Details of the Target

General Information of Target

Target ID LDTP07290
Target Name Lysophospholipid acyltransferase LPCAT4 (LPCAT4)
Gene Name LPCAT4
Gene ID 254531
Synonyms
AGPAT7; AYTL3; LPEAT2; Lysophospholipid acyltransferase LPCAT4; 1-acylglycerol-3-phosphate O-acyltransferase 7; 1-AGP acyltransferase 7; 1-AGPAT 7; 1-acylglycerophosphocholine O-acyltransferase; EC 2.3.1.23; 1-acylglycerophosphoserine O-acyltransferase; EC 2.3.1.n6; 1-alkenylglycerophosphoethanolamine O-acyltransferase; EC 2.3.1.121; 1-alkylglycerophosphocholine O-acetyltransferase; EC 2.3.1.67; Acyltransferase-like 3; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylethanolamine acyltransferase 2; EC 2.3.1.n7; Plasmalogen synthase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFL
LWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQ
APVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRR
VVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTT
SWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIP
ATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEF
ARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQ
AEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYG
KLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD
Target Bioclass
Enzyme
Family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.
Uniprot ID
Q643R3
Ensemble ID
ENST00000314891.11
HGNC ID
HGNC:30059

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K319(2.94)  LDD0277  [2]
DA-P3
 Probe Info  		4.08  LDD0180  [3]
Alkyne-RA190
 Probe Info  		4.39  LDD0299  [4]
DBIA
 Probe Info  		C206(1.02); C89(0.98)  LDD0531  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		C141(0.00); C261(0.00)  LDD2226  [7]
IPM
 Probe Info  		C141(0.00); C89(0.00); C304(0.00)  LDD2156  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		18.38  LDD1799  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C206(1.02); C89(0.98)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C89(0.84)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C206(0.73)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C206(0.73)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C206(0.61)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C206(0.65)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C206(0.64)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C206(0.80)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C206(0.65)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C206(0.67)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C206(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C206(0.81)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C89(0.88)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C206(0.83)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C206(0.90)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C206(0.87)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C206(0.96); C89(0.84)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C206(0.81); C89(0.87)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C206(0.79); C89(1.19)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C206(0.85); C89(0.95)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C206(1.02); C89(1.01)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C206(0.92); C89(1.09)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C206(0.84); C89(1.08)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C89(1.09)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C206(0.86); C89(0.83)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C206(1.01); C89(0.82)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C206(0.94); C89(0.81)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C206(0.91); C89(0.80)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C206(0.86); C89(0.80)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C206(0.84); C89(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C206(0.90); C89(0.76)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C206(0.88); C89(1.02)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C206(0.95)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C206(0.95)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C206(0.97)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C206(1.01)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C206(0.88)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C206(1.02)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C206(0.92)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C206(0.94)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C206(0.97)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C206(0.93)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C206(0.90)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C206(1.12)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C89(0.87)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C206(0.86)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C206(1.02)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C206(0.91)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C206(0.96)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C206(0.98)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C206(0.93)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C206(0.85)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C206(0.79)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C206(0.92)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C206(0.97)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C89(0.93)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C206(0.90)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C206(0.96)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C206(0.78)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C206(0.92)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C206(1.00)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C206(0.87)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C206(0.89)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C206(0.91)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C89(1.03); C206(1.30)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C89(0.50); C206(1.07)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C89(0.80); C206(1.09)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C89(0.99); C206(1.11)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C89(0.91); C206(1.21)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C89(0.69); C206(1.11)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C89(0.87); C206(1.18)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C89(0.81); C206(0.95)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C89(1.02); C206(1.18)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C206(0.88)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C206(0.86)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C206(0.82)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C206(0.88)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C206(0.95)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C89(1.03); C206(1.13)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C206(0.82)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C206(0.82)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C206(0.74)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C206(0.79)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C206(0.85)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C206(1.08)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C206(0.95)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C206(0.80)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C206(1.21)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C206(1.07)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C89(0.95); C206(1.01)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C206(1.06)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C206(1.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C206(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C206(1.01)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C206(1.02)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C206(1.05)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C206(1.00); C89(1.21)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C89(1.10); C206(1.12)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C89(1.01); C206(1.21)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C89(1.07); C206(1.30)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C206(1.25); C89(1.25)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C89(1.19); C206(1.21)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C206(1.11); C89(1.12)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C206(0.91); C89(1.07)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C89(0.93); C206(1.04)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C89(0.96); C206(1.14)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C89(1.04); C206(1.21)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C89(1.02); C206(1.46)  LDD0636  [5]
 LDCM0320  AC57 PaTu 8988t C206(0.96)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C206(1.01)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C206(1.03)  LDD1201  [5]
 LDCM0323  AC6 HCT 116 C89(1.03)  LDD0640  [5]
 LDCM0324  AC60 PaTu 8988t C206(0.98)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C206(1.03)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C206(0.95)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C206(0.99)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C206(1.04)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C206(0.99)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C206(1.00)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C206(1.11)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C206(0.91)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C206(1.09)  LDD1212  [5]
 LDCM0334  AC7 HCT 116 C89(0.93)  LDD0651  [5]
 LDCM0335  AC70 PaTu 8988t C206(1.02)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C206(1.06)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C206(0.99)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C206(1.15)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C206(0.83)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C206(0.89)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C206(0.99)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C206(0.83)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C206(0.99)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C206(0.79)  LDD1223  [5]
