Details of the Target

General Information of Target

Target ID LDTP03487
Target Name Transketolase (TKT)
Gene Name TKT
Gene ID 7086
Synonyms
Transketolase; TK; EC 2.2.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Transketolase family
Function Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
TTD ID
T67754
Uniprot ID
P29401
DrugMap ID
TT04R7I
Ensemble ID
ENST00000423516.5
HGNC ID
HGNC:11834
ChEMBL ID
CHEMBL4983

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.G567D DBIA    Probe Info 
MCC13 SNV: p.T511I DBIA    Probe Info 
RKO SNV: p.G329V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.00  LDD0452  [1]
P3
 Probe Info  		1.70  LDD0450  [1]
P8
 Probe Info  		1.57  LDD0451  [1]
A-EBA
 Probe Info  		3.56  LDD0215  [2]
CHEMBL5175495
 Probe Info  		8.06  LDD0196  [3]
CY4
 Probe Info  		4.07  LDD0244  [4]
N1
 Probe Info  		11.78  LDD0242  [4]
C-Sul
 Probe Info  		3.24  LDD0066  [5]
TH211
 Probe Info  		Y137(20.00); Y481(20.00); Y58(20.00); Y321(18.49)  LDD0257  [6]
TH214
 Probe Info  		Y275(8.87)  LDD0258  [6]
TH216
 Probe Info  		Y202(20.00); Y563(20.00); Y58(20.00); Y321(16.20)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
AZ-9
 Probe Info  		D297(1.29); E2(1.09)  LDD2208  [8]
ONAyne
 Probe Info  		K497(0.00); K543(0.00); K314(0.00); K16(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K538(1.86); K16(2.68); K59(4.48); K314(5.08)  LDD3494  [10]
Probe 1
 Probe Info  		Y202(21.88); Y321(54.90); Y447(16.55); Y481(27.81)  LDD3495  [11]
THZ1-DTB
 Probe Info  		C386(1.10); C413(0.99); C417(1.01)  LDD0460  [12]
BTD
 Probe Info  		C468(0.62)  LDD2089  [13]
AHL-Pu-1
 Probe Info  		C386(2.60)  LDD0169  [14]
DBIA
 Probe Info  		C225(4.73); C386(10.99)  LDD0209  [15]
HHS-482
 Probe Info  		Y137(0.88); Y202(1.01); Y275(0.82); Y309(1.09)  LDD0285  [16]
HHS-475
 Probe Info  		Y321(0.57); Y275(0.97); Y202(1.05); Y309(1.20)  LDD0264  [17]
HHS-465
 Probe Info  		Y202(10.00); Y275(9.63)  LDD2237  [18]
5E-2FA
 Probe Info  		H233(0.00); H110(0.00); H330(0.00); H197(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		N.A.  LDD0200  [20]
ATP probe
 Probe Info  		K232(0.00); K260(0.00); K314(0.00); K254(0.00)  LDD0199  [20]
m-APA
 Probe Info  		H5(0.00); H110(0.00); H197(0.00); H212(0.00)  LDD2231  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C206(0.00); C225(0.00); C41(0.00); C42(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C386(0.00); C206(0.00)  LDD0032  [22]
IPIAA_L
 Probe Info  		C41(0.00); C225(0.00); C386(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C413(0.00); C417(0.00); C206(0.00); C225(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		K543(0.00); K282(0.00); K281(0.00); K603(0.00)  LDD0035  [24]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [25]
NAIA_4
 Probe Info  		C417(0.00); C413(0.00); C133(0.00); C386(0.00)  LDD2226  [26]
TFBX
 Probe Info  		N.A.  LDD0027  [25]
1d-yne
 Probe Info  		K283(0.00); K282(0.00)  LDD0356  [27]
IPM
 Probe Info  		N.A.  LDD0147  [25]
NHS
 Probe Info  		K16(0.00); K310(0.00); K204(0.00); K352(0.00)  LDD0010  [28]
SF
 Probe Info  		Y275(0.00); Y4(0.00)  LDD0028  [29]
