Details of the Target

General Information of Target

Target ID LDTP04310
Target Name E3 SUMO-protein ligase RanBP2 (RANBP2)
Gene Name RANBP2
Gene ID 5903
Synonyms
NUP358; E3 SUMO-protein ligase RanBP2; EC 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLE
ENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKV
QEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLS
TRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVF
GTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKL
YRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSN
NALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSK
ETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDF
VCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAE
HLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
Target Bioclass
Enzyme
Family
RanBP2 E3 ligase family
Subcellular location
Nucleus
Function
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
Uniprot ID
P49792
Ensemble ID
ENST00000283195.11
HGNC ID
HGNC:9848

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.10  LDD0402  [1]
A-EBA
 Probe Info  		2.70  LDD0215  [2]
DAyne
 Probe Info  		3.14  LDD0261  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
W1
 Probe Info  		16.76  LDD0235  [5]
TH211
 Probe Info  		Y961(20.00)  LDD0257  [6]
TH216
 Probe Info  		Y903(8.50)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		K776(1.11)  LDD0274  [8]
STPyne
 Probe Info  		K1286(10.00); K1414(5.66); K1458(1.96); K1530(0.99)  LDD0277  [8]
BTD
 Probe Info  		C3032(2.55); C188(2.31); C2381(1.31); C2577(0.94)  LDD1700  [9]
DA-P3
 Probe Info  		6.99  LDD0185  [10]
AHL-Pu-1
 Probe Info  		C815(2.92); C50(2.31); C3071(6.64); C2696(2.05)  LDD0168  [11]
Alkyne-RA190
 Probe Info  		3.20  LDD0299  [12]
HHS-475
 Probe Info  		Y2609(1.21); Y1983(5.85)  LDD0264  [13]
DBIA
 Probe Info  		C2407(1.17); C2710(1.06); C1435(1.05); C1438(1.05)  LDD0078  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		K2125(0.00); K2127(0.00); K1286(0.00); K1415(0.00)  LDD0199  [16]
1d-yne
 Probe Info  		N.A.  LDD0358  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C319(0.00); C2696(0.00); C141(0.00); C3032(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C2142(0.00); C3071(0.00); C1563(0.00); C2407(0.00)  LDD0032  [19]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C3100(0.00); C319(0.00); C1296(0.00); C2710(0.00)  LDD0037  [18]
JW-RF-010
 Probe Info  		C707(0.00); C3071(0.00)  LDD0026  [21]
NAIA_4
 Probe Info  		C2407(0.00); C2696(0.00); C3071(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C188(0.00); C105(0.00); C815(0.00)  LDD0027  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [23]
WYneO
 Probe Info  		N.A.  LDD0022  [23]
Compound 10
 Probe Info  		N.A.  LDD2216  [24]
ENE
 Probe Info  		C815(0.00); C1335(0.00)  LDD0006  [23]
IPM
 Probe Info  		C348(0.00); C2577(0.00); C220(0.00); C1296(0.00)  LDD0005  [23]
NHS
 Probe Info  		K123(0.00); K1842(0.00); K2125(0.00); K1723, K1605, K1664(0.00)  LDD0010  [23]
SF
 Probe Info  		Y980(0.00); K983(0.00); Y593(0.00); K614(0.00)  LDD0028  [25]
VSF
 Probe Info  		C348(0.00); C3071(0.00); C815(0.00); C1296(0.00)  LDD0007  [23]
Phosphinate-6
 Probe Info  		C815(0.00); C2791(0.00); C3032(0.00); C3071(0.00)  LDD0018  [26]
1c-yne
 Probe Info  		K1842(0.00); K1899(0.00); K379(0.00); K2531(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C348(0.00); C206(0.00); C188(0.00); C1196(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		C1196(0.00); C188(0.00); C2982(0.00); C3040(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		C1243(0.00); C707(0.00); C1196(0.00); C188(0.00)  LDD0218  [27]
AOyne
 Probe Info  		4.40  LDD0443  [28]
NAIA_5
 Probe Info  		C3100(0.00); C1629(0.00); C1626(0.00); C2982(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		Y593(0.00); Y961(0.00); Y964(0.00); K983(0.00)  LDD2240  [29]
HHS-482
 Probe Info  		Y11(0.76); Y510(0.75); Y593(1.01); Y785(0.99)  LDD2239  [30]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		7.73  LDD0472  [31]
FFF probe13
 Probe Info  		8.61  LDD0476  [31]
FFF probe2
 Probe Info  		10.44  LDD0463  [31]
FFF probe3
 Probe Info  		10.84  LDD0464  [31]
FFF probe6
 Probe Info  		11.86  LDD0468  [31]
STS-1
 Probe Info  		1.00  LDD0137  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
OEA-DA
 Probe Info  		3.48  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C2982(0.88); C2381(1.07); C188(0.90); C82(0.79)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C2982(1.06); C2381(1.43); C188(0.99); C82(0.75)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C2982(0.56); C2381(0.42)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C2982(0.67); C2577(0.63)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C2982(1.08); C2381(1.00); C188(1.31); C82(0.90)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C2982(1.17); C2381(1.50); C188(2.34); C82(1.46)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2982(1.67); C3032(1.18); C2577(1.04); C524(0.78)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2982(0.44); C188(0.65); C3032(0.50); C1243(0.40)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C2982(0.47); C2381(0.68); C1243(0.39)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C815(2.92); C50(2.31); C3071(6.64); C2696(2.05)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C536(2.08); C220(2.15); C815(3.41); C50(2.22)  LDD0169  [11]
 LDCM0561  Abegg_cp(-)-10 HeLa C1335(2.46)  LDD0312  [21]
