Details of the Target

General Information of Target

Target ID LDTP03527
Target Name G1/S-specific cyclin-D2 (CCND2)
Gene Name CCND2
Gene ID 894
Synonyms
G1/S-specific cyclin-D2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA
TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA
EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH
AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV
DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
Target Bioclass
Other
Family
Cyclin family, Cyclin D subfamily
Subcellular location
Cytoplasm; Nucleus
Function
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Uniprot ID
P30279
Ensemble ID
ENST00000261254.8
HGNC ID
HGNC:1583
ChEMBL ID
CHEMBL2095942

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L100R .
HSC4 SNV: p.L174V .
KMS27 SNV: p.P117L DBIA    Probe Info 
RPMI8226 SNV: p.Q265Ter DBIA    Probe Info 
U118MG SNV: p.P281A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C242(6.13)  LDD0304  [1]
Alkyne-RA190
 Probe Info  		8.33  LDD0299  [1]
DBIA
 Probe Info  		C41(8.50)  LDD0080  [2]
IPM
 Probe Info  		C242(0.00); C41(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C124(1.38)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C124(0.89)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C242(1.10)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C124(1.02)  LDD1512  [4]
 LDCM0276  AC17 HEK-293T C124(0.99)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C124(1.26)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C124(0.95)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C242(0.95)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C124(1.06)  LDD1521  [4]
 LDCM0285  AC25 HEK-293T C124(1.20)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C124(1.18)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C242(1.07)  LDD1527  [4]
 LDCM0291  AC30 HEK-293T C124(1.11)  LDD1530  [4]
 LDCM0294  AC33 HEK-293T C124(1.28)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C124(0.97)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C242(1.03)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C124(1.14)  LDD1538  [4]
 LDCM0301  AC4 HEK-293T C242(1.02)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C124(1.12)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C124(1.01)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C242(1.06)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C124(1.08)  LDD1547  [4]
 LDCM0311  AC49 HEK-293T C124(1.07)  LDD1550  [4]
 LDCM0313  AC50 HEK-293T C124(1.10)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C242(1.16)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C124(1.46)  LDD1556  [4]
 LDCM0320  AC57 HEK-293T C124(1.71)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C124(0.88)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C124(1.15)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C242(0.95)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C124(0.83)  LDD1565  [4]
 LDCM0356  AKOS034007680 HEK-293T C124(1.73)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C124(0.91)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C124(1.63)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C124(0.74)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C124(1.35)  LDD1575  [4]
 LDCM0374  CL105 HEK-293T C124(0.77)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C124(1.11)  LDD1579  [4]
 LDCM0378  CL109 HEK-293T C124(1.00)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C124(1.22)  LDD1584  [4]
 LDCM0383  CL113 HEK-293T C124(0.77)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C124(1.19)  LDD1588  [4]
 LDCM0387  CL117 HEK-293T C124(0.91)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C124(1.12)  LDD1592  [4]
 LDCM0392  CL121 HEK-293T C124(0.53)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C124(0.94)  LDD1597  [4]
 LDCM0396  CL125 HEK-293T C124(0.95)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C124(0.99)  LDD1601  [4]
 LDCM0400  CL13 HEK-293T C124(0.66)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C124(0.96)  LDD1605  [4]
 LDCM0404  CL17 HEK-293T C124(1.04)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C124(1.25)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C124(1.02)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C242(1.11)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C124(1.05)  LDD1614  [4]
 LDCM0413  CL25 HEK-293T C124(1.26)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C124(1.03)  LDD1618  [4]
 LDCM0417  CL29 HEK-293T C124(1.14)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C124(1.14)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C242(1.02)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C124(1.04)  LDD1627  [4]
 LDCM0426  CL37 HEK-293T C124(0.50)  LDD1630  [4]
 LDCM0431  CL41 HEK-293T C124(1.18)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C124(1.24)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C242(1.14)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C124(1.14)  LDD1640  [4]
 LDCM0439  CL49 HEK-293T C124(0.90)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C124(1.71)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C124(0.99)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C124(1.68)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C124(1.47)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C242(1.14)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C124(0.98)  LDD1652  [4]
 LDCM0451  CL6 HEK-293T C124(1.53)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C124(0.80)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C124(1.32)  LDD1657  [4]
 LDCM0457  CL65 HEK-293T C124(0.92)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C124(0.90)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C242(0.99)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C124(1.33)  LDD1666  [4]
 LDCM0466  CL73 HEK-293T C124(1.10)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C124(1.10)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C124(1.35)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C124(1.05)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C242(1.38)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C242(1.00)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C124(0.95)  LDD1679  [4]
 LDCM0479  CL85 HEK-293T C124(0.78)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C124(1.03)  LDD1683  [4]
 LDCM0483  CL89 HEK-293T C124(1.13)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C124(2.01)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C242(1.12)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C124(1.09)  LDD1692  [4]
 LDCM0492  CL97 HEK-293T C124(0.90)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C124(1.27)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C124(0.91)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C41(8.50)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C41(10.38)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C41(12.23)  LDD0082  [2]
 LDCM0131  RA190 MM1.R 8.33  LDD0299  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 5 (CDK5) CMGC Ser/Thr protein kinase family Q00535
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402