Details of the Target

General Information of Target

Target ID LDTP13303
Target Name NADH-cytochrome b5 reductase 1 (CYB5R1)
Gene Name CYB5R1
Gene ID 51706
Synonyms
NQO3A2; NADH-cytochrome b5 reductase 1; b5R.1; EC 1.6.2.2; Humb5R2; NAD(P)H:quinone oxidoreductase type 3 polypeptide A2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKGEFHKLADAKIFLSDCLACDSCM
TAEEGVQLSQQNAKDFFRVLNLNKKCDTSKHKVLVVSVCPQSLPYFAAKFNLSVTDASRR
LCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRYRQHSEEERTLPMLTSACPGWVRYAE
RVLGRPITAHLCTAKSPQQVMGSLVKDYFARQQNLSPEKIFHVIVAPCYDKKLEALQESL
PPALHGSRGADCVLTSGEIAQIMEQGDLSVRDAAVDTLFGDLKEDKVTRHDGASSDGHLA
HIFRHAAKELFNEDVEEVTYRALRNKDFQEVTLEKNGEVVLRFAAAYGFRNIQNMILKLK
KGKFPFHFVEVLACAGGCLNGRGQAQTPDGHADKALLRQMEGIYADIPVRRPESSAHVQE
LYQEWLEGINSPKAREVLHTTYQSQERGTHSLDIKW
Target Bioclass
Enzyme
Family
Flavoprotein pyridine nucleotide cytochrome reductase family
Subcellular location
Membrane
Function NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Uniprot ID
Q9UHQ9
Ensemble ID
ENST00000367249.9
HGNC ID
HGNC:13397

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K167(6.87); K168(10.00); K46(8.56)  LDD0277  [1]
IPM
 Probe Info  		C278(0.00); C288(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y297(83.60)  LDD3495  [3]
DBIA
 Probe Info  		C208(1.93)  LDD3312  [4]
AHL-Pu-1
 Probe Info  		C208(9.12)  LDD0170  [5]
HPAP
 Probe Info  		3.12  LDD0064  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		16.45  LDD1865  [11]
C191
 Probe Info  		11.55  LDD1868  [11]
C193
 Probe Info  		6.19  LDD1869  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]
FFF probe3
 Probe Info  		18.16  LDD0464  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C208(9.12)  LDD0170  [5]
 LDCM0214  AC1 HEK-293T C208(0.90); C288(1.13); C278(0.96)  LDD1507  [15]
 LDCM0215  AC10 PaTu 8988t C278(0.50); C288(0.50); C208(0.35)  LDD1094  [16]
 LDCM0216  AC100 HEK-293T C288(1.03)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C288(0.63)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C288(1.20)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C288(1.04)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C288(0.85)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C288(0.83)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C288(0.67)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C288(0.59)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C288(1.01)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C288(0.58)  LDD0823  [16]
 LDCM0226  AC11 PaTu 8988t C278(0.18); C288(0.18); C208(0.16)  LDD1105  [16]
 LDCM0227  AC110 HEK-293T C288(1.40)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C288(1.58)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C288(1.49)  LDD0827  [16]
 LDCM0237  AC12 PaTu 8988t C278(0.30); C288(0.30); C208(0.24)  LDD1116  [16]
 LDCM0259  AC14 PaTu 8988t C278(0.21); C288(0.21); C208(0.22)  LDD1138  [16]
 LDCM0263  AC143 PaTu 8988t C278(0.47); C288(0.47)  LDD1142  [16]
 LDCM0264  AC144 PaTu 8988t C278(1.03); C288(1.03)  LDD1143  [16]
 LDCM0265  AC145 PaTu 8988t C278(0.72); C288(0.72)  LDD1144  [16]
 LDCM0266  AC146 PaTu 8988t C278(0.83); C288(0.83)  LDD1145  [16]
 LDCM0267  AC147 PaTu 8988t C278(0.68); C288(0.68)  LDD1146  [16]
 LDCM0268  AC148 PaTu 8988t C278(0.53); C288(0.53)  LDD1147  [16]
 LDCM0269  AC149 PaTu 8988t C278(0.28); C288(0.28)  LDD1148  [16]
 LDCM0270  AC15 PaTu 8988t C278(0.48); C288(0.48); C208(0.41)  LDD1149  [16]
 LDCM0271  AC150 PaTu 8988t C278(0.98); C288(0.98)  LDD1150  [16]
 LDCM0272  AC151 PaTu 8988t C278(0.40); C288(0.40)  LDD1151  [16]
 LDCM0273  AC152 PaTu 8988t C278(0.54); C288(0.54)  LDD1152  [16]
 LDCM0274  AC153 PaTu 8988t C278(0.33); C288(0.33)  LDD1153  [16]
 LDCM0621  AC154 PaTu 8988t C278(0.44); C288(0.44)  LDD2166  [16]
 LDCM0622  AC155 PaTu 8988t C278(0.80); C288(0.80)  LDD2167  [16]
 LDCM0623  AC156 PaTu 8988t C278(0.44); C288(0.44)  LDD2168  [16]
 LDCM0624  AC157 PaTu 8988t C278(0.88); C288(0.88)  LDD2169  [16]