 LDCM0214  AC1 HCT 116 C1499(0.74); C1502(0.74); C2407(1.04); C50(0.82)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C1499(1.21); C1502(1.21); C2407(1.24); C50(0.99)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C1499(0.89); C1502(0.89); C2407(1.18); C105(1.03)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C1499(1.03); C1502(1.03); C2407(1.18); C105(1.04)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C1499(1.21); C1502(1.21); C2407(1.22); C105(1.02)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C1499(1.01); C1502(1.01); C2407(1.28); C105(0.76)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C1499(1.06); C1502(1.06); C2407(1.02); C105(0.93)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C1499(0.98); C1502(0.98); C2407(1.31); C105(1.03)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C1499(1.25); C1502(1.25); C2407(1.33); C105(0.84)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C1499(1.21); C1502(1.21); C2407(0.76); C105(0.98)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C1499(0.97); C1502(0.97); C2407(0.89); C105(1.04)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C1499(1.16); C1502(1.16); C2407(0.78); C105(0.97)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C1499(1.16); C1502(1.16); C2407(1.19); C50(1.04)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C1499(1.11); C1502(1.11); C2407(0.99); C105(1.00)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C1499(1.07); C1502(1.07); C2407(0.94); C105(0.86)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C1499(1.26); C1502(1.26); C2407(0.88); C105(0.81)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C1499(0.94); C1502(0.96); C2407(0.96); C50(1.05)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C1499(1.07); C1502(1.03); C2407(1.01); C50(0.98)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C1499(1.10); C1502(1.06); C2407(1.03); C50(1.12)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C1499(0.93); C1502(0.94); C2407(0.97); C50(1.30)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C1499(0.91); C1502(0.80); C2407(1.01); C50(1.16)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C1499(1.00); C1502(0.85); C2407(0.96); C50(1.08)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C1499(1.12); C1502(0.83); C2407(1.09); C50(1.39)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C1499(1.13); C1502(1.13); C2407(1.03); C50(0.95)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C1499(0.99); C1502(1.00); C2407(0.94); C50(1.16)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C1499(0.92); C1502(0.95); C2407(0.88); C50(1.20)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C1499(0.94); C1502(1.01); C2407(0.97); C50(1.67)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C1499(0.78); C1502(0.98); C2407(0.89); C50(1.29)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C1499(0.83); C1502(0.91); C2407(0.92); C50(1.07)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C1499(0.99); C1502(0.95); C2407(0.99); C50(1.18)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C1499(1.05); C1502(1.12); C2407(0.96); C50(1.02)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C1499(1.13); C1502(0.89); C2407(0.96); C50(1.25)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C1499(0.39); C1502(0.39); C2407(1.46); C50(1.22)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C1499(0.34); C1502(0.34); C2407(0.97); C50(1.34)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C1499(0.37); C1502(0.37); C2407(1.20); C50(0.97)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C1499(0.40); C1502(0.40); C2407(0.77); C50(0.93)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C1499(0.44); C1502(0.44); C2407(0.98); C50(1.19)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C1499(0.39); C1502(0.39); C2407(1.11); C50(1.09)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C1499(0.45); C1502(0.45); C2407(1.05); C50(1.18)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C1499(0.43); C1502(0.43); C2407(1.20); C50(1.09)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C1499(0.44); C1502(0.44); C2407(1.09); C50(1.08)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C1499(0.38); C1502(0.38); C2407(1.18); C50(0.92)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C1499(0.41); C1502(0.41); C2407(0.97); C50(1.27)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C1499(0.38); C1502(0.38); C2407(1.11); C50(1.30)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C1499(1.61); C1502(1.61); C2407(1.20); C50(1.01)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C1499(0.53); C1502(0.53); C2407(1.16); C50(1.16)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C1499(0.51); C1502(0.51); C2407(1.00); C50(1.04)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C1499(0.38); C1502(0.38); C2407(0.77); C50(1.32)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C1499(1.35); C1502(1.26); C2407(1.27); C1421(0.84)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C1499(0.69); C348(0.84); C3122(0.88); C1435(0.91)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C1421(0.75); C1424(0.75); C1744(0.78); C1499(0.81)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C1421(0.86); C1424(0.86); C1563(0.91); C1566(0.91)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C1744(0.86); C1499(0.86); C3122(0.87); C1421(0.91)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C1421(0.82); C1424(0.82); C3122(0.87); C1502(0.88)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C1421(0.85); C1424(0.85); C2084(0.92); C1749(0.92)