Details of the Target

General Information of Target

Target ID LDTP13913
Target Name Inner nuclear membrane protein Man1 (LEMD3)
Gene Name LEMD3
Gene ID 23592
Synonyms
MAN1; Inner nuclear membrane protein Man1; LEM domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
AKLRPSADELLRHMFVHYH
Target Bioclass
Other
Subcellular location
Nucleus inner membrane
Function Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Uniprot ID
Q9Y2U8
Ensemble ID
ENST00000308330.3
HGNC ID
HGNC:28887

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		6.55  LDD0348  [2]
HRP
 Probe Info  		5.67  LDD0347  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y441(9.65)  LDD0260  [4]
STPyne
 Probe Info  		K787(0.08)  LDD0277  [5]
P12
 Probe Info  		7.33  LDD0202  [6]
BTD
 Probe Info  		C684(1.00)  LDD1700  [7]
YY4-yne
 Probe Info  		2.66  LDD0400  [8]
AHL-Pu-1
 Probe Info  		C346(3.96)  LDD0170  [9]
Alkyne-RA190
 Probe Info  		2.08  LDD0299  [10]
DBIA
 Probe Info  		C754(1.15)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
1d-yne
 Probe Info  		N.A.  LDD0358  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C547(0.00); C838(0.00); C684(0.00); C108(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C684(0.00); C108(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
WYneN
 Probe Info  		C547(0.00); C754(0.00)  LDD0021  [17]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
Compound 10
 Probe Info  		C108(0.00); C754(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		C754(0.00); C547(0.00); C108(0.00)  LDD0005  [17]
TFBX
 Probe Info  		C254(0.00); C108(0.00); C785(0.00)  LDD0148  [19]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C254(0.00); C346(0.00); C754(0.00); C108(0.00)  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C547(0.00); C684(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		C547(0.00); C684(0.00)  LDD0218  [21]
W1
 Probe Info  		C684(0.00); C108(0.00)  LDD0236  [22]
NAIA_5
 Probe Info  		C814(0.00); C547(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		5.03  LDD1945  [23]
C388
 Probe Info  		39.67  LDD2047  [23]
C390
 Probe Info  		24.59  LDD2049  [23]
FFF probe11
 Probe Info  		20.00  LDD0471  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
Alk-rapa
 Probe Info  		3.54  LDD0213  [25]
OEA-DA
 Probe Info  		6.52  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C684(0.76)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C108(0.71)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C547(0.87); C684(0.69)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C684(1.17)  LDD2152  [7]
 LDCM0025  4SU-RNA DM93 C346(3.96)  LDD0170  [9]
 LDCM0214  AC1 HCT 116 C254(1.17); C346(0.98); C684(0.85); C754(1.07)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C684(0.94); C754(1.22); C814(1.06); C833(0.63)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C108(1.34); C254(0.79); C346(0.97); C684(0.43)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C108(1.38); C254(0.85); C346(0.90); C684(0.44)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C108(1.24); C254(1.10); C346(0.78); C684(0.43)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C108(1.32); C254(1.74); C346(1.24); C684(0.27)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C108(1.08); C254(1.27); C346(1.09); C684(0.28)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C108(1.89); C254(1.17); C346(1.16); C684(0.28)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C108(1.99); C254(0.80); C346(1.15); C684(0.32)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C108(1.53); C254(1.13); C346(1.12); C684(0.34)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C108(2.01); C254(0.58); C346(0.96); C684(0.46)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C108(1.30); C254(1.36); C346(0.74); C684(0.43)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C684(0.91); C754(1.26); C814(1.15); C833(0.64)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C108(2.07); C254(1.11); C346(0.83); C684(0.42)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C108(2.91); C254(1.23); C346(0.70); C684(0.47)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C108(2.01); C254(0.96); C346(1.13); C684(0.36)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C108(0.90); C346(1.06); C622(0.93); C684(0.92)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C108(0.85); C346(1.64); C622(0.85); C684(0.57)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C108(0.95); C346(1.32); C622(1.02); C684(0.45)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C108(0.85); C346(1.51); C622(0.95); C684(0.40)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C108(1.15); C346(1.50); C622(0.87); C684(0.60)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C108(0.84); C346(1.30); C622(0.99); C684(0.63)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C108(0.88); C346(1.32); C622(1.00); C684(0.58)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C684(0.96); C754(1.11); C814(1.07); C833(0.77)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C108(0.85); C346(1.22); C622(0.94); C684(0.49)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C108(1.12); C346(1.19); C622(0.96); C684(0.81)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C108(0.81); C346(1.08); C622(0.94); C684(0.92)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C108(0.82); C346(1.01); C622(0.98); C684(0.89)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C108(1.10); C346(0.99); C622(0.99); C684(0.76)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C108(0.84); C346(1.18); C622(0.84); C684(0.74)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C108(0.90); C346(1.77); C622(0.91); C684(0.47)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C108(0.83); C346(1.85); C622(0.96); C684(0.48)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C622(