Details of the Target

General Information of Target

Target ID LDTP13094
Target Name Tuftelin-interacting protein 11 (TFIP11)
Gene Name TFIP11
Gene ID 24144
Synonyms
STIP; Tuftelin-interacting protein 11; Septin and tuftelin-interacting protein 1; STIP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCCDLAAAGQLGKASIMASDCEPALNQAEGRNPTLERYLGALREAKNDSEQFAALLLVT
KAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPEL
AAHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSA
LCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQKAEDASKFEL
CQLLPLFLPPTTVPPECYRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPAG
SSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQ
KVQLVSVMKEAIGAVIHYLLQVGSEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPF
LVRYAKTLYEEAEEANDLSQQVANLAISPTTPGPTWPGDALRLLLPGWCHLTVEDGPREI
LIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDA
CFTSLMNTLMTSLPALVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAI
LFLSQSHVARATPGSDQAVLALSPEYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALR
SRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMA
ALEQCLSEP
Target Bioclass
Other
Family
TFP11/STIP family
Subcellular location
Cytoplasm
Function
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
Uniprot ID
Q9UBB9
Ensemble ID
ENST00000405938.5
HGNC ID
HGNC:17165

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P569H .
COLO679 SNV: p.G814E .
MFE319 SNV: p.Y280C .
MIAPACA2 SNV: p.V53G .
MOLT4 SNV: p.G134Ter .
MSTO211H SNV: p.K249T .
SKMEL5 SNV: p.Q158Ter DBIA    Probe Info 
SW480 SNV: p.W54C .
SW620 SNV: p.W54C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K159(5.32)  LDD0277  [1]
Probe 1
 Probe Info  		Y745(8.67)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C667(2.31)  LDD0169  [3]
Alkyne-RA190
 Probe Info  		3.00  LDD0299  [4]
DBIA
 Probe Info  		C445(5.58); C391(1.25); C400(1.25)  LDD0080  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C445(0.00); C383(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C383(0.00); C445(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Acrolein
 Probe Info  		C391(0.00); C383(0.00)  LDD0217  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		13.90  LDD0443  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C445(3.91)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C667(2.31)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C391(1.06); C400(1.07); C445(1.19)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C391(0.98); C400(1.03); C445(0.93)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C391(0.78); C400(0.75); C445(0.89)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C391(0.71); C400(0.66); C445(0.95)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C391(0.73); C400(0.74); C445(0.96)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C391(0.67); C400(0.65); C445(1.05)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C391(0.74); C400(0.76); C445(0.87)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C391(0.70); C400(0.68); C445(0.91)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C391(0.78); C400(0.71); C445(1.08)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C391(0.79); C400(0.75); C445(0.97)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C391(0.76); C400(0.71); C445(1.03)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C391(0.73); C400(0.73); C445(0.97)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C391(0.99); C400(1.03); C445(0.92)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C391(0.75); C400(0.75); C445(0.82)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C391(0.73); C400(0.72); C445(0.89)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C391(0.74); C400(0.71); C445(1.02)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C391(0.96); C400(0.95); C445(0.92)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C391(0.88); C400(0.88); C445(0.97)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C391(0.92); C400(0.92); C445(0.90)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C391(0.99); C400(0.96); C445(0.92)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C391(0.85); C400(0.87); C445(0.85)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C391(0.93); C400(0.91); C445(0.90)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C391(0.98); C400(0.99); C445(0.94)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C391(1.04); C400(1.04); C445(0.91)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C391(1.00); C400(1.03); C445(1.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C391(0.95); C400(1.00); C445(0.85)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C391(1.08); C400(1.08); C445(0.93)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C391(0.98); C400(0.99); C445(1.02)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C391(0.96); C400(0.99); C445(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C391(0.93); C400(0.99); C445(0.96)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C391(0.93); C400(1.00); C445(0.94)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C391(0.94); C400(0.96); C445(0.98)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C391(1.21); C400(1.25); C445(1.22)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C391(0.95); C400(0.99); C445(1.11)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C391(1.04); C400(1.05); C445(1.29)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C391(0.95); C400(1.00); C445(1.14)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C391(1.04); C400(1.04); C445(1.01)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C391(1.08); C400(1.10); C445(1.11)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C391(1.07); C400(1.08); C445(1.16)