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C536(0.83); C3122(0.85); C220(0.92); C815(0.95)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C1421(0.69); C1424(0.69); C1563(0.74); C1566(0.74)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C348(0.72); C1421(0.74); C1424(0.74); C1749(0.87)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C3122(0.88); C348(0.89); C1196(0.91); C1421(0.93)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C1502(0.66); C1421(0.80); C1424(0.80); C1499(0.89)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C1499(1.00); C1502(1.08); C2407(1.03); C105(1.26)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C1499(1.01); C1502(0.97); C2407(1.42); C105(1.21)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C1499(0.86); C1502(1.17); C2407(1.08); C105(1.26)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C1499(0.81); C1502(1.23); C2407(1.40); C105(1.26)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C1499(0.61); C1502(0.61); C2142(0.62); C1563(0.67)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C1196(0.68); C2659(0.75); C1626(0.78); C1629(0.78)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C2142(0.49); C2659(0.73); C1626(0.73); C1629(0.73)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C581(0.56); C2659(0.79); C1499(0.85); C1502(0.85)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C1421(0.51); C1424(0.51); C2142(0.52); C1615(0.66)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C1499(0.61); C1502(0.61); C1421(0.61); C1424(0.61)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C2142(0.53); C2659(0.67); C1626(0.71); C1629(0.71)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C1552(0.56); C1626(0.59); C1629(0.59); C1615(0.60)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C2142(0.47); C1552(0.60); C1626(0.61); C1629(0.61)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C1563(0.66); C1566(0.66); C3040(0.74); C1612(0.75)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C581(0.59); C1563(0.62); C1566(0.62); C1612(0.63)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C3040(0.55); C581(0.62); C1790(0.76); C1612(0.77)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C581(0.56); C1612(0.71); C1615(0.71); C2084(0.71)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C581(0.57); C2084(0.67); C1612(0.67); C1615(0.67)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C581(0.42); C1563(0.74); C1566(0.74); C1499(0.77)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C1612(0.55); C1615(0.55); C581(0.68); C2982(0.68)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C581(0.57); C3040(0.59); C1612(0.65); C1615(0.65)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C1612(0.57); C1615(0.57); C581(0.58); C2084(0.69)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C3040(0.66); C1612(0.66); C1615(0.66); C2084(0.75)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C1612(0.68); C1615(0.68); C2084(0.71); C206(0.75)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C1196(0.59); C581(0.67); C50(0.67); C1801(0.71)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C581(0.61); C1485(0.65); C1488(0.65); C1549(0.66)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C581(0.61); C50(0.63); C2791(0.73); C815(0.79)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C1485(0.70); C1488(0.70); C3040(0.75); C581(0.79)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C581(0.45); C1485(0.79); C1488(0.79); C536(0.79)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C581(0.56); C1499(0.73); C1502(0.73); C1563(0.76)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C581(0.75); C3122(0.78); C220(0.90); C536(0.95)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C581(0.55); C1485(0.71); C1488(0.71); C1549(0.75)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C581(0.70); C50(0.74); C3100(0.74); C1791(0.78)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C581(0.57); C3100(0.67); C815(0.82); C1791(0.82)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C1801(0.56); C1804(0.56); C581(0.59); C1485(0.69)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C3122(0.76); C581(0.80); C220(0.90); C50(0.90)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C3040(0.59); C1563(0.71); C1566(0.71); C2982(0.72)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C581(0.63); C1563(0.64); C1566(0.64); C2982(0.91)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C581(0.50); C1563(0.53); C1566(0.53); C3040(0.77)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C3040(0.58); C1563(0.75); C1566(0.75); C2982(0.76)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C581(0.52); C1499(0.73); C1502(0.73); C1563(0.81)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C3040(0.68); C2982(0.76); C1612(0.91); C1615(0.91)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C3040(0.53); C581(0.72); C2982(0.79); C2710(0.87)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C3040(0.56); C2982(0.75); C581(0.77); C1563(0.89)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C3040(0.62); C581(0.73); C2982(0.77); C1801(0.85)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C3040(0.62); C2982(0.75); C581(0.80); C3071(0.86)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C1801(0.76); C1804(0.76); C3071(0.78); C3040(0.78)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C3040(0.64); C2982(0.80); C1801(0.81); C1804(0.81)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C105(0.85); C3122(0.87); C1549(0.88); C1552(0.88)