Details of the Target

General Information of Target

Target ID LDTP03367
Target Name Elongation factor 1-gamma (EEF1G)
Gene Name EEF1G
Gene ID 1937
Synonyms
EF1G; Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPA
FEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGI
MHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSF
RQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSREE
KQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNE
DTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASV
ILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYESYTWRKLDPGSEETQTLVREYFSWE
GAFQHVGKAFNQGKIFK
Target Bioclass
Other
Function Probably plays a role in anchoring the complex to other cellular components.
Uniprot ID
P26641
Ensemble ID
ENST00000329251.5
HGNC ID
HGNC:3213
ChEMBL ID
CHEMBL4295735

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.E90Ter; p.A256V; p.S396L DBIA    Probe Info 
HT3 SNV: p.P54S DBIA    Probe Info 
JURKAT SNV: p.R45H Compound 10    Probe Info 
MFE319 SNV: p.Y416C DBIA    Probe Info 
NCIH358 SNV: p.G4V DBIA    Probe Info 
SKOV3 SNV: p.E265K DBIA    Probe Info 
SNU1 SNV: p.G427D DBIA    Probe Info 
TOV21G SNV: p.P329H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P1
 Probe Info  		1.86  LDD0452  [2]
P3
 Probe Info  		1.55  LDD0450  [2]
P8
 Probe Info  		2.69  LDD0455  [2]
A-EBA
 Probe Info  		3.94  LDD0215  [3]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
CHEMBL5175495
 Probe Info  		7.41  LDD0196  [5]
CY-1
 Probe Info  		5.91  LDD0243  [6]
CY4
 Probe Info  		2.07  LDD0244  [6]
N1
 Probe Info  		2.70  LDD0242  [6]
TH211
 Probe Info  		Y78(20.00); Y145(13.16); Y24(12.68); Y416(8.23)  LDD0257  [7]
TH214
 Probe Info  		Y145(20.00); Y416(20.00); Y24(19.21)  LDD0258  [7]
TH216
 Probe Info  		Y145(20.00); Y416(20.00); Y24(15.73)  LDD0259  [7]
YN-4
 Probe Info  		100.00  LDD0445  [8]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [9]
AZ-9
 Probe Info  		E420(0.77); E407(0.87); S418(0.77)  LDD2208  [10]
ONAyne
 Probe Info  		K277(0.00); K434(0.00); K294(0.00); K220(0.00)  LDD0273  [11]
OPA-S-S-alkyne
 Probe Info  		K243(1.40); K241(1.40); K132(1.81); K401(2.74)  LDD3494  [12]
Probe 1
 Probe Info  		Y24(16.42)  LDD3495  [13]
JZ128-DTB
 Probe Info  		C194(0.00); C210(0.00); C266(0.00)  LDD0462  [14]
THZ1-DTB
 Probe Info  		C194(1.13); C68(1.11); C266(1.08); C210(1.00)  LDD0460  [14]
DA-P3
 Probe Info  		6.09  LDD0183  [15]
AHL-Pu-1
 Probe Info  		C339(2.62); C266(5.47)  LDD0168  [16]
EA-probe
 Probe Info  		C68(2.54); C266(0.90)  LDD2210  [17]
HHS-482
 Probe Info  		Y145(0.86); Y24(1.02); Y416(0.96)  LDD0285  [18]
HHS-475
 Probe Info  		Y145(0.91)  LDD0264  [19]
HHS-465
 Probe Info  		Y145(10.00)  LDD2237  [20]
DBIA
 Probe Info  		C194(1.62); C266(1.20)  LDD0080  [21]
5E-2FA
 Probe Info  		H425(0.00); H37(0.00); H39(0.00)  LDD2235  [22]
AMP probe
 Probe Info  		K277(0.00); K147(0.00)  LDD0200  [23]
ATP probe
 Probe Info  		K277(0.00); K147(0.00); K434(0.00); K220(0.00)  LDD0199  [23]
4-Iodoacetamidophenylacetylene
 Probe Info  		C266(0.00); C68(0.00); C194(0.00); C339(0.00)  LDD0038  [24]
IA-alkyne
 Probe Info  		C194(0.00); C266(0.00); C68(0.00)  LDD0032  [25]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [26]
IPIAA_L
 Probe Info  		C194(0.00); C266(0.00)  LDD0031  [26]
Lodoacetamide azide
 Probe Info  		C266(0.00); C68(0.00); C166(0.00); C194(0.00)  LDD0037  [24]
ATP probe
 Probe Info  		K241(0.00); K220(0.00); K434(0.00); K227(0.00)  LDD0035  [27]
BTD
 Probe Info  		N.A.  LDD0004  [28]
JW-RF-010
 Probe Info  		C266(0.00); C68(0.00); C210(0.00)  LDD0026  [29]
NAIA_4