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C391(1.14); C400(1.13); C445(1.15)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C391(1.06); C400(1.09); C445(1.22)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C391(1.08); C400(1.12); C445(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C391(1.07); C400(1.09); C445(1.31)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C391(1.05); C400(1.04); C445(1.14)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C391(1.06); C400(1.07); C445(0.91)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C391(1.05); C400(1.08); C445(1.30)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C391(1.08); C400(1.11); C445(1.25)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C391(1.13); C400(1.17); C445(1.00)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C445(1.01); C391(1.01); C400(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C400(0.94); C391(0.97); C445(1.03)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C445(1.06); C400(1.11); C391(1.14)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C400(1.00); C445(1.06); C391(1.20)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C400(1.05); C391(1.07); C445(1.17)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C400(1.09); C391(1.21); C445(1.29)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C400(0.96); C445(0.98); C391(1.17)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C445(0.90); C391(0.96); C400(0.99)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C400(0.96); C445(1.03); C391(1.07)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C445(0.89); C400(1.05); C391(1.08)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C445(1.07); C400(1.30); C391(1.36)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C445(1.33); C400(1.39); C391(1.66)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C391(1.23); C400(1.12); C445(1.02)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C391(1.09); C400(0.99); C445(1.03)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C391(1.21); C400(1.07); C445(0.96)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C391(1.12); C400(1.05); C445(0.93)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C400(0.83); C391(0.85); C445(1.08)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C391(1.03); C445(1.06); C400(1.07)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C391(0.85); C400(0.90); C445(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C400(0.93); C391(1.04); C445(1.19)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C391(0.87); C400(0.89); C445(1.18)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C391(0.94); C400(1.02); C445(1.30)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C391(0.96); C400(0.99); C445(1.11)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C391(0.94); C400(0.97); C445(1.20)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C391(0.87); C400(0.89); C445(1.17)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C400(0.85); C391(0.85); C445(1.11)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C400(0.82); C391(0.85); C445(1.00)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C400(0.84); C391(0.85); C445(0.86)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C400(0.86); C391(0.88); C445(1.21)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C400(0.87); C391(0.89); C445(0.98)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C400(1.05); C445(1.06); C391(1.09)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C400(0.92); C391(0.96); C445(1.00)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C400(0.83); C391(0.83); C445(0.89)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C400(0.87); C391(0.90); C445(0.92)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C400(0.82); C391(0.82); C445(0.91)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C400(0.84); C391(0.84); C445(0.92)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C400(0.84); C391(0.88); C445(1.15)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C400(0.84); C391(0.86); C445(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C400(0.82); C391(0.87); C445(0.98)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C391(0.83); C400(0.86); C445(0.95)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C400(0.88); C391(0.89); C445(1.11)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C400(1.01); C391(1.01); C445(1.23)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C400(0.88); C391(0.91); C445(1.22)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C400(0.87); C391(0.88); C445(1.13)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C391(0.86); C400(0.88); C445(1.08)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C391(0.80); C400(0.85); C445(1.07)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C445(0.95); C400(0.95); C391(0.97)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C445(0.95); C400(1.11); C391(1.13)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C445(0.59); C400(0.94); C391(0.99)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C445(0.64); C391(0.95); C400(0.96)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C445(0.61); C400(1.03); C391(1.04)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C445(1.02); C400(1.06); C391(1.11)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C400(1.04); C391(1.08); C445(1.11)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C445(0.98); C400(1.02); C391(1.10)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C400(0.91); C391(0.95); C445(1.03)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C445(0.90); C400(0.95); C391(0.98)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C445(0.81); C391(1.05); C400(1.06)