Details of the Target

General Information of Target

Target ID LDTP13675
Target Name COP9 signalosome complex subunit 3 (COPS3)
Gene Name COPS3
Gene ID 8533
Synonyms
CSN3; COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3; JAB1-containing signalosome subunit 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQI
LQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPKEPSFRHHFLQVLTYLQAY
KEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKID
DDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQG
RLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKG
LHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGS
VKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYE
MMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRE
LFLALFRKFDERCQPRSFLRDLVETTHLFLKMLERFCRSRGNLVVQNKQKKRRKKKKKVL
DQAIVSGNVPSSPEEVEAVWPALAEQLQCCAQNSELSMDSVVPFDAASEVPVEEQRAEAM
VRIQDCLLAGQAPQALTLLRSAREVWPEGDVFGSQDISPEEEIQLLKQILSAPLPRQQGP
EERGAEEEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAH
TNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFAL
AAVNQKAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLANKDV
EGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRL
FEEFRDSDDVLGHIMKNITAKRSRARIVDKLLALGLVAERRELYKKRQKKLASSILPNGA
ESLKDFCQEDLEEEENLPEEDSEEEEEGGSEAEQVQGSLVLSNENLGQSLHQEGFSIPLL
WLQNCLIRAADDREEDGCSQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPASGQETFW
RIPAKLSPTQLRRAAASLSQPEEEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLA
HKKKAGLASPEEEDAVGKEPLKAAPKKRQLLDSDEEQEEDEGRNRAPELGAPGIQKKKRY
QIEDDEDD
Target Bioclass
Enzyme
Family
CSN3 family
Subcellular location
Cytoplasm
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Uniprot ID
Q9UNS2
Ensemble ID
ENST00000268717.10
HGNC ID
HGNC:2239

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G415 SNV: p.R13P DBIA    Probe Info 
IGROV1 SNV: p.I121N; p.K281E DBIA    Probe Info 
JHH4 SNV: p.L162V DBIA    Probe Info 
JURKAT SNV: p.C146Y; p.G416R Compound 10    Probe Info 
MFE319 Deletion: p.E91SfsTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.12  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
STPyne
 Probe Info  		K281(0.20)  LDD0277  [3]
BTD
 Probe Info  		C298(1.16)  LDD2093  [4]
Alkyne-RA190
 Probe Info  		2.07  LDD0299  [5]
HHS-475
 Probe Info  		Y422(0.78); Y95(0.85)  LDD0264  [6]
HHS-465
 Probe Info  		Y422(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C104(0.67); C170(1.19); C25(0.97); C298(0.91)  LDD0531  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C383(0.00); C298(0.00); C25(0.00); C104(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C25(0.00); C383(0.00)  LDD0032  [12]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C383(0.00); C298(0.00); C25(0.00); C104(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		C25(0.00); C383(0.00)  LDD0026  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
1d-yne
 Probe Info  		N.A.  LDD0356  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
IPM
 Probe Info  		N.A.  LDD0147  [14]
1c-yne
 Probe Info  		K254(0.00); K336(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C25(0.00); C104(0.00)  LDD0217  [17]
W1
 Probe Info  		C25(0.00); C170(0.00); Y367(0.00); N369(0.00)  LDD0236  [18]
AOyne
 Probe Info  		5.30  LDD0443  [19]
NAIA_5
 Probe Info  		C383(0.00); C298(0.00); C88(0.00); C25(0.00)  LDD2223  [20]
HHS-482
 Probe Info  		Y422(1.35)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		22.01  LDD1783  [21]
C094
 Probe Info  		31.12  LDD1785  [21]
C106
 Probe Info  		17.03  LDD1793  [21]
C143
 Probe Info  		12.38  LDD1825  [21]
C246
 Probe Info  		12.38  LDD1919  [21]
C278
 Probe Info  		51.98  LDD1948  [21]
C282
 Probe Info  		16.45  LDD1952  [21]
C310
 Probe Info  		7.84  LDD1977  [21]
FFF probe13
 Probe Info  		19.48  LDD0475  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
OEA-DA
 Probe Info  		5.02  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.87)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C25(1.02)  LDD2112  [4]
 LDCM0214  AC1 HCT 116 C104(0.67); C170(1.19); C25(0.97); C298(0.91)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C25(1.05); C298(0.96); C383(1.10)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C170(0.71); C25(0.80); C298(0.57); C383(1.20)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C170(0.82); C25(0.76); C298(0.62); C383(1.03)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C170(0.76); C25(0.77); C298(0.68); C383(1.20)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C170(0.97); C25(0.75); C298(0.57); C383(1.11)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C170(0.84); C25(0.79); C298(0.61); C383(1.09)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C170(0.98); C25(0.71); C298(0.58); C383(1.03)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C170(0.95); C25(0.76); C298(0.56); C383(1.24)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C170(1.15); C25(1.02); C298(0.62); C383(1.35)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C170(0.81); C25(1.00); C298(0.62); C383(1.05)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C170(0.91); C25(0.84); C298(0.74); C383(1.22)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