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C3122(0.82); C105(0.84); C220(0.88); C1549(0.89)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C3122(0.76); C105(0.82); C50(0.93); C2084(0.94)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C581(0.75); C3100(0.82); C3122(0.82); C1615(0.89)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C105(0.80); C50(0.87); C2982(1.00); C3122(1.01)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C2659(0.80); C581(0.80); C50(0.95); C220(0.96)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C3122(0.72); C50(0.88); C581(0.89); C1549(0.89)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C105(0.60); C50(0.88); C1549(0.91); C1552(0.91)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C105(0.70); C3122(0.83); C50(0.92); C1549(0.94)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C2659(0.70); C105(0.82); C1485(0.82); C1435(0.83)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C2659(0.71); C1485(0.74); C1435(0.79); C1438(0.79)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C3122(0.61); C2659(0.67); C105(0.74); C1435(0.84)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C2710(0.78); C220(0.79); C3100(0.81); C581(0.82)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C2710(0.66); C1563(0.78); C1566(0.78); C1549(0.79)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C581(0.61); C1612(0.78); C1626(0.79); C1629(0.79)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C1563(0.37); C1566(0.37); C1549(0.67); C1552(0.67)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C1563(0.58); C1566(0.58); C1549(0.60); C1552(0.60)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C1563(0.36); C1566(0.36); C2710(0.76); C581(0.80)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C1563(0.45); C1566(0.45); C3122(0.77); C581(0.87)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C1563(0.43); C1566(0.43); C3122(0.81); C2710(0.83)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C581(0.77); C3122(0.78); C2710(0.83); C1563(0.86)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C1563(0.59); C1566(0.59); C3122(0.81); C1549(0.81)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C2710(0.61); C815(0.79); C2084(0.84); C3122(0.85)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C581(0.68); C2710(0.72); C1549(0.81); C1552(0.81)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C1549(0.62); C1552(0.62); C1563(0.64); C1566(0.64)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C581(0.68); C1626(0.83); C1629(0.83); C3100(0.84)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C1563(0.59); C1566(0.59); C1549(0.77); C1552(0.77)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C1563(0.50); C1566(0.50); C1549(0.59); C1552(0.59)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C1563(0.51); C1566(0.51); C2710(0.78); C3122(0.82)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C1563(0.28); C1566(0.28); C50(0.61); C2084(0.62)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C1563(0.36); C1566(0.36); C50(0.58); C3040(0.73)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C1563(0.24); C1566(0.24); C50(0.60); C3122(0.67)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C1563(0.30); C1566(0.30); C50(0.61); C2084(0.66)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C1563(0.45); C1566(0.45); C50(0.54); C3122(0.75)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C1563(0.32); C1566(0.32); C50(0.61); C3040(0.64)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C1563(0.26); C1566(0.26); C50(0.53); C3040(0.70)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C1563(0.50); C1566(0.50); C50(0.62); C581(0.62)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C1563(0.32); C1566(0.32); C50(0.61); C105(0.69)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C1563(0.22); C1566(0.22); C581(0.62); C50(0.63)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C2084(0.59); C50(0.61); C581(0.68); C3040(0.71)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C1563(0.26); C1566(0.26); C581(0.54); C105(0.62)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C1563(0.37); C1566(0.37); C50(0.61); C3122(0.66)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C1563(0.52); C1566(0.52); C581(0.60); C50(0.63)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C1563(0.27); C1566(0.27); C581(0.59); C50(0.64)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C3122(0.38); C2982(0.68); C2084(0.69); C1563(0.70)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C3122(0.62); C2737(0.64); C2740(0.64); C536(0.65)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C2982(0.33); C188(0.28); C2577(0.45); C105(0.71)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C2982(0.98); C82(0.94); C105(0.86)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C1499(1.20); C1502(1.20); C2407(1.25); C50(0.98)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C581(0.50); C1435(0.76); C1438(0.76); C536(0.83)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C581(0.72); C3122(0.77); C220(0.97); C2982(1.00)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C2407(1.17); C2710(1.06); C1435(1.05); C1438(1.05)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C2982(0.42); C2381(0.64); C188(0.48); C3032(0.46)  LDD2091  [9]
 LDCM0087  Capsaicin HEK-293T 6.99  LDD0185  [10]