 LDCM0276  AC17 HEK-293T C208(0.91); C288(1.05); C278(0.93)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C208(0.97); C288(1.16)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C208(0.90); C288(1.00)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C208(1.08); C288(1.06)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C208(1.10); C288(0.95)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C208(1.01); C288(1.11); C278(1.03)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C208(1.09)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C208(0.98)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C208(1.06); C288(0.96); C278(0.91)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C208(0.87); C288(1.04); C278(0.89)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C208(1.09); C288(0.84)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C208(0.93); C288(1.07)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C208(1.07); C288(1.01)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C208(1.04); C288(1.04); C278(1.02)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C208(1.03); C288(1.27)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C208(1.07)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C208(0.89)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C208(1.00); C288(1.28); C278(1.11)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C208(0.89); C288(1.04); C278(1.06)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C208(0.98); C288(1.06)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C208(1.02); C288(0.97)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C208(1.07); C288(1.00)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C208(1.22); C288(1.07); C278(1.21)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C208(1.07)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C208(1.04)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C208(0.98); C288(0.98)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C208(0.92); C288(0.90); C278(1.08)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C208(0.90); C288(1.25); C278(1.07)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C208(0.92); C288(1.06)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C208(1.03); C288(1.04)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C208(1.03); C288(0.95)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C208(1.00); C288(1.06); C278(1.05)  LDD1546  [15]
 LDCM0308  AC46 PaTu 8988t C278(1.98); C288(1.98); C208(0.69)  LDD1187  [16]
 LDCM0309  AC47 PaTu 8988t C278(0.96); C288(0.96); C208(0.56)  LDD1188  [16]
 LDCM0310  AC48 PaTu 8988t C278(0.45); C288(0.45); C208(0.29)  LDD1189  [16]
 LDCM0311  AC49 PaTu 8988t C278(0.37); C288(0.37); C208(0.27)  LDD1190  [16]
 LDCM0312  AC5 HEK-293T C208(1.08); C288(1.09); C278(1.07)  LDD1551  [15]
 LDCM0313  AC50 PaTu 8988t C278(0.42); C288(0.42); C208(0.27)  LDD1192  [16]
 LDCM0314  AC51 PaTu 8988t C278(2.56); C288(2.56); C208(0.56)  LDD1193  [16]
 LDCM0315  AC52 PaTu 8988t C278(0.40); C288(0.40); C208(0.24)  LDD1194  [16]
 LDCM0316  AC53 PaTu 8988t C278(0.32); C288(0.32); C208(0.16)  LDD1195  [16]
 LDCM0317  AC54 PaTu 8988t C278(0.19); C288(0.19); C208(0.11)  LDD1196  [16]
 LDCM0318  AC55 PaTu 8988t C278(1.29); C288(1.29); C208(0.42)  LDD1197  [16]
 LDCM0319  AC56 PaTu 8988t C278(1.17); C288(1.17); C208(0.61)  LDD1198  [16]
 LDCM0320  AC57 PaTu 8988t C208(0.19)  LDD1199  [16]
 LDCM0321  AC58 PaTu 8988t C208(0.15)  LDD1200  [16]
 LDCM0322  AC59 PaTu 8988t C208(0.28)  LDD1201  [16]
 LDCM0323  AC6 PaTu 8988t C278(20.00); C288(20.00); C208(0.53)  LDD1202  [16]
 LDCM0324  AC60 PaTu 8988t C208(0.17)  LDD1203  [16]
 LDCM0325  AC61 PaTu 8988t C208(0.36)  LDD1204  [16]
 LDCM0326  AC62 PaTu 8988t C208(0.35)  LDD1205  [16]
 LDCM0327  AC63 PaTu 8988t C208(0.35)  LDD1206  [16]
 LDCM0328  AC64 PaTu 8988t C208(0.69)  LDD1207  [16]
 LDCM0329  AC65 PaTu 8988t C208(0.83)  LDD1208  [16]
 LDCM0330  AC66 PaTu 8988t C208(0.60)  LDD1209  [16]
 LDCM0331  AC67 PaTu 8988t C208(0.67)  LDD1210  [16]
 LDCM0332  AC68 HEK-293T C288(0.82)  LDD0930  [16]
 LDCM0333  AC69 HEK-293T C288(0.78)  LDD0931  [16]
