  CL113 HEK-293T C52(0.86)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C52(0.94)  LDD1589  [8]
 LDCM0387  CL117 HEK-293T C52(0.81)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C52(1.12)  LDD1593  [8]
 LDCM0392  CL121 HEK-293T C52(0.85)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C52(0.82)  LDD1598  [8]
 LDCM0396  CL125 HEK-293T C52(1.27)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C52(1.01)  LDD1602  [8]
 LDCM0400  CL13 HEK-293T C52(0.88)  LDD1604  [8]
 LDCM0402  CL15 HEK-293T C52(0.93)  LDD1606  [8]
 LDCM0409  CL21 HEK-293T C52(0.94)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C52(0.90)  LDD1614  [8]
 LDCM0413  CL25 HEK-293T C52(1.08)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C52(0.96)  LDD1619  [8]
 LDCM0418  CL3 HEK-293T C52(1.08)  LDD1622  [8]
 LDCM0422  CL33 HEK-293T C52(0.85)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C52(0.91)  LDD1627  [8]
 LDCM0426  CL37 HEK-293T C52(0.95)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C52(0.84)  LDD1632  [8]
 LDCM0435  CL45 HEK-293T C52(0.68)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C52(0.80)  LDD1640  [8]
 LDCM0439  CL49 HEK-293T C52(0.87)  LDD1643  [8]
 LDCM0448  CL57 HEK-293T C52(0.86)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C52(0.84)  LDD1652  [8]
 LDCM0453  CL61 HEK-293T C52(1.04)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C52(1.13)  LDD1658  [8]
 LDCM0461  CL69 HEK-293T C52(1.19)  LDD1664  [8]
 LDCM0463  CL70 HEK-293T C52(0.84)  LDD1666  [8]
 LDCM0466  CL73 HEK-293T C52(0.95)  LDD1669  [8]
 LDCM0475  CL81 HEK-293T C52(1.48)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C52(0.98)  LDD1679  [8]
 LDCM0479  CL85 HEK-293T C52(1.92)  LDD1682  [8]
 LDCM0481  CL87 HEK-293T C52(0.98)  LDD1684  [8]
 LDCM0484  CL9 HEK-293T C52(1.18)  LDD1687  [8]
 LDCM0488  CL93 HEK-293T C52(1.02)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C52(0.85)  LDD1692  [8]
 LDCM0492  CL97 HEK-293T C52(0.80)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C52(0.89)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C52(0.87)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C52(1.06)  LDD1671  [8]
 LDCM0014  Panhematin hPBMC 3.11  LDD0064  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
Rhomboid-related protein 4 (RHBDD1) Peptidase S54 family Q8TEB9
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clarin-1 (CLRN1) Clarin family P58418
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) Complex I NDUFA12 subunit family Q8N183
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Gap junction beta-5 protein (GJB5) Connexin family O95377
Gap junction beta-6 protein (GJB6) Connexin family O95452
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Protein kish-B (TMEM167B) KISH family Q9NRX6
LHFPL tetraspan subfamily member 1 protein (LHFPL1) LHFP family Q86WI0
RELT-like protein 2 (RELL2) RELT family Q8NC24
Syntaxin-18 (STX18) Syntaxin family Q9P2W9
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
19 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.