Details of the Target

General Information of Target

Target ID LDTP09820
Target Name La-related protein 4B (LARP4B)
Gene Name LARP4B
Gene ID 23185
Synonyms
KIAA0217; LARP5; La-related protein 4B; La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La-related protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRL
EISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQR
AAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHP
GPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTM
LDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSG
DSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGF
SLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESS
VLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQT
AYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLE
AFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYY
LLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQK
ACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKG
GTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQH
SLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENI
ELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLER
LFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPR
LLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKS
LCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHC
EAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNY
IVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACR
GYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKD
EEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL
RAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVR
EVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ
DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQ
QLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE
QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE
DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP
SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE
KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL
QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERD
QRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA
DLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRV
DGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYL
SDSDTEAKLTETNA
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function Stimulates mRNA translation.
Uniprot ID
Q92615
Ensemble ID
ENST00000316157.8
HGNC ID
HGNC:28987

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y470(20.19); Y693(16.95)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C679(2.04)  LDD0168  [3]
Alkyne-RA190
 Probe Info  		2.40  LDD0300  [4]
DBIA
 Probe Info  		C633(2.04); C167(1.54); C654(1.74); C679(1.16)  LDD0080  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C167(0.00); C679(0.00); C654(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C167(0.00); C679(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C167(0.00); C679(0.00); C633(0.00); C654(0.00)  LDD0037  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
NAIA_4
 Probe Info  		C590(0.00); C633(0.00); C654(0.00)  LDD2226  [9]
TFBX
 Probe Info  		C236(0.00); C167(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C679(0.00); C633(0.00); C590(0.00)  LDD0021  [8]
DA-P3
 Probe Info  		N.A.  LDD0178  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		C633(0.00); C679(0.00); C590(0.00)  LDD0006  [8]
IPM
 Probe Info  		C236(0.00); C633(0.00); C679(0.00); C654(0.00)  LDD0005  [8]
SF
 Probe Info  		N.A.  LDD0028  [13]
VSF
 Probe Info  		C679(0.00); C633(0.00); C590(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C679(0.00); C654(0.00); C236(0.00); C590(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
W1
 Probe Info  		C654(0.00); C590(0.00)  LDD0236  [16]
AOyne
 Probe Info  		11.30  LDD0443  [17]
NAIA_5
 Probe Info  		C633(0.00); C654(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0476  [18]
FFF probe3
 Probe Info  		13.29  LDD0465  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C633(0.75); C167(0.90)  LDD2117  [19]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C633(1.24)  LDD2152  [19]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C679(1.05)  LDD2103  [19]
 LDCM0025  4SU-RNA HEK-293T C679(2.04)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C679(2.17)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C167(0.99); C633(1.01); C654(0.64); C679(0.85)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C167(1.08); C633(0.74); C654(0.91); C679(2.12)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C590(1.23); C167(0.77); C633(0.95); C654(0.94)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C590(1.29); C167(0.81); C633(0.92); C654(1.03)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C590(1.39); C167(0.76); C633(0.97); C654(1.04)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C590(1.35); C167(0.71); C633(1.26); C654(1.17)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C590(1.30); C167(0.77); C633(1.07); C654(0.98)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C590(1.50); C167(0.71); C633(1.13); C654(1.01)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C590(1.27); C167(0.68); C633(1.11); C654(1.12)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C590(1.35); C167(0.77); C633(1.03); C654(1.05)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C590(1.16); C167(0.98); C633(0.88); C654(0.76)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C590(1.01); C167(1.43); C633(0.83); C654(0.80)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C167(0.92); C633(0.94); C654(1.06); C679(1.37)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C590(1.92); C167(0.90); C633(0.97); C654(1.24)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C590(1.33); C167(0.89); C633(1.05); C654(0.97)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C590(1.40); C167(0.90); C633(0.98); C654(1.21)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C167(0.94); C633(1.14); C654(1.29); C679(0.81)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C167(0.63); C633(1.16); C654(1.14); C679(1.07)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C167(0.55); C633(1.18); C654(1.00); C679(1.25)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C167(0.56); C633(1.08); C654(0.91); C679(1.00)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