Details of the Target

General Information of Target

Target ID LDTP05043
Target Name 14-3-3 protein zeta/delta (YWHAZ)
Gene Name YWHAZ
Gene ID 7534
Synonyms
14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWR
VVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLK
MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYE
ILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAG
EGGEN
Target Bioclass
Transporter and channel
Family
14-3-3 family
Subcellular location
Cytoplasm
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity.
Uniprot ID
P63104
Ensemble ID
ENST00000353245.7
HGNC ID
HGNC:12855
ChEMBL ID
CHEMBL4105899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.Y178C DBIA    Probe Info 
AU565 SNV: p.S45L DBIA    Probe Info 
MDAMB436 Deletion: p.L191CfsTer6 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.90  LDD0402  [2]
P2
 Probe Info  		1.88  LDD0449  [3]
P3
 Probe Info  		1.53  LDD0450  [3]
P8
 Probe Info  		3.06  LDD0451  [3]
A-EBA
 Probe Info  		3.21  LDD0215  [4]
8RK64
 Probe Info  		N.A.  LDD0039  [5]
CHEMBL5175495
 Probe Info  		7.90  LDD0196  [6]
CY-1
 Probe Info  		5.56  LDD0243  [7]
CY4
 Probe Info  		5.84  LDD0244  [7]
N1
 Probe Info  		3.49  LDD0242  [7]
TH211
 Probe Info  		Y118(19.92); Y211(16.98); Y48(14.89)  LDD0257  [8]
TH214
 Probe Info  		Y48(13.97); Y118(13.77); Y128(5.43)  LDD0258  [8]
TH216
 Probe Info  		Y149(16.54)  LDD0259  [8]
YN-4
 Probe Info  		100.00  LDD0445  [9]
AZ-9
 Probe Info  		D143(0.97); E154(1.03); E113(1.18); D137(0.98)  LDD2208  [10]
ONAyne
 Probe Info  		K75(0.00); K68(0.00); K157(0.00)  LDD0273  [11]
OPA-S-S-alkyne
 Probe Info  		K85(3.38)  LDD3494  [12]
Probe 1
 Probe Info  		Y128(105.85); Y149(8.77); Y211(62.00)  LDD3495  [13]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [14]
BTD
 Probe Info  		C25(2.50)  LDD1700  [15]
HHS-482
 Probe Info  		Y118(0.91); Y128(1.07); Y149(1.44); Y19(1.51)  LDD0285  [16]
HHS-475
 Probe Info  		Y19(0.64); Y149(0.77); Y118(0.86); Y128(0.90)  LDD0264  [17]
HHS-465
 Probe Info  		Y125(2.82); Y126(1.47); Y128(10.00); Y211(10.00)  LDD2237  [18]
DBIA
 Probe Info  		C25(1.58)  LDD0080  [19]
AMP probe
 Probe Info  		N.A.  LDD0200  [20]
ATP probe
 Probe Info  		K68(0.00); K9(0.00); K11(0.00); K157(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C94(0.00); C25(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C94(0.00); C25(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		C25(0.00); C94(0.00)  LDD0030  [23]
IPIAA_L
 Probe Info  		C94(0.00); C25(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C94(0.00); C25(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		K193(0.00); K9(0.00); K49(0.00); K68(0.00)  LDD0035  [24]
IPM
 Probe Info  		N.A.  LDD0025  [25]
NAIA_4
 Probe Info  		N.A.  LDD2226  [26]
TFBX
 Probe Info  		N.A.  LDD0027  [25]
WYneN
 Probe Info  		N.A.  LDD0021  [27]
WYneO
 Probe Info  		N.A.  LDD0022  [27]
ENE
 Probe Info  		N.A.  LDD0006  [27]
NHS
 Probe Info  		K138(0.00); K157(0.00); K49(0.00); K68(0.00)  LDD0010  [27]
OSF
 Probe Info  		N.A.  LDD0029  [28]
PF-06672131
 Probe Info  		N.A.  LDD0152  [29]
SF
 Probe Info  		Y128(0.00); Y48(0.00); K11(0.00); K68(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K11(0.00); K9(0.00); K68(0.00); K49(0.00)  LDD0009  [27]
VSF
 Probe Info  		N.A.  LDD0007  [27]
Ox-W18
 Probe Info  		N.A.  LDD2175  [30]
1c-yne
 Probe Info  		K139(0.00); K27(0.00); K115(0.00); K193(0.00)  LDD0228  [31]
Acrolein
 Probe Info  		C25(0.00); K27(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [32]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [32]
Methacrolein
 Probe Info  		N.A.  LDD0218  [32]
W1
 Probe Info  		N.A.  LDD0236  [33]
AOyne
 Probe Info  		7.90  LDD0443  [34]
MPP-AC
 Probe Info  		N.A.  LDD0428  [35]
NAIA_5
 Probe Info  		C25(0.00); C94(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		49.87  LDD1948  [36]
FFF probe12
 Probe Info  		5.38  LDD0473  [37]
FFF probe13
 Probe Info  		5.87  LDD0475  [37]
FFF probe14
 Probe Info  		6.99  LDD0477  [37]
STS-2
 Probe Info  		N.A.  LDD0138  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
BD-F
 Probe Info  		E209(0.00); E208(0.00)  LDD0024  [40]
LD-F
 Probe Info  		T205(0.00); S207(0.00); L203(0.00); A201(0.00)  LDD0015  [40]
STS-1
 Probe Info  		N.A.  LDD0068  [41]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.34)  LDD2142  [15]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.65)  LDD2112  [15]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C25(0.76)  LDD2095  [15]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C25(0.97)  LDD2130  [15]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C25(0.94)  LDD2117  [15]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C25(1.21)  LDD2152  [15]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C25(1.26)  LDD2103  [15]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C25(0.56)  LDD2132  [15]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C25(0.77)  LDD2131  [15]
 LDCM0214  AC1 HCT 116 C25(1.21)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C25(0.93)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C25(0.78)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C25(0.74)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C25(0.71)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C25(0.61)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C25(0.65)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C25(0.59)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C25(0.66)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C25(0.61)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C25(0.74)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C25(0.77)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C25(0.75)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C25(0.68)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C25(0.60)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C25(0.55)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C25(1.47)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C25(1.33)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C25(1.13)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C25(1.33)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C25(1.26)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C25(1.57)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