STPyne
 Probe Info  		K16(0.00); K232(0.00)  LDD0009  [28]
Phosphinate-6
 Probe Info  		C42(0.00); C41(0.00)  LDD0018  [30]
1c-yne
 Probe Info  		K254(0.00); K465(0.00); K343(0.00); K281(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		H110(0.00); H197(0.00); H233(0.00); C225(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		H233(0.00); H330(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		H233(0.00); H330(0.00)  LDD0218  [31]
NAIA_5
 Probe Info  		C468(0.00); C206(0.00); C41(0.00); C386(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [32]
STS-1
 Probe Info  		N.A.  LDD0069  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C468(0.48)  LDD2142  [13]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C133(1.00)  LDD2117  [13]
 LDCM0025  4SU-RNA DM93 C417(3.18); C413(2.92)  LDD0170  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C386(2.60)  LDD0169  [14]
 LDCM0214  AC1 HEK-293T C133(1.08); C386(0.98); C151(0.93); C206(1.10)  LDD1507  [34]
 LDCM0215  AC10 HEK-293T C133(1.02); C386(0.93); C151(1.05); C206(1.13)  LDD1508  [34]
 LDCM0226  AC11 HEK-293T C133(0.99); C386(0.91); C151(0.89); C206(1.04)  LDD1509  [34]
 LDCM0237  AC12 HEK-293T C133(0.99); C386(0.84); C151(1.07); C206(1.00)  LDD1510  [34]
 LDCM0259  AC14 HEK-293T C133(1.02); C386(0.84); C151(0.97); C206(1.14)  LDD1512  [34]
 LDCM0270  AC15 HEK-293T C133(1.08); C386(0.84); C151(1.00); C206(1.11)  LDD1513  [34]
 LDCM0276  AC17 HEK-293T C133(1.06); C386(1.00); C151(0.94); C206(1.14)  LDD1515  [34]
 LDCM0277  AC18 HEK-293T C133(0.98); C386(0.92); C151(0.96); C206(1.08)  LDD1516  [34]
 LDCM0278  AC19 HEK-293T C133(1.16); C386(1.01); C151(0.76); C206(1.00)  LDD1517  [34]
 LDCM0279  AC2 HEK-293T C133(1.06); C386(0.94); C151(1.03); C206(1.04)  LDD1518  [34]
 LDCM0280  AC20 HEK-293T C133(1.05); C386(0.93); C151(1.05); C206(1.10)  LDD1519  [34]
 LDCM0281  AC21 HEK-293T C133(1.10); C386(0.91); C151(0.94); C206(1.20)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C133(1.08); C386(0.93); C151(0.81); C206(1.04)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C133(1.04); C386(0.96); C151(0.94); C206(1.04)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C133(1.09); C386(0.92); C151(0.99); C206(0.96)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C133(0.99); C386(0.94); C151(0.91); C206(1.08)  LDD1524  [34]
 LDCM0286  AC26 HEK-293T C133(1.05); C386(0.93); C151(1.02); C206(1.17)  LDD1525  [34]
 LDCM0287  AC27 HEK-293T C133(0.99); C386(0.93); C151(0.95); C206(1.05)  LDD1526  [34]
 LDCM0288  AC28 HEK-293T C133(1.02); C386(0.93); C151(0.93); C206(1.09)  LDD1527  [34]
 LDCM0289  AC29 HEK-293T C133(1.07); C386(0.87); C151(0.96); C206(1.10)  LDD1528  [34]
 LDCM0290  AC3 HEK-293T C133(1.06); C386(0.98); C151(1.07); C206(1.06)  LDD1529  [34]
 LDCM0291  AC30 HEK-293T C133(0.97); C386(0.95); C151(0.88); C206(1.13)  LDD1530  [34]
 LDCM0292  AC31 HEK-293T C133(1.01); C386(0.92); C151(0.99); C206(1.14)  LDD1531  [34]
 LDCM0293  AC32 HEK-293T C133(0.98); C386(0.99); C151(1.03); C206(1.01)  LDD1532  [34]