C167(0.62); C633(1.07); C654(1.27); C679(0.86)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C167(0.67); C633(1.02); C654(1.11); C679(0.90)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C167(0.68); C633(1.03); C654(1.16); C679(1.10)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C167(1.12); C633(0.88); C654(0.93); C679(1.07)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C167(0.57); C633(1.10); C654(1.29); C679(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C167(0.65); C633(0.79); C654(1.00); C679(0.88)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C167(0.75); C633(1.04); C654(1.54); C679(1.00)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C167(0.78); C633(0.83); C654(0.88); C679(0.91)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C167(0.70); C633(1.07); C654(1.13); C679(0.94)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C167(0.70); C633(0.85); C654(0.95); C679(1.19)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C167(0.62); C633(1.04); C654(1.30); C679(1.10)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C167(0.66); C633(1.07); C654(1.23); C679(0.95)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C590(1.92); C167(0.93); C633(1.15); C654(0.74)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C590(1.45); C167(1.10); C633(0.94); C654(0.56)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C590(1.66); C167(0.97); C633(1.03); C654(0.68)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C590(1.50); C167(1.03); C633(1.53); C654(0.58)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C590(1.14); C167(1.22); C633(0.66); C654(0.48)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C590(1.43); C167(1.03); C633(0.79); C654(0.54)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C590(1.66); C167(0.96); C633(0.99); C654(0.61)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C590(1.57); C167(0.96); C633(0.89); C654(0.54)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C590(1.21); C167(1.02); C633(0.84); C654(0.59)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C590(1.20); C167(1.09); C633(0.71); C654(0.50)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C590(1.53); C167(1.04); C633(0.76); C654(0.53)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C590(1.30); C167(1.05); C633(0.77); C654(0.57)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C167(1.07); C633(0.75); C654(1.00); C679(1.09)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C590(1.59); C167(0.99); C633(0.82); C654(0.56)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C590(1.31); C167(1.04); C633(0.81); C654(0.50)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C590(1.13); C167(1.38); C633(0.71); C654(0.47)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C590(0.98); C654(0.91); C167(1.07); C679(1.15)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C167(0.71); C590(0.90); C679(0.91); C654(1.03)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C590(0.79); C167(0.85); C654(1.02); C679(1.06)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C167(0.89); C590(0.96); C679(1.07); C633(1.21)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C167(0.71); C590(0.91); C679(1.01); C654(1.20)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C167(0.74); C679(1.01); C590(1.02); C654(1.52)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C167(0.85); C590(0.95); C679(1.06); C654(1.34)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C633(0.89); C167(1.02); C654(1.13); C679(1.50)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C167(0.87); C590(0.94); C654(1.04); C633(1.14)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C679(0.81); C590(0.88); C654(0.91); C167(1.01)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C167(0.75); C679(1.01); C590(1.06); C654(1.17)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C167(0.81); C590(1.20); C679(1.47); C654(1.77)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C590(0.96); C167(0.86); C633(1.42); C654(1.02)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C590(1.10); C167(0.82); C633(1.41); C654(1.24)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C590(1.10); C167(0.88); C633(1.14); C654(0.98)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C590(0.96); C167(0.97); C633(1.54); C654(1.25)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C679(0.58); C654(0.82); C167(0.85); C590(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C590(0.76); C654(0.80); C167(0.85); C679(1.04)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C679(0.57); C654(0.74); C590(0.89); C167(0.98)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C654(0.63); C679(0.76); C633(0.92); C167(0.98)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C679(0.67); C654(0.77); C167(1.00); C590(1.10)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C590(0.86); C654(0.90); C167(0.91); C679(0.95)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C679(0.64); C654(0.77); C590(0.89); C633(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C679(0.61); C654(0.65); C590(0.84); C167(0.85)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C679(0.57); C654(0.75); C633(0.85); C590(1.01)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C167(0.83); C654(1.27)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C167(0.82); C654(1.22)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C167(0.81); C654(1.35)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C167(0.93); C654(1.32)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C167(0.80); C654(1.19)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C679(0.67); C654(0.72); C633(0.93); C167(0.99)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C167(0.81); C654(0.97)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C167(0.81); C654(1.37)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C167(0.84); C654(1.06)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C167(0.82); C654(0.94)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C167(0.81); C654(1.33)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C590(0.63); C633(0.85); C654(0.98); C167(1.01)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C633(0.86); C654(0.90); C590(0.96); C167(1.02)