Details of the Target

General Information of Target

Target ID LDTP04163
Target Name Prolyl endopeptidase (PREP)
Gene Name PREP
Gene ID 5550
Synonyms
PEP; Prolyl endopeptidase; PE; EC 3.4.21.26; Post-proline cleaving enzyme
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase S9A family
Subcellular location
Cytoplasm
Function Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
TTD ID
T86161
Uniprot ID
P48147
DrugMap ID
TTNGKET
Ensemble ID
ENST00000652536.2
HGNC ID
HGNC:9358
ChEMBL ID
CHEMBL3202

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.76  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y76(20.00); Y510(8.08)  LDD0260  [3]
TH216
 Probe Info  		Y471(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K684(8.01)  LDD0277  [4]
BTD
 Probe Info  		C57(0.89)  LDD2089  [5]
Sulforaphane-probe2
 Probe Info  		1.93  LDD0160  [6]
AHL-Pu-1
 Probe Info  		C78(2.24); C264(2.14); C175(2.57); C25(2.73)  LDD0169  [7]
HHS-482
 Probe Info  		Y71(0.30)  LDD0285  [8]
HHS-475
 Probe Info  		Y471(0.70); Y71(0.70); Y473(1.89)  LDD0264  [9]
DBIA
 Probe Info  		C601(1.10); C255(1.04); C25(0.96); C57(0.93)  LDD0078  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C703(0.00); C410(0.00); C343(0.00); C255(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C526(0.00); C57(0.00)  LDD0032  [13]
IPIAA_L
 Probe Info  		C225(0.00); C25(0.00); C255(0.00); C526(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C703(0.00); C410(0.00); C343(0.00); C255(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
IPM
 Probe Info  		N.A.  LDD0147  [18]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [19]
TFBX
 Probe Info  		C255(0.00); C57(0.00)  LDD0148  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [21]
Acrolein
 Probe Info  		C57(0.00); C255(0.00); C78(0.00); C601(0.00)  LDD0217  [22]
W1
 Probe Info  		C57(0.00); C25(0.00); C255(0.00)  LDD0236  [23]
NAIA_5
 Probe Info  		C410(0.00); C57(0.00); C175(0.00); C343(0.00)  LDD2223  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [24]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		20.39  LDD1937  [25]
FFF probe13
 Probe Info  		13.29  LDD0475  [26]
FFF probe14
 Probe Info  		16.59  LDD0477  [26]
FFF probe2
 Probe Info  		5.81  LDD0463  [26]
FFF probe3
 Probe Info  		6.97  LDD0465  [26]
STS-2
 Probe Info  		N.A.  LDD0139  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
OEA-DA
 Probe Info  		4.27  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C78(2.24); C264(2.14); C175(2.57); C25(2.73)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C526(1.04); C532(1.04); C25(1.16); C255(0.98)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C526(0.49); C532(0.63); C175(0.95); C25(1.28)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C532(1.06); C175(0.94); C25(0.96); C255(1.49)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C532(1.13); C175(0.92); C25(1.07); C255(1.21)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C532(0.99); C175(0.91); C25(1.06); C255(1.05)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C532(1.08); C175(0.91); C25(1.03); C255(1.33)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C532(1.20); C175(0.82); C25(1.01); C255(1.12)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C532(1.02); C175(0.94); C25(1.13); C255(1.45)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C532(1.06); C175(0.82); C25(1.28); C255(1.71)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C532(1.18); C175(1.00); C25(1.12); C255(1.27)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C532(0.99); C175(0.82); C25(1.02); C255(1.51)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C532(1.14); C175(0.81); C25(1.04); C255(0.93)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C526(0.47); C532(0.57); C175(0.83); C25(1.36)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C532(1.07); C175(0.85); C25(1.08); C255(1.39)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C532(1.12); C175(0.88); C25(1.07); C255(1.59)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C532(2.03); C175(0.98); C25(1.09); C255(1.54)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C175(1.02); C25(1.11); C255(1.03); C57(0.93)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C175(0.85); C25(1.15); C255(1.04); C57(0.94)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C175(0.77); C25(1.39); C255(1.08); C57(0.86)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C175(0.73); C25(1.30); C255(1.02); C57(0.99)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C175(0.94); C25(1.20); C255(1.07); C57(1.05)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C175(0.88); C25(1.20); C255(0.98); C57(0.94)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C175(0.89); C25(1.21); C255(1.14); C57(1.01)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C526(1.12); C532(0.97); C175(0.98); C25(1.08)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C175(0.78); C25(1.08); C255(0.94); C57(1.07)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C175(0.82); C25(1.10); C255(0.80); C57(1.01)