 LDCM0294  AC33 HEK-293T C133(1.01); C386(0.97); C151(0.95); C206(1.10)  LDD1533  [34]
 LDCM0295  AC34 HEK-293T C133(1.01); C386(0.89); C151(1.17); C206(1.13)  LDD1534  [34]
 LDCM0296  AC35 HEK-293T C133(1.07); C386(0.96); C151(0.98); C206(1.07)  LDD1535  [34]
 LDCM0297  AC36 HEK-293T C133(1.00); C386(0.95); C151(1.10); C206(1.02)  LDD1536  [34]
 LDCM0298  AC37 HEK-293T C133(0.99); C386(0.91); C151(0.95); C206(1.01)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C133(1.00); C386(0.88); C151(0.93); C206(1.07)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C133(1.02); C386(0.89); C151(1.03); C206(1.10)  LDD1539  [34]
 LDCM0301  AC4 HEK-293T C133(1.00); C386(0.93); C151(1.09); C206(1.03)  LDD1540  [34]
 LDCM0302  AC40 HEK-293T C133(0.96); C386(0.92); C151(1.07); C206(1.03)  LDD1541  [34]
 LDCM0303  AC41 HEK-293T C133(1.04); C386(0.96); C151(0.93); C206(1.06)  LDD1542  [34]
 LDCM0304  AC42 HEK-293T C133(1.09); C386(0.96); C151(1.01); C206(1.07)  LDD1543  [34]
 LDCM0305  AC43 HEK-293T C133(1.04); C386(0.89); C151(1.01); C206(1.06)  LDD1544  [34]
 LDCM0306  AC44 HEK-293T C133(0.98); C386(0.99); C151(1.04); C206(1.14)  LDD1545  [34]
 LDCM0307  AC45 HEK-293T C133(1.06); C386(0.90); C151(0.98); C206(1.08)  LDD1546  [34]
 LDCM0308  AC46 HEK-293T C133(1.04); C386(0.87); C151(1.10); C206(1.05)  LDD1547  [34]
 LDCM0309  AC47 HEK-293T C133(1.06); C386(0.97); C151(1.03); C206(1.01)  LDD1548  [34]
 LDCM0310  AC48 HEK-293T C133(0.96); C386(0.97); C151(1.00); C206(1.03)  LDD1549  [34]
 LDCM0311  AC49 HEK-293T C133(0.99); C386(0.95); C151(0.86); C206(1.12)  LDD1550  [34]
 LDCM0312  AC5 HEK-293T C133(1.14); C386(0.83); C151(1.07); C206(1.00)  LDD1551  [34]
 LDCM0313  AC50 HEK-293T C133(1.04); C386(0.95); C151(1.02); C206(1.05)  LDD1552  [34]
 LDCM0314  AC51 HEK-293T C133(0.99); C386(0.97); C151(0.96); C206(0.96)  LDD1553  [34]
 LDCM0315  AC52 HEK-293T C133(1.02); C386(0.92); C151(0.90); C206(1.10)  LDD1554  [34]
 LDCM0316  AC53 HEK-293T C133(1.03); C386(0.90); C151(0.98); C206(1.09)  LDD1555  [34]
 LDCM0317  AC54 HEK-293T C133(1.00); C386(0.82); C151(0.87); C206(1.01)  LDD1556  [34]
 LDCM0318  AC55 HEK-293T C133(1.06); C386(1.03); C151(1.07); C206(1.14)  LDD1557  [34]
 LDCM0319  AC56 HEK-293T C133(0.98); C386(0.83); C151(0.99); C206(1.08)  LDD1558  [34]
 LDCM0320  AC57 HEK-293T C133(1.03); C386(0.93); C151(1.03); C206(1.04)  LDD1559  [34]
 LDCM0321  AC58 HEK-293T C133(1.09); C386(0.97); C151(1.06); C206(0.99)  LDD1560  [34]
 LDCM0322  AC59 HEK-293T C133(1.07); C386(0.97); C151(0.89); C206(0.97)  LDD1561  [34]
 LDCM0323  AC6 HEK-293T C133(1.06); C386(0.97); C151(0.94); C206(0.96)  LDD1562  [34]
 LDCM0324  AC60 HEK-293T C133(1.03); C386(1.02); C151(0.96); C206(1.00)  LDD1563  [34]
 LDCM0325  AC61 HEK-293T C133(1.09); C386(0.91); C151(1.00); C206(1.11)  LDD1564  [34]
 LDCM0326  AC62 HEK-293T C133(1.08); C386(1.00); C151(0.99); C206(1.02)  LDD1565  [34]
 LDCM0327  AC63 HEK-293T C133(1.13); C386(0.99); C151(1.09); C206(0.97)  LDD1566  [34]
 LDCM0328  AC64 HEK-293T C133(1.06); C386(1.03); C151(1.11); C206(1.11)  LDD1567  [34]