C25(1.33)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C25(1.18)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C25(1.28)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C25(1.54)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C25(1.42)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C25(1.54)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C25(1.49)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C25(1.47)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C25(1.26)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C25(1.48)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C25(0.78)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C25(0.98)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C25(0.69)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C25(0.92)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C25(0.81)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C25(0.74)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C25(0.69)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C25(0.70)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C25(0.76)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C25(0.86)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C25(0.67)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C25(0.72)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C25(0.99)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C25(0.61)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C25(0.66)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C25(0.92)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C94(0.85); C25(1.14)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C94(0.63); C25(0.78)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C94(0.76); C25(0.94)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C94(0.70); C25(0.96)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C94(0.67); C25(0.87)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C94(0.40); C25(0.66)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C94(0.61); C25(0.70)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C25(0.94)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C94(0.92); C25(1.03)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C94(0.72); C25(0.85)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C94(0.57); C25(0.83)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C94(0.31); C25(0.74)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C25(0.91); C94(0.67)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C25(0.93); C94(0.65)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C25(1.02); C94(0.81)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C25(1.12); C94(0.97)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C25(0.89)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C25(0.82)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C25(0.75)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C25(0.97)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C25(0.93)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C25(1.14)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C25(1.33)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C25(0.92)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C25(0.92)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C25(1.03)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C25(0.82)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C25(1.02)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C25(1.02)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C25(0.91)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C25(1.13)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C25(0.79)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C25(0.89)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C25(0.82)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C25(0.81)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C25(0.77)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C25(1.24)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C25(0.98)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C25(1.02)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C25(0.90)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C25(0.94)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C25(1.29)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C25(0.85)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C25(0.92)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C25(0.85)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C25(0.79)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C25(0.88)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C25(0.84)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C25(0.89); C94(1.12)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C25(0.90); C94(1.36)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C25(0.93); C94(1.10)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C25(0.75); C94(0.99)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C25(1.22)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C94(0.59); C25(0.81)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C25(1.16); C94(1.27)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C25(1.09); C94(1.25)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C25(0.92); C94(0.99)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C25(1.02); C94(1.07)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C94(0.86); C25(0.89)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C94(0.47); C25(0.75)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C25(0.92)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C25(0.90)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C25(0.56)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C25(0.73)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C25(0.53)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C25(0.75)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C25(0.49)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C25(0.72)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C25(0.50)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C25(0.70)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C25(0.87)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