Details of the Target

General Information of Target

Target ID LDTP11070
Target Name Vitamin K epoxide reductase complex subunit 1 (VKORC1)
Gene Name VKORC1
Gene ID 79001
Synonyms
VKOR; Vitamin K epoxide reductase complex subunit 1; EC 1.17.4.4; Vitamin K1 2,3-epoxide reductase subunit 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
DFGTEAARPQKGRKPRPRARSAKANQAELENAY
Target Type
Successful
Target Bioclass
Enzyme
Family
VKOR family
Subcellular location
Endoplasmic reticulum membrane
Function
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
TTD ID
T11843
Uniprot ID
Q9BQB6
DrugMap ID
TTEUC8H
Ensemble ID
ENST00000319788.11
HGNC ID
HGNC:23663
ChEMBL ID
CHEMBL1930

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.05  LDD0402  [1]
CHEMBL5175495
 Probe Info  		7.56  LDD0196  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K152(10.00)  LDD0277  [4]
BTD
 Probe Info  		C43(1.11)  LDD1699  [5]
JZ128-DTB
 Probe Info  		C43(0.00); C51(0.00)  LDD0462  [6]
THZ1-DTB
 Probe Info  		C43(1.08); C51(1.02)  LDD0460  [6]
HPAP
 Probe Info  		3.85  LDD0064  [7]
BDBM50514113
 Probe Info  		4.63  LDD0041  [8]
DBIA
 Probe Info  		C51(0.94)  LDD0078  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
JW-RF-010
 Probe Info  		C43(0.00); C51(0.00)  LDD0026  [11]
TFBX
 Probe Info  		C43(0.00); C51(0.00)  LDD0027  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
IPM
 Probe Info  		C51(0.00); C43(0.00)  LDD0005  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
Acrolein
 Probe Info  		C43(0.00); C51(0.00)  LDD0217  [15]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [15]
Crotonaldehyde
 Probe Info  		C43(0.00); C51(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C43(0.00); C51(0.00)  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		12.70  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C43(1.05); C51(1.15)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C43(0.98); C51(0.99)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C43(0.82); C51(0.89)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C43(0.78); C51(0.73)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C43(0.74); C51(0.77)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C43(0.76); C51(0.75)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C43(0.80); C51(0.82)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C43(0.74); C51(0.73)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C43(0.86); C51(0.84)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C43(0.77); C51(0.88)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C43(0.82); C51(0.80)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C43(0.93); C51(0.89)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C43(0.95); C51(0.95)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C43(0.89); C51(0.89)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C43(0.80); C51(0.79)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C43(0.75); C51(0.82)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C43(0.77); C51(0.97)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C43(0.82); C51(0.95)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C43(0.80); C51(0.96)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C43(0.68); C51(0.88)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C43(0.81); C51(0.94)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C43(0.82); C51(0.98)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C43(0.75); C51(0.88)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C43(1.06); C51(1.04)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C43(0.72); C51(0.94)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C43(0.87); C51(0.96)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C43(0.76); C51(0.89)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C43(1.03); C51(1.06)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C43(0.92); C51(1.03)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C43(0.83); C51(0.96)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C43(1.06); C51(1.29)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C43(1.00); C51(1.19)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C43(1.16); C51(0.92)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C43(1.42); C51(1.61)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C43(1.17); C51(1.14)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C43(1.79); C51(1.74)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C43(1.25); C51(1.62)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C43(1.04); C51(1.05)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C43(1.17); C51(1.07)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C43(1.12); C51(0.98)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C43(1.09); C51(1.07)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C43(1.19); C51(1.61)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C43(1.30); C51(1.22)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C43(1.23); C51(1.23)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C43(0.91); C51(0.95)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C43(1.22); C51(1.18)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C43(0.96); C51(1.05)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C43(1.19); C51(3.20)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C51(1.83); C43(1.84)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C43(0.86); C51(1.01)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C51(1.30); C43(1.46)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C51(0.95); C43(1.42)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C51(1.11); C43(1.35)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C51(1.40); C43(1.45)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C51(1.20); C43(1.51)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C43(0.90); C51(0.96)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C51(1.17); C43(3.32)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C51(0.97); C43(1.57)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C51(1.16); C43(1.60)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C51(1.05); C43(1.44)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C43(1.25); C51(1.00)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C43(2.72); C51(1.92)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C43(2.55); C51(0.94)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C43(1.13); C51(0.99)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C43(1.06); C51(1.20)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C43(1.07); C51(1.08)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C51(1.12); C43(1.15)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C43(0.95); C51(1.16)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C43(1.07); C51(1.13)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C51(1.20); C43(1.29)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C43(1.08); C51(1.11)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C43(1.38); C51(1.62)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C51(1.09); C43(1.21)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C43(0.72); C51(0.85)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C43(0.59); C51(0.73)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C43(0.71); C51(0.78)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C43(0.91); C51(1.07)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C43(0.75); C51(0.77)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C43(1.05); C51(1.13)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C43(0.63); C51(0.71)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C43(0.70); C51(0.79)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C43(0.58); C51(0.72)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C43(0.64); C51(0.78)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C43(0.59); C51(0.73)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C51(1.04); C43(1.05)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C43(0.90); C51(0.96)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C43(0.90); C51(0.92)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C43(0.97); C51(1.04)