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C175(0.86); C25(1.19); C255(0.96); C57(1.06)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C175(0.81); C25(1.13); C255(0.91); C57(1.02)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C175(0.77); C25(1.06); C255(0.90); C57(0.95)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C175(0.87); C25(1.27); C255(1.04); C57(0.99)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C175(0.78); C25(1.23); C255(1.01); C57(0.84)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C175(0.76); C25(1.27); C255(0.96); C57(0.96)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C526(0.15); C532(0.15); C175(0.94); C25(1.06)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C526(1.82); C532(1.82); C175(0.87); C25(0.99)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C526(0.34); C532(0.34); C175(0.96); C25(1.19)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C526(1.72); C532(1.72); C175(0.94); C25(0.96)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C526(1.88); C532(1.88); C175(0.79); C25(1.17)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C526(0.59); C532(0.59); C175(0.85); C25(1.37)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C526(0.36); C532(0.36); C175(0.91); C25(1.35)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C526(0.33); C532(0.33); C175(0.76); C25(1.12)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C526(0.60); C532(0.60); C175(0.84); C25(1.11)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C526(1.12); C532(1.12); C175(0.77); C25(1.08)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C526(0.55); C532(0.55); C175(0.80); C25(1.25)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C526(0.79); C532(0.79); C175(0.99); C25(1.25)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C526(0.69); C532(0.84); C175(0.90); C25(1.33)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C526(0.45); C532(0.45); C175(0.83); C25(1.45)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C526(0.68); C532(0.68); C175(0.71); C25(1.39)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C526(2.16); C532(2.16); C175(0.85); C25(1.33)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C526(0.98); C532(0.98); C175(0.98); C255(1.01)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C526(0.26); C532(0.26); C343(0.78); C175(0.84)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C175(0.81); C526(0.88); C532(0.88); C343(0.97)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C526(0.63); C532(0.63); C175(0.78); C25(0.94)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C526(0.19); C532(0.19); C343(0.65); C57(0.83)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C526(0.04); C532(0.04); C343(0.15); C25(0.91)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C526(0.15); C532(0.15); C343(0.58); C25(0.98)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C526(0.46); C343(0.76); C532(0.79); C175(0.88)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C25(1.02); C175(1.11); C255(1.11); C601(1.15)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C175(0.95); C601(1.05); C25(1.14); C57(1.16)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C526(0.13); C532(0.13); C343(0.49); C57(0.73)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C526(0.04); C532(0.04); C343(0.11); C175(0.74)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C526(0.30); C532(0.30); C175(0.79); C25(0.90)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C526(0.48); C532(0.48); C175(0.86); C25(0.89)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C526(1.04); C532(1.04); C175(0.88); C25(0.96)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C526(1.01); C532(1.01); C175(0.76); C25(0.95)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C175(0.89); C57(0.90); C255(0.93); C343(0.95)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C526(0.25); C343(0.48); C175(0.71); C532(0.76)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C343(0.79); C526(0.80); C175(0.83); C532(0.97)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C526(0.99); C532(0.99); C255(1.00); C57(1.05)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C255(0.82); C526(0.82); C175(0.87); C343(0.95)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C255(0.75); C343(0.86); C526(0.87); C175(0.88)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C526(0.82); C343(0.85); C255(0.87); C601(0.87)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C526(0.81); C255(0.81); C343(0.82); C175(0.85)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C255(0.75); C601(0.94); C25(0.96); C175(0.97)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C526(0.76); C532(1.00); C175(1.02); C57(1.02)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C526(0.60); C532(0.91); C175(0.92); C601(1.00)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C526(0.44); C532(0.84); C175(0.92); C57(1.00)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C526(0.48); C532(0.81); C175(0.94); C57(1.02)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C526(0.51); C175(