C25(0.56)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C94(0.74); C25(0.89)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C94(0.65); C25(0.98)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C25(0.98)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C94(0.40); C25(0.87)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C94(1.06); C25(1.15)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C94(0.77); C25(1.12)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C94(0.34); C25(0.81)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C94(0.34); C25(0.81)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C94(0.21); C25(0.75)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C94(0.65); C25(1.03)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C94(0.67); C25(0.96)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C94(0.85); C25(1.06)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C94(0.82); C25(1.04)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C25(0.81)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C94(0.78); C25(0.94)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C94(0.67); C25(1.07)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C94(0.10); C25(0.56)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C25(0.59)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C25(0.60)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C25(0.71)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C25(0.78)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C25(0.80)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C25(0.79)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C25(0.62)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C25(1.15)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C25(0.67)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C25(0.59)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C25(0.72)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C25(0.90)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C25(0.82)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C25(0.82)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C25(0.62)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C25(0.41)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C25(0.66)  LDD0683  [19]
 LDCM0545  Acetamide MDA-MB-231 C25(0.83)  LDD2138  [15]
 LDCM0520  AKOS000195272 MDA-MB-231 C25(0.69)  LDD2113  [15]
 LDCM0248  AKOS034007472 HCT 116 C25(0.99)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C25(0.97)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C25(0.78)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C25(0.88)  LDD2091  [15]
 LDCM0108  Chloroacetamide HeLa C25(0.00); K27(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C25(20.00); C25(0.95); C25(0.90)  LDD2227  [26]
 LDCM0367  CL1 HCT 116 C25(0.94)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C25(0.82)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C25(0.99)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C25(0.76)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C25(0.90)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C25(1.07)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C25(1.01)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C25(0.85)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C25(0.74)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C25(0.76)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C25(0.72)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C25(0.75)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C25(0.93)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C25(0.72)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C25(0.69)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C25(1.07)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C25(0.83)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C25(0.94)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C25(0.94)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C25(0.88)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C25(0.73)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C25(0.90)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C25(0.88)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C25(0.85)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C25(0.95)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C25(0.92); C94(2.42)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C94(0.85); C25(0.90)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C94(0.86); C25(0.93)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C25(0.90); C94(1.10)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C25(0.79)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C25(0.77)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C25(0.59)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C25(0.66)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C25(0.87)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C25(0.92)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C25(0.73)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C25(0.89)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C25(0.94)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C25(0.88)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C25(0.89)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C25(0.95)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C25(0.78)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C25(0.76)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C25(0.77)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C25(0.88)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C25(0.79)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C25(0.78)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C25(0.77)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C25(0.88)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C25(0.72)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C25(0.78)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C25(1.03)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C25(1.06)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C25(0.72)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C25(0.61)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C25(0.