 LDCM0108  Chloroacetamide HeLa C188(0.00); C206(0.00); C2982(0.00); C3071(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C188(3.72); C536(2.39); C1335(1.35); C2696(1.08)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C1612(0.56); C1615(0.56); C1791(0.58); C1790(0.62)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C581(0.44); C3122(0.84); C1791(0.89); C206(0.91)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C581(0.53); C1499(0.68); C1502(0.68); C536(0.89)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C581(0.61); C105(0.78); C3122(0.78); C536(0.90)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C581(0.51); C105(0.70); C1612(0.73); C1615(0.73)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C581(0.64); C1612(0.80); C1615(0.81); C3122(0.86)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C581(0.79); C105(0.83); C2710(0.89); C220(0.90)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C2659(0.60); C1552(0.60); C3040(0.68); C1626(0.68)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C3100(0.55); C2659(0.57); C1626(0.65); C1629(0.65)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C3040(0.55); C2659(0.62); C1615(0.73); C1552(0.77)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C1626(0.64); C1629(0.64); C1552(0.68); C2659(0.68)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C2659(0.63); C2142(0.66); C1615(0.72); C1552(0.73)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C581(0.53); C2084(0.80); C1749(0.88); C3122(0.89)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C1563(0.53); C1566(0.53); C3100(0.63); C2659(0.67)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C1563(0.55); C1566(0.55); C2142(0.63); C2659(0.66)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C3040(0.57); C1790(0.62); C2084(0.78); C1563(0.79)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C2084(0.63); C1612(0.68); C1615(0.68); C2982(0.74)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C1612(0.53); C1615(0.53); C3040(0.55); C2084(0.61)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C3040(0.59); C1790(0.69); C2084(0.69); C1612(0.71)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C3040(0.67); C206(0.79); C2084(0.80); C581(0.81)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C3122(0.67); C3100(0.77); C581(0.79); C1747(0.80)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C581(0.66); C1485(0.76); C1488(0.76); C3122(0.79)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C581(0.76); C50(0.77); C815(0.79); C3040(0.81)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C581(0.50); C2084(0.78); C3122(0.85); C105(1.00)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C581(0.49); C3100(0.64); C1801(0.66); C1804(0.66)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C3122(0.59); C1563(0.63); C1566(0.63); C206(0.67)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C3040(0.62); C1563(0.65); C1566(0.65); C2982(0.73)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C1801(0.63); C1804(0.63); C2982(0.72); C3040(0.72)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C3040(0.68); C2982(0.77); C581(0.81); C1563(0.81)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C581(0.80); C1801(0.81); C1804(0.81); C2659(0.83)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C1549(0.80); C1552(0.80); C1626(0.85); C1629(0.85)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C1801(0.77); C1804(0.77); C2659(0.80); C581(0.83)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C3122(0.82); C1549(0.89); C1552(0.89); C2084(0.92)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C2084(0.77); C581(0.81); C2710(0.88); C536(0.88)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C1791(0.65); C536(0.73); C581(0.74); C1790(0.80)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C1749(0.76); C536(0.80); C2084(0.81); C105(0.82)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C188(0.84); C105(0.88); C2710(0.90); C2659(0.93)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C2142(0.58); C2710(0.64); C105(0.87); C2696(0.87)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C2142(0.57); C188(0.85); C2710(0.86); C2659(0.90)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C2142(0.72); C2710(0.75); C1499(0.78); C1502(0.78)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C1791(0.67); C1612(0.72); C1615(0.72); C2737(0.74)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C2142(0.47); C3122(0.67); C2710(0.77); C2982(0.90)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C2142(0.55); C2710(0.56); C3122(0.62); C1626(0.80)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C3122(0.58); C1499(0.73); C1502(0.73); C1563(0.77)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C3122(0.85); C2710(0.97); C105(1.00); C2982(1.00)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C1499(1.05); C1502(1.05); C2407(1.41); C105(1.08)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C1499(1.20); C1502(1.20); C2407(1.28); C105(1.24)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C1499(0.96); C1502(0.96); C2407(1.19); C105(0.99)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C1499(1.02); C1502(1.02); C2407(1.24); C105(1.07)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C1499(0.97); C1502(0.97); C2407(1.32); C105(1.06)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C1499(0.95); C1502(0.95); C2407(1.24); C105(1.09)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C1499(2.20); C1502(2.20); C2407(0.92); C50(0.90)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C1499(0.90); C1502(0.90); C2407(1.18); C105(1.15)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C1499(0.83); C1502(0.83); C2407(1.06); C50(1.13)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C1499(0.82); C1502(0.82); C2407(1.11); C50(1.03)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C1499(0.61); C1502(0.61); C2407(1.03); C50(0.99)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C1499(0.81); C1502(0.81); C2407(1.32); C50(1.44)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C1499(0.81); C1502(0.81); C2407(1.27); C50(1.43)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C1499(0.87); C1502(0.87); C2407(1.15); C50(1.52)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C1499(0.90); C1502(0.90); C2407(1.30); C50(1.37)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C1499(1.01); C1502(1.01); C2407(1.27); C50(1.37)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C1499(1.00); C1502(1.00); C2407(0.93); C50(0.90)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C1499(1.36); C1502(1.36); C2407(1.14); C50(1.13)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C1499(0.91); C1502(0.91); C2407(1.14); C50(1.46)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C1499(0.90); C1502(0.90); C2407(1.70); C50(2.01)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C1499(0.90); C1502(0.90); C2407(1.30); C50(1.72)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C1499(1.07); C1502(1.07); C2407(1.31); C50(1.31)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C1499(0.90); C1502(0.90); C2407(1.39); C50(1.50)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C1499(1.22); C1502(1.24); C2407(1.17); C50(1.28)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C1499(1.05); C1502(1.24); C2407(1.23); C50(1.16)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C1499(0.92); C1502(1.13); C2407(1.12); C50(1.16)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C1499(1.41); C1502(1.29); C2407(0.99); C50(0.97)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C1499(1.48); C1502(1.48); C2407(0.96); C50(0.89)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C1499(1.74); C1502(1.34); C2407(0.97); C50(1.07)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C1499(0.99); C1502(1.04); C2407(1.18); C50(1.33)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C1499(1.12); C1502(0.99); C2407(1.23); C50(1.24)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C1499(0.94); C1502(1.14); C2407(1.14); C50(1.69)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C1499(1.56); C1502(1.28); C2407(1.07); C50(1.35)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C1499(1.21); C1502(1.08); C2407(1.04); C50(1.36)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C1499(1.11); C1502(1.01); C2407(0.99); C50(1.19)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C1499(1.25); C1502(1.06); C2407(1.14); C50(1.13)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C1499(1.54); C1502(1.47); C2407(1.10); C50(1.52)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C1499(0.96); C1502(0.95); C2407(1.07); C50(1.47)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C1499(1.47); C1502(1.47); C2407(1.00); C50(1.09)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C1499(1.23); C1502(1.12); C2407(1.21); C50(1.24)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C2407(1.03); C50(1.07); C1196(1.15); C1372(1.01)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C2407(1.11); C50(1.27); C1196(0.96); C1372(1.08)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C2407(1.25); C50(1.22); C1196(1.04); C1372(1.04)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C2407(1.48); C50(1.38); C1196(1.16); C1372(1.17)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C2407(1.03); C50(1.06); C1196(1.08); C1372(1.01)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C2407(1.67); C50(1.47); C1196(1.33); C1372(1.27)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C2407(1.38); C50(1.52); C1196(0.96); C1372(1.31)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C2407(1.21); C50(1.19); C1196(1.14); C1372(1.14)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C2407(0.99); C50(1.40); C1196(1.10); C1372(1.17)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C1499(1.51); C1502(1.51); C2407(1.19); C50(1.06)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C2407(1.21); C50(1.44); C1196(1.16); C1372(1.14)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C2407(1.27); C50(1.29); C1196(0.99); C1372(1.13)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C2407(1.03); C50(1.17); C1196(0.98); C1372(1.24)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C2407(1.22); C50(4.31); C1196(1.09); C1372(1.03)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C2407(1.21); C50(2.02); C1196(1.21); C1372(1.17)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C1499(0.83); C1502(0.83); C2407(1.04); C50(0.91)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C1499(0.66); C1502(0.66); C2407(1.02); C50(0.92)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C1499(0.67); C1502(0.67); C2407(1.13); C50(0.99)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C1499(1.01); C1502(1.01); C2407(1.17); C50(0.88)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C1499(1.11); C1502(1.11); C2407(1.30); C50(1.23)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C1499(0.96); C1502(0.96); C2407(0.98); C50(0.87)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C1499(0.74); C1502(0.74); C2407(1.09); C50(0.94)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C1499(0.74); C1502(0.74); C2407(1.29); C50(0.98)