1.34); C684(0.98); C754(1.45); C814(0.80)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C622(1.19); C684(1.47); C754(0.97); C814(1.01)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C622(1.40); C684(1.00); C754(1.48); C814(0.84)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C622(1.31); C684(1.19); C754(0.88); C814(1.16)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C622(1.39); C684(1.54); C754(1.05); C814(1.21)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C622(1.28); C684(1.27); C754(1.30); C814(0.89)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C622(1.29); C684(1.05); C754(1.34); C814(0.81)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C622(1.45); C684(1.15); C754(1.37); C814(0.75)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C622(1.45); C684(1.07); C754(1.21); C814(0.88)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C622(1.52); C684(1.14); C754(1.14); C814(0.96)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C622(1.28); C684(1.11); C754(1.36); C814(0.89)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C622(1.38); C684(1.12); C754(1.29); C814(0.90)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C684(1.00); C754(1.04); C814(1.21); C833(0.78)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C622(1.30); C684(1.04); C754(1.45); C814(0.83)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C622(1.54); C684(1.17); C754(1.39); C814(0.83)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C622(1.43); C684(1.93); C754(1.10); C814(1.20)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C684(0.77); C346(1.14); C754(1.21)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C684(0.63); C754(1.42); C346(2.16)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C684(0.75); C754(1.11); C346(1.13)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C684(0.70); C754(1.45); C346(2.19)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C684(0.58); C754(1.54); C346(1.77)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C684(0.72); C754(2.05); C346(2.10)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C684(0.76); C754(1.89); C346(2.04)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C833(0.67); C684(0.78); C814(0.98); C754(1.08)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C684(0.72); C346(1.19); C754(1.24)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C684(0.85); C754(1.14); C346(1.15)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C684(0.65); C754(1.55); C346(1.59)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C684(0.91); C754(2.17); C346(3.33)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C346(2.03); C684(0.71); C754(1.28)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C346(1.68); C684(0.72); C754(1.46)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C346(1.53); C684(0.91); C754(1.06)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C346(1.52); C684(0.93); C754(0.99)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C346(0.44); C684(0.78); C833(0.86); C814(1.09)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C684(0.53); C833(0.62); C346(1.00); C108(1.05)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C684(0.66); C346(0.72); C833(0.78); C785(1.12)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C684(0.83); C754(1.10); C346(1.13); C254(1.34)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C346(0.58); C684(0.80); C833(0.80); C785(0.85)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C684(0.62); C833(0.71); C346(0.78); C754(1.06)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C346(0.53); C684(0.81); C833(0.83); C785(0.93)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C346(0.53); C684(0.78); C833(0.79); C785(1.07)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C346(0.40); C684(0.87); C833(0.92); C814(0.99)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C684(0.92); C754(1.10)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C684(0.71); C754(1.12)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C684(0.67); C754(1.13)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C684(0.67); C754(1.23)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C684(0.66); C754(1.18)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C684(0.80); C346(0.96); C254(1.03); C754(1.11)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C684(0.64); C754(1.19)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C684(0.70); C754(1.23)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C684(0.52); C754(1.59)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C684(0.58); C754(1.13)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C684(0.52); C754(1.47)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C754(0.80); C785(1.19); C814(1.23); C684(1.28)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C785(1.02); C754(1.05); C814(1.13); C838(1.17)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C838(0.72); C754(1.14); C814(1.22); C684(1.23)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C754(0.97); C838(0.98); C785(0.99); C684(1.16)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C838(0.97); C785(0.99); C754(0.99); C684(0.99)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C684(0.62); C254(1.00); C346(1.04); C754(1.20)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C838(0.74); C814(0.92); C684(0.97); C785(1.07)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C838(0.93); C684(0.97); C814(1.06); C754(1.10)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C838(0.76); C785(1.01); C684(1.05); C754(1.09)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C785(0.91); C838(1.00); C684(1.02); C754(1.07)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C814(1.04); C838(1.04); C754(1.07); C684(1.09)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C838(0.74