 LDCM0334  AC7 PaTu 8988t C278(0.85); C288(0.85); C208(1.93)  LDD1213  [16]
 LDCM0335  AC70 HEK-293T C288(0.83)  LDD0933  [16]
 LDCM0336  AC71 HEK-293T C288(3.33)  LDD0934  [16]
 LDCM0337  AC72 HEK-293T C288(1.10)  LDD0935  [16]
 LDCM0338  AC73 HEK-293T C288(1.71)  LDD0936  [16]
 LDCM0339  AC74 HEK-293T C288(1.43)  LDD0937  [16]
 LDCM0340  AC75 HEK-293T C288(0.85)  LDD0938  [16]
 LDCM0341  AC76 HEK-293T C288(1.17)  LDD0939  [16]
 LDCM0342  AC77 HEK-293T C288(1.74)  LDD0940  [16]
 LDCM0343  AC78 HEK-293T C288(2.15)  LDD0941  [16]
 LDCM0344  AC79 HEK-293T C288(0.97)  LDD0942  [16]
 LDCM0345  AC8 PaTu 8988t C278(0.75); C288(0.75); C208(0.72)  LDD1224  [16]
 LDCM0346  AC80 HEK-293T C288(1.51)  LDD0944  [16]
 LDCM0347  AC81 HEK-293T C288(0.97)  LDD0945  [16]
 LDCM0348  AC82 HEK-293T C288(1.23)  LDD0946  [16]
 LDCM0349  AC83 HEK-293T C288(0.64)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C288(1.28)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C288(1.16)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C288(2.28)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C288(0.99)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C288(1.21)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C288(1.36)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C288(3.03)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C288(0.99)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C288(1.93)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C288(0.72)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C288(1.73)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C288(0.90)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C288(0.98)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C288(1.86)  LDD0962  [16]
 LDCM0365  AC98 HEK-293T C288(0.86)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C288(0.84)  LDD0964  [16]
 LDCM0248  AKOS034007472 PaTu 8988t C278(0.22); C288(0.22); C208(0.17)  LDD1127  [16]
 LDCM0356  AKOS034007680 PaTu 8988t C278(0.68); C288(0.68); C208(0.87)  LDD1235  [16]
 LDCM0275  AKOS034007705 PaTu 8988t C278(0.99); C288(0.99); C208(0.94)  LDD1154  [16]
 LDCM0367  CL1 HEK-293T C288(1.67)  LDD0965  [16]
 LDCM0368  CL10 HEK-293T C288(2.81)  LDD0966  [16]
 LDCM0369  CL100 HEK-293T C208(0.91); C288(0.94); C278(0.87)  LDD1573  [15]
 LDCM0370  CL101 PaTu 8988t C278(1.26); C288(1.26); C208(0.68)  LDD1249  [16]
 LDCM0371  CL102 PaTu 8988t C278(0.69); C288(0.69); C208(0.49)  LDD1250  [16]
 LDCM0372  CL103 PaTu 8988t C278(0.17); C288(0.17); C208(0.16)  LDD1251  [16]
 LDCM0373  CL104 PaTu 8988t C278(0.72); C288(0.72); C208(0.33)  LDD1252  [16]
 LDCM0374  CL105 HEK-293T C208(1.01); C288(0.83)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C208(1.02); C288(0.94)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C208(1.05); C288(0.94)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C208(0.84); C288(0.83); C278(0.81)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C208(0.94); C288(1.09)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C288(2.43)  LDD0977  [16]
 LDCM0380  CL110 HEK-293T C208(0.99); C288(1.07)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C208(0.99); C288(1.36)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C208(0.89); C288(0.89); C278(0.92)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C208(0.99); C288(0.83)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C208(1.00); C288(0.96)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C208(1.07); C288(1.00)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C208(0.96); C288(1.13); C278(0.93)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C208(1.16); C288(0.86)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C208(1.10); C288(0.94)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C208(1.11); C288(1.11)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C288(1.41)  LDD0988  [16]
 LDCM0391  CL120 HEK-293T C208(0.99); C288(0.91); C278(0.99)  LDD1595  [15]
 LDCM0392  CL121 PaTu 8988t C278(1.05); C288(1.05); C208(0.58)  LDD1271  [16]
 LDCM0393  CL122 PaTu 8988t C278(0.74); C288(0.74); C208(0.76)  LDD1272  [16]