 LDCM0334  AC7 HEK-293T C133(1.03); C386(0.95); C151(1.11); C206(1.00)  LDD1568  [34]
 LDCM0345  AC8 HEK-293T C133(0.98); C386(0.92); C151(1.02); C206(1.03)  LDD1569  [34]
 LDCM0248  AKOS034007472 HEK-293T C133(1.07); C386(0.89); C151(0.98); C206(1.09)  LDD1511  [34]
 LDCM0356  AKOS034007680 HEK-293T C133(1.00); C386(0.95); C151(0.97); C206(1.15)  LDD1570  [34]
 LDCM0275  AKOS034007705 HEK-293T C133(0.98); C386(0.87); C151(0.94); C206(1.04)  LDD1514  [34]
 LDCM0108  Chloroacetamide HeLa C133(0.00); H513(0.00); H258(0.00); H197(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C133(1.85); C386(0.18); C41(0.13)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C133(1.17); C386(1.14); C151(1.03); C206(0.95)  LDD1571  [34]
 LDCM0368  CL10 HEK-293T C133(1.05); C386(0.74); C151(0.81); C206(1.73)  LDD1572  [34]
 LDCM0369  CL100 HEK-293T C133(1.01); C386(1.12); C151(0.98); C206(1.05)  LDD1573  [34]
 LDCM0370  CL101 HEK-293T C133(1.00); C386(1.03); C151(0.97); C206(1.00)  LDD1574  [34]
 LDCM0371  CL102 HEK-293T C133(1.00); C386(1.18); C151(0.89); C206(1.13)  LDD1575  [34]
 LDCM0372  CL103 HEK-293T C133(0.91); C386(0.91); C151(0.90); C206(1.03)  LDD1576  [34]
 LDCM0373  CL104 HEK-293T C133(1.03); C386(1.00); C151(0.92); C206(1.06)  LDD1577  [34]
 LDCM0374  CL105 HEK-293T C133(1.06); C386(1.09); C151(1.01); C206(1.06)  LDD1578  [34]
 LDCM0375  CL106 HEK-293T C133(1.11); C386(1.00); C151(0.86); C206(1.13)  LDD1579  [34]
 LDCM0376  CL107 HEK-293T C133(1.04); C386(0.89); C151(0.94); C206(1.04)  LDD1580  [34]
 LDCM0377  CL108 HEK-293T C133(0.96); C386(1.07); C151(0.95); C206(1.07)  LDD1581  [34]
 LDCM0378  CL109 HEK-293T C133(1.00); C386(1.15); C151(0.95); C206(1.12)  LDD1582  [34]
 LDCM0379  CL11 HEK-293T C133(1.00); C386(0.63); C151(1.22); C206(1.42)  LDD1583  [34]
 LDCM0380  CL110 HEK-293T C133(1.03); C386(1.11); C151(0.84); C206(1.31)  LDD1584  [34]
 LDCM0381  CL111 HEK-293T C133(1.00); C386(1.02); C151(0.86); C206(1.02)  LDD1585  [34]
 LDCM0382  CL112 HEK-293T C133(0.97); C386(1.14); C151(0.80); C206(1.05)  LDD1586  [34]
 LDCM0383  CL113 HEK-293T C133(1.03); C386(1.09); C151(1.12); C206(0.92)  LDD1587  [34]
 LDCM0384  CL114 HEK-293T C133(1.05); C386(1.20); C151(0.77); C206(1.15)  LDD1588  [34]
 LDCM0385  CL115 HEK-293T C133(0.89); C386(0.97); C151(0.96); C206(1.02)  LDD1589  [34]
 LDCM0386  CL116 HEK-293T C133(0.95); C386(1.01); C151(1.08); C206(1.05)  LDD1590  [34]
 LDCM0387  CL117 HEK-293T C133(1.02); C386(1.00); C151(0.93); C206(0.99)  LDD1591  [34]
 LDCM0388  CL118 HEK-293T C133(1.02); C386(1.01); C151(0.92); C206(0.99)  LDD1592  [34]
 LDCM0389  CL119 HEK-293T C133(0.94); C386(0.99); C151(0.97); C206(1.03)  LDD1593  [34]
 LDCM0390  CL12 HEK-293T C133(0.89); C386(0.73); C151(1.19); C206(1.17)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C133(0.95); C386(1.02); C151(1.00); C206(1.02)  LDD1595  [34]
 LDCM0392  CL121 HEK-293T C133(1.08); C386(1.10); C151(1.00); C206(1.07)  LDD1596  [34]
 LDCM0393  CL122 HEK-293T C133(1.01); C386(1.09); C151(0.95); C206(1.05)  LDD1597  [34]
 LDCM0394  CL123 HEK-293T C133(0.97); C386(1.22); C151(0.87); C206(1.28)  LDD1598  [34]