 LDCM0345  AC8 HCT 116 C89(1.00)  LDD0662  [5]
 LDCM0346  AC80 PaTu 8988t C206(0.97)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C206(1.03)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C206(0.82)  LDD1227  [5]
 LDCM0349  AC83 HCT 116 C89(0.89)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C89(0.91)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C89(0.92)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C89(0.99)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C89(1.03)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C89(1.02)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C89(0.86)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C89(0.94)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C89(0.89)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C89(1.26)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C89(1.01)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C89(0.85)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C89(0.84)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C89(0.85)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C89(0.85)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C206(0.58)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C206(0.83)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C89(0.89)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C89(1.07)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C89(1.04)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.80  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 4.25  LDD0185  [3]
 LDCM0367  CL1 HCT 116 C206(1.28)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C206(0.98)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C206(1.00); C89(1.03)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C89(1.09)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C89(1.00)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C89(0.96)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C89(0.97)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C89(0.51); C206(1.11)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C89(0.37); C206(0.93)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C89(0.33); C206(0.97)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C89(0.33); C206(1.12)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C89(0.54); C206(0.99)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C206(1.09)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C89(0.38); C206(0.95)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C89(0.64); C206(1.14)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C206(0.95)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C206(0.81)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C206(0.89)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C206(0.83)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C206(0.88)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C206(1.29)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C206(1.07)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C206(0.93)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C206(1.21)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C206(1.08)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C206(0.54); C89(1.10)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C206(1.08); C89(1.18)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C89(1.04); C206(1.13)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C89(1.15); C206(1.19)  LDD0712  [5]
 LDCM0396  CL125 PaTu 8988t C206(1.09)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C206(1.10)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C206(1.06)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C206(0.89)  LDD1278  [5]
 LDCM0400  CL13 HCT 116 C206(1.04)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C206(1.11)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C206(1.14)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C206(0.84)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C206(0.82); C89(0.99)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C206(0.70); C89(0.92)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C206(0.69); C89(1.06)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C206(1.28)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C206(0.68); C89(0.99)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C206(0.71); C89(0.95)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C89(0.94); C206(1.04)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C206(0.67); C89(1.49)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C206(0.79); C89(0.90)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C206(0.78); C89(0.87)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C206(0.61); C89(1.09)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C206(0.81); C89(0.91)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C206(0.65); C89(0.95)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C206(0.79); C89(0.82)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C206(1.13)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C206(0.74); C89(1.24)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C206(0.73); C89(1.04)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C206(0.77); C89(0.82)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C206(0.70); C89(0.90)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C206(0.74); C89(1.00)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C206(0.76); C89(0.94)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C206(0.66); C89(0.81)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C206(0.76); C89(0.83)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C206(0.74); C89(0.77)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C206(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C206(0.59); C89(0.78)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C206(0.77); C89(0.74)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C206(0.90); C89(0.90)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C206(0.81); C89(0.75)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C206(0.68); C89(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C206(0.73); C89(0.86)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C89(1.09)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C89(0.92)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C89(1.27)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C89(0.88)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C206(1.11)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C89(0.93)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C89(1.39)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C89(1.04)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C89(0.81)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C89(0.91)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C89(0.72)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C89(0.96)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C89(0.85)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C89(1.05)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C89(0.96)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C206(1.17)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C89(1.07)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C206(0.91)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C206(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C206(0.88)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C206(0.80)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C206(0.94)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C206(0.87)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C206(0.89)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C206(0.80)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C206(0.85)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C206(1.21)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C206(0.79)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C206(0.87)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C206(1.01)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C206(0.86)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C206(0.94)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C206(0.88)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C206(0.88)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C206(0.76)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C206(0.72)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C206(1.12)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C206(0.80)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C206(0.84)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C206(0.88)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C206(0.94)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C206(1.00)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C206(0.90)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C206(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C206(0.89)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C206(0.87)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C206(1.10)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C206(1.01)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C206(1.22)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C206(1.07); C89(1.00)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C206(1.27); C89(0.95)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C206(1.03); C89(0.92)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C206(0.95); C89(0.84)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C206(0.97); C89(0.93)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C206(1.03); C89(1.07)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C206(0.92); C89(1.03)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C206(1.13); C89(0.91)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C206(0.98); C89(0.92)  LDD0811  [5]
 LDCM0028  Dobutamine HEK-293T 4.08  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C206(1.15); C304(1.22)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C206(0.83)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C206(1.00); C89(0.64)  LDD0744  [5]
 LDCM0029  Quercetin HEK-293T 6.08  LDD0181  [3]
 LDCM0131  RA190 MM1.R 4.39  LDD0299  [4]

References

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Mass spectrometry data entry: PXD028270
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402