Details of the Target

General Information of Target

Target ID LDTP10914
Target Name Translin-associated protein X (TSNAX)
Gene Name TSNAX
Gene ID 7257
Synonyms
TRAX; Translin-associated protein X; Translin-associated factor X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAP
QLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGG
ILLALIEGAGILLTRFASAQFPNGPQFAEDPSQLPSTQLPSSPFGDYRQYQ
Target Bioclass
Other
Family
Translin family
Subcellular location
Cytoplasm, perinuclear region
Function Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Uniprot ID
Q99598
Ensemble ID
ENST00000366639.9
HGNC ID
HGNC:12380
ChEMBL ID
CHEMBL4524025

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y187(8.17)  LDD0260  [1]
BTD
 Probe Info  		C257(0.60)  LDD2141  [2]
Alkyne-RA190
 Probe Info  		2.36  LDD0299  [3]
HHS-475
 Probe Info  		Y237(0.85)  LDD0264  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
DBIA
 Probe Info  		C257(1.17)  LDD0080  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K68(0.00); K269(0.00); K241(0.00); K242(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H15(0.00); H270(0.00); H114(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C202(0.00); C257(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C202(0.00); C257(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		N.A.  LDD0147  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-465
 Probe Info  		K241(0.00); Y237(0.00)  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C350
 Probe Info  		37.27  LDD2011  [17]
FFF probe13
 Probe Info  		12.93  LDD0475  [18]
FFF probe14
 Probe Info  		11.44  LDD0477  [18]
FFF probe2
 Probe Info  		6.74  LDD0463  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]
STS-2
 Probe Info  		N.A.  LDD0139  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C257(1.03); C202(1.06)  LDD1507  [20]
 LDCM0215  AC10 HCT 116 C257(1.61)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C257(1.02)  LDD0543  [6]
 LDCM0230  AC113 HEK-293T C257(0.91)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C257(0.94)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C257(0.93)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C257(0.97)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C257(1.04)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C257(1.22)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C257(1.08)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C257(1.08)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C257(1.10)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C257(0.98)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C257(1.01)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C257(1.16)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C257(1.03)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C257(1.08)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C257(1.11)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C257(1.22)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C257(0.86)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C257(0.82)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C257(1.14)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C257(1.22)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C257(0.90)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C257(1.06)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C257(1.41)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C257(1.12)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C257(0.78)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C257(0.69)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C257(1.16)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C257(0.95)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C257(1.18)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C257(0.86)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C257(0.80)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C257(0.86)  LDD0860  [6]
 LDCM0270  AC15 HCT 116 C257(1.21)  LDD0587  [6]
 LDCM0276  AC17 HEK-293T C257(1.05); C202(1.01)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C257(1.02); C202(0.75)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C257(0.87); C202(0.80)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C257(0.89); C202(0.92)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C257(0.98); C202(1.05)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C257(1.01); C202(1.09)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C257(1.06); C202(1.07)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C257(0.94); C202(1.01)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C257(1.00); C202(1.07)  LDD1523  [20]
 LDCM0285  AC25 HCT 116 C257(1.12)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C257(1.04)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C257(1.02)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C257(1.38)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C257(1.20)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C257(0.97); C202(1.04)  LDD1529  [20]
 LDCM0291  AC30 HCT 116 C257(0.95)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C257(0.98)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C257(1.03)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C257(1.11)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C257(0.97)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C257(1.51)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C257(1.33)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C257(1.21)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C257(1.14)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C257(1.04)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C257(0.92); C202(0.96)  LDD1540  [20]
 LDCM0302  AC40 HCT 116 C257(1.02)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C257(1.03)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C257(1.11)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C257(0.93)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C257(0.96)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C257(1.10)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C257(0.88)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C257(0.81)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C257(0.51)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C257(0.72)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C257(0.89); C202(1.00)  LDD1551  [20]
 LDCM0313  AC50 HCT 116 C257(0.71)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C257(0.93)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C257(0.82)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C257(0.75)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C257(0.83)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C257(0.72)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C257(0.66)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C257(1.45)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C257(1.20)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C257(0.96)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C257(1.19)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C257(0.68)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C257(1.37)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C257(1.04)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C257(1.13)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C257(1.18)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C257(1.17)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C257(1.51)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C257(1.01)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C257(0.78)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C257(0.95)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C257(1.64)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C257(0.77)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C257(0.90)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C257(0.86)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C257(0.78)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C257(0.67)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C257(0.83)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C257(0.97)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C257(0.85)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C257(0.77)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C257(0.83)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C257(1.45)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C257(0.90)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C257(1.02)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C257(0.70)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C257(0.69)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C257(0.72)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C257(0.69)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C257(1.16)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C257(0.93)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C257(1.02)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C257(1.16)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C257(1.23)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C257(0.90)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C257(1.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C257(0.89)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C257(0.89)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C257(0.64)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C257(0.84)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C257(1.04)  LDD0681  [6]
 LDCM0248  AKOS034007472 HCT 116 C257(1.15)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C257(1.42)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C257(1.20)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C257(1.41)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C257(2.88)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C257(0.97)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C257(1.20)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C257(1.02); C202(1.11)  LDD1573  [20]
 LDCM0370  CL101 HCT 116 C257(1.27)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C257(1.30)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C257(1.32)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C257(1.48)  LDD0690  [6]
 LDCM0374  CL105 HEK-293T C257(1.08); C202(0.66)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C257(1.00); C202(0.99)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C257(1.02); C202(1.34)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C257(1.03); C202(0.85)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C257(0.99); C202(0.95)  LDD1582  [20]