 LDCM0395  CL124 HEK-293T C133(0.97); C386(1.07); C151(0.99); C206(1.08)  LDD1599  [34]
 LDCM0396  CL125 HEK-293T C133(1.14); C386(1.20); C151(1.07); C206(1.06)  LDD1600  [34]
 LDCM0397  CL126 HEK-293T C133(1.14); C386(1.18); C151(0.95); C206(1.07)  LDD1601  [34]
 LDCM0398  CL127 HEK-293T C133(1.07); C386(1.17); C151(0.95); C206(1.03)  LDD1602  [34]
 LDCM0399  CL128 HEK-293T C133(1.02); C386(1.10); C151(0.95); C206(0.97)  LDD1603  [34]
 LDCM0400  CL13 HEK-293T C133(1.11); C386(1.02); C151(0.97); C206(0.90)  LDD1604  [34]
 LDCM0401  CL14 HEK-293T C133(1.07); C386(0.84); C151(0.87); C206(0.97)  LDD1605  [34]
 LDCM0402  CL15 HEK-293T C133(1.08); C386(1.00); C151(0.88); C206(1.14)  LDD1606  [34]
 LDCM0403  CL16 HEK-293T C133(1.05); C386(0.96); C151(1.04); C206(0.98)  LDD1607  [34]
 LDCM0404  CL17 HEK-293T C133(1.08); C386(0.90); C151(0.91); C206(1.22)  LDD1608  [34]
 LDCM0405  CL18 HEK-293T C133(1.05); C386(0.74); C151(1.06); C206(1.16)  LDD1609  [34]
 LDCM0406  CL19 HEK-293T C133(1.04); C386(0.68); C151(0.99); C206(1.15)  LDD1610  [34]
 LDCM0407  CL2 HEK-293T C133(1.07); C386(0.88); C151(0.94); C206(0.97)  LDD1611  [34]
 LDCM0408  CL20 HEK-293T C133(0.96); C386(0.71); C151(1.06); C206(1.30)  LDD1612  [34]
 LDCM0409  CL21 HEK-293T C133(0.99); C386(0.66); C151(0.88); C206(1.49)  LDD1613  [34]
 LDCM0410  CL22 HEK-293T C133(0.95); C386(0.35); C151(0.89); C206(1.32)  LDD1614  [34]
 LDCM0411  CL23 HEK-293T C133(0.91); C386(0.62); C151(1.21); C206(1.33)  LDD1615  [34]
 LDCM0412  CL24 HEK-293T C133(0.87); C386(0.64); C151(1.25); C206(1.22)  LDD1616  [34]
 LDCM0413  CL25 HEK-293T C133(1.28); C386(1.18); C151(1.04); C206(1.01)  LDD1617  [34]
 LDCM0414  CL26 HEK-293T C133(1.06); C386(0.94); C151(0.88); C206(1.03)  LDD1618  [34]
 LDCM0415  CL27 HEK-293T C133(1.11); C386(0.92); C151(0.96); C206(1.07)  LDD1619  [34]
 LDCM0416  CL28 HEK-293T C133(1.12); C386(1.04); C151(0.92); C206(1.18)  LDD1620  [34]
 LDCM0417  CL29 HEK-293T C133(1.07); C386(0.79); C151(1.00); C206(1.05)  LDD1621  [34]
 LDCM0418  CL3 HEK-293T C133(0.86); C386(0.97); C151(1.02); C206(0.94)  LDD1622  [34]
 LDCM0419  CL30 HEK-293T C133(1.06); C386(0.74); C151(1.07); C206(1.12)  LDD1623  [34]
 LDCM0420  CL31 HEK-293T C133(1.05); C386(0.72); C151(0.93); C206(1.14)  LDD1624  [34]
 LDCM0421  CL32 HEK-293T C133(0.93); C386(0.70); C151(1.14); C206(1.23)  LDD1625  [34]
 LDCM0422  CL33 HEK-293T C133(1.07); C386(0.83); C151(0.83); C206(1.83)  LDD1626  [34]
 LDCM0423  CL34 HEK-293T C133(0.86); C386(0.57); C151(1.11); C206(1.41)  LDD1627  [34]
 LDCM0424  CL35 HEK-293T C133(0.91); C386(0.59); C151(1.16); C206(1.39)  LDD1628  [34]
 LDCM0425  CL36 HEK-293T C133(0.84); C386(0.67); C151(1.16); C206(1.52)  LDD1629  [34]
 LDCM0426  CL37 HEK-293T C133(1.17); C386(1.16); C151(1.03); C206(0.92)  LDD1630  [34]
 LDCM0428  CL39 HEK-293T C133(1.05); C386(0.96); C151(0.99); C206(1.00)  LDD1632  [34]
 LDCM0429  CL4 HEK-293T C133(0.97); C386(0.98); C151(1.10); C206(0.99)  LDD1633  [34]
 LDCM0430  CL40 HEK-293T C133(1.03); C386(1.02); C151(0.96); C206(1.01)  LDD1634  [34]