0.90); C57(1.04); C532(1.07)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C526(0.84); C532(0.84); C57(1.01); C255(1.05)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C526(0.38); C175(0.87); C532(1.02); C57(1.07)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C526(0.44); C532(0.91); C175(0.96); C57(1.06)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C526(0.18); C175(0.70); C532(0.83); C57(0.90)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C526(0.29); C175(0.72); C532(0.73); C57(0.90)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C526(0.17); C175(0.62); C532(0.75); C57(0.83)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C255(0.92); C25(0.99); C601(0.99); C57(1.57)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C601(0.90); C25(0.92); C255(0.99); C264(1.34)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C601(0.90); C255(0.95); C25(0.96); C264(1.01)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C601(0.93); C255(0.94); C25(0.99); C264(1.05)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C264(0.60); C526(0.65); C532(0.65); C343(0.80)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C526(0.50); C532(0.50); C255(0.91); C57(0.99)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C526(0.48); C532(0.48); C264(0.50); C343(0.52)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C601(1.02); C264(1.09); C343(1.10); C25(1.16)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C264(0.81); C343(0.84); C175(0.90); C526(0.92)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C264(0.77); C526(0.83); C532(0.83); C343(0.83)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C264(0.68); C526(0.72); C532(0.72); C343(0.77)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C264(0.35); C526(0.35); C532(0.35); C343(0.41)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C601(0.93); C343(0.98); C264(1.01); C255(1.05)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C343(0.69); C526(0.81); C532(0.81); C601(0.90)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C601(0.96); C255(1.14); C25(1.17); C264(1.18)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C526(0.13); C532(0.13); C343(0.14); C175(0.19)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C526(0.48); C532(0.48); C255(0.96); C343(0.97)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C526(0.15); C532(0.15); C343(0.19); C175(0.24)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C601(0.78); C25(0.91); C255(0.93); C57(1.17)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C526(0.82); C532(0.82); C264(0.92); C601(0.94)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C526(0.30); C532(0.30); C343(0.45); C175(0.48)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C526(0.27); C532(0.27); C343(0.28); C175(0.45)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C526(0.14); C532(0.14); C343(0.14); C175(0.18)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C343(0.08); C526(0.09); C532(0.09); C175(0.10)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C526(0.55); C343(0.61); C57(0.81); C175(0.89)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C343(0.49); C526(0.55); C175(0.73); C57(0.83)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C343(0.31); C526(0.31); C175(0.65); C57(0.73)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C526(0.62); C343(0.79); C175(0.82); C532(0.91)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C343(0.55); C175(0.80); C526(0.84); C57(0.97)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C343(0.73); C175(0.94); C57(1.17); C255(1.19)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C343(0.18); C526(0.25); C175(0.58); C57(0.68)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C343(0.59); C526(0.65); C175(0.86); C57(0.90)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C343(0.22); C526(0.32); C175(0.62); C57(0.67)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C343(0.35); C526(0.39); C175(0.67); C57(0.72)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C343(0.37); C526(0.55); C175(0.67); C57(0.78)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C343(0.07); C526(0.23); C175(0.44); C57(0.57)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C526(0.26); C532(0.26); C343(0.53); C264(0.59)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C526(0.08); C532(0.08); C264(0.23); C343(0.49)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C526(0.84); C532(0.90); C175(0.92); C601(1.00)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C526(0.06); C532(0.06); C264(0.19); C343(0.39)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C526(0.34); C532(0.34); C601(0.84); C264(0.86)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C526(0.16); C532(0.16); C343(0.65); C264(0.74)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C526(0.04); C532(0.04); C264(0.07); C343(0.32)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C526(0.04); C532(0.04); C264(0.08); C343(0.41)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C526(0.03); C532(0.03); C264(0.06); C343(0.47)