 LDCM0394  CL123 PaTu 8988t C278(0.32); C288(0.32); C208(0.18)  LDD1273  [16]
 LDCM0395  CL124 PaTu 8988t C278(0.41); C288(0.41); C208(0.23)  LDD1274  [16]
 LDCM0396  CL125 PaTu 8988t C208(0.48)  LDD1275  [16]
 LDCM0397  CL126 PaTu 8988t C208(0.68)  LDD1276  [16]
 LDCM0398  CL127 PaTu 8988t C208(0.65)  LDD1277  [16]
 LDCM0399  CL128 PaTu 8988t C208(0.42)  LDD1278  [16]
 LDCM0400  CL13 HEK-293T C288(1.90)  LDD0998  [16]
 LDCM0401  CL14 HEK-293T C288(1.94)  LDD0999  [16]
 LDCM0402  CL15 HEK-293T C288(3.02)  LDD1000  [16]
 LDCM0403  CL16 HEK-293T C208(0.92); C288(0.92); C278(1.30)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C208(0.82); C288(1.06); C278(1.05)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C208(0.99); C288(1.19)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C208(1.03); C288(1.20)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C288(1.84)  LDD1005  [16]
 LDCM0408  CL20 HEK-293T C208(1.02); C288(1.06)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C208(0.97); C288(1.06); C278(1.06)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C208(1.02)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C208(1.00)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C208(1.00); C288(1.07); C278(0.94)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C208(1.07); C288(1.18)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C208(1.01); C288(1.08)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C208(1.11); C288(1.02)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C208(1.07); C288(0.91); C278(1.25)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C208(0.90); C288(1.36); C278(0.89)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C288(1.32)  LDD1016  [16]
 LDCM0419  CL30 HEK-293T C208(1.08); C288(1.38)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C208(0.95); C288(1.22)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C208(1.04); C288(0.93)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C208(0.96); C288(1.04); C278(0.96)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C208(1.01)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C208(0.95)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C208(0.92); C288(1.02); C278(1.24)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C208(1.00); C288(0.85)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C208(1.06); C288(1.04)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C288(1.59)  LDD1027  [16]
 LDCM0430  CL40 HEK-293T C208(0.92); C288(0.92); C278(1.04)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C208(0.97); C288(1.16); C278(0.99)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C208(1.01); C288(1.01)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C208(1.02); C288(1.32)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C208(1.08); C288(1.03)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C208(0.94); C288(1.13); C278(1.05)  LDD1639  [15]
 LDCM0436  CL46 PaTu 8988t C278(0.78); C288(0.78)  LDD1315  [16]
 LDCM0437  CL47 PaTu 8988t C278(0.78); C288(0.78)  LDD1316  [16]
 LDCM0438  CL48 PaTu 8988t C278(1.43); C288(1.43)  LDD1317  [16]
 LDCM0439  CL49 PaTu 8988t C278(1.16); C288(1.16)  LDD1318  [16]
 LDCM0440  CL5 HEK-293T C288(1.54)  LDD1038  [16]
 LDCM0441  CL50 PaTu 8988t C278(0.88); C288(0.88)  LDD1320  [16]
 LDCM0442  CL51 PaTu 8988t C278(0.85); C288(0.85)  LDD1321  [16]
 LDCM0443  CL52 PaTu 8988t C278(0.74); C288(0.74)  LDD1322  [16]
 LDCM0444  CL53 PaTu 8988t C278(0.53); C288(0.53)  LDD1323  [16]
 LDCM0445  CL54 PaTu 8988t C278(1.29); C288(1.29)  LDD1324  [16]
 LDCM0446  CL55 PaTu 8988t C278(1.38); C288(1.38)  LDD1325  [16]
 LDCM0447  CL56 PaTu 8988t C278(0.13); C288(0.13)  LDD1326  [16]
 LDCM0448  CL57 PaTu 8988t C278(0.31); C288(0.31)  LDD1327  [16]
 LDCM0449  CL58 PaTu 8988t C278(0.50); C288(0.50)  LDD1328  [16]
 LDCM0450  CL59 PaTu 8988t C278(0.34); C288(0.34)  LDD1329  [16]
 LDCM0451  CL6 HEK-293T C288(1.86)  LDD1049  [16]
 LDCM0452  CL60 PaTu 8988t C278(0.32); C288(0.32)  LDD1331  [16]