 LDCM0431  CL41 HEK-293T C133(1.06); C386(0.85); C151(0.93); C206(1.07)  LDD1635  [34]
 LDCM0432  CL42 HEK-293T C133(1.14); C386(0.79); C151(0.92); C206(1.12)  LDD1636  [34]
 LDCM0433  CL43 HEK-293T C133(0.98); C386(0.69); C151(0.91); C206(1.07)  LDD1637  [34]
 LDCM0434  CL44 HEK-293T C133(0.95); C386(0.69); C151(1.30); C206(1.17)  LDD1638  [34]
 LDCM0435  CL45 HEK-293T C133(0.88); C386(0.79); C151(0.87); C206(1.44)  LDD1639  [34]
 LDCM0436  CL46 HEK-293T C133(0.86); C386(0.61); C151(1.25); C206(1.55)  LDD1640  [34]
 LDCM0437  CL47 HEK-293T C133(0.87); C386(0.60); C151(1.25); C206(1.39)  LDD1641  [34]
 LDCM0438  CL48 HEK-293T C133(0.85); C386(0.66); C151(1.09); C206(1.30)  LDD1642  [34]
 LDCM0439  CL49 HEK-293T C133(1.25); C386(1.17); C151(1.08); C206(1.00)  LDD1643  [34]
 LDCM0440  CL5 HEK-293T C133(1.02); C386(0.90); C151(1.07); C206(1.03)  LDD1644  [34]
 LDCM0441  CL50 HEK-293T C133(1.10); C386(0.96); C151(0.88); C206(1.09)  LDD1645  [34]
 LDCM0443  CL52 HEK-293T C133(0.97); C386(0.93); C151(0.92); C206(1.05)  LDD1646  [34]
 LDCM0444  CL53 HEK-293T C133(1.07); C386(0.88); C151(0.87); C206(1.23)  LDD1647  [34]
 LDCM0445  CL54 HEK-293T C133(1.03); C386(0.94); C151(0.97); C206(1.33)  LDD1648  [34]
 LDCM0446  CL55 HEK-293T C133(0.99); C386(0.69); C151(0.90); C206(1.17)  LDD1649  [34]
 LDCM0447  CL56 HEK-293T C133(1.01); C386(0.70); C151(1.42); C206(1.15)  LDD1650  [34]
 LDCM0448  CL57 HEK-293T C133(0.84); C386(0.66); C151(0.86); C206(1.39)  LDD1651  [34]
 LDCM0449  CL58 HEK-293T C133(0.84); C386(0.64); C151(1.17); C206(1.38)  LDD1652  [34]
 LDCM0450  CL59 HEK-293T C133(0.81); C386(0.60); C151(1.21); C206(1.30)  LDD1653  [34]
 LDCM0451  CL6 HEK-293T C133(1.10); C386(0.89); C151(1.01); C206(1.25)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C133(0.78); C386(0.68); C151(1.12); C206(1.18)  LDD1655  [34]
 LDCM0453  CL61 HEK-293T C133(1.20); C386(1.10); C151(1.19); C206(0.87)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C133(1.06); C386(0.95); C151(0.94); C206(1.01)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C133(0.97); C386(0.93); C151(1.05); C206(0.97)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C133(1.07); C386(0.98); C151(0.94); C206(1.07)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C133(1.08); C386(0.81); C151(1.02); C206(1.08)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C133(1.11); C386(0.80); C151(1.09); C206(1.15)  LDD1661  [34]
 LDCM0459  CL67 HEK-293T C133(1.00); C386(0.73); C151(0.97); C206(1.04)  LDD1662  [34]
 LDCM0460  CL68 HEK-293T C133(0.97); C386(0.74); C151(0.98); C206(1.08)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C133(0.94); C386(0.71); C151(0.93); C206(1.32)  LDD1664  [34]
 LDCM0462  CL7 HEK-293T C133(1.01); C386(0.78); C151(0.98); C206(1.13)  LDD1665  [34]
 LDCM0463  CL70 HEK-293T C133(0.85); C386(0.62); C151(1.73); C206(1.29)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C133(0.83); C386(0.63); C151(1.01); C206(1.41)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C133(0.81); C386(0.63); C151(1.04); C206(1.21)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C133(1.14); C386(1.10); C151(1.13); C206(1.00)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C133(1.09); C386(1.02); C151(1.01); C206(1.01)  LDD1670  [34]
