Details of the Target

General Information of Target

Target ID LDTP00294
Target Name 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
Gene Name PSMD14
Gene ID 10213
Synonyms
POH1; 26S proteasome non-ATPase regulatory subunit 14; EC 3.4.19.-; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
Target Bioclass
Enzyme
Family
Peptidase M67A family, PSMD14 subfamily
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Uniprot ID
O00487
Ensemble ID
ENST00000409682.8
HGNC ID
HGNC:16889
ChEMBL ID
CHEMBL2007629

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y234(20.00)  LDD0257  [3]
TH216
 Probe Info  		Y234(19.46)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K154(6.65); K222(7.83); K277(2.94); K43(5.98)  LDD0277  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
OPA-S-S-alkyne
 Probe Info  		K154(0.53)  LDD3494  [6]
P11
 Probe Info  		6.61  LDD0201  [7]
AHL-Pu-1
 Probe Info  		C238(3.09)  LDD0169  [8]
Alkyne-RA190
 Probe Info  		8.02  LDD0299  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
DBIA
 Probe Info  		C238(1.76)  LDD0080  [11]
5E-2FA
 Probe Info  		H172(0.00); H183(0.00); H237(0.00)  LDD2235  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C238(0.00); C120(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C238(0.00); C120(0.00); C299(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C120(0.00); C238(0.00); C299(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		C238(0.00); 0.00  LDD2226  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
Acrolein
 Probe Info  		C238(0.00); H237(0.00); H240(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		C299(0.00); C238(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.09  LDD0471  [21]
FFF probe13
 Probe Info  		13.47  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe2
 Probe Info  		9.44  LDD0463  [21]
FFF probe3
 Probe Info  		10.69  LDD0465  [21]
STS-1
 Probe Info  		2.50  LDD0137  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
Alk-rapa
 Probe Info  		5.29  LDD0213  [23]
DA-2
 Probe Info  		N.A.  LDD0070  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C238(3.09)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C238(1.10)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C238(0.79)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C238(0.82)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C238(0.95)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C238(0.93)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C238(1.00)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C238(1.01)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C238(0.90)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C238(0.89)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C238(0.91)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C238(0.84)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C238(0.79)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C238(1.01)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C238(0.98)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C238(0.80)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C238(0.98)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C238(1.03)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C238(1.01)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C238(1.16)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C238(1.23)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C238(1.04)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C238(1.01)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C238(1.01)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C238(0.89)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C238(1.32)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C238(1.14)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C238(1.03)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C238(1.05)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C238(1.02)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C238(1.10)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C238(1.08)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C238(1.09)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C238(1.00)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C238(1.07)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C238(1.05)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C238(1.17)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C238(1.12)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C238(1.17)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C238(1.32)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C238(1.06)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C238(1.27)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C238(1.26)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C238(1.59)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C238(1.27)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C238(1.03)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C238(1.54)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C238(1.44)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C238(1.19)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C238(1.10)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C238(1.08)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C238(1.03)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C238(1.26)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C238(1.12)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C238(1.42)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C238(1.45)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C238(1.12)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C238(1.15)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C238(1.11)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C238(1.24)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C238(1.54)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C238(1.11)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C238(1.04)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C238(1.07)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C238(1.00)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C238(1.04)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C238(1.44)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C238(0.94)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C238(1.01)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C238(0.97)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C238(1.00)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C238(0.92)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C238(1.01)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C238(0.92)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C238(1.08)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C238(1.05)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C238(0.91)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C238(1.19)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C238(0.97)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C238(0.94)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C238(1.06)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C238(1.13)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C238(1.02)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C238(0.91)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C238(1.20)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C238(1.23)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C238(0.98)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C238(0.87)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C238(0.92)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C238(1.25)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C238(0.98)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C238(0.98)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C238(0.98)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C238(0.94)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C238(1.10)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C238(1.00)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C238(0.99)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C238(0.96)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C238(0.87)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C238(0.77)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C238(1.02)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C238(1.11)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C238(0.92)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C238(0.77)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C238(0.77)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C238(0.79)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C238(0.97)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C238(0.89)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C238(0.83)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C238(1.14)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C238(1.00)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C238(1.23)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C238(0.96)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C238(1.18)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C238(1.10)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C238(1.12)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C238(1.04)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C238(1.19)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C238(1.13)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C238(1.07)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C238(1.08)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C238(1.07)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C238(0.97)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C238(0.93)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C238(1.00)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C238(1.04)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C238(1.07)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C238(1.12)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C238(1.21)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C238(1.16)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C238(0.99)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C238(0.97)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C238(1.12)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C238(1.15)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C238(1.27)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C238(1.07)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C238(1.04)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C238(1.23)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C238(1.47)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C238(1.60)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C238(1.33)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C238(0.94)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C238(0.94)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C238(1.05)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C238(0.89)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C238(1.12)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C238(1.09)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C238(1.01)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C238(0.95)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C238(1.04)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C238(0.93)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C238(0.95)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C238(1.27)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C238(1.04)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C238(0.87)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C238(0.92)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C238(0.86)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C238(1.15)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.43  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C238(1.16)  LDD2171  [11]