61)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C25(0.56)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C25(0.64)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C25(0.63)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C25(0.65)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C25(0.67)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C25(0.98)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C25(0.64)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C25(0.71)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C25(0.55)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C25(0.62)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C25(0.66)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C25(0.51)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C25(1.31)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C25(1.23)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C25(1.38)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C25(1.20)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C25(1.01)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C25(1.26)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C25(1.32)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C25(1.31)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C25(1.42)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C25(1.23)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C25(1.38)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C25(1.09)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C25(1.33)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C25(1.31)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C25(1.29)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C25(0.83)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C25(1.19)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C25(1.00)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C25(0.90)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C25(0.86)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C25(0.90)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C25(0.92)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C25(0.87)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C25(0.94)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C25(0.90)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C25(0.81)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C25(0.93)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C25(0.90)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C25(0.90)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C25(0.95)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C25(0.85)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C25(0.89)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C25(0.80); C94(0.82)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C25(0.83); C94(1.16)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C25(0.80); C94(1.50)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C25(0.68); C94(1.23)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C25(0.84)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C25(0.80); C94(0.70)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C25(0.79); C94(0.83)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C25(0.92); C94(0.69)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C25(0.73); C94(1.10)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C25(0.61); C94(0.73)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C25(0.72); C94(1.11)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C25(0.87); C94(1.29)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C25(0.87); C94(1.62)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C25(0.74); C94(1.01)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C25(0.65); C94(0.44)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C25(0.98)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C25(1.01); C94(0.81)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C25(0.79)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C25(1.00)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C25(1.15)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C25(1.06)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C25(1.14)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C25(1.04)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C25(0.89)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C25(0.87)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C25(0.94)  LDD0811  [19]
 LDCM0634  CY-0357 Hep-G2 C25(3.67)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C25(0.85); C94(0.87)  LDD1698  [42]
 LDCM0625  F8 Ramos C25(0.85); C94(0.57)  LDD2187  [43]
 LDCM0572  Fragment10 Ramos C25(0.99); C94(0.45)  LDD2189  [43]
 LDCM0573  Fragment11 Ramos C25(0.31); C94(0.03)  LDD2190  [43]
 LDCM0574  Fragment12 Ramos C25(1.07); C94(0.34)  LDD2191  [43]
 LDCM0575  Fragment13 Ramos C25(1.40); C94(0.83)  LDD2192  [43]
 LDCM0576  Fragment14 Ramos C25(0.71); C94(1.05)  LDD2193  [43]
 LDCM0579  Fragment20 Ramos C25(0.94); C94(0.32)  LDD2194  [43]
 LDCM0580  Fragment21 Ramos C25(1.26); C94(0.63)  LDD2195  [43]
 LDCM0582  Fragment23 Ramos C25(1.57); C94(0.74)  LDD2196  [43]
 LDCM0578  Fragment27 Ramos C25(1.28); C94(0.63)  LDD2197  [43]
 LDCM0586  Fragment28 Ramos C25(0.67); C94(0.31)  LDD2198  [43]
 LDCM0588  Fragment30 Ramos C25(1.78); C94(0.62)  LDD2199  [43]
 LDCM0589  Fragment31 Ramos C25(1.64); C94(0.58)  LDD2200  [43]
 LDCM0590  Fragment32 Ramos C25(0.91); C94(0.41)  LDD2201  [43]
 LDCM0468  Fragment33 HCT 116 C25(0.89)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C25(1.46); C94(0.74)  LDD2203  [43]
 LDCM0566  Fragment4 Ramos C25(0.93); C94(0.66)  LDD2184  [43]
 LDCM0427  Fragment51 HCT 116 C25(0.61)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C25(1.96); C94(0.79)  LDD2204  [43]
 LDCM0614  Fragment56 Ramos C25(1.69); C94(0.55)  LDD2205  [43]
 LDCM0569  Fragment7 Ramos C25(0.72); C94(0.88)  LDD2186  [43]
 LDCM0571  Fragment9 Ramos C25(0.82); C94(0.48)  LDD2188  [43]
 LDCM0116  HHS-0101 DM93 Y19(0.64); Y149(0.77); Y118(0.86); Y128(0.90)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y19(0.49); Y149(0.70); Y118(0.71); Y211(0.76)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y19(0.64); Y149(0.70); Y118(0.77); Y128(0.81)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y149(0.75); Y118(0.81); Y48(0.89); Y128(0.97)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y118(0.75); Y48(0.75); Y149(0.79); Y128(1.01)  LDD0268  [17]