C25(0.97); C298(0.90); C383(1.02)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C170(0.86); C25(0.91); C298(0.65); C383(1.07)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C170(0.93); C25(0.87); C298(0.58); C383(1.01)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C170(0.97); C25(0.95); C298(0.55); C383(1.15)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C25(1.03); C298(1.07); C383(1.00)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C25(1.00); C298(0.86); C383(1.09)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C25(1.02); C298(0.83); C383(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C25(1.00); C298(0.82); C383(1.01)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C25(0.95); C298(0.82); C383(1.06)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C25(1.05); C298(0.96); C383(1.13)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C25(0.96); C298(0.84); C383(1.10)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C25(1.17); C298(1.12); C383(1.15)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C25(0.86); C298(0.84); C383(0.98)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C25(1.16); C298(1.10); C383(1.26)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C25(0.95); C298(0.84); C383(1.07)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C25(1.47); C298(1.07); C383(1.18)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C25(1.10); C298(1.13); C383(1.19)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C25(1.02); C298(1.00); C383(1.15)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C25(1.15); C298(1.00); C383(1.30)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C25(1.04); C298(0.93); C383(1.13)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C170(1.18); C25(1.29); C298(1.10); C383(0.75)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C170(1.01); C25(1.23); C298(1.27); C383(0.75)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C170(0.91); C25(1.23); C298(0.91); C383(0.69)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C170(0.95); C25(1.10); C298(1.06); C383(0.72)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C170(0.98); C25(1.21); C298(1.22); C383(0.77)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C170(1.21); C25(1.16); C298(0.96); C383(0.75)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C170(1.13); C25(1.16); C298(0.94); C383(0.70)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C170(1.08); C25(1.09); C298(0.98); C383(0.74)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C170(0.95); C25(1.09); C298(1.05); C383(0.75)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C170(1.00); C25(1.06); C298(1.10); C383(0.72)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C170(1.04); C25(1.17); C298(0.98); C383(0.76)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C170(1.17); C25(1.14); C298(0.91); C383(0.75)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C25(0.99); C298(0.88); C383(1.09)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C170(1.11); C25(1.18); C298(0.98); C383(0.69)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C170(1.04); C25(1.17); C298(1.00); C383(0.74)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C170(0.98); C25(1.14); C298(1.08); C383(0.68)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C104(0.90); C170(1.08); C25(0.96); C298(0.81)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C383(0.78); C298(0.95); C104(0.97); C25(1.10)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C298(0.79); C383(0.86); C104(1.12); C170(1.16)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C383(0.71); C298(0.79); C170(1.03); C104(1.05)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C298(0.65); C383(0.86); C104(1.08); C25(1.24)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C298(0.71); C383(0.97); C25(1.10); C104(1.12)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C298(0.70); C383(0.84); C25(1.05); C104(1.06)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C298(0.92); C383(1.01); C25(1.08)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C298(0.77); C383(0.96); C25(0.97); C170(1.12)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C298(0.89); C383(0.96); C104(1.01); C25(1.09)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C298(0.70); C383(0.85); C25(1.07); C104(1.12)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C298(0.64); C383(1.12); C104(1.21); C25(1.32)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C104(1.00); C170(1.16); C25(1.32); C298(0.89)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C104(1.00); C170(1.09); C25(1.14); C298(0.83)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C104(1.08); C170(1.25); C25(1.16); C298(0.94)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C104(1.00); C170(1.11); C25(1.25); C298(0.99)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C383(0.82); C170(0.97); C25(1.10); C298(1.22)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C383(0.77); C170(0.90); C25(0.97); C298(1.19)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C383(0.81); C170(1.03); C25(1.09); C298(1.18)