Details of the Target

General Information of Target

Target ID LDTP07274
Target Name MICOS complex subunit MIC13 (MICOS13)
Gene Name MICOS13
Gene ID 125988
Synonyms
C19orf70; MIC13; QIL1; MICOS complex subunit MIC13; Protein P117
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVARVWSLMRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVC
QQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK
Target Bioclass
Other
Family
MICOS complex subunit Mic13 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
Uniprot ID
Q5XKP0
Ensemble ID
ENST00000309324.9
HGNC ID
HGNC:33702

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y112(20.00)  LDD0260  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
THZ1-DTB
 Probe Info  		C60(1.08)  LDD0460  [3]
AHL-Pu-1
 Probe Info  		C60(2.32)  LDD0169  [4]
HPAP
 Probe Info  		3.10  LDD0062  [5]
EA-probe
 Probe Info  		C60(1.03); C60(1.09)  LDD2210  [6]
DBIA
 Probe Info  		C60(0.87)  LDD0531  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
NHS
 Probe Info  		N.A.  LDD0010  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 68 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.17  LDD1728  [16]
C040
 Probe Info  		11.00  LDD1740  [16]
C055
 Probe Info  		20.53  LDD1752  [16]
C056
 Probe Info  		44.63  LDD1753  [16]
C070
 Probe Info  		9.78  LDD1766  [16]
C091
 Probe Info  		36.25  LDD1782  [16]
C092
 Probe Info  		59.71  LDD1783  [16]
C094
 Probe Info  		81.57  LDD1785  [16]
C106
 Probe Info  		29.04  LDD1793  [16]
C108
 Probe Info  		7.89  LDD1795  [16]
C112
 Probe Info  		33.13  LDD1799  [16]
C134
 Probe Info  		36.00  LDD1816  [16]
C143
 Probe Info  		14.03  LDD1825  [16]
C153
 Probe Info  		24.08  LDD1834  [16]
C159
 Probe Info  		12.21  LDD1839  [16]
C160
 Probe Info  		9.65  LDD1840  [16]
C161
 Probe Info  		18.13  LDD1841  [16]
C169
 Probe Info  		42.52  LDD1849  [16]
C178
 Probe Info  		19.16  LDD1857  [16]
C194
 Probe Info  		9.65  LDD1870  [16]
C196
 Probe Info  		12.21  LDD1872  [16]
C198
 Probe Info  		11.63  LDD1874  [16]
C201
 Probe Info  		53.45  LDD1877  [16]
C206
 Probe Info  		15.24  LDD1881  [16]
C210
 Probe Info  		91.77  LDD1884  [16]
C218
 Probe Info  		18.13  LDD1892  [16]
C220
 Probe Info  		28.44  LDD1894  [16]
C228
 Probe Info  		34.78  LDD1901  [16]
C231
 Probe Info  		33.82  LDD1904  [16]
C232
 Probe Info  		54.19  LDD1905  [16]
C233
 Probe Info  		11.16  LDD1906  [16]
C235
 Probe Info  		39.40  LDD1908  [16]
C238
 Probe Info  		11.24  LDD1911  [16]
C243
 Probe Info  		12.64  LDD1916  [16]
C246
 Probe Info  		23.10  LDD1919  [16]
C264
 Probe Info  		23.26  LDD1935  [16]
C277
 Probe Info  		10.63  LDD1947  [16]
C278
 Probe Info  		99.73  LDD1948  [16]
C282
 Probe Info  		25.46  LDD1952  [16]
C284
 Probe Info  		23.43  LDD1954  [16]
C285
 Probe Info  		73.01  LDD1955  [16]
C287
 Probe Info  		26.91  LDD1957  [16]
C288
 Probe Info  		11.00  LDD1958  [16]
C289
 Probe Info  		99.73  LDD1959  [16]
C293
 Probe Info  		30.06  LDD1963  [16]
C296
 Probe Info  		15.14  LDD1966  [16]
C310
 Probe Info  		11.47  LDD1977  [16]
C314
 Probe Info  		11.79  LDD1981  [16]
C322
 Probe Info  		5.94  LDD1988  [16]
C343
 Probe Info  		22.32  LDD2005  [16]
C349
 Probe Info  		11.24  LDD2010  [16]
C350
 Probe Info  		39.12  LDD2011  [16]
C355
 Probe Info  		25.99  LDD2016  [16]
C356
 Probe Info  		7.89  LDD2017  [16]
C362
 Probe Info  		77.17  LDD2023  [16]
C364
 Probe Info  		18.90  LDD2025  [16]
C366
 Probe Info  		5.50  LDD2027  [16]
C388
 Probe Info  		99.73  LDD2047  [16]
C390
 Probe Info  		45.57  LDD2049  [16]
C407
 Probe Info  		16.00  LDD2064  [16]
C429
 Probe Info  		11.71  LDD2084  [16]
C431
 Probe Info  		17.88  LDD2086  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
BD-F
 Probe Info  		Y23(0.00); P49(0.00); G64(0.00); Y26(0.00)  LDD0024  [18]
LD-F
 Probe Info  		D27(0.00); L24(0.00)  LDD0015  [18]
OEA-DA
 Probe Info  		20.00  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C60(2.32)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C60(0.87)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C60(0.89)  LDD0532  [7]
 LDCM0216  AC100 PaTu 8988t C60(0.66)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C60(0.78)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C60(0.97)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C60(0.72)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C60(0.77)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C60(0.75)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C60(0.81)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C60(0.97)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C60(0.74)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C60(0.79)  LDD1104  [7]
 LDCM0226  AC11 HCT 116 C60(0.90)  LDD0543  [7]
 LDCM0227  AC110 PaTu 8988t C60(0.89)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C60(0.76)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C60(0.93)  LDD1108  [7]
 LDCM0230  AC113 HCT 116 C60(0.87)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C60(0.74)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C60(0.74)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C60(0.80)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C60(0.87)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C60(0.80)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C60(0.78)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C60(0.96)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C60(1.01)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C60(0.82)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C60(0.74)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C60(0.97)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C60(0.78)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C60(0.90)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C60(0.85)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C60(0.74)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C60(0.99)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C60(1.19)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C60(0.95)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C60(1.10)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C60(0.96)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C60(0.88)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C60(0.95)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C60(1.05)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C60(1.07)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C60(1.14)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C60(0.88)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C60(0.97)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C60(0.92)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C60(0.99)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C60(1.06)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C60(1.09)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C60(0.84)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C60(0.77)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C60(1.06)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C60(0.91)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C60(0.86)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C60(0.92)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C60(0.87)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C60(0.99)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C60(0.77)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C60(0.87)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C60(0.95)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C60(1.02)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C60(0.91)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