 LDCM0453  CL61 PaTu 8988t C278(1.20); C288(1.20); C208(1.96)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C278(20.00); C288(20.00); C208(2.35)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C278(2.41); C288(2.41); C208(2.00)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C278(0.64); C288(0.64); C208(0.97)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C278(0.49); C288(0.49); C208(0.75)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C278(0.48); C288(0.48); C208(0.76)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C278(0.25); C288(0.25); C208(0.28)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C278(0.25); C288(0.25); C208(0.25)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C278(0.26); C288(0.26); C208(0.26)  LDD1340  [16]
 LDCM0462  CL7 HEK-293T C288(1.69)  LDD1060  [16]
 LDCM0463  CL70 PaTu 8988t C278(0.29); C288(0.29); C208(0.33)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C278(1.50); C288(1.50); C208(3.95)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C278(1.74); C288(1.74); C208(3.34)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C278(0.28); C288(0.28); C208(0.29)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C278(20.00); C288(20.00); C208(1.97)  LDD1346  [16]
 LDCM0469  CL76 HEK-293T C208(0.98); C288(0.92); C278(1.01)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C208(0.87); C288(1.16); C278(0.91)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C208(1.07); C288(1.16)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C208(1.08); C288(1.15)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C288(1.41)  LDD1071  [16]
 LDCM0474  CL80 HEK-293T C208(1.09); C288(0.98)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C208(1.04); C288(1.10); C278(1.07)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C208(1.11)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C208(0.93)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C208(0.94); C288(1.01); C278(1.13)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C208(1.07); C288(1.29)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C208(1.18); C288(0.88)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C208(1.18); C288(0.95)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C208(1.01); C288(0.94); C278(1.22)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C208(1.00); C288(1.49); C278(0.91)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C288(1.07)  LDD1082  [16]
 LDCM0485  CL90 HEK-293T C208(0.91); C288(0.84)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C208(1.12); C288(1.39)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C208(0.93); C288(0.97)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C208(1.01); C288(1.12); C278(1.03)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C208(1.03)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C208(0.87)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C208(1.00); C288(1.03); C278(1.12)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C208(0.96); C288(0.78)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C208(0.98); C288(0.82)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C208(1.10); C288(0.89)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C208(1.03); C288(0.98)  LDD1698  [15]
 LDCM0468  Fragment33 PaTu 8988t C278(0.61); C288(0.61); C208(0.85)  LDD1347  [16]
 LDCM0427  Fragment51 HEK-293T C208(1.05); C288(1.31)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C208(1.07); C278(1.01)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C208(1.05); C278(0.77)  LDD1497  [15]
 LDCM0024  KB05 HMCB C208(1.93)  LDD3312  [4]
 LDCM0014  Panhematin hPBMC 3.12  LDD0064  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Organic solute transporter subunit beta (SLC51B) OST-beta family Q86UW2
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
HIG1 domain family member 1C (HIGD1C) . A8MV81
Tetratricopeptide repeat protein 1 (TTC1) . Q99614
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavin Adenine Dinucleotide Small molecular drug DB03147

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.