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C104(0.74); C298(0.87); C25(0.94); C383(0.96)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C383(0.71); C25(0.92); C170(0.99); C298(1.26)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C383(0.88); C25(1.03); C170(1.05); C298(1.41)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C383(0.80); C25(0.97); C170(1.00); C298(1.16)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C383(0.82); C170(0.98); C25(1.06); C298(1.35)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C383(0.89); C25(1.06); C170(1.07); C298(1.31)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C25(1.00); C170(1.00); C298(1.01)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C298(0.77); C25(0.86); C170(1.18)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C25(0.90); C298(0.94); C170(1.15)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C170(0.86); C298(0.87); C25(0.89)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C25(0.83); C298(0.83); C170(1.07)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C104(0.69); C25(0.81); C298(0.94); C383(1.04)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C298(0.61); C25(0.89); C170(0.98)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C298(0.85); C25(0.91); C170(0.97)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C298(0.69); C25(0.85); C170(1.09)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C298(0.65); C25(0.94); C170(1.20)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C298(0.69); C25(0.85); C170(1.23)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C383(0.95); C170(1.02); C25(1.03); C298(1.16)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C25(0.69); C298(0.87); C383(0.98); C170(1.23)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C25(0.77); C383(0.88); C298(0.95); C170(1.05)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C298(0.94); C25(0.95); C383(1.07); C170(1.09)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C170(1.03); C25(1.06); C383(1.06); C298(1.11)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C104(0.73); C25(0.82); C298(0.90); C383(1.19)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C25(0.82); C298(0.95); C383(0.99); C170(1.22)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C298(0.73); C25(0.81); C383(0.83); C170(1.10)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C25(0.88); C298(0.95); C383(0.96); C170(1.49)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C298(0.73); C25(0.84); C383(0.85); C170(1.03)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C383(0.85); C25(0.92); C298(0.95); C170(1.18)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C25(0.73); C383(0.81); C298(0.96); C170(1.28)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C298(0.77); C383(0.93); C25(1.10)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C298(0.87); C383(1.05); C25(1.07)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C298(0.99); C25(1.01); C383(1.17)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C298(0.77); C25(0.87); C383(0.96)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C104(0.57); C25(0.91); C298(0.92); C383(1.08)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C298(0.81); C25(0.84); C383(0.96)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C25(0.83); C298(0.86); C383(1.12)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C25(0.86); C298(0.91); C383(1.08)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C298(0.93); C25(0.96); C383(1.05)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C25(0.92); C298(1.12); C383(1.22)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C298(0.97); C25(1.07); C383(1.15)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C25(0.91); C298(1.03); C383(1.16)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C298(0.72); C25(0.93); C383(0.98)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C25(0.89); C383(0.90); C298(1.03)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C298(0.53); C383(0.87); C25(1.04)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C298(0.83); C383(0.88); C25(0.88)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C298(0.54); C383(0.74); C25(0.84)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C298(0.80); C25(0.84); C383(1.07)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C298(0.50); C383(0.76); C25(0.95)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C298(0.43); C25(0.82); C383(0.88)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C298(0.46); C383(0.87); C25(0.97)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C298(0.44); C383(0.74); C25(1.03)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C298(0.65); C383(0.80); C25(1.04)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C298(0.39); C383(0.76); C25(0.85)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C298(0.92); C170(0.92); C25(0.97); C383(1.29)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C170(0.89); C298(0.96); C25(1.03); C383(1.20)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C25(0.83); C298(0.94); C383(0.99)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