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C445(0.76); C400(1.08); C391(1.08)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C445(0.70); C400(1.16); C391(1.17)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C445(1.01); C391(1.26); C400(1.26)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C391(0.95); C400(0.95); C445(1.04)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C400(1.04); C391(1.04); C445(1.07)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C445(0.98); C391(1.18); C400(1.19)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C445(0.88); C391(0.95); C400(0.96)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C445(0.95); C391(1.03); C400(1.03)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C445(0.98); C391(1.13); C400(1.14)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C445(1.15); C391(1.18); C400(1.19)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C445(0.95); C391(1.09); C400(1.12)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C445(1.09); C391(1.20); C400(1.25)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C445(1.11); C391(1.23); C400(1.25)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C445(1.13); C400(1.26); C391(1.27)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C391(1.17); C445(1.20); C400(1.20)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C391(0.96); C400(1.00); C445(1.17)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C391(0.96); C400(1.03); C445(1.12)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C445(0.89); C400(0.97); C391(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C391(0.90); C400(0.93); C445(1.04)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C391(0.94); C400(1.02); C445(1.21)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C400(0.89); C391(0.91); C445(1.02)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C445(0.96); C400(1.10); C391(1.13)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C391(1.08); C400(1.13); C445(1.25)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C445(1.06); C391(1.19); C400(1.23)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C391(0.92); C400(0.98); C445(1.05)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C391(0.97); C445(1.00); C400(1.03)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C391(0.94); C445(0.97); C400(0.99)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C391(0.93); C400(0.98); C445(1.13)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C391(0.96); C400(0.96); C445(1.02)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C391(1.00); C445(1.00); C400(1.07)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C445(0.97); C391(1.16); C400(1.20)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C445(0.98); C391(1.21); C400(1.26)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C400(0.91); C391(1.00); C445(1.23)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C400(0.91); C391(0.96); C445(1.21)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C400(0.84); C391(0.92); C445(1.07)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C400(0.82); C391(0.86); C445(0.92)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C400(0.96); C391(0.99); C445(1.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C400(0.86); C391(0.91); C445(1.03)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C400(0.90); C445(0.93); C391(0.96)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C445(0.92); C400(0.96); C391(1.00)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C400(0.97); C391(0.99); C445(1.14)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C400(0.91); C391(0.95); C445(1.09)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C400(0.80); C391(0.85); C445(0.97)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C391(0.90); C400(0.90); C445(1.07)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C400(0.79); C391(0.85); C445(0.95)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C391(0.87); C400(0.87); C445(1.09)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C400(0.84); C391(0.91); C445(1.08)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C400(0.78); C391(0.84); C445(1.12)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C400(0.71); C391(0.75); C445(0.91)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C391(1.06); C400(1.08); C445(0.93)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C445(0.92); C400(0.94); C391(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C445(1.08); C391(1.12); C400(1.13)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C445(0.95); C391(1.05); C400(1.05)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C445(1.01); C391(1.19); C400(1.19)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C391(1.02); C400(1.02); C445(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C445(0.91); C391(0.98); C400(1.05)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C445(0.85); C391(0.98); C400(1.02)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C445(0.83); C391(0.92); C400(0.97)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C445(0.89); C391(0.90); C400(0.94)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C391(0.95); C400(1.03); C445(1.11)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C391(1.06); C400(1.17); C445(1.33)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C391(1.06); C400(1.09); C445(1.16)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C391(0.99); C400(1.04); C445(1.17)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C391(0.88); C400(0.88); C445(1.02)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C445(1.18); C400(1.26); C391(1.27)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C391(1.02); C400(1.05); C445(1.19)