Details of the Target
General Information of Target
| Target ID | LDTP05091 | |||||
|---|---|---|---|---|---|---|
| Target Name | Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) |
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| Gene Name | ADAM8 | |||||
| Gene ID | 101 | |||||
| Synonyms |
MS2; Disintegrin and metalloproteinase domain-containing protein 8; ADAM 8; EC 3.4.24.-; Cell surface antigen MS2; CD antigen CD156a |
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| 3D Structure | ||||||
| Sequence |
MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYV
LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKL NFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTT VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAG RCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE QCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCD GRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCK ASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKG RCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVV VLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFA PPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Subcellular location |
Membrane
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| Function | Possible involvement in extravasation of leukocytes. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| HCC44 | SNV: p.R277L | DBIA Probe Info | |||
| HEC1 | SNV: p.L268P | . | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.E428G | . | |||
| LNCaP clone FGC | SNV: p.L654I | . | |||
| MDAMB231 | SNV: p.A744T | . | |||
| MFE319 | SNV: p.L139P; p.S261N | . | |||
| NCIH2286 | SNV: p.G500W | . | |||
| OCUM1 | SNV: p.Q238E | . | |||
| SNGM | SNV: p.Q392Ter | . | |||
| TE10 | SNV: p.K713N | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K693(10.00); K809(7.14) | LDD0277 | [1] | |
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Alkyne-RA190 Probe Info |
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2.37 | LDD0300 | [2] | |
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IA-alkyne Probe Info |
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C362(5.55) | LDD1704 | [3] | |
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DBIA Probe Info |
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C566(1.02); C571(1.02) | LDD0078 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0020 | ARS-1620 | HCC44 | C566(1.02); C571(1.02) | LDD0078 | [4] |
| LDCM0022 | KB02 | T cell-activated | C362(5.55) | LDD1704 | [3] |
| LDCM0023 | KB03 | WM115 | C362(2.05) | LDD2910 | [5] |
| LDCM0024 | KB05 | UACC257 | C362(1.34) | LDD3325 | [5] |
| LDCM0131 | RA190 | MM1.R | 2.37 | LDD0300 | [2] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Tyrosine-protein kinase Tec (TEC) | Tyr protein kinase family | P42680 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Cdc42-interacting protein 4 (TRIP10) | FNBP1 family | Q15642 | |||
| Formin-binding protein 1-like (FNBP1L) | FNBP1 family | Q5T0N5 | |||
| Neutrophil cytosol factor 1 (NCF1) | . | P14598 | |||
References