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C633(0.59); C590(1.00); C654(1.05); C167(1.14)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C590(0.62); C633(0.87); C654(1.04); C167(1.08)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C590(0.87); C633(0.88); C167(1.00); C654(1.21)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C679(0.61); C654(0.62); C167(0.94); C633(0.99)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C633(0.80); C167(0.94); C590(1.22); C654(1.32)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C590(0.67); C654(0.77); C633(0.80); C167(1.10)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C590(0.80); C654(0.89); C633(0.90); C167(1.05)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C590(0.75); C654(0.99); C167(1.15); C633(1.18)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C590(0.66); C654(0.81); C633(0.83); C167(1.02)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C633(0.75); C167(1.04); C590(1.05); C654(1.20)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C654(0.96); C633(1.08); C167(1.27)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C633(1.11); C654(1.11); C167(1.13)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C633(0.94); C654(1.04); C167(1.41)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C167(1.07); C633(1.17); C654(1.55)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C679(0.55); C654(0.61); C633(0.93); C167(0.94)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C633(1.02); C167(1.08); C654(1.08)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C654(0.62); C633(0.98); C167(1.35)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C654(0.67); C167(1.12); C633(1.14)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C654(0.86); C167(1.02); C633(1.36)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C633(1.00); C167(1.11); C654(1.27)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C167(0.96); C654(1.07); C633(1.45)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C167(1.05); C633(1.58); C654(2.44)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C167(0.70); C654(1.18); C633(1.24)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C167(0.72); C654(1.21); C633(1.23)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C167(0.68); C654(1.21); C633(1.24)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C633(0.95); C167(0.95); C654(1.11); C679(1.60)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C167(0.87); C654(1.34); C633(1.69)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C654(0.85); C167(0.88); C633(0.98)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C167(0.64); C654(1.20); C633(1.29)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C167(0.82); C654(1.07); C633(1.10)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C167(0.73); C654(1.29); C633(1.53)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C654(0.42); C633(0.55); C167(0.80)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C654(0.49); C633(0.60); C167(0.79)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C654(0.57); C633(0.61); C167(0.72)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C590(0.86); C167(0.91); C633(0.96); C654(1.22)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C167(0.88); C633(1.08); C654(1.28); C590(1.30)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C633(0.81); C654(1.00); C679(1.01); C167(1.06)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C167(0.74); C590(0.96); C633(1.02); C654(1.20)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C633(0.87); C167(0.94); C590(0.98); C654(1.02)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C167(0.89); C633(1.17); C654(1.28); C590(1.35)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C167(0.83); C633(1.39); C590(1.58); C654(1.68)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C167(0.84); C633(1.23); C654(1.67); C590(1.81)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C167(0.88); C633(1.53); C654(2.00); C590(2.18)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C167(0.83); C654(1.04); C633(1.11); C590(1.28)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C167(0.85); C654(0.97); C633(1.13); C590(1.35)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C654(0.98); C167(1.01); C633(1.09); C590(1.24)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C167(0.91); C633(0.98); C654(1.04); C590(1.39)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C679(0.88); C633(0.89); C167(0.96); C654(1.18)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C167(0.86); C633(1.16); C590(1.27); C654(1.28)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C633(0.95); C590(0.98); C167(1.01); C654(1.02)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C167(0.96); C633(1.49); C590(1.90); C654(1.96)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C167(0.60); C590(1.02); C654(1.36); C633(1.95)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C167(0.63); C590(0.89); C654(1.41); C633(1.72)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C590(0.69); C167(0.72); C654(1.09); C633(1.33)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C167(0.75); C590(0.82); C654(1.06); C633(1.32)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C590(0.64); C167(0.96); C654(1.09); C633(1.24)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C167(0.73); C590(0.73); C654(1.11); C633(1.55)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C167(0.70); C590(0.87); C654(0.93); C633(1.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C590(0.51); C633(0.86); C654(1.01); C167(1.01)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C167(0.65); C654(1.03); C590(1.11); C633(2.32)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C167(0.67); C654(1.01); C590(1.14); C633(2.20)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C167(0.71); C590(0.81); C654(0.94); C633(1.68)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C167(0.79); C590(0.90); C654(0.93); C633(1.63)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C167(0.93); C654(1.10); C590(1.17); C633(1.76)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C167(0.70); C654(0.90); C633(2.11); C590(20.00)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C167(0.66); C654(1.24); C590(1.26); C633(2.13)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C167(0.65); C633(1.40); C679(1.43); C654(1.51)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C167(0.81); C633(0.92); C654(0.93); C590(0.95)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C633(0.35)  LDD2138  [19]