C60(0.82)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C60(0.83)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C60(0.99)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C60(1.04)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C60(1.02)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C60(1.05)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C60(0.90)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C60(1.04)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C60(1.09)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C60(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C60(1.21)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C60(1.30)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C60(0.96)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C60(1.14)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C60(1.34)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C60(1.05)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C60(1.06)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C60(0.98)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C60(1.43)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C60(1.04)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C60(1.28)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C60(0.96)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C60(1.30)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C60(1.17)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C60(0.95)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C60(0.97)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C60(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C60(0.93)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C60(1.00)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C60(0.96)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C60(0.88)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C60(1.02)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C60(0.87)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C60(0.96)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C60(0.94)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C60(0.93)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C60(0.83)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C60(0.64)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C60(1.10)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C60(1.02)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C60(0.93)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C60(0.76)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C60(0.88)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C60(0.91)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C60(0.98)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C60(1.10)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C60(1.27)  LDD0636  [7]
 LDCM0320  AC57 PaTu 8988t C60(1.04)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C60(0.93)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C60(0.89)  LDD1201  [7]
 LDCM0323  AC6 HCT 116 C60(0.93)  LDD0640  [7]
 LDCM0324  AC60 PaTu 8988t C60(0.88)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C60(0.91)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C60(0.87)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C60(1.06)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C60(0.97)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C60(0.86)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C60(1.02)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C60(0.99)  LDD1210  [7]
 LDCM0332  AC68 HCT 116 C60(0.94)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C60(0.97)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C60(0.98)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C60(0.91)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C60(1.08)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C60(1.09)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C60(1.23)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C60(1.42)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C60(1.31)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C60(1.04)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C60(0.95)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C60(0.92)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C60(1.20)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C60(1.11)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C60(1.08)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C60(0.72)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C60(1.39)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C60(1.14)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C60(1.23)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C60(1.09)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C60(1.52)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C60(0.96)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C60(0.96)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C60(1.47)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C60(1.24)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C60(1.45)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C60(1.17)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C60(1.23)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C60(1.27)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C60(1.08)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C60(1.03)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C60(1.10)  LDD0681  [7]
 LDCM0365  AC98 PaTu 8988t C60(0.79)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C60(1.03)  LDD1245  [7]
 LDCM0248  AKOS034007472 HCT 116 C60(0.89)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C60(0.97)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C60(0.95)  LDD0592  [7]
 LDCM0367  CL1 HCT 116 C60(1.28)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C60(1.06)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C60(0.99)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C60(1.00)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C60(0.92)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C60(0.94)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C60(1.00)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C60(0.93)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C60(1.03)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C60(0.95)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C60(1.23)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C60(1.08)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C60(1.04)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C60(1.40)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C60(1.41)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C60(0.95)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C60(1.19)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C60(0.87)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C60(1.23)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C60(1.24)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C60(1.04)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C60(1.09)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C60(1.05)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C60(0.98)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C60(0.80)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C60(0.85)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C60(0.88)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C60(1.77)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C60(1.00)  LDD0712  [7]