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C526(0.09); C532(0.09); C264(0.22); C343(0.53)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C526(0.07); C532(0.07); C264(0.23); C343(0.45)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C526(0.53); C532(0.53); C264(0.56); C343(0.75)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C526(0.23); C532(0.23); C264(0.65); C343(0.69)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C526(0.69); C532(0.81); C175(0.90); C343(0.92)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C526(0.15); C532(0.15); C264(0.63); C57(0.70)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C526(0.46); C532(0.46); C264(0.61); C343(0.62)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C526(0.04); C532(0.04); C264(0.07); C343(0.29)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C175(0.54); C57(0.70); C601(1.20); C255(1.28)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C175(0.62); C57(0.64); C255(1.16); C25(1.26)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C175(0.82); C57(0.88); C25(1.19); C601(1.32)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C57(1.00); C601(1.09); C175(1.13); C25(1.13)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C175(0.92); C25(0.99); C601(1.03); C57(1.04)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C57(0.95); C175(1.03); C25(1.10); C601(1.13)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C175(0.79); C57(0.87); C601(1.10); C25(1.21)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C601(0.94); C25(1.06); C57(1.16); C175(1.24)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C175(0.55); C57(0.64); C601(1.17); C25(1.33)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C175(0.58); C57(0.73); C601(1.15); C25(1.34)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C175(0.94); C57(1.00); C25(1.14); C601(1.20)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C25(1.05); C57(1.09); C175(1.10); C601(1.18)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C175(0.93); C57(0.96); C601(1.02); C25(1.12)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C175(0.79); C57(0.90); C601(1.06); C25(1.12)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C175(0.68); C57(0.82); C25(1.27); C601(1.29)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C343(0.08); C57(0.12); C175(0.91); C532(1.05)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C343(0.69); C57(0.73); C175(0.84); C532(0.97)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C526(0.98); C532(0.87); C175(0.98); C25(1.16)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C532(0.92); C526(1.02); C601(1.06); C57(1.08)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C526(0.06); C343(0.21); C175(0.25); C532(0.47)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C601(1.10); C255(1.04); C25(0.96); C57(0.93)  LDD0078  [10]
 LDCM0104  BDHI 13 Jurkat C255(5.33)  LDD0206  [30]
 LDCM0498  BS-3668 MDA-MB-231 C57(0.59)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C57(0.00); C255(0.00); C225(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C57(1.08)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C601(0.74); C343(0.88); C25(0.90); C255(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C526(0.15); C532(0.15); C343(0.24); C57(0.59)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C526(0.62); C532(0.62); C255(1.00); C57(1.01)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C526(0.47); C532(0.72); C343(0.88); C175(0.91)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C532(0.90); C526(0.96); C175(0.98); C601(1.01)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C175(0.87); C532(0.90); C601(0.91); C25(0.92)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C532(0.83); C526(0.83); C175(0.87); C343(0.92)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C526(0.55); C343(0.71); C175(0.85); C532(0.86)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C526(0.14); C343(0.24); C175(0.47); C532(0.48)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C526(0.17); C343(0.35); C175(0.58); C532(0.62)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C526(0.10); C343(0.23); C175(0.39); C532(0.62)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C343(0.64); C526(0.68); C532(0.88); C175(0.93)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C526(0.16); C532(0.16); C343(0.27); C57(0.63)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C526(0.32); C343(0.44); C175(0.69); C532(0.72)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C526(0.64); C343(0.76); C175(0.84); C532(0.85)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C526(0.79); C532(0.94); C57(0.97); C601(0.98)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C526(0.27); C175(0.81); C532(0.88); C57(0.99)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C526(0.71); C175(0.84); C532(1.12); C25(1.15)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C526(0.61); C175(0.91); C532(1.01); C57(1.13)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C526(0.54); C175(0.91); C532(0.94); C57(1.05)