Details of the Target

General Information of Target

Target ID LDTP02812
Target Name Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)
Gene Name ST6GAL1
Gene ID 6480
Synonyms
SIAT1; Beta-galactoside alpha-2,6-sialyltransferase 1; Alpha 2,6-ST 1; EC 2.4.3.1; B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDS
QSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMN
KYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGP
WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE
KRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQM
PWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFF
DSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
Target Bioclass
Enzyme
Family
Glycosyltransferase 29 family
Subcellular location
Golgi apparatus, Golgi stack membrane
Function Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Uniprot ID
P15907
Ensemble ID
ENST00000169298.8
HGNC ID
HGNC:10860
ChEMBL ID
CHEMBL3596075

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC9 SNV: p.Q235E .
MELHO SNV: p.D339N .
REH SNV: p.A368P .
U118MG SNV: p.K88Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C184(1.82)  LDD3424  [1]
Alkyne-RA190
 Probe Info  		8.96  LDD0299  [2]
IA-alkyne
 Probe Info  		C364(1.26)  LDD2185  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C364(1.55)  LDD2187  [3]
 LDCM0573  Fragment11 Ramos C364(0.15)  LDD2190  [3]
 LDCM0575  Fragment13 Ramos C364(1.23)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C364(1.74)  LDD2193  [3]
 LDCM0580  Fragment21 Ramos C364(1.33)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C364(1.11)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C364(0.82)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C364(1.75)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C364(1.36)  LDD2199  [3]
 LDCM0468  Fragment33 Ramos C364(1.03)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C364(0.55)  LDD2203  [3]
 LDCM0610  Fragment52 Ramos C364(1.36)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C364(1.03)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C364(2.01)  LDD2186  [3]
 LDCM0022  KB02 AU565 C353(4.73)  LDD2265  [1]
 LDCM0023  KB03 AU565 C353(9.00)  LDD2682  [1]
 LDCM0024  KB05 SK-HEP1 C184(1.82)  LDD3424  [1]
 LDCM0131  RA190 MM1.R 8.96  LDD0299  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578