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C1499(0.87); C1502(0.87); C2407(1.34); C50(0.83)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C1499(0.88); C1502(0.88); C2407(1.42); C50(0.87)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C1499(0.75); C1502(0.75); C2407(1.13); C50(1.11)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C1499(0.79); C1502(0.79); C2407(1.08); C50(0.98)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C1499(0.61); C1502(0.61); C2407(1.19); C50(0.90)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C1499(0.94); C1502(0.94); C2407(1.27); C50(1.11)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C1499(0.73); C1502(0.73); C2407(1.71); C50(0.96)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C1499(1.78); C1502(1.78); C2407(1.01); C50(1.00)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C1499(0.64); C1502(0.64); C2407(0.94); C50(1.28)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C1499(0.70); C1502(0.70); C2407(1.41); C50(0.88)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C1499(0.65); C1502(0.65); C2407(1.03); C50(0.91)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C1499(0.62); C1502(0.62); C2407(1.07); C50(1.10)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C1499(0.78); C1502(0.78); C2407(0.90); C50(1.04)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C1499(0.72); C1502(0.72); C2407(1.04); C50(0.82)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C1499(0.84); C1502(0.84); C2407(1.09); C50(0.89)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C1499(1.03); C1502(1.03); C2407(1.19); C50(0.94)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C1499(0.95); C1502(0.95); C2407(1.14); C50(0.80)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C1499(0.79); C1502(0.79); C2407(1.04); C50(0.82)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C105(1.82); C206(0.69); C220(0.15)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C188(0.87); C2696(0.85); C2982(0.98); C707(0.97)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C105(6.91); C815(4.38); C82(1.98); C2381(1.41)  LDD1702  [9]
 LDCM0625  F8 Ramos C1196(1.11); C348(0.93); C2982(0.92); C815(2.07)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C1196(0.94); C348(1.04); C2982(0.61); C105(0.46)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C1196(1.60); C348(0.14); C2982(6.85); C105(0.41)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C1196(0.99); C348(1.47); C2982(0.61); C105(1.02)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C1196(1.03); C348(0.96); C105(0.40); C815(1.03)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C1196(1.18); C348(1.62); C2982(0.79); C105(1.01)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C1196(0.86); C348(1.68); C2982(0.52); C3040(0.40)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C1196(1.13); C348(1.21); C2982(0.84); C105(0.69)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C1196(1.15); C348(0.84); C2982(0.24); C3040(0.46)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C1196(0.96); C348(1.00); C2982(1.03); C815(0.72)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C1196(0.97); C348(1.19); C2982(0.75); C105(0.55)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C1196(1.30); C348(1.19); C2982(0.89); C815(1.09)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C1196(1.04); C348(0.97); C105(0.55); C3040(1.02)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C1196(0.98); C348(1.45); C2982(0.66); C815(2.63)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C2407(1.22); C50(1.46); C1196(1.20); C1372(1.19)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C1196(1.10); C348(0.78); C2982(0.59); C105(0.64)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C1196(0.60); C348(1.05); C105(2.02); C815(2.08)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C1499(0.88); C1502(0.88); C2407(1.62); C50(1.96)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C1196(1.15); C348(1.18); C2982(0.59); C105(0.26)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C1196(1.34); C348(0.87); C2982(0.99); C815(1.06)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C1196(0.64); C348(1.04); C2982(0.57); C105(1.05)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C1196(0.94); C348(1.93); C2982(0.59); C3040(0.49)  LDD2188  [35]
 LDCM0116  HHS-0101 DM93 Y2609(1.21); Y1983(5.85)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y2609(1.87); Y1983(3.57)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y2609(1.10)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y2609(1.50); Y1983(3.89)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y1983(0.92); Y2609(1.79)  LDD0268  [13]
 LDCM0107  IAA HeLa H1830(0.00); C3100(0.00); H557(0.00); H2418(0.00)  LDD0221  [27]
 LDCM0022  KB02 HCT 116 C536(2.38); C1801(1.28); C1804(1.28); C1549(1.57)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C536(3.53); C1801(1.40); C1804(1.40); C1549(1.34)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C536(4.49); C1801(2.14); C1804(2.14); C1549(2.04)  LDD0082  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C2982(1.08); C2381(1.28); C2577(0.97); C105(1.12)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C2982(0.43); C188(0.77); C2577(0.41); C1243(0.57)  LDD2121  [9]