 LDCM0469  CL76 HEK-293T C133(1.14); C386(1.00); C151(0.97); C206(0.97)  LDD1672  [34]
 LDCM0470  CL77 HEK-293T C133(1.08); C386(1.04); C151(0.97); C206(1.27)  LDD1673  [34]
 LDCM0471  CL78 HEK-293T C133(1.04); C386(0.75); C151(1.01); C206(1.11)  LDD1674  [34]
 LDCM0472  CL79 HEK-293T C133(0.98); C386(0.79); C151(1.10); C206(1.06)  LDD1675  [34]
 LDCM0473  CL8 HEK-293T C133(1.21); C386(0.94); C151(1.23); C206(2.29)  LDD1676  [34]
 LDCM0474  CL80 HEK-293T C133(0.95); C386(0.75); C151(1.09); C206(1.15)  LDD1677  [34]
 LDCM0475  CL81 HEK-293T C133(0.92); C386(0.74); C151(0.89); C206(1.30)  LDD1678  [34]
 LDCM0476  CL82 HEK-293T C133(0.87); C386(0.64); C151(1.05); C206(1.26)  LDD1679  [34]
 LDCM0477  CL83 HEK-293T C133(0.87); C386(0.54); C151(1.12); C206(1.28)  LDD1680  [34]
 LDCM0478  CL84 HEK-293T C133(0.88); C386(0.74); C151(1.11); C206(1.24)  LDD1681  [34]
 LDCM0479  CL85 HEK-293T C133(1.25); C386(1.35); C151(1.30); C206(0.96)  LDD1682  [34]
 LDCM0480  CL86 HEK-293T C133(1.19); C386(1.29); C151(1.01); C206(0.91)  LDD1683  [34]
 LDCM0481  CL87 HEK-293T C133(1.10); C386(1.03); C151(0.95); C206(0.94)  LDD1684  [34]
 LDCM0482  CL88 HEK-293T C133(1.10); C386(1.13); C151(1.04); C206(0.88)  LDD1685  [34]
 LDCM0483  CL89 HEK-293T C133(1.08); C386(0.95); C151(1.11); C206(0.99)  LDD1686  [34]
 LDCM0484  CL9 HEK-293T C133(1.04); C386(0.68); C151(0.98); C206(1.26)  LDD1687  [34]
 LDCM0485  CL90 HEK-293T C133(1.20); C386(1.25); C151(1.10); C206(1.34)  LDD1688  [34]
 LDCM0486  CL91 HEK-293T C133(1.10); C386(0.81); C151(0.94); C206(1.00)  LDD1689  [34]
 LDCM0487  CL92 HEK-293T C133(0.95); C386(0.82); C151(1.19); C206(1.00)  LDD1690  [34]
 LDCM0488  CL93 HEK-293T C133(0.97); C386(0.74); C151(0.93); C206(1.25)  LDD1691  [34]
 LDCM0489  CL94 HEK-293T C133(0.83); C386(0.70); C151(1.37); C206(0.98)  LDD1692  [34]
 LDCM0490  CL95 HEK-293T C133(1.03); C386(0.74); C151(0.97); C206(1.64)  LDD1693  [34]
 LDCM0491  CL96 HEK-293T C133(0.92); C386(0.86); C151(1.22); C206(1.19)  LDD1694  [34]
 LDCM0492  CL97 HEK-293T C133(1.05); C386(1.03); C151(0.95); C206(1.04)  LDD1695  [34]
 LDCM0493  CL98 HEK-293T C133(1.00); C386(1.01); C151(0.85); C206(1.06)  LDD1696  [34]
 LDCM0494  CL99 HEK-293T C133(1.08); C386(1.06); C151(0.95); C206(0.97)  LDD1697  [34]
 LDCM0495  E2913 HEK-293T C133(1.04); C386(0.90); C151(1.01); C206(1.00)  LDD1698  [34]
 LDCM0573  Fragment11 Ramos C133(1.26)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C133(1.07)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C133(0.90)  LDD2192  [35]
 LDCM0580  Fragment21 Ramos C133(0.62)  LDD2195  [35]
 LDCM0586  Fragment28 Ramos C133(2.99)  LDD2198  [35]
 LDCM0468  Fragment33 HEK-293T C133(1.06); C386(0.41); C151(1.00); C206(1.00)  LDD1671  [34]
 LDCM0596  Fragment38 Ramos C133(0.49)  LDD2203  [35]
 LDCM0427  Fragment51 HEK-293T C133(1.07); C386(0.94); C151(0.96); C206(0.89)  LDD1631  [34]