 LDCM0379  CL11 HCT 116 C257(1.36)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C257(1.11); C202(1.07)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C257(0.98); C202(1.11)  LDD1585  [20]
 LDCM0382  CL112 HCT 116 C257(1.03)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C257(0.91)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C257(0.84)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C257(0.97)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C257(1.01)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C257(0.95)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C257(0.98)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C257(1.28)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C257(1.96)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C257(1.03)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C257(0.98)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C257(0.57)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C257(0.88)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C257(0.82)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C257(0.81)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C257(1.17)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C257(1.02)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C257(1.40)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C257(1.36)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C257(1.49)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C257(1.44)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C257(1.44)  LDD1001  [6]
 LDCM0404  CL17 HCT 116 C257(0.65)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C257(0.89)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C257(0.94)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C257(0.86)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C257(0.78)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C257(0.67)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C257(1.20)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C257(0.79)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C257(0.94)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C257(0.78)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C257(0.94)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C257(0.88)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C257(0.77)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C257(0.86)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C257(1.85)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C257(1.15)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C257(0.93)  LDD0737  [6]
 LDCM0421  CL32 HEK-293T C257(1.01); C202(0.84)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C257(1.33); C202(0.78)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C257(1.08); C202(0.90)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C257(0.99); C202(0.84)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C257(1.05); C202(1.14)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C257(1.00); C202(0.91)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C257(0.95); C202(0.89)  LDD1632  [20]
 LDCM0429  CL4 HCT 116 C257(0.98)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C257(0.99); C202(1.04)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C257(1.07); C202(0.88)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C257(0.93); C202(0.95)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C257(0.93); C202(1.04)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C257(1.03); C202(0.89)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C257(0.99); C202(0.83)  LDD1639  [20]
 LDCM0436  CL46 HCT 116 C257(0.60)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C257(0.70)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C257(0.69)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C257(0.84)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C257(1.09)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C257(0.86)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C257(0.69)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C257(0.78)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C257(0.90)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C257(0.66)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C257(0.92)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C257(0.93)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C257(0.97)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C257(0.89)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C257(0.84)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C257(0.89)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C257(0.63)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C257(0.80)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C257(0.73)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C257(0.80)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C257(0.85)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C257(1.15)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C257(0.93)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C257(1.66)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C257(1.30)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C257(0.83)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C257(0.89)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C257(1.16)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C257(1.00)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C257(1.23)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C257(1.25)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C257(1.49)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C257(0.96); C202(1.04)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C257(1.05); C202(0.84)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C257(0.91); C202(0.75)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C257(0.94); C202(1.07)  LDD1675  [20]
 LDCM0473  CL8 HCT 116 C257(1.10)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C257(0.97); C202(0.81)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C257(0.92); C202(1.03)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C257(0.99); C202(0.88)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C257(0.92); C202(0.89)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C257(1.00); C202(0.99)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C257(0.92); C202(0.89)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C257(0.97); C202(1.13)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C257(0.87); C202(0.97)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C257(0.94); C202(1.05)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C257(0.97); C202(1.13)  LDD1686  [20]
 LDCM0484  CL9 HCT 116 C257(0.90)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C257(1.30); C202(0.74)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C257(0.96); C202(1.16)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C257(0.92); C202(0.88)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C257(0.98); C202(0.93)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C257(0.97); C202(0.91)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C257(1.21); C202(0.87)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C257(1.07); C202(1.06)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C257(0.99); C202(0.97)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C257(0.97); C202(1.01)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C257(0.90); C202(0.94)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C257(0.89); C202(0.94)  LDD1698  [20]
 LDCM0625  F8 Ramos C257(1.06); C202(0.48)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C257(0.41); C202(0.76)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C257(0.63); C202(0.04)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C257(0.48); C202(1.22)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C257(0.84); C202(0.74)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C257(1.11); C202(2.33)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C257(0.37); C202(1.07)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C257(0.70); C202(1.73)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C257(0.91); C202(1.22)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C257(0.65); C202(1.96)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C257(0.90)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C257(0.92); C202(1.26)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C257(0.88); C202(0.97)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C257(0.47); C202(1.25)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C257(0.72)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C257(0.83); C202(1.35)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C257(0.80); C202(0.70)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C257(0.93); C202(1.08)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C257(1.24); C202(1.03)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C257(0.97); C202(2.28)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C257(0.81); C202(0.48)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C257(0.45); C202(0.95)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y237(0.85)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y237(0.69)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y237(0.63)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y237(0.90)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y237(0.88)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C257(1.17)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C257(1.14)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C257(2.29)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C257(0.60)  LDD2141  [2]
 LDCM0131  RA190 MM1.R 2.36  LDD0299  [3]
 LDCM0021  THZ1 HCT 116 C257(1.41)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication factor C subunit 5 (RFC5) Activator 1 small subunits family P40937
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Translin (TSN) Translin family Q15631
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein B2 (HMGB2) HMGB family P26583
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Transcription factor 12 (TCF12) . Q99081
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX3 (BEX3) BEX family Q00994
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
LIM domain-binding protein 2 (LDB2) LDB family O43679
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Synaptonemal complex central element protein 2 (SYCE2) SYCE family Q6PIF2
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
Gelsolin (GSN) Villin/gelsolin family P06396
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) . Q12904
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Merlin (NF2) . P35240
Polyamine-modulated factor 1 (PMF1) . Q6P1K2
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578