Details of the Target

General Information of Target

Target ID LDTP15874
Target Name Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29)
Gene Name TIMM29
Gene ID 90580
Synonyms
c19orf52; Mitochondrial import inner membrane translocase subunit Tim29; TIM29
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMM
RLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLM
VADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVG
LLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQ
GFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQ
ALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV
Target Bioclass
Other
Subcellular location
Mitochondrion inner membrane
Function
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.
Uniprot ID
Q9BSF4
Ensemble ID
ENST00000270502.7
HGNC ID
HGNC:25152

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		6.91  LDD0196  [1]
STPyne
 Probe Info  		K24(8.78)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
m-APA
 Probe Info  		14.76  LDD0403  [4]
BTD
 Probe Info  		C46(1.91)  LDD2117  [5]
Alkyne-RA190
 Probe Info  		5.20  LDD0300  [6]
DBIA
 Probe Info  		C46(0.85)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C46(0.00); C182(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		19.43  LDD0471  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
OEA-DA
 Probe Info  		3.21  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C46(1.91)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C46(0.99); C130(1.00)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C46(0.81)  LDD0813  [7]
 LDCM0226  AC11 HEK-293T C46(0.92)  LDD0824  [7]
 LDCM0230  AC113 HCT 116 C46(1.06)  LDD0547  [7]
 LDCM0237  AC12 HEK-293T C46(0.88)  LDD0835  [7]
 LDCM0246  AC128 HCT 116 C46(0.49)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C46(0.48)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C46(0.41)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C46(0.51)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C46(0.64)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C46(0.63)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C46(0.77)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C46(0.67)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C46(0.68)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C46(0.69)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C46(1.20)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C46(1.11)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C46(1.05)  LDD0857  [7]
 LDCM0260  AC140 HCT 116 C46(1.38)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C46(1.38)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C46(0.78)  LDD0579  [7]
 LDCM0270  AC15 HEK-293T C46(1.16)  LDD0868  [7]
 LDCM0276  AC17 HCT 116 C46(0.79)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C46(0.64)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C46(0.63)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C46(0.97); C130(1.07)  LDD1518  [18]
 LDCM0280  AC20 HCT 116 C46(0.83)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C46(0.62)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C46(0.81)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C46(0.62)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C46(0.85)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C46(0.86)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C46(0.98)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C46(1.00)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C46(0.95)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C46(1.16)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C46(1.04); C130(0.92); C182(0.59)  LDD1529  [18]
 LDCM0291  AC30 HCT 116 C46(1.16)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C46(1.00)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C46(1.12)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C46(0.93)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C46(0.92)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C46(0.94)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C46(1.24)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C46(0.90)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C46(1.02)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C46(1.05)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C46(0.98); C130(1.11)  LDD1540  [18]
 LDCM0302  AC40 HCT 116 C46(1.02)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C46(1.29)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C46(1.13)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C46(1.22)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C46(0.95)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C46(0.94)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C46(1.01)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C46(1.21)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C46(1.20)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C46(1.01)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C46(1.02); C130(1.20)  LDD1551  [18]
 LDCM0313  AC50 HCT 116 C46(0.88)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C46(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C46(1.20)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C46(1.16)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C46(1.25)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C46(1.19)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C46(1.21)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C46(0.96)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C46(0.88)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C46(1.02)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C46(1.01)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C46(1.08)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C46(1.16)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C46(1.14)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C46(1.30)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C46(0.98)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C46(1.10)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C46(1.03)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C46(1.09)  LDD0929  [7]
 LDCM0334  AC7 HEK-293T C46(1.03)  LDD0932  [7]
 LDCM0345  AC8 HEK-293T C46(1.20)  LDD0943  [7]
 LDCM0248  AKOS034007472 HEK-293T C46(1.01)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C46(0.79)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C46(1.04)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 14.76  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C46(0.85)  LDD0078  [7]
 LDCM0367  CL1 HEK-293T C46(0.86)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C46(1.15)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C46(0.99); C130(1.03)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C46(1.07)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C46(0.89)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C46(1.06)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C46(1.14)  LDD0971  [7]
 LDCM0374  CL105 HCT 116 C46(0.91)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C46(0.68)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C46(0.70)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C46(0.68)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C46(0.76)  LDD0695  [7]
 LDCM0379  CL11 HEK-293T C46(1.03)  LDD0977  [7]
 LDCM0380  CL110 HCT 116 C46(0.57)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C46(0.57)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C46(1.06)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C46(1.17)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C46(1.19)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C46(1.12)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C46(1.05)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C46(1.25)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C46(1.06)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C46(1.11)  LDD0706  [7]
 LDCM0390  CL12 HEK-293T C46(1.09)  LDD0988  [7]
 LDCM0391  CL120 HCT 116 C46(1.35)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C46(1.77)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C46(1.17)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C46(1.28)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C46(1.29)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C46(0.92)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C46(1.13)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C46(0.90)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C46(0.87)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C46(0.88)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C46(0.91)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C46(1.06)  LDD1000  [7]