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C264(0.13); C343(0.14); C526(0.17); C532(0.17)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C264(0.58); C526(0.72); C532(0.72); C343(0.78)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C526(0.51); C532(0.51); C343(0.67); C175(0.69)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C526(0.13); C532(0.13); C343(0.24); C57(0.61)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C601(0.92); C264(1.00); C25(1.09); C175(1.14)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C175(0.65); C343(0.78); C57(0.80); C264(0.99)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C526(0.27); C532(0.27); C343(0.32); C175(0.42)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C526(0.24); C532(0.24); C343(0.29); C175(0.39)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C526(0.18); C532(0.18); C343(0.24); C175(0.30)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C601(0.93); C57(0.97); C175(0.97); C343(1.00)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C526(0.81); C343(0.90); C175(1.01); C57(1.04)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C343(0.86); C526(1.07); C57(1.07); C175(1.09)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C526(0.39); C343(0.46); C57(0.73); C175(0.78)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C526(0.29); C532(0.29); C343(0.41); C57(0.71)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C601(0.71); C526(0.80); C532(0.80); C343(0.86)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C343(0.48); C526(0.53); C532(0.53); C601(0.74)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C343(0.70); C264(0.87); C526(0.93); C532(0.93)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C526(0.82); C532(0.82); C57(0.83); C175(0.84)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C264(0.68); C343(0.86); C175(0.88); C57(0.92)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C264(0.60); C526(0.68); C532(0.68); C343(0.71)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C601(0.69); C343(0.90); C57(0.98); C25(1.03)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C526(0.21); C532(0.21); C264(0.34); C343(0.47)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C526(0.11); C532(0.11); C264(0.13); C343(0.29)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C264(0.05); C526(0.06); C532(0.06); C343(0.13)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C526(0.38); C532(0.38); C264(0.41); C343(0.74)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C526(0.13); C532(0.13); C264(0.15); C343(0.36)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C526(0.19); C532(0.19); C175(0.68); C25(1.20)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C526(0.55); C532(0.55); C175(0.83); C25(1.20)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C526(0.52); C532(0.52); C175(0.82); C25(1.15)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C526(0.29); C532(0.29); C175(0.73); C25(1.10)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C526(0.14); C532(0.14); C175(0.65); C25(1.20)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C526(1.19); C532(1.19); C25(0.92); C255(1.10)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C526(0.61); C532(0.61); C175(0.88); C25(1.02)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C526(0.46); C532(0.68); C175(0.88); C25(1.05)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C526(1.47); C532(1.15); C175(0.81); C25(1.14)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C526(1.20); C532(1.03); C175(0.72); C25(1.05)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C526(0.10); C532(0.65); C175(0.41); C25(1.32)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C526(0.12); C532(0.55); C175(0.44); C25(1.71)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C526(0.17); C532(0.49); C175(0.54); C25(1.28)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C526(0.10); C532(0.50); C175(0.43); C25(1.54)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C526(0.11); C532(0.50); C175(0.47); C25(1.17)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C526(0.78); C532(0.78); C25(0.96); C255(1.07)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C526(0.18); C532(0.43); C175(0.54); C25(1.23)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C526(0.24); C532(0.49); C175(0.56); C25(1.14)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C526(0.04); C532(0.43); C175(0.25); C25(2.02)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C526(0.09); C532(0.49); C175(0.32); C25(1.31)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C526(0.43); C532(0.63); C175(0.63); C25(1.20)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C526(0.07); C532(0.44); C175(0.33); C25(1.29)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C532(1.14); C175(1.02); C25(0.80); C255(1.24)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C532(1.13); C175(0.98); C25(0.76); C255(1.21)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C532(0.96); C175(1.15); C25(0.79); C255(1.12)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