Details of the Target

General Information of Target

Target ID LDTP06644
Target Name Discoidin domain-containing receptor 2 (DDR2)
Gene Name DDR2
Gene ID 4921
Synonyms
NTRKR3; TKT; TYRO10; Discoidin domain-containing receptor 2; Discoidin domain receptor 2; EC 2.7.10.1; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD antigen CD167b
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Subcellular location
Cell membrane
Function
Tyrosine kinase involved in the regulation of tissues remodeling. It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
TTD ID
T11764
Uniprot ID
Q16832
DrugMap ID
TTU98HG
Ensemble ID
ENST00000367921.8
HGNC ID
HGNC:2731
ChEMBL ID
CHEMBL5122

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		7.36  LDD0318  [1]
DBIA
 Probe Info  		C831(5.56); C716(3.71); C288(3.24)  LDD3310  [2]
TFBX
 Probe Info  		C716(0.00); C288(0.00)  LDD0148  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0069  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C820(1.32)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C820(1.15)  LDD1574  [5]
 LDCM0374  CL105 HEK-293T C820(0.72)  LDD1578  [5]
 LDCM0378  CL109 HEK-293T C820(1.00)  LDD1582  [5]
 LDCM0383  CL113 HEK-293T C820(1.23)  LDD1587  [5]
 LDCM0387  CL117 HEK-293T C820(1.83)  LDD1591  [5]
 LDCM0392  CL121 HEK-293T C820(1.33)  LDD1596  [5]
 LDCM0396  CL125 HEK-293T C820(1.53)  LDD1600  [5]
 LDCM0400  CL13 HEK-293T C820(1.86)  LDD1604  [5]
 LDCM0413  CL25 HEK-293T C820(1.12)  LDD1617  [5]
 LDCM0426  CL37 HEK-293T C820(1.29)  LDD1630  [5]
 LDCM0439  CL49 HEK-293T C820(1.75)  LDD1643  [5]
 LDCM0453  CL61 HEK-293T C820(1.34)  LDD1656  [5]
 LDCM0466  CL73 HEK-293T C820(1.69)  LDD1669  [5]
 LDCM0479  CL85 HEK-293T C820(1.21)  LDD1682  [5]
 LDCM0492  CL97 HEK-293T C820(1.44)  LDD1695  [5]
 LDCM0022  KB02 42-MG-BA C831(2.74); C820(2.54)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C831(4.28)  LDD2661  [2]
 LDCM0024  KB05 COLO792 C831(5.56); C716(3.71); C288(3.24)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epithelial discoidin domain-containing receptor 1 (DDR1) Tyr protein kinase family Q08345
NT-3 growth factor receptor (NTRK3) Tyr protein kinase family Q16288
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Collagen alpha-2(XI) chain (COL11A2) Fibrillar collagen family P13942

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Imatinib Small molecular drug DB00619
Regorafenib Small molecular drug DB08896
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us9156852, 1 Small molecular drug D0CI3N
Us9156852, 105 Small molecular drug D0T8BO
Us9156852, 38 Small molecular drug D05AFD

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402