); C814(1.11); C684(1.11); C754(1.16)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C684(0.95); C814(1.10); C754(1.14); C785(1.21)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C684(0.90); C814(0.91); C838(0.93); C754(1.10)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C684(1.11); C754(1.11); C785(1.12); C814(1.19)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C684(0.81); C785(0.86); C814(0.86); C838(0.86)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C684(0.65); C346(0.86); C254(1.15); C754(1.17)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C684(0.74); C838(0.76); C814(0.81); C785(1.05)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C754(0.93); C684(0.98); C814(1.70); C838(1.95)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C785(0.82); C684(0.85); C838(0.90); C814(1.00)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C684(0.79); C785(0.90); C838(0.93); C814(0.94)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C838(0.80); C684(0.85); C814(0.95); C785(1.04)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C785(0.81); C838(0.82); C814(0.86); C684(0.87)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C684(0.77); C785(0.98); C814(1.00); C838(1.00)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C785(0.36); C684(0.73); C754(1.68)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C785(0.41); C684(0.66); C754(1.73)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C785(0.37); C684(0.74); C754(1.75)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C833(0.64); C684(0.77); C814(0.91); C754(1.21)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C785(0.49); C684(0.97); C754(1.62)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C785(0.43); C684(0.82); C754(1.52)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C785(0.34); C684(0.68); C754(2.06)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C785(0.41); C684(0.94); C754(1.59)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C785(0.39); C684(1.01); C754(2.00)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C785(0.43); C684(0.70); C754(2.16)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C785(0.43); C684(0.75); C754(1.97)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C785(0.39); C684(0.66); C754(2.54)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C785(0.69); C833(0.69); C838(0.85); C684(0.95)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C785(0.69); C838(0.73); C833(0.78); C684(1.00)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C833(0.85); C684(1.01); C814(1.03); C754(1.11)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C838(0.57); C785(0.59); C833(0.65); C684(0.96)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C833(0.85); C785(0.94); C838(1.00); C684(1.09)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C785(0.64); C838(0.67); C833(0.69); C684(0.95)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C785(0.75); C838(0.78); C684(0.86); C833(0.90)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C785(0.68); C838(0.80); C684(0.93); C833(0.96)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C785(0.75); C838(0.88); C833(0.95); C684(1.02)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C785(0.61); C833(0.61); C838(0.69); C684(0.99)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C833(0.61); C785(0.62); C838(0.63); C684(0.93)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C785(0.79); C833(0.84); C684(1.03); C838(1.04)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C785(0.77); C838(0.83); C684(0.93); C833(0.95)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C833(0.76); C684(0.84); C814(0.92); C754(1.23)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C785(0.56); C833(0.65); C838(0.72); C684(0.82)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C785(1.00); C754(1.09); C684(1.15); C833(1.16)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C785(0.62); C838(0.70); C684(1.03); C833(1.13)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C838(0.39); C684(0.41); C814(0.57); C254(0.58)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C838(0.37); C684(0.41); C254(0.56); C833(0.62)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C254(0.40); C684(0.54); C838(0.59); C814(0.69)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C254(0.34); C684(0.50); C838(0.54); C814(0.73)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C254(0.41); C838(0.79); C684(0.80); C833(0.87)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C254(0.42); C684(0.48); C838(0.60); C833(0.73)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C254(0.34); C838(0.42); C684(0.44); C833(0.59)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C254(0.48); C814(1.04); C622(1.08); C833(1.09)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C684(0.37); C838(0.38); C254(0.39); C833(0.59)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C254(0.32); C838(0.35); C684(0.38); C833(0.55)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C838(0.45); C684(0.47); C254(0.50); C833(0.70)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C254(0.29); C684(0.54); C838(0.68); C833(0.80)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C254(0.41); C838(0.84); C833(0.91); C814(0.97)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C254(0.42); C684(0.46); C838(0.54); C833(0.64)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C684(0.37); C838(0.37); C254(0.41); C833(0.61)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C838(0.22); C684(0.26); C785(0.64); C754(1.73)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C838(0.51); C684(0.59); C785(0.72); C346(0.78)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C547(0.98); C684(0.91)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C684(1.10); C754(1.04); C814(1.14); C833(0.98)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C833(0.82); C684(0.98); C754(1.13); C814(1.23)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C833(0.43); C684(0.66); C814(0.79); C754(1.67)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C754(1.15)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C547(0.56)  LDD2091  [7]