C532(0.92); C175(0.99); C25(0.77); C255(1.22)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C526(0.72); C532(0.72); C25(1.09); C255(1.05)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C532(0.87); C175(1.16); C25(0.84); C255(1.27)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C532(0.95); C175(1.08); C25(0.81); C255(1.18)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C532(1.03); C175(1.19); C25(0.75); C255(1.19)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C532(1.45); C175(0.98); C25(0.82); C255(1.10)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C532(1.10); C175(1.06); C25(0.75); C255(1.09)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C532(0.88); C175(1.07); C25(0.80); C255(1.05)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C532(0.99); C175(1.15); C25(0.76); C255(1.14)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C532(1.11); C175(1.02); C25(0.89); C255(1.03)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C532(1.05); C175(1.20); C25(0.90); C255(1.22)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C532(0.99); C175(1.12); C25(0.79); C255(1.12)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C526(0.89); C532(0.89); C25(1.07); C255(1.46)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C532(1.14); C175(1.02); C25(0.75); C255(1.11)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C526(0.84); C532(0.93); C25(1.12); C255(1.09)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C526(0.56); C532(0.86); C25(1.18); C255(1.04)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C526(0.54); C532(0.93); C25(1.15); C255(1.11)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C526(0.25); C532(0.83); C25(1.31); C255(1.03)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C526(0.70); C532(0.84); C25(1.10); C255(1.03)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C526(0.12); C532(0.91); C25(1.38); C255(1.06)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C526(0.21); C532(0.86); C25(1.21); C255(1.00)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C526(0.68); C532(1.22); C25(1.20); C255(1.05)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C526(0.77); C532(0.90); C25(1.04); C255(1.18)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C526(0.18); C532(0.18); C25(1.23); C255(0.97)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C526(0.56); C532(0.75); C25(1.12); C255(1.10)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C526(0.33); C532(0.88); C25(1.15); C255(1.07)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C526(0.85); C532(0.94); C25(1.10); C255(1.06)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C526(0.52); C532(0.91); C25(1.08); C255(1.12)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C526(0.34); C532(0.91); C25(1.13); C255(1.13)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C526(1.09); C532(1.09); C175(0.84); C25(1.05)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C526(0.97); C532(0.97); C175(0.78); C25(0.99)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C526(0.73); C532(0.73); C175(0.84); C25(1.18)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C526(0.25); C532(0.25); C175(0.84); C25(1.16)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C526(0.12); C532(0.12); C25(1.22); C255(0.98)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C526(1.16); C532(1.16); C175(0.95); C25(1.03)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C526(0.68); C532(0.68); C175(1.08); C25(1.08)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C526(0.10); C532(0.10); C175(1.15); C25(1.36)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C526(0.14); C532(0.14); C175(1.00); C25(1.32)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C526(0.08); C532(0.08); C175(0.85); C25(1.49)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C526(0.62); C532(0.62); C175(0.87); C25(1.12)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C526(1.33); C532(1.33); C175(0.82); C25(1.03)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C526(0.60); C532(0.60); C175(0.91); C25(1.16)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C526(0.17); C532(0.17); C175(1.05); C25(1.25)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C526(0.07); C532(0.07); C175(1.02); C25(1.63)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C526(0.49); C532(0.49); C25(1.12); C255(1.09)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C526(0.88); C532(0.88); C175(0.85); C25(0.81)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C526(0.83); C532(0.83); C25(1.07); C255(1.23)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C526(0.75); C532(0.75); C25(0.94); C255(1.04)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C526(0.67); C532(0.67); C25(1.01); C255(0.89)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C526(0.58); C532(0.58); C25(1.01); C255(0.88)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C526(0.63); C532(0.63); C25(1.04); C255(1.18)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C526(0.82); C532(0.82); C25(1.08); C255(1.05)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C526(0.70); C532(0.70); C25(1.14); C255(1.10)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C526(0.55); C532(0.55); C25(1.11); C255(1.11)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C526(0.60); C532(0.60); C25(1.14); C255(1.15)  LDD0811  [10]