 LDCM0107  IAA HeLa C25(0.00); K27(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y118(0.91); Y128(1.07); Y149(1.44); Y19(1.51)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y118(0.39); Y128(0.57); Y149(1.44); Y19(0.45)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y118(0.63); Y128(0.97); Y149(1.34); Y19(1.03)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y118(3.04); Y128(2.85); Y149(3.19); Y19(4.24)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y118(1.90); Y128(2.12); Y149(2.81); Y19(7.72)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y118(0.41); Y128(1.06); Y149(1.45); Y19(0.74)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y118(0.63); Y128(0.50); Y149(1.23); Y19(0.64)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y118(0.54); Y128(0.86); Y149(2.27); Y19(0.62)  LDD0292  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [14]
 LDCM0022  KB02 HCT 116 C25(1.58)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C25(0.97)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C25(1.46)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C25(1.00)  LDD2102  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C25(1.05)  LDD2121  [15]
 LDCM0109  NEM HeLa C25(0.00); C94(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C25(1.01)  LDD2089  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C25(1.03)  LDD2090  [15]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C25(1.40)  LDD2092  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C25(1.17)  LDD2093  [15]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C25(2.31)  LDD2094  [15]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C25(0.14)  LDD2096  [15]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C25(0.90)  LDD2097  [15]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C25(0.72)  LDD2098  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C25(1.13)  LDD2099  [15]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C25(0.48)  LDD2100  [15]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C25(0.73)  LDD2101  [15]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C25(0.38)  LDD2104  [15]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C25(1.48)  LDD2105  [15]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C25(0.33)  LDD2106  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C25(0.78)  LDD2107  [15]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C25(0.48)  LDD2108  [15]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C25(0.62)  LDD2109  [15]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C25(0.37)  LDD2110  [15]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C25(1.15)  LDD2111  [15]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C25(0.41)  LDD2114  [15]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C25(0.42)  LDD2115  [15]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C25(0.32)  LDD2116  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C25(0.33)  LDD2118  [15]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C25(1.73)  LDD2119  [15]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C25(0.93)  LDD2120  [15]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C25(0.20)  LDD2122  [15]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C25(0.88)  LDD2123  [15]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C25(0.22)  LDD2124  [15]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C25(0.93)  LDD2125  [15]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C25(0.21)  LDD2126  [15]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C25(1.06)  LDD2127  [15]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C25(0.99)  LDD2128  [15]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C25(1.04)  LDD2129  [15]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C25(0.44)  LDD2133  [15]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C25(0.45)  LDD2134  [15]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C25(1.00)  LDD2135  [15]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C25(1.16)  LDD2136  [15]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C25(0.93)  LDD2137  [15]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C25(2.50)  LDD1700  [15]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(0.88)  LDD2140  [15]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C25(0.61)  LDD2141  [15]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C25(1.09)  LDD2143  [15]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C25(2.42)  LDD2144  [15]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C25(0.54)  LDD2145  [15]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C25(0.91)  LDD2146  [15]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C25(3.05)  LDD2147  [15]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C25(0.44)  LDD2148  [15]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C25(0.28)  LDD2149  [15]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C25(0.71)  LDD2150  [15]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C25(0.19)  LDD2151  [15]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C25(2.53)  LDD2153  [15]
 LDCM0131  RA190 MM1.R C25(1.55); C94(1.30)  LDD0304  [44]
 LDCM0113  W17 Hep-G2 K9(1.04); K11(1.04); Q8(1.04)  LDD0240  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 48 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Actin, cytoplasmic 1 (ACTB) Actin family P60709
ATP synthase subunit beta, mitochondrial (ATP5F1B) ATPase alpha/beta chains family P06576
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Alpha-enolase (ENO1) Enolase family P06733
GTP cyclohydrolase 1 (GCH1) GTP cyclohydrolase I family P30793
Histone deacetylase 4 (HDAC4) Histone deacetylase family P56524
Histone deacetylase 5 (HDAC5) Histone deacetylase family Q9UQL6
Histone deacetylase 7 (HDAC7) Histone deacetylase family Q8WUI4
M-phase inducer phosphatase 1 (CDC25A) MPI phosphatase family P30304
M-phase inducer phosphatase 2 (CDC25B) MPI phosphatase family P30305
M-phase inducer phosphatase 3 (CDC25C) MPI phosphatase family P30307
NAD kinase (NADK) NAD kinase family O95544