C298(0.87); C25(1.08); C170(1.09); C383(1.24)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C298(1.08); C170(1.12); C25(1.16); C383(1.26)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C170(0.78); C298(0.90); C25(1.14); C383(1.33)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C298(0.81); C25(0.96); C170(1.13); C383(1.20)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C298(0.93); C170(1.05); C25(1.10); C383(1.14)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C298(0.84); C25(0.98); C170(1.03); C383(1.37)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C170(0.69); C298(0.99); C25(1.11); C383(1.27)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C170(0.77); C25(0.85); C298(0.86); C383(1.13)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C298(0.87); C25(0.98); C170(0.98); C383(1.20)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C170(0.92); C298(0.96); C25(1.00); C383(1.15)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C25(0.85); C298(0.91); C383(0.96)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C298(0.96); C170(0.97); C25(1.01); C383(1.13)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C170(0.84); C25(0.99); C298(1.17); C383(1.18)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C170(0.82); C298(0.89); C25(0.98); C383(1.14)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C298(0.66); C25(0.84); C383(0.91)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C298(0.68); C25(0.82); C383(0.93)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C298(0.69); C25(0.80); C383(0.97)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C25(0.88); C298(0.90); C383(0.96)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C25(0.87); C383(0.92); C298(0.98)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C25(0.91); C383(0.94); C298(0.98)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C298(0.72); C25(0.83); C383(0.87)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C25(1.01); C383(1.18); C298(1.68)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C298(0.75); C25(0.92); C383(1.04)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C298(0.79); C25(0.92); C383(1.03)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C298(0.86); C25(0.86); C383(1.13)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C25(0.86); C298(0.88); C383(0.96)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C298(0.68); C25(0.77); C383(0.95)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C298(0.75); C25(0.77); C383(1.04)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C298(0.69); C25(0.81); C383(0.88)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C298(0.52); C25(0.63); C170(0.88); C383(1.05)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C298(0.59); C170(0.75); C25(0.76); C383(1.00)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C298(0.77)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C25(1.08); C298(1.01); C383(1.07)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C298(0.85); C383(0.94); C25(1.24)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C298(0.82); C25(0.96); C383(1.17)  LDD0592  [8]
 LDCM0108  Chloroacetamide HeLa C25(0.00); H374(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C25(20.00)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C25(0.68); C383(0.95); C298(0.95); C104(1.36)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C25(0.79); C298(0.98); C383(1.10); C104(1.73)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C104(0.69); C298(0.89); C383(0.89); C25(1.06)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C298(0.81); C383(0.90); C25(1.10)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C25(0.89); C383(0.96); C298(0.97)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C25(0.97); C298(1.01); C383(1.01)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C25(0.91); C383(0.94); C298(0.96)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C383(0.94); C170(0.97); C25(1.09); C298(1.37)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C383(0.87); C170(0.98); C25(1.02); C298(1.76)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C383(0.80); C25(0.99); C170(1.11); C298(1.23)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C383(1.00); C170(1.03); C25(1.21); C298(1.40)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C383(0.80); C25(0.93); C170(1.03); C298(1.05)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C25(0.88); C104(1.04); C298(1.14); C383(1.18)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C383(0.98); C25(1.10); C170(1.10); C298(1.37)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C383(0.91); C170(1.01); C298(1.05); C25(1.13)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C170(0.76); C25(0.91); C298(1.24)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C298(0.75); C25(0.82); C170(1.30)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C298(0.64); C25(0.77); C170(0.94)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C298(0.72); C25(0.82); C170(1.06)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C298(0.84); C25(0.87); C170(1.02)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