Details of the Target

General Information of Target

Target ID LDTP10584
Target Name Junctional sarcoplasmic reticulum protein 1 (JSRP1)
Gene Name JSRP1
Gene ID 126306
Synonyms
JP45; Junctional sarcoplasmic reticulum protein 1; Junctional-face membrane protein of 45 kDa homolog; JP-45
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYS
MDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKLLVEKKFLALQSKNSDADF
QNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIVTQSQTNFTCPITKEEMKKPV
KNKVCGHTYEEDAIVRMIESRQKRKKKAYCPQIGCSHTDIRKSDLIQDEALRRAIENHNK
KRHRHSE
Target Bioclass
Other
Subcellular location
Sarcoplasmic reticulum membrane
Function
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.
Uniprot ID
Q96MG2
Ensemble ID
ENST00000300961.10
HGNC ID
HGNC:24963

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C18(1.10)  LDD0304  [1]
DBIA
 Probe Info  		C18(0.98)  LDD3404  [2]
Alkyne-RA190
 Probe Info  		5.70  LDD0299  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 RD C18(1.62)  LDD2984  [2]
 LDCM0024  KB05 SJRH30 C18(0.98)  LDD3404  [2]
 LDCM0131  RA190 MM1.R 5.70  LDD0299  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Growth hormone-inducible transmembrane protein (GHITM) BI1 family Q9H3K2
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840