 LDCM0088  C45 HEK-293T 7.33  LDD0202  [6]
 LDCM0087  Capsaicin HEK-293T 6.42  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa C108(0.00); C684(0.00)  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C108(0.71); C754(0.92); C785(0.98); C814(0.98)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C254(0.27); C108(0.62); C814(0.72); C684(0.87)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C684(0.65); C346(1.05); C254(1.08); C754(1.24)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C833(0.62); C684(0.78); C814(0.97); C754(1.14)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C833(0.85); C684(0.95); C814(1.00); C754(1.12)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C833(0.92); C754(1.07); C684(1.14); C814(1.15)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C833(0.87); C684(0.97); C754(1.05); C814(1.11)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C684(0.58); C833(0.61); C346(0.89); C814(1.25)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C833(0.46); C684(0.48); C814(1.44); C785(1.48)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C833(0.45); C684(0.49); C346(0.77); C814(1.16)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C684(0.41); C833(0.44); C346(0.91); C814(1.17)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C684(0.51); C833(0.56); C346(0.94); C785(1.07)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C254(0.32); C814(0.73); C108(0.75); C684(0.84)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C684(0.44); C833(0.51); C346(0.93); C814(0.93)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C684(0.60); C346(0.60); C833(0.75); C785(0.91)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C684(0.86); C754(1.17)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C684(0.53); C754(1.33)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C684(0.68); C754(1.26)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C684(0.62); C754(1.18)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C684(0.66); C754(1.30)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C838(0.80); C785(0.90); C684(0.94); C814(1.21)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C838(0.82); C814(1.00); C684(1.03); C754(1.09)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C838(0.77); C684(0.88); C814(1.00); C785(1.02)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C254(0.20); C108(0.75); C814(0.76); C684(0.87)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C785(0.99); C684(1.04); C838(1.13); C754(1.16)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C785(0.45); C684(0.81); C754(0.92); C814(1.07)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C684(0.85); C814(1.05); C838(1.06); C785(1.14)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C684(0.71); C838(0.81); C785(0.87); C814(0.88)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C684(0.74); C838(0.82); C814(0.87); C785(1.02)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C785(0.63); C684(0.86); C754(1.15)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C785(0.56); C684(0.65); C754(1.16)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C785(0.62); C684(0.84); C754(1.26)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C785(0.38); C684(0.83); C754(1.55)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C108(0.71); C814(0.90); C254(0.93); C684(0.99)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C108(0.63); C254(0.98); C814(0.98); C684(1.00)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C108(0.71); C684(0.94); C814(0.97); C754(1.26)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C785(0.65); C814(0.76); C684(0.80); C833(0.90)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C785(0.63); C814(0.65); C833(0.80); C108(0.89)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C814(0.62); C785(0.62); C833(0.77); C108(0.95)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C785(0.56); C833(0.74); C814(0.77); C684(0.81)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C108(0.77); C754(0.95); C785(1.16); C684(1.17)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C785(0.41); C833(0.52); C814(0.56); C684(0.70)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C785(0.38); C814(0.50); C833(0.54); C684(0.73)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C785(0.47); C814(0.67); C108(0.74); C833(0.77)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C785(0.43); C814(0.55); C833(0.59); C684(0.71)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C785(0.37); C814(0.51); C833(0.56); C684(0.62)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C108(1.01); C622(0.91); C684(0.72); C754(1.33)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C108(1.30); C622(0.98); C684(0.65); C754(1.10)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C108(1.01); C622(1.13); C684(0.78); C754(1.04)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C108(1.07); C622(1.01); C684(0.71); C754(1.15)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C108(1.01); C622(0.98); C684(0.82); C754(1.10)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C108(0.77); C254(0.97); C684(0.97); C754(0.91)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C108(1.08); C622(1.06); C684(0.82); C754(0.97)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C108(0.90); C684(0.60); C754(1.04); C814(0.79)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C108(0.96); C684(0.83); C754(1.16); C814(0.63)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