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C43(0.95); C51(1.04)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C43(0.93); C51(1.09)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C43(1.03); C51(1.04)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C43(0.89); C51(0.97)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C43(0.92); C51(0.98)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C43(0.92); C51(1.02)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C43(0.99); C51(1.02)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C43(1.00); C51(1.06)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C43(1.11); C51(1.13)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C51(1.34); C43(1.34)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C43(1.22); C51(1.23)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C43(0.91); C51(0.91)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C43(1.10); C51(1.25)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C43(0.98); C51(0.99)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C43(1.14); C51(1.15)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C43(1.13); C51(1.14)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C51(1.04); C43(1.04)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C43(1.18); C51(1.20)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C51(1.20); C43(1.21)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C51(1.21); C43(1.22)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C51(0.82); C43(1.05)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C51(0.79); C43(0.96)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C51(0.70); C43(0.97)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C43(0.95); C51(0.99)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C51(0.85); C43(0.95)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C43(1.00); C51(1.28)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C51(0.70); C43(0.93)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C51(0.98); C43(1.13)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C51(0.74); C43(1.09)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C51(0.73); C43(0.94)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C51(0.81); C43(0.95)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C51(0.57); C43(0.89)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C43(1.07); C51(1.10)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C51(1.07); C43(1.18)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C43(0.96); C51(0.98)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C43(0.88); C51(0.92)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C51(1.08); C43(1.14)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C43(0.99); C51(1.05)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C43(1.01); C51(1.04)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C51(1.01); C43(1.07)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C51(1.00); C43(1.02)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C43(1.35); C51(1.37)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C51(1.00); C43(1.04)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C51(0.98); C43(1.06)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C51(1.02); C43(1.02)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C43(0.89); C51(0.95)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C51(1.02); C43(1.11)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C51(1.21); C43(1.34)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C51(0.97); C43(1.03)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C43(0.93); C51(0.96)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C43(0.86); C51(0.93)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C43(0.99); C51(1.02)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C43(0.90); C51(0.92)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C51(0.92); C43(0.92)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C43(0.93); C51(0.96)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C51(0.96); C43(0.97)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C51(1.14); C43(1.23)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C43(0.86); C51(0.96)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C43(0.88); C51(0.92)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C43(0.95); C51(0.97)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C43(0.87); C51(0.95)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C43(0.92); C51(0.93)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C43(0.87); C51(0.94)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C43(0.90); C51(0.98)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C43(0.73); C51(0.82)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C51(0.76); C43(0.88)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C43(1.05); C51(1.03)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C43(0.98); C51(1.02)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C43(0.95); C51(1.05)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C51(0.94)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C43(0.00); C51(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C51(1.25); C43(1.39)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C43(1.44); C51(1.57)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C43(1.09); C51(1.12)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C43(1.10); C51(1.12)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C43(1.36); C51(1.38)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C51(1.15); C43(1.20)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C51(1.12); C43(1.14)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C51(1.31); C43(1.49)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C51(1.42); C43(1.43)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C43(1.21); C51(1.26)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C43(1.53); C51(2.09)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C43(1.28); C51(1.31)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C43(1.57); C51(1.59)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C51(1.17); C43(1.30)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C51(1.24); C43(1.38)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C43(0.74); C51(0.80)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C43(0.63); C51(0.77)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C43(0.88); C51(1.02)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C43(0.93); C51(1.16)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C43(0.65); C51(0.82)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C43(1.34); C51(1.45)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C43(1.11); C51(1.20)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C43(1.12); C51(1.22)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C43(1.29); C51(1.46)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C43(0.95); C51(1.02)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C43(1.80); C51(1.80)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C51(1.13); C43(1.15)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C51(1.52); C43(1.53)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C43(1.53); C51(1.55)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C43(0.98); C51(1.33)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C43(0.90); C51(1.04)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C43(0.96); C51(1.04)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C51(0.74); C43(1.02)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C43(1.21); C51(1.28)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C43(1.46); C51(1.56)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C43(1.30); C51(1.42)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C43(1.11); C51(1.13)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C43(0.96); C51(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C43(0.82); C51(0.90)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C43(1.24); C51(1.31)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C51(1.52); C43(1.83)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C43(1.06); C51(1.29)