C383(0.98); C25(1.02); C298(1.05); C170(1.36)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C298(0.82); C383(0.82); C25(0.87); C170(1.20)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C25(0.77); C298(0.80); C383(0.86); C170(1.01)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C25(0.84); C298(0.99); C383(1.33); C104(1.85)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C298(0.78); C383(0.82); C25(0.85); C170(1.29)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C298(0.78); C25(0.99); C383(1.08)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C25(0.85); C298(0.91); C383(1.21)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C25(0.93); C298(0.98); C383(1.18)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C298(0.85); C25(0.98); C383(1.10)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C383(0.82); C298(1.08); C25(1.12)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C383(0.81); C25(0.96); C298(1.39)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C383(0.81); C298(0.91); C25(1.03)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C298(0.84); C25(0.98); C383(1.15)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C25(0.81); C383(1.09); C298(1.10); C104(1.62)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C25(0.93); C383(1.05); C298(1.07); C104(1.71)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C25(0.84); C383(1.05); C298(1.10); C104(1.33)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C298(0.81); C383(0.89); C25(0.89)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C298(0.83); C383(0.96); C104(0.97); C25(1.06)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C25(0.59); C298(0.66); C383(0.99); C104(0.99)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C25(0.74); C298(0.76); C104(0.93); C383(1.00)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C298(0.92); C383(1.03); C25(1.10); C104(1.11)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C298(0.69); C25(0.86); C104(0.92); C383(1.19)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C25(0.77); C298(0.80); C104(0.83); C383(1.18)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C298(0.77); C25(0.95); C104(0.97); C383(1.54)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C298(0.81); C25(0.82); C104(0.91); C383(1.09)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C298(0.76); C25(0.82); C383(1.17); C104(1.25)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C104(0.84); C25(0.90); C298(0.77); C383(1.22)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C104(0.95); C25(0.87); C298(0.73); C383(1.17)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C104(1.31); C25(0.99); C298(0.80); C383(1.14)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C104(1.10); C25(0.80); C298(0.64); C383(0.93)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C104(1.21); C25(0.81); C298(0.66); C383(1.17)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C104(1.18); C25(1.01); C298(1.10); C383(0.99)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C104(1.07); C25(0.99); C298(0.87); C383(1.13)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C104(1.08); C170(1.05); C25(0.97); C298(0.77)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C170(1.29); C25(0.80); C298(0.67); C383(1.02)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C170(1.18); C25(0.77); C298(0.66); C383(0.91)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C170(1.15); C25(0.86); C298(0.68); C383(0.91)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C170(1.00); C25(0.86); C298(0.70); C383(0.94)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C170(1.07); C25(0.91); C298(0.78); C383(0.87)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C170(1.04); C25(0.94); C298(0.73); C383(0.96)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C170(1.01); C25(0.90); C298(0.74); C383(1.06)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C104(1.19); C25(0.94); C298(1.01); C383(1.08)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C170(1.02); C25(0.93); C298(0.74); C383(0.99)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C170(0.93); C25(0.92); C298(0.74); C383(0.87)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C170(0.97); C25(1.02); C298(0.77); C383(0.96)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C170(1.08); C25(0.88); C298(0.66); C383(1.00)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C170(1.05); C25(0.80); C298(0.69); C383(1.06)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C170(1.16); C25(0.83); C298(0.65); C383(0.96)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C170(1.07); C25(1.11); C298(1.27); C383(0.94)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C170(1.02); C25(1.12); C298(1.19); C383(0.87)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C170(0.96); C25(1.09); C298(1.21); C383(0.97)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C170(1.07); C25(0.99); C298(1.07); C383(1.03)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C104(1.26); C25(0.89); C298(1.00); C383(1.07)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C170(1.04); C25(1.05); C298(1.12); C383(0.93)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C170(1.06); C25(1.22); C298(1.16); C383(0.96)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C170(1.05); C25(1.09); C298(1.04); C383(1.06)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C170(0.93); C25(1.20); C298(1.18); C383(0.82)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C170(0.94); C25(1.08); C298(1.08); C383(1.08)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C170(0.96); C25(1.12); C298(1.21); C383(1.02)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C170(1.10); C25(1.00); C298(1.11); C383(1.00)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C170(1.00); C25(1.12); C298(1.19); C383(0.94)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C170(1.02); C25(0.96); C298(1.12); C383(0.92)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C170(1.07); C25(1.11); C298(1.08); C383(1.01)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C104(1.38); C25(0.83); C298(0.84); C383(1.03)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C170(1.09); C25(1.14); C298(1.07); C383(0.99)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C104(0.98); C25(0.89); C298(0.87); C383(1.03)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C104(0.77); C25(0.97); C298(0.89); C383(0.98)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C104(0.58); C25(0.88); C298(0.84); C383(1.01)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C104(1.03); C25(0.83); C298(0.75); C383(1.16)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C104(0.93); C25(0.99); C298(1.00); C383(1.07)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C104(0.60); C25(0.94); C298(0.78); C383(1.04)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C104(0.65); C25(0.93); C298(0.86); C383(1.13)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C104(1.12); C25(0.90); C298(0.71); C383(1.00)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C104(0.93); C25(0.74); C298(0.62); C383(0.92)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C104(1.92); C25(0.87); C298(1.03); C383(1.25)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C104(0.59); C25(0.90); C298(0.71); C383(1.02)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C104(0.43); C25(0.92); C298(0.79); C383(1.07)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C104(1.06); C25(0.88); C298(0.91); C383(1.07)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C104(1.07); C25(0.86); C298(0.82); C383(0.97)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C104(0.55); C25(0.93); C298(0.80); C383(1.06)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C170(0.90); C25(0.94); C298(1.16); C383(0.87)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C170(0.98); C25(1.01); C298(1.18); C383(0.97)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C170(1.07); C25(1.04); C298(1.17); C383(0.91)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C170(1.23); C25(0.99); C298(1.41); C383(1.03)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C104(1.32); C25(0.81); C298(1.00); C383(1.18)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C170(0.89); C25(1.06); C298(1.35); C383(1.10)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C170(1.11); C25(1.02); C298(1.27); C383(0.91)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C170(1.23); C25(1.33); C298(1.43); C383(0.97)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C170(1.10); C25(1.00); C298(1.42); C383(1.22)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C170(1.31); C25(1.07); C298(1.27); C383(1.24)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C170(1.14); C25(1.03); C298(1.13); C383(1.09)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C170(0.90); C25(1.01); C298(1.31); C383(1.02)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C170(1.12); C25(1.01); C298(1.39); C383(1.21)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C170(1.28); C25(1.08); C298(1.47); C383(1.24)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C170(1.45); C25(1.27); C298(1.40); C383(1.21)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C104(1.37); C25(0.89); C298(0.99); C383(1.03)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C170(0.86); C25(1.09); C298(1.39); C383(0.96)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C104(1.11); C170(1.19); C25(0.92); C298(0.84)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C104(1.39); C170(1.08); C25(0.96); C298(0.99)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C104(1.03); C170(1.27); C25(0.87); C298(1.01)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C104(1.01); C170(1.22); C25(0.92); C298(0.81)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C104(1.21); C170(0.98); C25(0.89); C298(0.84)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C104(1.12); C170(1.08); C25(0.79); C298(0.89)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C104(0.99); C170(1.15); C25(1.09); C298(0.82)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C104(0.64); C170(1.23); C25(0.82); C298(0.82)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C104(0.75); C170(1.18); C25(0.87); C298(0.90)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C383(1.00); C104(1.03); C170(1.00); C25(1.01)  LDD1698  [25]