C108(1.12); C684(0.66); C754(1.08); C814(0.73)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C108(0.96); C684(0.66); C754(1.17); C814(0.51)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C108(1.03); C684(0.64); C754(1.33); C814(0.48)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C108(1.04); C684(0.69); C754(1.10); C814(0.54)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C108(1.00); C684(0.72); C754(1.24); C814(0.59)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C108(1.15); C684(0.55); C754(1.30); C814(0.54)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C108(0.98); C254(0.86); C684(0.88); C754(1.04)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C108(1.35); C684(0.65); C754(1.19); C814(0.53)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C108(1.07); C684(0.65); C754(1.10); C814(0.67)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C108(0.98); C684(0.65); C754(1.30); C814(0.61)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C108(1.16); C684(0.60); C754(1.22); C814(0.55)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C108(1.10); C684(0.68); C754(1.29); C814(0.58)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C108(1.10); C684(0.68); C754(1.28); C814(0.57)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C108(1.12); C254(0.77); C684(0.85); C754(0.89)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C108(0.97); C254(0.83); C684(0.87); C754(0.87)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C108(0.92); C254(0.86); C684(0.90); C754(0.84)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C108(0.90); C254(0.68); C684(1.04); C754(0.80)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C108(0.77); C254(0.93); C684(1.05); C754(0.98)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C108(1.02); C254(0.91); C684(0.88); C754(0.87)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C108(0.96); C254(0.82); C684(1.04); C754(0.93)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C108(1.26); C254(0.92); C684(0.63); C754(0.86)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C108(1.18); C254(1.44); C684(0.78); C754(0.79)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C108(0.98); C254(1.12); C684(0.80); C754(0.82)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C108(1.09); C254(0.95); C684(0.85); C754(0.84)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C108(0.96); C254(1.16); C684(0.94); C754(0.92)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C108(0.92); C254(1.06); C684(0.95); C754(0.86)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C108(1.11); C254(1.23); C684(0.79); C754(0.87)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C108(0.86); C254(0.89); C684(0.85); C754(0.94)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C108(0.83); C254(1.07); C684(1.14); C754(1.08)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C108(0.95); C254(0.88); C684(0.94); C754(1.04)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C108(0.99); C346(0.64); C684(0.92); C754(1.18)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C108(1.07); C346(1.02); C684(0.79); C754(1.24)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C108(1.04); C346(0.78); C684(0.74); C754(1.27)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C108(0.84); C346(0.68); C684(0.59); C754(1.51)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C108(0.88); C346(0.57); C684(0.76); C754(1.19)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C108(0.95); C346(0.58); C684(0.51); C754(1.69)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C108(1.11); C346(0.54); C684(0.54); C754(1.40)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C108(0.87); C346(1.17); C684(0.65); C754(1.31)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C108(1.25); C346(0.68); C684(1.14); C754(1.14)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C108(0.88); C254(0.28); C684(1.01); C754(1.18)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C108(1.19); C346(0.66); C684(0.76); C754(1.19)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C108(1.07); C346(0.70); C684(0.56); C754(1.36)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C108(1.06); C346(1.07); C684(0.86); C754(1.19)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C108(1.16); C346(0.69); C684(0.61); C754(1.35)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C108(1.17); C346(0.75); C684(0.63); C754(1.33)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C108(1.04); C684(0.94); C754(1.05); C838(0.69)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C108(0.81); C684(0.83); C754(1.09); C838(0.53)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C108(1.01); C684(0.81); C754(1.15); C838(0.50)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C108(1.00); C684(0.81); C754(1.28); C838(0.44)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C108(0.75); C254(2.04); C684(0.80); C754(1.48)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C108(0.87); C684(1.13); C754(1.05); C838(0.75)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C108(0.83); C684(0.77); C754(1.18); C838(0.56)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C108(0.75); C684(0.76); C754(1.56); C838(0.44)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C108(0.72); C684(0.74); C754(1.48); C838(0.40)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C108(0.87); C684(0.69); C754(1.86); C838(0.45)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C108(0.96); C684(0.81); C754(1.14); C838(0.52)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C108(1.13); C684(0.86); C754(1.03); C838(0.78)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C108(0.89); C684(0.92); C754(1.31); C838(0.56)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C108(0.86); C684(0.81); C754(1.46); C838(0.45)