 LDCM0248  AKOS034007472 HCT 116 C167(1.15); C633(0.93); C654(0.89); C679(1.19)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C633(0.69); C679(1.00); C167(1.01); C654(1.04)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C167(0.87); C633(1.03); C654(1.69); C679(2.15)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C633(1.03); C167(1.24); C654(0.96)  LDD2171  [5]
 LDCM0102  BDHI 8 Jurkat C167(4.38)  LDD0204  [20]
 LDCM0498  BS-3668 MDA-MB-231 C633(0.51); C679(0.86)  LDD2091  [19]
 LDCM0087  Capsaicin HEK-293T 34.75  LDD0185  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C633(0.78); C654(0.41); C633(0.33)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C633(0.74); C654(0.83); C167(0.96); C679(1.09)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C654(0.65); C633(0.74); C167(0.91); C590(1.13)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C654(0.69); C167(0.90); C679(0.93); C633(0.94)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C633(0.81); C167(0.90); C654(1.06); C679(1.63)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C633(0.66); C167(0.85); C654(0.93); C679(0.99)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C633(0.86); C654(0.98); C167(1.12); C679(1.14)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C633(0.72); C654(0.95); C679(0.98); C167(1.08)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C679(0.83); C654(0.85); C167(0.85); C590(0.86)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C590(0.82); C167(0.86); C679(0.94); C654(1.13)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C633(0.76); C679(0.83); C590(0.85); C167(0.91)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C167(0.89); C679(0.89); C654(0.90); C590(1.02)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C679(0.68); C654(0.85); C167(0.90); C590(0.98)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C654(0.61); C633(0.70); C590(0.91); C679(1.09)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C654(0.67); C633(0.79); C679(0.80); C167(0.87)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C633(0.74); C654(0.75); C679(0.81); C590(0.87)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C167(0.82); C654(0.89)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C167(0.73); C654(1.05)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C654(0.62); C167(0.87)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C167(0.84); C654(0.87)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C167(0.88); C654(1.00)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C633(0.84); C167(0.92); C654(1.65); C590(2.28)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C633(0.93); C167(1.02); C654(1.05); C590(1.17)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C633(0.86); C167(0.98); C654(1.11); C590(1.25)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C654(0.66); C633(0.76); C167(0.83); C590(1.19)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C654(0.87); C633(0.93); C167(1.05); C590(1.06)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C167(1.07); C654(1.19); C633(1.59)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C654(0.94); C167(1.11); C633(1.22)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C633(0.96); C167(0.98); C654(1.18)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C167(1.01); C654(1.29); C633(1.73)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C167(0.82); C633(0.88); C654(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C654(0.58); C167(0.73); C633(0.80)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C654(0.78); C167(0.89); C633(0.91)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C167(0.80); C633(1.60); C654(1.81)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C654(0.76); C633(0.78); C679(0.99); C590(1.03)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C654(0.68); C633(0.81); C167(1.05); C590(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C654(0.62); C633(0.79); C590(0.83); C679(0.87)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C167(1.00); C654(1.12); C633(1.13); C679(1.21)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C167(0.90); C654(1.05); C679(1.07); C633(1.12)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C633(1.30); C679(1.30); C167(1.46); C654(1.63)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C167(1.05); C633(1.25); C679(1.34); C654(1.76)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C633(0.82); C167(0.99); C654(1.14); C679(1.26)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C167(0.73); C679(1.43); C654(1.48); C633(1.61)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C167(0.69); C679(1.39); C633(1.50); C654(1.83)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C167(0.76); C679(1.80); C633(2.02); C654(2.72)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C167(0.81); C679(1.38); C633(1.50); C654(1.53)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C167(0.81); C633(1.57); C654(1.69); C679(1.87)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C167(0.75); C633(1.31); C654(1.43); C679(1.32)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C167(0.79); C633(1.29); C654(1.49); C679(1.14)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C167(0.91); C633(1.27); C654(1.40); C679(1.24)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C167(0.97); C633(1.42); C654(1.48); C679(1.18)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C167(1.01); C633(1.37); C654(1.45); C679(1.24)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C590(0.89); C167(0.97); C633(0.75); C654(0.90)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C167(0.85); C633(1.43); C654(1.78); C679(1.04)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C167(0.98); C633(1.07); C654(0.91)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C167(1.11); C633(1.07); C654(1.15)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C167(0.93); C633(0.91); C654(0.83)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C167(0.84); C633(1.16); C654(1.10)