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C391(0.94); C400(0.97); C445(1.06)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C400(0.83); C391(0.84); C445(0.97)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C400(0.81); C391(0.82); C445(0.96)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C400(0.79); C391(0.79); C445(0.98)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C400(0.81); C391(0.82); C445(0.96)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C391(0.84); C400(0.84); C445(0.98)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C391(1.05); C400(1.08); C445(1.22)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C391(0.94); C400(0.96); C445(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C400(0.90); C391(0.90); C445(1.03)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C400(1.21); C391(1.22); C445(1.29)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C391(0.85); C400(0.86); C445(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C445(0.80); C400(1.85); C391(1.93)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C445(0.86); C400(1.04); C391(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C445(0.51); C391(1.00); C400(1.03)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C445(0.48); C400(1.06); C391(1.06)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C445(0.89); C391(0.99); C400(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C445(0.87); C400(0.97); C391(0.99)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C445(0.87); C400(1.00); C391(1.01)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C445(1.05); C391(1.09); C400(1.11)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C400(1.08); C391(1.08); C445(1.14)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C391(0.91); C400(0.91); C445(0.96)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C445(1.00); C391(1.14); C400(1.15)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C445(0.92); C391(1.11); C400(1.11)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C445(0.79); C391(1.16); C400(1.16)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C445(0.70); C391(1.10); C400(1.10)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C445(0.73); C391(1.29); C400(1.29)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C445(0.94); C391(1.02); C400(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C445(1.09); C391(1.10); C400(1.10)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C445(1.06); C391(1.37); C400(1.37)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C445(1.32); C391(1.33); C400(1.33)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C445(0.76); C391(1.14); C400(1.14)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C391(1.40); C400(1.40); C445(0.80)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C391(1.38); C400(1.38); C445(1.04)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C391(1.30); C400(1.30); C445(0.83)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C391(1.31); C400(1.31); C445(0.65)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C391(1.12); C400(1.12); C445(0.74)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C391(1.19); C400(1.19); C445(0.89)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C391(0.97); C400(1.00); C445(1.07)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C391(1.22); C400(1.22); C445(0.77)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C391(1.05); C400(1.14); C445(1.11)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C391(0.94); C400(0.92); C445(1.19)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C391(0.86); C400(0.87); C445(1.08)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C391(1.06); C400(1.08); C445(1.23)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C391(1.04); C400(1.03); C445(1.12)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C391(0.93); C400(0.91); C445(1.27)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C391(1.04); C400(1.08); C445(1.25)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C391(1.01); C400(1.04); C445(1.44)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C391(0.96); C400(0.95); C445(0.89)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C391(0.99); C400(1.02); C445(1.12)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C391(0.99); C400(0.94); C445(1.12)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C391(1.37); C400(1.35); C445(1.68)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C391(1.09); C400(1.14); C445(1.25)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C391(0.91); C400(1.00); C445(1.13)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C391(1.20); C400(1.11); C445(1.31)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C391(0.88); C400(0.88); C445(0.74)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C391(0.82); C400(0.84); C445(0.79)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C391(0.76); C400(0.75); C445(0.86)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C391(0.86); C400(0.89); C445(0.78)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C391(1.03); C400(1.04); C445(1.02)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C391(0.87); C400(0.82); C445(0.79)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C391(0.86); C400(0.88); C445(0.76)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C391(0.85); C400(0.86); C445(0.79)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C391(0.84); C400(0.82); C445(0.84)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C391(0.79); C400(0.85); C445(0.78)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C391(0.87); C400(0.92); C445(0.84)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C391(0.90); C400(0.94); C445(0.85)