 LDCM0572  Fragment10 Ramos C104(1.32)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C104(6.03)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C104(0.90)  LDD2191  [26]
 LDCM0576  Fragment14 Ramos C104(1.23)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C104(1.15)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C104(1.73)  LDD2195  [26]
 LDCM0578  Fragment27 Ramos C104(1.70)  LDD2197  [26]
 LDCM0588  Fragment30 Ramos C104(1.08)  LDD2199  [26]
 LDCM0590  Fragment32 Ramos C104(1.12)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C104(0.79); C25(0.98); C298(0.81); C383(1.05)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C104(2.06)  LDD2203  [26]
 LDCM0427  Fragment51 HCT 116 C170(1.17); C25(0.99); C298(0.84); C383(0.88)  LDD0744  [8]
 LDCM0614  Fragment56 Ramos C104(1.25)  LDD2205  [26]
 LDCM0571  Fragment9 Ramos C104(1.01)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y422(0.78); Y95(0.85)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y422(0.62); Y95(1.12)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y422(0.68); Y95(1.25)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y422(0.72); Y95(3.05)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y422(0.72); Y95(1.36)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C383(0.96); C298(0.92); C25(0.99); C104(1.06)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C383(1.01); C298(0.94); C25(1.03); C104(1.14)  LDD1497  [25]
 LDCM0024  KB05 G361 C383(2.32)  LDD3311  [27]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C298(1.11)  LDD2121  [4]
 LDCM0109  NEM HeLa H374(0.00); H282(0.00)  LDD0223  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C298(1.16)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C298(1.11)  LDD2097  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C25(1.11)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C298(0.86)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C25(0.90)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C25(0.73)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C25(0.71)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C298(0.56); C25(0.73)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C25(0.95)  LDD2110  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C298(0.74)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C298(0.83); C25(0.88)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C298(0.51)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C298(0.89)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C25(0.85)  LDD2127  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C298(0.70)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C298(0.84)  LDD2135  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C25(0.66)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(0.89)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C25(0.98)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C298(0.90)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C298(0.26)  LDD2145  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C383(2.73)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C383(0.48)  LDD2207  [28]
 LDCM0131  RA190 MM1.R 2.07  LDD0299  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
Aspartoacylase (ASPA) AspA/AstE family P45381
Tyrosine--tRNA ligase, cytoplasmic (YARS1) Class-I aminoacyl-tRNA synthetase family P54577
Glycine--tRNA ligase (GARS1) Class-II aminoacyl-tRNA synthetase family P41250
Torsin-1A (TOR1A) ClpA/ClpB family O14656
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Beta-hexosaminidase subunit beta (HEXB) Glycosyl hydrolase 20 family P07686
Nitric oxide synthase 3 (NOS3) NOS family P29474
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
COP9 signalosome complex subunit 6 (COPS6) Peptidase M67A family Q7L5N1
Prostamide/prostaglandin F synthase (PRXL2B) Peroxiredoxin-like PRXL2 family Q8TBF2
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
ADP-ribosylation factor 4 (ARF4) Arf family P18085
Ras-related protein Rab-7a (RAB7A) Rab family P51149
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Alpha-synuclein (SNCA) Synuclein family P37840
Beta-synuclein (SNCB) Synuclein family Q16143
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D10 (HOXD10) Abd-B homeobox family P28358
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
COP9 signalosome complex subunit 7a (COPS7A) CSN7/EIF3M family Q9UBW8
COP9 signalosome complex subunit 8 (COPS8) CSN8 family Q99627
Progranulin (GRN) Granulin family P28799
Peripherin (PRPH) Intermediate filament family P41219
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
SOSS complex subunit B2 (NABP1) SOSS-B family Q96AH0
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Merlin (NF2) . P35240
Methyl-CpG-binding protein 2 (MECP2) . P51608
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Protein Njmu-R1 (C17orf75) . Q9HAS0
RING finger protein 11 (RNF11) . Q9Y3C5
Son of sevenless homolog 1 (SOS1) . Q07889

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.