 LDCM0109  NEM HeLa H1830(0.00); H557(0.00); H2155(0.00); C3100(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C2982(0.55); C188(0.68); C1243(0.65); C105(0.74)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C82(1.04); C3032(1.07); C105(1.09); C524(1.08)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C2982(1.30); C2381(1.08); C2577(0.86); C815(0.75)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C2982(1.17); C2381(1.03); C188(1.03); C82(1.01)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C2982(1.59); C2381(1.22); C2577(1.05); C105(0.93)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C2982(0.81); C2381(0.73); C3032(0.31); C2577(0.70)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C2982(1.44); C2381(1.62); C1243(1.30)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C2982(1.56); C2381(1.17); C188(0.79); C82(0.73)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C2982(1.43); C2381(1.10); C188(1.68); C82(0.99)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C2982(0.66); C2381(0.88); C188(0.96); C3032(0.54)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C2982(1.02); C2577(0.69); C1243(1.04); C105(0.75)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C2982(0.73); C2381(0.92); C188(0.75); C3032(0.68)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C2982(0.95); C2381(1.01); C82(1.19); C3032(0.38)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C2381(0.78); C82(0.76); C3032(0.53); C1243(0.79)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2982(1.12); C188(1.35); C82(1.09); C3032(1.17)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C2982(0.94); C2381(1.07); C188(0.97); C82(0.71)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2982(1.19); C2381(0.71); C188(1.34); C82(0.69)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C2982(0.87); C2381(0.96); C188(0.84); C82(0.91)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C2982(0.74); C188(1.72); C82(1.11); C3032(0.85)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C2982(0.62); C2381(0.92); C188(0.68); C82(0.59)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C2982(1.01); C1243(0.81); C105(0.58)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C2982(1.12); C2381(0.87); C2577(0.98)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C2381(0.79); C2577(0.96); C1296(0.38)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C2982(0.90); C2381(1.49); C188(2.10); C2577(2.46)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C2982(0.36); C2381(1.00); C2577(0.80)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C2982(0.67); C2577(1.03); C105(0.29)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2982(1.01); C188(1.30); C82(0.94); C2577(0.86)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C2381(1.24); C3032(0.40); C2577(0.94)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2982(1.00); C188(1.54); C82(0.82); C3032(0.89)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C3032(0.45); C2577(0.91); C2142(1.21)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C2982(1.04); C82(0.99); C3032(0.98); C2577(0.89)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C2381(0.59); C3032(0.90); C2577(1.25)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2982(1.10); C2381(1.13); C188(1.23); C82(1.20)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C2982(0.68); C2577(0.72); C1243(0.93)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1243(0.84); C105(0.47)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2982(1.09); C2381(1.06); C188(1.27); C82(1.24)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C2982(1.44); C188(2.15); C82(1.28); C3032(1.17)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2982(0.97); C2381(0.85); C188(1.73); C82(0.97)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C3032(2.55); C188(2.31); C2381(1.31); C2577(0.94)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2982(0.91); C2381(0.72); C188(1.09); C82(0.98)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C2982(0.75); C2381(1.22); C188(0.95); C3032(1.08)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2577(1.13)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2982(1.34); C2381(1.29); C188(2.80); C82(1.84)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C2982(0.94); C2381(2.31); C1243(1.55)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C2982(0.91); C2381(0.86); C188(1.67); C82(0.94)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C2982(0.65); C1243(0.91); C105(0.50)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C2381(0.92); C2577(1.03)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C2381(0.32); C188(0.60); C1243(0.38); C105(0.57)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C2381(0.84); C3032(0.55); C2577(2.87)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C82(0.99); C3032(1.08); C2577(1.33)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C815(0.89); C82(0.24)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C188(0.86); C105(0.82); C524(0.69); C82(0.63)  LDD2207  [36]
 LDCM0131  RA190 MM1.R 3.20  LDD0299  [12]
 LDCM0021  THZ1 HCT 116 C1549(1.32); C1552(1.32); C1499(1.66); C1502(1.66)  LDD2173  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
E3 ubiquitin-protein ligase parkin (PRKN) RBR family, Parkin subfamily O60260
GTP-binding nuclear protein Ran (RAN) Ran family P62826
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ran GTPase-activating protein 1 (RANGAP1) RNA1 family P46060
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein bicaudal D homolog 2 (BICD2) BicD family Q8TD16
PDZ and LIM domain protein 3 (PDLIM3) . Q53GG5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
30 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.