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C43(0.93); C51(1.00)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C43(0.94); C51(1.19)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C43(0.81); C51(0.88)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C43(0.88); C51(1.02)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C43(0.78); C51(0.87)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C43(1.40); C51(1.78)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C43(1.15); C51(1.30)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C43(0.88); C51(0.95)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C43(0.77); C51(0.86)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C43(1.88); C51(2.03)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C43(0.83); C51(0.89)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C43(1.20); C51(1.22)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C43(1.06); C51(1.07)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C43(1.27); C51(1.31)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C43(1.06); C51(1.04)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C43(0.99); C51(0.94)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C43(1.69); C51(1.75)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C43(1.09); C51(1.08)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C43(1.12); C51(1.08)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C43(1.60); C51(1.65)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C43(0.85); C51(0.81)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C43(0.93); C51(0.89)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C43(1.06); C51(0.96)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C43(1.12); C51(1.06)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C43(1.23); C51(1.24)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C43(1.16); C51(1.14)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C43(1.39); C51(1.22)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C43(1.40); C51(1.28)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C43(1.50); C51(1.37)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C43(1.51); C51(1.55)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C43(1.30); C51(1.33)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C43(1.29); C51(1.12)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C43(1.09); C51(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C43(1.20); C51(1.20)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C43(1.42); C51(1.31)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C43(1.38); C51(1.32)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C43(1.33); C51(1.26)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C43(1.21); C51(1.09)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C43(1.23); C51(1.04)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C43(1.19); C51(1.07)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C43(1.24); C51(1.20)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C43(1.35); C51(1.35)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C43(1.90); C51(1.75)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C43(1.16); C51(1.05)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C43(0.99); C51(1.04)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C43(1.16); C51(0.95)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C43(1.19); C51(1.21)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C43(1.22); C51(1.10)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C43(1.71); C51(1.63)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C43(1.36); C51(1.10)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C43(1.25); C51(1.10)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C43(1.17); C51(1.05)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C43(1.49); C51(1.61)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C43(1.26); C51(1.63)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C43(1.17); C51(1.06)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C43(0.97); C51(0.96)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C43(1.02); C51(0.95)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C43(1.00); C51(1.10)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C43(0.98); C51(0.99)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C43(1.04); C51(1.05)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C43(1.05); C51(1.05)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C43(1.01); C51(1.10)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C43(2.41); C51(2.60)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C43(0.94); C51(0.94)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C43(1.56); C51(1.69)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C43(1.41); C51(1.54)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C43(0.97); C51(1.03)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C43(0.99); C51(1.07)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C43(0.89); C51(0.95)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C43(0.98); C51(1.03)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C43(1.39); C51(1.40)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C43(1.01); C51(0.99)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C43(1.28); C51(1.43)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C43(1.75); C51(1.86)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C43(2.19); C51(2.21)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C43(1.62); C51(1.58)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C43(1.00); C51(1.09)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C43(1.64); C51(1.61)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C43(1.10); C51(1.14)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C43(1.10); C51(1.14)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C43(1.10); C51(1.09)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C43(1.46); C51(1.50)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C43(1.30); C51(1.46)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C43(1.27); C51(1.31)  LDD0811  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C51(1.56)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C43(1.27); C51(1.24)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C43(1.37); C51(1.25)  LDD0744  [9]
 LDCM0107  IAA HeLa C43(0.00); C51(0.00)  LDD0221  [15]
 LDCM0179  JZ128 PC-3 C43(0.00); C51(0.00)  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C51(2.68); C43(2.25)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C51(7.17); C43(4.64)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C51(4.70); C43(4.06)  LDD0082  [9]
 LDCM0109  NEM HeLa C43(0.00); C51(0.00)  LDD0223  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C43(1.11)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C43(0.77)  LDD2101  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C51(0.61)  LDD2115  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C43(1.15)  LDD2125  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C51(0.91)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C43(1.05)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C43(1.69)  LDD2136  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C43(0.71); C51(0.71); C16(0.54)  LDD2207  [20]
 LDCM0014  Panhematin hPBMC 3.85  LDD0064  [7]
 LDCM0021  THZ1 HeLa S3 C43(1.08); C51(1.02)  LDD0460  [6]
 LDCM0002  Ward_cp1 U2OS 4.63  LDD0041  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Regulator of microtubule dynamics protein 3 (RMDN3) RMDN family Q96TC7
Protein MANBAL (MANBAL) UPF0239 family Q9NQG1
Bcl-2-interacting killer (BIK) . Q13323

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acenocoumarol Small molecular drug D05HFY
Dicoumarol Small molecular drug DB00266
Dicumarol Small molecular drug D02TJS
Kappadione Small molecular drug DB09332
Menadione Small molecular drug DB00170
Phenindione Small molecular drug D08FTG
Phenprocoumon Small molecular drug D0QV5T
Phylloquinone Small molecular drug DB01022
Warfarin Small molecular drug D0E3OF
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tecarfarin Small molecular drug D07VIB

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.