Details of the Target

General Information of Target

Target ID LDTP12506
Target Name DNA polymerase epsilon subunit 3 (POLE3)
Gene Name POLE3
Gene ID 54107
Synonyms
CHRAC17; DNA polymerase epsilon subunit 3; Arsenic-transactivated protein; AsTP; Chromatin accessibility complex 17 kDa protein; CHRAC-17; HuCHRAC17; DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFV
LNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDA
VQEWVMNQAKVPVDGNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHV
SLVPQLSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQ
VICIHDVSSTYRVPVLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICS
IALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQK
LCKADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCLGMQLAVIEFARNCLNLKDAD
STEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRH
RFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPY
LGLLLAATGNLNAYLQQGCKLSSSDRYSDASDDSFSEPRIAELEIS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Uniprot ID
Q9NRF9
Ensemble ID
ENST00000374169.7
HGNC ID
HGNC:13546
ChEMBL ID
CHEMBL3833525

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y92(70.93)  LDD3495  [1]
Alkyne-RA190
 Probe Info  		4.18  LDD0299  [2]
DBIA
 Probe Info  		C51(0.88)  LDD0531  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
NHS
 Probe Info  		K20(0.00); K31(0.00)  LDD0010  [7]
STPyne
 Probe Info  		K31(0.00); K86(0.00)  LDD0009  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
m-APA
 Probe Info  		N.A.  LDD0404  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		18.90  LDD1865  [13]
C191
 Probe Info  		10.48  LDD1868  [13]
C193
 Probe Info  		5.74  LDD1869  [13]
C285
 Probe Info  		19.56  LDD1955  [13]
C287
 Probe Info  		9.00  LDD1957  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C51(0.88)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C51(0.80)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C51(0.59)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C51(0.61)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C51(0.64)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C51(0.91)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C51(0.74)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C51(0.79)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C51(0.70)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C51(0.75)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C51(0.71)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C51(0.77)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C51(0.81)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C51(0.61)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C51(0.80)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C51(0.73)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C51(0.91)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C51(0.85)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C51(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C51(0.88)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C51(0.95)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C51(0.79)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C51(0.83)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C51(0.88)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C51(0.77)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C51(0.71)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C51(0.80)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C51(0.80)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C51(0.95)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C51(0.96)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C51(0.97)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C51(1.01)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C51(1.38)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C51(1.20)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C51(1.37)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C51(1.28)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C51(1.03)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C51(1.08)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C51(1.13)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C51(1.15)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C51(1.05)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C51(1.05)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C51(0.96)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C51(1.04)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C51(0.67)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C51(1.06)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C51(1.01)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C51(0.99)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C51(0.94)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C51(1.17)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C51(0.91)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C51(1.00)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C51(1.19)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C51(1.33)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C51(1.06)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C51(0.86)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C51(1.06)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C51(1.16)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C51(1.31)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C51(1.36)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C51(1.13)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C51(1.31)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C51(1.28)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C51(1.29)  LDD2161  [3]
 LDCM0276  AC17 PaTu 8988t C51(1.09)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C51(0.95)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C51(1.06)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C51(0.79)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C51(1.03)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C51(1.06)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C51(1.10)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C51(1.13)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C51(1.10)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C51(0.92)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C51(1.03)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C51(1.01)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C51(1.08)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C51(0.94)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C51(0.79)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C51(0.98)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C51(1.00)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C51(1.12)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C51(1.13)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C51(1.15)  LDD1174  [3]
 LDCM0296  AC35 HEK-293T C51(0.77)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C51(0.82)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C51(0.71)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C51(0.84)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C51(0.74)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C51(0.89)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C51(0.92)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C51(0.83)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C51(0.82)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C51(0.95)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C51(0.69)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C51(0.64)  LDD0905  [3]
 LDCM0308  AC46 PaTu 8988t C51(0.92)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C51(0.93)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C51(1.02)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C51(1.13)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C51(0.69)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C51(1.17)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C51(0.87)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C51(0.99)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C51(1.15)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C51(1.26)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C51(0.94)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C51(1.35)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C51(0.82)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C51(1.04)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C51(0.87)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C51(1.08)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C51(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C51(0.93)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C51(0.89)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C51(0.87)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C51(0.99)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C51(0.72)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C51(0.73)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C51(0.64)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C51(0.95)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C51(1.14)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C51(0.91)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C51(0.92)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C51(0.87)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C51(1.11)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C51(1.24)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C51(1.20)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C51(1.22)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C51(1.02)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C51(1.01)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C51(0.82)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C51(0.92)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C51(0.84)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C51(1.00)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C51(0.83)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C51(1.14)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C51(0.65)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C51(0.30)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C51(0.39)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C51(0.48)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C51(0.69)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C51(0.28)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C51(0.21)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C51(0.29)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C51(0.58)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C51(0.51)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C51(0.19)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C51(0.17)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C51(0.28)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C51(0.34)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C51(0.05)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C51(0.50)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C51(0.76)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C51(0.80)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C51(0.85)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C51(1.04)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [10]