 LDCM0403  CL16 HCT 116 C46(1.22)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C46(0.79)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C46(0.78)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C46(1.01)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C46(0.82)  LDD1005  [7]
 LDCM0408  CL20 HCT 116 C46(0.99)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C46(1.04)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C46(1.27)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C46(0.69)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C46(1.22)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C46(1.05)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C46(0.83)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C46(1.08)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C46(0.79)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C46(1.10)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C46(1.04)  LDD1016  [7]
 LDCM0419  CL30 HCT 116 C46(0.85)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C46(1.03)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C46(0.74)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C46(1.10)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C46(1.21)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C46(1.23)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C46(1.25)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C46(1.22)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C46(0.60)  LDD0745  [7]
 LDCM0429  CL4 HEK-293T C46(0.98)  LDD1027  [7]
 LDCM0430  CL40 HCT 116 C46(0.40)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C46(0.56)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C46(0.46)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C46(0.78)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C46(0.52)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C46(0.68)  LDD0752  [7]
 LDCM0436  CL46 HEK-293T C46(1.17); C130(0.90)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C46(1.06); C130(1.06)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C46(1.22); C130(0.88)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C46(1.00); C130(1.11)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C46(1.04)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C46(0.96); C130(1.09)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C46(1.06); C130(1.00)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C46(1.05); C130(1.09)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C46(1.00); C130(0.92)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C46(1.04); C130(0.96); C182(1.60)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C46(1.03); C130(0.93)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C46(1.08); C130(0.81)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C46(1.11); C130(1.01)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C46(1.01); C130(0.99)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C46(1.03)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C46(1.21); C130(1.07)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C46(0.96); C130(1.29)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C46(0.96); C130(1.08)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C46(1.05); C130(1.17)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C46(1.05); C130(1.05)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C46(1.01); C130(1.10)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C46(1.01); C130(1.01)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C46(1.04); C130(0.97); C182(0.94)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C46(1.00); C130(1.26)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C46(1.07); C130(0.92)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C46(1.00)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C46(1.11); C130(0.97)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C46(1.03); C130(0.97)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C46(1.14); C130(0.98)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C46(0.98); C130(1.17)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C46(0.94); C130(1.30)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C46(1.05); C130(1.01)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C46(1.00); C130(1.05)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C46(1.01); C130(1.08)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C46(1.05); C130(0.99); C182(0.85)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C46(1.24)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C46(1.03); C130(1.11)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C46(1.09); C130(1.07)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C46(1.08); C130(1.06)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C46(1.04); C130(1.00)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C46(1.17); C130(1.01)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C46(0.95); C130(1.19)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C46(0.99); C130(1.24)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C46(1.03); C130(1.05)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C46(1.01); C130(1.08)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C46(1.04); C130(1.12)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C46(1.30)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C46(1.09); C130(1.07)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C46(1.05); C130(1.06); C182(0.98)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C46(1.03); C130(0.98)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C46(1.07); C130(1.08)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C46(1.11); C130(1.04)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C46(1.06); C130(1.14)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C46(1.14); C130(1.14)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C46(0.98); C130(0.95)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C46(0.98); C130(1.07)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C46(0.99); C130(0.96)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C46(0.96); C130(1.09)  LDD1698  [18]
 LDCM0625  F8 Ramos C46(0.89); C182(1.09)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C46(0.90); C182(1.81)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C46(0.40); C182(0.65)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C46(1.05); C182(2.48)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C46(0.76); C182(0.72)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C46(0.81); C182(1.63)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C46(0.29)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C46(1.07); C182(0.87)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C46(1.39); C182(1.35)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C46(0.70); C182(1.14)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C46(0.58); C182(0.86)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C46(0.83); C182(1.04)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C46(0.93); C182(1.08)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C46(1.16); C182(1.72)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C46(1.00); C130(0.94)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C46(0.84); C182(1.50)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C46(0.92); C182(1.51)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C46(1.25)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C46(0.55); C182(1.36)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C46(0.78); C182(0.89)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C46(1.32); C182(1.73)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C182(3.04)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C46(1.29)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C46(2.17)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C46(3.37)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0225  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C46(1.03)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C46(0.46)  LDD2207  [20]
 LDCM0131  RA190 MM1.R 5.20  LDD0300  [6]
 LDCM0021  THZ1 HCT 116 C46(0.85)  LDD2173  [7]

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.