 LDCM0116  HHS-0101 DM93 Y321(0.57); Y275(0.97); Y202(1.05); Y309(1.20)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y321(0.57); Y202(0.81); Y275(0.83); Y309(1.24)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y321(0.51); Y202(0.78); Y275(1.61); Y309(2.27)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y309(0.50); Y321(0.52); Y202(0.68); Y275(0.78)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y321(0.53); Y275(1.18); Y202(1.37); Y309(3.32)  LDD0268  [17]
 LDCM0107  IAA HeLa H110(0.00); H197(0.00); H233(0.00); C225(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y137(0.88); Y202(1.01); Y275(0.82); Y309(1.09)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y137(0.40); Y202(0.45); Y275(0.93); Y309(0.99)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y137(1.32); Y202(0.97); Y275(0.96); Y309(0.83)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y137(12.78); Y202(2.78); Y275(2.75); Y309(4.43)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y137(1.62); Y202(1.10); Y275(1.84); Y309(0.90)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y137(1.74); Y202(0.78); Y275(1.38); Y309(0.92)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y137(0.28); Y202(0.32); Y275(0.64); Y309(1.45)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y137(1.04); Y202(0.86); Y275(1.10); Y309(3.30)  LDD0292  [16]
 LDCM0022  KB02 HEK-293T C133(0.96); C206(0.99); C413(1.23); C417(0.93)  LDD1492  [34]
 LDCM0023  KB03 Jurkat C225(4.73); C386(10.99)  LDD0209  [15]
 LDCM0024  KB05 COLO792 C133(0.92)  LDD3310  [36]
 LDCM0109  NEM HeLa H197(0.00); H110(0.00); H258(0.00); H233(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C468(0.62)  LDD2089  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C133(1.64)  LDD2099  [13]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C468(0.34)  LDD2100  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C468(0.43)  LDD2104  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C133(0.55)  LDD2109  [13]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C468(0.45)  LDD2114  [13]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C468(0.58); C133(0.72)  LDD2120  [13]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C133(0.90)  LDD2123  [13]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.96)  LDD2125  [13]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C133(0.75)  LDD2134  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C133(0.90)  LDD2136  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C133(0.89)  LDD2137  [13]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C468(0.41)  LDD2141  [13]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C468(0.46)  LDD2143  [13]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C133(0.62)  LDD2148  [13]
 LDCM0131  RA190 MM1.R C133(1.68)  LDD0304  [37]
 LDCM0021  THZ1 HeLa S3 C386(1.10); C413(0.99); C417(1.01)  LDD0460  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane Small molecular drug D0OD8N

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
29 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
30 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.