 LDCM0088  C45 HEK-293T 6.61  LDD0201  [7]
 LDCM0630  CCW28-3 231MFP C299(1.79); C238(0.95)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa H237(0.00); H240(0.00); H172(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C238(1.13)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C238(1.16)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C238(1.06)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C238(1.05)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C238(0.90)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C238(1.15)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C238(1.02)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C238(0.95)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C238(1.03)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C238(1.36)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C238(1.19)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C238(1.41)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C238(1.03)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C238(1.24)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C238(1.09)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C238(1.21)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C238(1.05)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C238(1.14)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C238(1.45)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C238(1.20)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C238(1.07)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C238(1.31)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C238(1.31)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C238(1.03)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C238(1.00)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C238(1.04)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C238(0.77)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C238(0.92)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C238(0.97)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C238(0.91)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C238(1.09)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C238(1.10)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C238(1.00)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C238(1.08)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C238(1.08)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C238(1.00)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C238(1.17)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C238(0.79)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C238(0.99)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C238(0.85)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C238(1.16)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C238(1.06)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C238(1.07)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C238(0.93)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C238(0.92)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C238(0.85)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C238(0.85)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C238(0.90)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C238(0.83)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C238(0.95)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C238(0.92)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C238(0.74)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C238(1.13)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C238(0.83)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C238(1.32)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C238(1.11)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C238(1.24)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C238(1.46)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C238(1.60)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C238(1.25)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C238(1.31)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C238(1.07)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C238(1.47)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C238(1.20)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C238(1.02)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C238(1.34)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C238(1.03)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C238(1.24)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C238(1.18)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C238(0.76)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C238(0.94)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C238(0.85)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C238(0.89)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C238(0.89)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C238(1.01)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C238(0.84)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C238(1.26)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C238(1.49)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C238(1.01)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C238(0.93)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C238(1.27)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C238(1.07)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C238(0.80)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C238(1.04)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C238(0.95)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C238(0.91)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C238(0.96)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C238(0.88)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C238(1.07)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C238(1.01)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C238(1.18)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C238(1.25)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C238(1.08)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C238(1.15)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C238(1.11)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C238(0.87)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C238(1.00)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C238(1.12)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C238(1.02)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C238(1.07)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C238(1.00)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C238(1.40)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C238(1.80)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C238(0.99)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C238(1.18)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C238(1.13)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C238(1.11)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C238(1.06)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C238(1.13)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C238(1.23)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C238(1.17)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C238(1.46)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C238(1.28)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C238(1.88)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C238(1.69)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C238(1.43)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C238(1.05)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C238(2.11)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C238(1.07)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C238(1.33)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C238(0.99)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C238(1.11)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C238(1.29)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C238(1.12)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C238(1.19)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C238(1.10)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C238(1.04)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C238(0.50)  LDD2228  [14]
 LDCM0495  E2913 HEK-293T C238(0.99); C120(1.05); C299(0.98)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C238(2.90)  LDD1702  [27]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C238(1.31)  LDD2187  [28]
 LDCM0573  Fragment11 Ramos C238(1.34)  LDD2190  [28]
 LDCM0575  Fragment13 Ramos C238(0.41)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C238(1.73)  LDD2193  [28]
 LDCM0580  Fragment21 Ramos C238(0.55)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C238(2.29)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C238(1.64)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C238(0.95)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C238(1.11)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C238(0.55)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C238(0.73)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C238(1.00)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C238(1.71)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C238(1.34)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C238(1.59)  LDD0744  [11]
 LDCM0614  Fragment56 Ramos C238(0.42)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C238(1.10)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C238(2.05)  LDD2188  [28]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C238(1.76)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C238(2.58)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C238(2.11)  LDD0082  [11]
 LDCM0109  NEM HeLa H172(0.00); H240(0.00)  LDD0223  [18]
 LDCM0131  RA190 MM1.R 8.02  LDD0299  [9]
 LDCM0090  Rapamycin JHH-7 5.29  LDD0213  [23]
 LDCM0021  THZ1 HCT 116 C238(1.16)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) Peptidase M67A family P51665
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein dpy-30 homolog (DPY30) Dpy-30 family Q9C005
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578