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C167(0.82); C633(1.14); C654(1.19)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C167(0.73); C633(1.06); C654(0.92)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C167(0.80); C633(1.18); C654(1.22)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C167(0.71); C633(1.12); C654(1.16)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C590(1.03); C167(0.88); C633(0.73); C654(0.71)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C167(0.72); C633(0.98); C654(0.97)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C167(0.84); C633(1.13); C654(1.02)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C167(0.77); C633(1.35); C654(1.35)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C167(0.74); C633(1.24); C654(1.27)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C167(0.86); C633(1.16); C654(1.04)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C167(0.80); C633(1.24); C654(1.64)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C167(1.00); C654(0.74); C679(0.70)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C167(1.19); C654(0.93); C679(0.76)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C167(0.95); C654(0.72); C679(0.93)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C167(1.32); C654(0.66); C679(0.54)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C590(1.18); C167(1.02); C633(0.83); C654(0.76)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C167(0.99); C654(0.66); C679(0.92)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C167(1.37); C654(0.63); C679(0.65)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C167(1.17); C654(0.60); C679(1.06)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C167(0.81); C654(0.67); C679(1.50)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C167(0.95); C654(0.53); C679(1.00)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C167(1.19); C654(0.50); C679(0.76)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C167(0.99); C654(0.44); C679(0.82)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C167(1.09); C654(0.40); C679(0.96)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C167(1.14); C654(0.45); C679(0.74)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C167(1.06); C654(0.46); C679(0.65)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C590(1.16); C167(1.04); C633(0.88); C654(0.83)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C167(1.26); C654(0.47); C679(0.90)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C590(0.38); C167(1.10); C633(1.11); C654(1.15)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C590(0.37); C167(1.25); C633(1.14); C654(1.14)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C590(0.41); C167(1.03); C633(1.17); C654(0.93)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C590(0.63); C167(1.06); C633(1.30); C654(1.06)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C590(0.61); C167(1.12); C633(1.09); C654(0.98)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C590(1.25); C167(1.09); C633(1.54); C654(1.00)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C590(0.71); C167(1.02); C633(1.48); C654(1.20)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C590(0.66); C167(0.78); C633(1.12); C654(0.84)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C590(0.49); C167(1.26); C633(1.12); C654(0.91)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C590(1.06); C167(0.93); C633(0.78); C654(0.75)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C590(0.91); C167(0.78); C633(1.23); C654(0.89)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C590(0.66); C167(0.98); C633(1.16); C654(0.88)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C590(0.66); C167(1.37); C633(0.98); C654(1.10)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C590(0.88); C167(1.10); C633(1.04); C654(0.98)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C590(0.64); C167(1.10); C633(1.28); C654(0.85)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C167(1.10); C654(1.18)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C167(0.88); C654(0.91)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C167(0.92); C654(1.02)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C167(0.86); C654(1.28)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C590(1.06); C167(0.97); C633(0.92); C654(0.92)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C167(1.06); C654(1.02)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C167(0.95); C654(1.17)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C167(1.05); C654(1.47)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C167(0.80); C654(1.13)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C167(0.81); C654(1.01)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C167(0.86); C654(0.76)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C167(0.95); C654(0.66)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C167(0.95); C654(0.73)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C167(0.85); C654(0.99)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C167(1.03); C654(1.25)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C590(0.90); C167(1.17); C633(0.72); C654(0.76)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C167(1.06); C654(0.57)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C167(0.94); C633(1.00); C654(1.00); C679(0.94)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C167(0.90); C633(0.82); C654(1.16); C679(0.90)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C167(0.91); C633(1.10); C654(0.88); C679(0.64)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C167(0.84); C633(1.18); C654(0.91); C679(0.86)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C167(0.85); C633(0.85); C654(0.90); C679(0.73)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C167(0.90); C633(1.04); C654(0.91); C679(0.66)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C167(0.92); C633(0.97); C654(0.74); C679(0.67)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C167(0.88); C633(0.93); C654(0.86); C679(1.03)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C167(0.93); C633(1.14); C654(0.65); C679(0.94)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C654(0.74); C633(0.73)  LDD2228  [9]