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C391(1.08); C400(1.09); C445(0.75)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C391(0.87); C400(0.87); C445(0.76)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C391(0.84); C400(0.84); C445(0.82)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C391(0.99); C400(0.98); C445(0.99)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C391(0.77); C400(0.75); C445(0.87)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C391(0.89); C400(0.89); C445(0.95)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C391(0.83); C400(0.88); C445(1.09)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C391(0.91); C400(0.91); C445(1.00)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C391(0.94); C400(0.97); C445(0.97)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C391(0.85); C400(0.91); C445(1.13)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C391(1.10); C400(1.14); C445(1.07)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C391(0.89); C400(0.98); C445(1.41)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C391(0.93); C400(1.07); C445(1.00)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C391(0.84); C400(0.87); C445(0.95)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C391(1.15); C400(1.13); C445(1.14)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C391(1.00); C400(1.09); C445(0.96)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C391(0.88); C400(0.94); C445(1.10)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C391(0.97); C400(1.00); C445(0.84)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C391(0.95); C400(1.06); C445(0.97)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C391(0.81); C400(0.90); C445(1.02)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C391(0.97); C400(0.96); C445(1.21)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C391(0.95); C400(0.95); C445(1.38)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C391(0.98); C400(0.99); C445(1.13)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C391(1.16); C400(1.11); C445(1.01)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C391(1.23); C400(1.24); C445(1.30)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C391(1.06); C400(1.06); C445(1.44)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C391(1.08); C400(1.06); C445(1.32)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C391(1.31); C400(1.30); C445(1.28)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C391(1.35); C400(1.35); C445(1.45)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C391(1.27); C400(1.31); C445(0.98)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C391(0.97); C400(0.98); C445(1.04)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C391(1.09); C400(1.12); C445(1.44)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C391(1.08); C400(1.10); C445(1.36)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C391(1.21); C400(1.23); C445(1.10)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C391(1.45); C400(1.49); C445(1.32)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C391(0.99); C400(1.00); C445(1.00)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C391(1.03); C400(1.03); C445(1.45)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C391(0.99); C400(0.98); C445(1.03)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C391(0.85); C400(0.84); C445(1.15)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C391(0.92); C400(0.95); C445(1.30)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C391(0.88); C400(0.86); C445(1.10)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C391(0.86); C400(0.89); C445(0.95)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C391(0.94); C400(0.94); C445(1.04)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C391(0.95); C400(0.98); C445(1.04)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C391(0.97); C400(0.95); C445(0.95)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C391(1.05); C400(1.06); C445(1.16)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C445(1.01); C383(1.06); C667(2.11); C391(1.01)  LDD1698  [12]
 LDCM0625  F8 Ramos C445(1.54)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C445(0.67)  LDD2190  [13]
 LDCM0576  Fragment14 Ramos C445(0.92)  LDD2193  [13]
 LDCM0586  Fragment28 Ramos C445(1.56)  LDD2198  [13]
 LDCM0468  Fragment33 HCT 116 C391(0.93); C400(0.97); C445(0.95)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C391(1.21); C400(1.24); C445(1.52)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C445(5.58); C391(1.25); C400(1.25)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C445(6.08); C391(1.97); C400(1.97)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C445(3.78); C391(1.44); C400(1.44)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C391(1.61); C445(0.64)  LDD2207  [14]
 LDCM0131  RA190 MM1.R 3.00  LDD0299  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 8 (PSMC5) AAA ATPase family P62195
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
ATP-dependent RNA helicase DDX25 (DDX25) DEAD box helicase family Q9UHL0
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Protein mab-21-like 2 (MAB21L2) Mab-21 family Q9Y586
Methyltransferase-like protein 17, mitochondrial (METTL17) Rsm22 family Q9H7H0
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit alpha type-4 (PSMA4) Peptidase T1A family P25789
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Serine/threonine-protein kinase N3 (PKN3) AGC Ser/Thr protein kinase family Q6P5Z2
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
GTP-binding protein GEM (GEM) RGK family P55040
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Kinesin-like protein KIF3C (KIF3C) Kinesin family O14782