 LDCM0632  CL-Sc Hep-G2 C51(20.00)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C51(1.06)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C51(1.13)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C51(0.78)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C51(0.77)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C51(0.83)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C51(0.88)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C51(0.95)  LDD0690  [3]
 LDCM0374  CL105 PaTu 8988t C51(0.99)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C51(1.14)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C51(0.99)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C51(0.97)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C51(0.95)  LDD1257  [3]
 LDCM0379  CL11 HCT 116 C51(1.20)  LDD0696  [3]
 LDCM0380  CL110 PaTu 8988t C51(1.04)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C51(1.13)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C51(0.89)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C51(1.09)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C51(1.00)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C51(1.04)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C51(1.10)  LDD1265  [3]
 LDCM0387  CL117 HEK-293T C51(0.82)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C51(0.81)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C51(0.79)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C51(1.14)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C51(0.64)  LDD0989  [3]
 LDCM0392  CL121 PaTu 8988t C51(1.00)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C51(1.66)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C51(0.95)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C51(0.99)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C51(0.69)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C51(0.88)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C51(0.78)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C51(0.98)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C51(1.28)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C51(1.21)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C51(1.07)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C51(0.98)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C51(0.98)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C51(0.80)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C51(1.12)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C51(0.89)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C51(1.13)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C51(1.01)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C51(1.11)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C51(1.13)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C51(0.82)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C51(0.99)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C51(0.98)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C51(1.02)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C51(0.85)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C51(1.24)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C51(0.97)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C51(1.18)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C51(1.76)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C51(1.38)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C51(1.26)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C51(1.97)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C51(1.70)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C51(1.33)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C51(1.81)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C51(1.34)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C51(1.12)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C51(1.30)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C51(1.63)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C51(1.35)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C51(1.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C51(1.72)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C51(1.60)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C51(0.89)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C51(0.99)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C51(1.15)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C51(0.89)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C51(1.26)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C51(0.41)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C51(0.88)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C51(1.24)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C51(1.06)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C51(0.77)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C51(0.77)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C51(1.09)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C51(0.97)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C51(0.87)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C51(0.68)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C51(1.30)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C51(0.42)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C51(0.79)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C51(0.80)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C51(0.72)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C51(0.85)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C51(0.68)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C51(0.65)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C51(0.73)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C51(0.60)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C51(0.73)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C51(1.47)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C51(0.72)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C51(0.72)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C51(0.80)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C51(1.00)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C51(0.72)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C51(1.07)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C51(1.18)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C51(0.96)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C51(1.32)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C51(1.24)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C51(1.39)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C51(1.12)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C51(1.20)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C51(1.08)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C51(1.09)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C51(0.90)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C51(0.96)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C51(0.82)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C51(1.06)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C51(1.09)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C51(1.34)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C51(1.10)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C51(0.68)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C51(0.77)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C51(0.95)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C51(0.81)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C51(0.84)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C51(0.88)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C51(0.78)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C51(0.82)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C51(0.81)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C51(1.05)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C51(0.63)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C51(1.40)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C51(1.08)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C51(1.16)  LDD1497  [14]
 LDCM0024  KB05 G361 C51(2.08)  LDD3311  [15]
 LDCM0131  RA190 MM1.R 4.18  LDD0299  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Chromatin accessibility complex protein 1 (CHRAC1) . Q9NRG0
DNA polymerase epsilon subunit 4 (POLE4) . Q9NR33
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cladribine Small molecular drug DB00242

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840