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C108(0.89); C684(0.80); C754(1.84); C838(0.58)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C108(0.87); C254(0.83); C684(0.92); C754(1.18)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C108(0.94); C684(0.90); C754(1.03); C838(0.85)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C254(1.54); C346(0.81); C684(0.82); C754(1.13)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C254(1.02); C346(0.79); C684(0.80); C754(1.16)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C254(0.76); C346(0.85); C684(0.73); C754(0.96)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C254(1.07); C346(1.08); C684(0.47); C754(1.14)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C254(1.03); C346(0.87); C684(0.52); C754(1.63)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C254(1.12); C346(0.81); C684(0.76); C754(1.23)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C254(1.22); C346(0.92); C684(0.72); C754(1.23)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C254(1.07); C346(0.96); C684(0.63); C754(1.19)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C254(1.12); C346(1.02); C684(0.61); C754(1.23)  LDD0811  [11]
 LDCM0028  Dobutamine HEK-293T 4.04  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 5.39  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C684(1.02); C547(0.86); C254(0.89); C346(1.05)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C785(5.31); C108(1.69); C754(1.48)  LDD1702  [7]
 LDCM0625  F8 Ramos C108(1.25); C547(1.29)  LDD2187  [28]
 LDCM0573  Fragment11 Ramos C547(1.78)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C108(1.09); C547(2.93)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C108(1.22); C547(0.81)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C108(0.90)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C108(1.14)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C108(1.04); C547(0.88)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C108(1.17)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C108(0.99); C547(0.80)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C547(0.94)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C108(1.45); C547(1.13)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C108(1.31); C547(1.03)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C547(1.21)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C108(1.06); C346(0.53); C684(0.65); C754(1.24)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C108(1.01); C547(1.15)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C108(1.22)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C108(0.96); C684(0.74); C754(1.45); C814(0.60)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C108(1.29)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C108(1.55); C547(2.72)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C108(1.77); C547(1.85)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C108(0.95)  LDD2188  [28]
 LDCM0022  KB02 HCT 116 C754(3.09); C108(2.61); C346(1.59)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C754(2.07); C108(1.68); C346(1.31)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C754(2.29); C108(1.94); C346(1.21)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C547(0.60)  LDD2121  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C108(0.81)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C684(0.94)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C547(1.06); C785(0.67); C684(0.43)  LDD2093  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C684(0.58)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C547(0.93); C684(0.84)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C684(0.90); C108(1.21)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C547(0.92); C684(0.90)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C684(0.97); C108(1.00)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C684(0.95)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C547(0.99); C785(1.65); C684(1.01)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C547(0.90); C684(0.88); C108(0.69)  LDD2108  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C547(0.93); C785(1.50); C684(1.07)  LDD2111  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C684(0.69); C108(0.28)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C547(0.73); C684(0.53); C108(0.38)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C785(0.78); C684(0.86)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C547(0.99); C785(0.82); C684(0.75)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C547(0.90)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C547(1.10)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C785(0.77); C684(0.86)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C547(0.91); C684(1.00)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C684(1.00)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C547(0.86); C785(0.83); C684(0.48)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C547(1.50); C785(0.95); C684(0.98); C108(1.02)  LDD2141  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C547(0.64)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C547(1.12); C108(1.25)  LDD2153  [7]
 LDCM0032  Oleacein HEK-293T 4.10  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 5.48  LDD0181  [2]
 LDCM0131  RA190 MM1.R 2.08  LDD0299  [10]
 LDCM0090  Rapamycin JHH-7 3.54  LDD0213  [25]
 LDCM0021  THZ1 HCT 116 C684(0.97)  LDD2173  [11]
 LDCM0112  W16 Hep-G2 C108(0.66)  LDD0239  [22]
 LDCM0154  YY4 T cell 2.66  LDD0400  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 1 (SMAD1) Dwarfin/SMAD family Q15797
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4

References

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2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578