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Coiled-coil domain-containing protein 68 (CCDC68) . Q9H2F9
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Sorting nexin-20 (SNX20) Sorting nexin family Q7Z614
Sorting nexin-32 (SNX32) Sorting nexin family Q86XE0
Nuclear pore complex protein Nup88 (NUP88) . Q99567
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
SAP30-binding protein (SAP30BP) HCNGP family Q9UHR5
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 777 (ZNF777) Krueppel C2H2-type zinc-finger protein family Q9ULD5
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
PHD finger protein 1 (PHF1) Polycomblike family O43189
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Teashirt homolog 2 (TSHZ2) Teashirt C2H2-type zinc-finger protein family Q9NRE2
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
Bromodomain-containing protein 1 (BRD1) . O95696
Class A basic helix-loop-helix protein 9 (BHLHA9) . Q7RTU4
Max dimerization protein 3 (MXD3) . Q9BW11
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
THAP domain-containing protein 7 (THAP7) . Q9BT49
THAP domain-containing protein 8 (THAP8) . Q8NA92
Upstream-binding factor 1-like protein 1 (UBTFL1) . P0CB47
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Other
Click To Hide/Show 111 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Bystin (BYSL) Bystin family Q13895
Caveolae-associated protein 3 (CAVIN3) CAVIN family Q969G5
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Centromere protein U (CENPU) CENP-U/AME1 family Q71F23
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Coiled-coil domain-containing protein 42 (CCDC42) CFAP73 family Q96M95
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
Cyclin-G1 (CCNG1) Cyclin family P51959
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Armadillo repeat-containing X-linked protein 1 (ARMCX1) Eutherian X-chromosome-specific Armcx family Q9P291
Protein FAM13C (FAM13C) FAM13 family Q8NE31
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM81A (FAM81A) FAM81 family Q8TBF8
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Intron Large complex component GCFC2 (GCFC2) GCF family P16383
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Keratin, type II cytoskeletal 6B (KRT6B) Intermediate filament family P04259
Keratin, type II cytoskeletal 6C (KRT6C) Intermediate filament family P48668
Keratin, type II cytoskeletal 8 (KRT8) Intermediate filament family P05787
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Centrosomal protein kizuna (KIZ) Kizuna family Q2M2Z5
Lebercilin (LCA5) LCA5 family Q86VQ0
Lebercilin-like protein (LCA5L) LCA5 family O95447
Liprin-alpha-3 (PPFIA3) Liprin family O75145
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Protein Mis18-beta (OIP5) Mis18 family O43482
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Mitochondrial fission regulator 2 (MTFR2) MTFR1 family Q6P444
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
Testis-specific Y-encoded-like protein 4 (TSPYL4) Nucleosome assembly protein (NAP) family Q9UJ04
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) PTCD1 family O75127
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Ribosomal RNA-processing protein 7 homolog A (RRP7A) RRP7 family Q9Y3A4
Protein S100-P (S100P) S-100 family P25815
Exocyst complex component 3-like protein (EXOC3L1) SEC6 family Q86VI1
Swi5-dependent recombination DNA repair protein 1 homolog (SFR1) SFR1/MEI5 family Q86XK3
SAGA-associated factor 29 (SGF29) SGF29 family Q96ES7
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Alpha-taxilin (TXLNA) Taxilin family P40222
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Centrosomal protein of 57 kDa (CEP57) Translokin family Q86XR8
Troponin T, slow skeletal muscle (TNNT1) Troponin T family P13805
Large ribosomal subunit protein uL11m (MRPL11) Universal ribosomal protein uL11 family Q9Y3B7
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) Universal ribosomal protein uS4 family Q9NV31
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) WAL family Q9UIF8
Striatin (STRN) WD repeat striatin family O43815
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Alanine and arginine-rich domain-containing protein (AARD) . Q4LEZ3
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Axin-1 (AXIN1) . O15169
Cancer/testis antigen 55 (CT55) . Q8WUE5
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Centrosomal protein of 95 kDa (CEP95) . Q96GE4
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 121 (CCDC121) . Q6ZUS5
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Coiled-coil domain-containing protein 96 (CCDC96) . Q2M329
Developmental pluripotency-associated protein 3 (DPPA3) . Q6W0C5
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
G protein pathway suppressor 2 (GPS2) . Q13227
Genetic suppressor element 1 (GSE1) . Q14687
Golgin subfamily A member 1 (GOLGA1) . Q92805
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Heat shock factor 2-binding protein (HSF2BP) . O75031
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) . Q70UQ0
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
LIM domain transcription factor LMO4 (LMO4) . P61968
LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1) . Q96S90
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Phostensin (PPP1R18) . Q6NYC8
PRKCA-binding protein (PICK1) . Q9NRD5
Protein FAM156A/FAM156B (FAM156A; FAM156B) . Q8NDB6
Protein lin-37 homolog (LIN37) . Q96GY3
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1) . Q9BSD3
Rhombotin-1 (LMO1) . P25800
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Stimulated by retinoic acid gene 8 protein homolog (STRA8) . Q7Z7C7
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.