Ubiquitin carboxyl-terminal hydrolase 8 (USP8) Peptidase C19 family P40818
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) Phosphoglycerate mutase family O60825
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) PI3/PI4-kinase family O00750
Protein kinase C epsilon type (PRKCE) AGC Ser/Thr protein kinase family Q02156
Serine/threonine-protein kinase SIK1 (SIK1) CAMK Ser/Thr protein kinase family P57059
Serine/threonine-protein kinase STK11 (STK11) CAMK Ser/Thr protein kinase family Q15831
MAP/microtubule affinity-regulating kinase 3 (MARK3) CAMK Ser/Thr protein kinase family P27448
Serine/threonine-protein kinase MARK2 (MARK2) CAMK Ser/Thr protein kinase family Q7KZI7
Serine/threonine-protein kinase SIK3 (SIK3) CAMK Ser/Thr protein kinase family Q9Y2K2
Cyclin-dependent kinase 17 (CDK17) CMGC Ser/Thr protein kinase family Q00537
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
Wee1-like protein kinase (WEE1) Ser/Thr protein kinase family P30291
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) STE Ser/Thr protein kinase family Q9NYL2
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) STE Ser/Thr protein kinase family Q99759
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Serine/threonine-protein kinase 25 (STK25) STE Ser/Thr protein kinase family O00506
Serine/threonine-protein kinase PAK 4 (PAK4) STE Ser/Thr protein kinase family O96013
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Serine/threonine-protein kinase B-raf (BRAF) TKL Ser/Thr protein kinase family P15056
TGF-beta receptor type-1 (TGFBR1) TKL Ser/Thr protein kinase family P36897
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) RING-Cys relay (RCR) family O75592
Rho-related GTP-binding protein RhoE (RND3) Rho family P61587
Kinesin-like protein KIF23 (KIF23) Kinesin family Q02241
Elongation factor 1-alpha 1 (EEF1A1) Classic translation factor GTPase family P68104
Small ribosomal subunit protein uS3 (RPS3) Universal ribosomal protein uS3 family P23396
Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1) . P31327
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) . Q9P0K1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Probable E3 ubiquitin-protein ligase HECTD4 (HECTD4) . Q9Y4D8
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
ATP synthase subunit alpha, mitochondrial (ATP5F1A) ATPase alpha/beta chains family P25705
Exportin-1 (XPO1) Exportin family O14980
Cellular tumor antigen p53 (TP53) P53 family P04637
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
TBC1 domain family member 4 (TBC1D4) . O60343
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein O1 (FOXO1) . Q12778
Forkhead box protein O3 (FOXO3) . O43524
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolactin receptor (PRLR) Type I cytokine receptor family P16471
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Cofilin-1 (CFL1) Actin-binding proteins ADF family P23528
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Ataxin-1 (ATXN1) ATXN1 family P54253
Bcl2-associated agonist of cell death (BAD) Bcl-2 family Q92934
Protein chibby homolog 1 (CBY1) Chibby family Q9Y3M2
Cingulin (CGN) Cingulin family Q9P2M7
Fascin (FSCN1) Fascin family Q16658
Histone H2A type 1 (H2AC11; H2AC13; H2AC15; H2AC16; H2AC17) Histone H2A family P0C0S8
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Prelamin-A/C (LMNA) Intermediate filament family P02545
Vimentin (VIM) Intermediate filament family P08670
Kinesin light chain 2 (KLC2) Kinesin light chain family Q9H0B6
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Protein Mdm4 (MDM4) MDM2/MDM4 family O15151
Nucleophosmin (NPM1) Nucleoplasmin family P06748
Partitioning defective 3 homolog (PARD3) PAR3 family Q8TEW0
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
SH3 domain-binding protein 5-like (SH3BP5L) SH3BP5 family Q7L8J4
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Protein Smaug homolog 2 (SAMD4B) SMAUG family Q5PRF9
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
A-kinase anchor protein 13 (AKAP13) . Q12802
Ankycorbin (RAI14) . Q9P0K7
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
C-myc promoter-binding protein (DENND4A) . Q7Z401
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Insulin receptor substrate 2 (IRS2) . Q9Y4H2
Microtubule-associated protein tau (MAPT) . P10636
Myosin phosphatase Rho-interacting protein (MPRIP) . Q6WCQ1
Nucleolin (NCL) . P19338
Protein phosphatase 1 regulatory subunit 3D (PPP1R3D) . O95685
RalBP1-associated Eps domain-containing protein 2 (REPS2) . Q8NFH8
Rho GTPase-activating protein 21 (ARHGAP21) . Q5T5U3
Rho guanine nucleotide exchange factor 16 (ARHGEF16) . Q5VV41
Rho guanine nucleotide exchange factor 2 (ARHGEF2) . Q92974
Signal-induced proliferation-associated 1-like protein 3 (SIPA1L3) . O60292
SLIT-ROBO Rho GTPase-activating protein 1 (SRGAP1) . Q7Z6B7
SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) . O75044
Sorbin and SH3 domain-containing protein 2 (SORBS2) . O94875
Tuberin (TSC2) . P49815

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
5 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
6 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
10 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
11 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
12 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
13 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
14 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
30 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
31 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
32 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
33 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
34 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
35 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
36 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
37 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
38 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
39 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
40 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
41 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
42 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
43 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
44 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.