 LDCM0634  CY-0357 Hep-G2 C25(0.39)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C255(0.87); C601(1.09); C25(1.21); C57(1.12)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C601(1.24)  LDD1702  [5]
 LDCM0625  F8 Ramos C57(0.60); C25(0.82)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C57(0.64); C25(0.86)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C57(1.22); C25(1.10)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C57(0.72); C25(0.78)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C57(1.14); C25(0.98)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C57(0.71); C25(0.58)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C57(0.54); C25(0.59)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C57(0.94); C25(1.03)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C57(0.98); C25(1.06)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C57(1.05); C25(1.03)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C57(0.33)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C57(1.07); C25(1.09)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C57(1.26); C25(1.06)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C57(0.74); C25(0.84)  LDD2201  [32]
 LDCM0468  Fragment33 HCT 116 C526(0.40); C532(0.91); C25(1.19); C255(1.05)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C57(0.91); C25(0.71)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C25(0.88)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C526(0.05); C532(0.43); C175(0.26); C25(1.47)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C57(0.90); C25(0.67)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C57(1.31)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C57(0.45); C25(1.01)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C57(0.61); C25(0.75)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y471(0.70); Y71(0.70); Y473(1.89)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y71(0.63); Y471(3.75); Y473(5.45)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y71(0.59); Y471(1.31); Y473(3.73)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y71(0.75); Y471(1.42); Y473(3.31)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y71(0.64); Y471(2.35); Y473(4.54)  LDD0268  [9]
 LDCM0107  IAA HeLa C57(0.00); H207(0.00); C255(0.00)  LDD0221  [22]
 LDCM0123  JWB131 DM93 Y71(0.30)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y71(1.20)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y71(0.74)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y71(2.43)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y71(2.44)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y71(0.67)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y71(0.31)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y71(1.07)  LDD0292  [8]
 LDCM0022  KB02 HCT 116 C526(5.48); C532(5.48); C57(1.59); C255(1.21)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C526(7.91); C532(7.91); C57(1.51); C255(0.84)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C526(5.89); C532(5.89); C57(1.57); C255(1.08)  LDD0082  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C57(0.89)  LDD2089  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C78(0.89)  LDD2120  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C57(1.05)  LDD2141  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C57(0.61)  LDD2150  [5]
 LDCM0131  RA190 MM1.R C25(1.04)  LDD0304  [33]
 LDCM0003  Sulforaphane MDA-MB-231 1.93  LDD0160  [6]
 LDCM0021  THZ1 HCT 116 C57(1.26); C526(1.06); C532(1.06); C255(1.05)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Oxytocin Protein/peptide DB00107
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baicalein Small molecular drug D00YEV
Ono-1603 Small molecular drug D0F5JR
Alv-003 . D00WBN
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-17092-1 Small molecular drug D09RJN
Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-hydroxy-1-thio-glycerol Small molecular drug D0M9VP
Ari-3531 Small molecular drug D0N2UF
Double Oxidized Cysteine Small molecular drug D0H1GU
Monothioglycerol Small molecular drug D01WXB
Z-pro-prolinal Small molecular drug D06FNK
(6s)-1-chloro-3-[(4-fluorobenzyl)Oxy]-6-(Pyrrolidin-1-ylcarbonyl)Pyrrolo[12-a]Pyrazin-4(6h)-one . DB07148
1-{3-oxo-3-[(2s)-2-(Pyrrolidin-1-ylcarbonyl)Pyrrolidin-1-yl]Propyl}-3-phenylquinoxalin-2(1h)-one . DB08738
2-{3-[(2s)-44-difluoro-2-(Pyrrolidin-1-ylcarbonyl)Pyrrolidin-1-yl]-3-oxopropyl}-isoindole-13(2h)-dione . DB08739
S-oxy-l-cysteine . DB03382
Discontinued
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baicalin Small molecular drug D08PUW
Jtp-4819 Small molecular drug D01XGX
Y-29794 Small molecular drug D0M8AS
Z-321 Small molecular drug D08RUX

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.