 LDCM0028  Dobutamine HEK-293T 4.79  LDD0180  [11]
 LDCM0027  Dopamine HEK-293T 13.37  LDD0179  [11]
 LDCM0495  E2913 HEK-293T C679(1.00); C654(1.05); C590(0.90); C167(1.08)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C633(1.75); C654(1.14); C679(1.10)  LDD1702  [19]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.95  LDD0183  [11]
 LDCM0625  F8 Ramos C167(0.68); C654(2.24); C590(2.01); C633(0.87)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C167(0.77); C654(0.69); C590(2.31); C633(1.18)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C167(0.27); C654(4.61); C590(1.16); C633(4.12)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C167(0.77); C654(0.44); C590(1.85); C633(0.78)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C167(0.93); C654(0.55); C590(1.75); C633(1.14)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C167(0.99); C654(0.63); C590(1.25); C633(0.75)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C167(0.95); C654(0.42); C590(1.63); C633(0.73)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C167(1.02); C654(0.70); C590(1.75); C633(0.98)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C167(1.39); C654(1.40); C590(0.93); C633(0.83)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C167(1.00); C654(0.66); C590(1.24); C633(0.97)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C633(0.45)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C167(1.33); C654(0.43); C590(1.58); C633(1.31)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C654(0.76); C590(1.09); C633(1.08)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C167(0.71); C654(0.72); C590(2.20); C633(0.99)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C590(0.79); C167(1.23); C633(1.14); C654(0.91)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C167(0.76); C654(1.54); C590(0.73); C633(1.45)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C167(0.82); C654(1.57); C590(1.64); C633(0.78)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C167(0.72); C633(1.41); C654(1.62)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C167(0.94); C654(0.49); C590(2.58); C633(1.46)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C654(0.81); C590(1.11); C633(1.11)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C167(0.77); C654(1.13); C590(3.20); C633(1.06)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C167(1.12); C654(0.52); C590(1.73); C633(1.36)  LDD2188  [22]
 LDCM0022  KB02 HCT 116 C633(2.04); C167(1.54); C654(1.74); C679(1.16)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C633(1.25); C167(1.91); C654(1.22); C679(0.67)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C633(1.86); C167(1.73); C654(1.51); C679(1.25)  LDD0082  [5]
 LDCM0030  Luteolin HEK-293T 11.69  LDD0182  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C679(1.03)  LDD2102  [19]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C679(0.33)  LDD2121  [19]
 LDCM0109  NEM HeLa N.A.  LDD0233  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C633(1.04); C679(1.52)  LDD2090  [19]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C679(1.03); C654(0.79)  LDD2092  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C633(0.85)  LDD2093  [19]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C679(1.30); C654(0.93)  LDD2094  [19]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C679(1.85)  LDD2096  [19]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C633(0.69); C654(0.92)  LDD2097  [19]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C679(1.23)  LDD2098  [19]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C633(1.04)  LDD2101  [19]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C679(0.81)  LDD2104  [19]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C679(2.18)  LDD2105  [19]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C633(0.59)  LDD2106  [19]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C167(0.90)  LDD2109  [19]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C633(0.89)  LDD2111  [19]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C633(0.76); C654(0.36)  LDD2115  [19]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C679(1.42)  LDD2118  [19]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C633(1.64)  LDD2119  [19]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C679(0.75)  LDD2120  [19]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C167(1.27)  LDD2123  [19]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C679(2.02)  LDD2124  [19]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C167(0.78)  LDD2125  [19]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C679(2.26)  LDD2126  [19]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C633(1.07)  LDD2127  [19]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C679(0.73)  LDD2128  [19]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C633(0.90)  LDD2129  [19]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C633(0.79)  LDD2133  [19]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C167(1.61)  LDD2136  [19]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C633(0.88)  LDD1700  [19]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C679(1.10)  LDD2143  [19]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C633(0.93); C654(1.12)  LDD2144  [19]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C633(0.78)  LDD2145  [19]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C679(1.08)  LDD2146  [19]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C633(0.35); C679(0.37)  LDD2150  [19]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C679(1.48)  LDD2151  [19]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C679(2.35)  LDD2153  [19]
 LDCM0029  Quercetin HEK-293T 15.97  LDD0181  [11]
 LDCM0131  RA190 MM1.R 2.40  LDD0300  [4]
 LDCM0021  THZ1 HCT 116 C633(1.03); C167(1.24); C654(0.96)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Beta-secretase 2 (BACE2) Peptidase A1 family Q9Y5Z0
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
Cytochrome b-c1 complex subunit 7 (UQCRB) UQCRB/QCR7 family P14927
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1-like (ATXN1L) ATXN1 family P0C7T5
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
20 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578