 LDCM0396  CL125 PaTu 8988t C60(0.97)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C60(1.04)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C60(0.96)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C60(1.03)  LDD1278  [7]
 LDCM0400  CL13 HCT 116 C60(0.97)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C60(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C60(0.96)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C60(0.92)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C60(0.83)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C60(0.75)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C60(0.84)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C60(1.06)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C60(0.92)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C60(1.02)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C60(1.00)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C60(1.02)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C60(0.87)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C60(0.77)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C60(0.77)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C60(0.88)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C60(0.89)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C60(0.78)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C60(1.11)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C60(0.85)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C60(1.16)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C60(1.21)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C60(0.90)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C60(1.04)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C60(1.25)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C60(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C60(1.14)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C60(1.14)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C60(0.96)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C60(1.20)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C60(1.02)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C60(1.18)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C60(1.48)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C60(1.00)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C60(1.25)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C60(1.05)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C60(0.95)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C60(1.08)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C60(1.09)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C60(1.03)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C60(1.01)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C60(0.91)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C60(0.89)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C60(0.92)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C60(1.68)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C60(1.15)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C60(0.95)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C60(0.97)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C60(0.98)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C60(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C60(0.91)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C60(1.15)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C60(0.99)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C60(0.98)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C60(0.87)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C60(1.10)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C60(1.00)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C60(1.10)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C60(1.07)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C60(0.85)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C60(0.93)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C60(1.10)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C60(0.84)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C60(0.99)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C60(1.02)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C60(1.20)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C60(1.10)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C60(0.80)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C60(1.21)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C60(0.86)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C60(0.86)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C60(1.29)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C60(0.88)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C60(0.93)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C60(1.01)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C60(1.05)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C60(1.26)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C60(0.90)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C60(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C60(0.83)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C60(0.95)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C60(1.17)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C60(1.06)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C60(1.02)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C60(1.00)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C60(1.10)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C60(1.24)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C60(1.01)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C60(1.10)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C60(0.93)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C60(1.02)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C60(1.06)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C60(0.95)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C60(0.95)  LDD1698  [20]
 LDCM0175  Ethacrynic acid HeLa C60(1.03); C60(1.09)  LDD2210  [6]
 LDCM0625  F8 Ramos C60(0.36)  LDD2187  [21]
 LDCM0573  Fragment11 Ramos C60(0.17)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C60(2.04)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C60(0.32)  LDD2192  [21]
 LDCM0580  Fragment21 Ramos C60(0.46)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C60(0.49)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C60(0.47)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C60(0.46)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C60(0.54)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C60(0.56)  LDD2200  [21]
 LDCM0468  Fragment33 HCT 116 C60(0.94)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C60(0.77)  LDD2203  [21]
 LDCM0427  Fragment51 HCT 116 C60(1.17)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C60(0.23)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C60(0.23)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C60(0.89)  LDD2186  [21]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HEK-293T C60(0.78)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C60(0.99)  LDD1497  [20]
 LDCM0024  KB05 HMCB C60(3.57)  LDD3312  [22]
 LDCM0627  NUDT7-COV-1 HEK-293T C60(0.82)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C60(1.20)  LDD2207  [23]
 LDCM0014  Panhematin HEK-293T 3.10  LDD0062  [5]
 LDCM0131  RA190 MM1.R C60(2.45)  LDD0304  [24]
 LDCM0021  THZ1 HeLa S3 C60(1.08)  LDD0460  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock transcription factor, X-linked (HSFX1; HSFX2) HSF family Q9UBD0
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Testis-expressed protein 44 (TEX44) . Q53QW1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.