 Probe Info  		C210(0.00); C266(0.00)  LDD2226  [30]
TFBX
 Probe Info  		C266(0.00); C210(0.00)  LDD0027  [29]
WYneN
 Probe Info  		N.A.  LDD0021  [28]
WYneO
 Probe Info  		N.A.  LDD0022  [28]
aHNE
 Probe Info  		N.A.  LDD0001  [28]
1d-yne
 Probe Info  		K253(0.00); K277(0.00)  LDD0356  [31]
Compound 10
 Probe Info  		C194(0.00); C266(0.00)  LDD2216  [32]
Compound 11
 Probe Info  		C194(0.00); C266(0.00)  LDD2213  [32]
ENE
 Probe Info  		N.A.  LDD0006  [28]
IPM
 Probe Info  		C339(0.00); C266(0.00)  LDD0005  [28]
NHS
 Probe Info  		K253(0.00); K275(0.00); K147(0.00); K401(0.00)  LDD0010  [28]
PF-06672131
 Probe Info  		N.A.  LDD0017  [33]
PPMS
 Probe Info  		N.A.  LDD0008  [28]
SF
 Probe Info  		K219(0.00); K434(0.00); K277(0.00); Y9(0.00)  LDD0028  [34]
STPyne
 Probe Info  		K277(0.00); K401(0.00); K275(0.00); K212(0.00)  LDD0009  [28]
VSF
 Probe Info  		N.A.  LDD0007  [28]
YN-1
 Probe Info  		N.A.  LDD0446  [8]
Phosphinate-6
 Probe Info  		C266(0.00); C210(0.00); C68(0.00)  LDD0018  [35]
Ox-W18
 Probe Info  		W13(0.00); W98(0.00); W390(0.00); W419(0.00)  LDD2175  [36]
1c-yne
 Probe Info  		K275(0.00); K253(0.00); K285(0.00); K428(0.00)  LDD0228  [31]
Acrolein
 Probe Info  		C266(0.00); H282(0.00); C194(0.00); H425(0.00)  LDD0217  [37]
Crotonaldehyde
 Probe Info  		C266(0.00); H39(0.00)  LDD0219  [37]
Methacrolein
 Probe Info  		C266(0.00); C194(0.00); H37(0.00)  LDD0218  [37]
W1
 Probe Info  		C266(0.00); C194(0.00)  LDD0236  [38]
AOyne
 Probe Info  		15.00  LDD0443  [39]
NAIA_5
 Probe Info  		C266(0.00); C210(0.00); C339(0.00); C68(0.00)  LDD2223  [30]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.78  LDD0475  [40]
FFF probe3
 Probe Info  		6.04  LDD0464  [40]
VE-P
 Probe Info  		N.A.  LDD0396  [41]
Diazir
 Probe Info  		E262(0.00); E267(0.00); C266(0.00)  LDD0011  [28]
LD-F
 Probe Info  		E261(0.00); D264(0.00)  LDD0015  [42]
STS-1
 Probe Info  		N.A.  LDD0068  [43]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C266(0.83); C210(0.37)  LDD2142  [44]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C266(1.04)  LDD2112  [44]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C266(0.68); C210(0.63)  LDD2095  [44]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C266(0.96); C210(1.09)  LDD2130  [44]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C266(1.27)  LDD2117  [44]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C210(3.10)  LDD2103  [44]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C266(0.88); C210(0.54)  LDD2132  [44]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C266(0.94); C210(0.82)  LDD2131  [44]
 LDCM0025  4SU-RNA HEK-293T C339(2.62); C266(5.47)  LDD0168  [16]
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(2.01); C266(3.98); C194(2.25)  LDD0169  [16]
 LDCM0214  AC1 HCT 116 C68(0.97); C194(1.15); C266(1.09); C339(0.83)  LDD0531  [21]
 LDCM0215  AC10 HCT 116 C68(0.60); C166(0.83); C194(0.78); C266(1.22)  LDD0532  [21]
 LDCM0216  AC100 HCT 116 C194(0.91); C266(1.02); C339(1.00)  LDD0533  [21]
 LDCM0217  AC101 HCT 116 C194(0.55); C266(0.94); C339(1.00)  LDD0534  [21]
 LDCM0218  AC102 HCT 116 C194(0.71); C266(0.99); C339(0.98)  LDD0535  [21]
 LDCM0219  AC103 HCT 116 C194(0.52); C266(1.19); C339(1.16)  LDD0536  [21]
 LDCM0220  AC104 HCT 116 C194(0.69); C266(0.98); C339(1.19)  LDD0537  [21]
 LDCM0221  AC105 HCT 116 C194(0.67); C266(1.14); C339(1.37)  LDD0538  [21]
 LDCM0222  AC106 HCT 116 C194(0.63); C266(1.29); C339(1.02)  LDD0539  [21]
 LDCM0223  AC107 HCT 116 C194(0.68); C266(1.14); C339(0.91)  LDD0540  [21]
 LDCM0224  AC108 HCT 116 C194(0.77); C266(1.05); C339(0.67)  LDD0541  [21]
 LDCM0225  AC109 HCT 116 C194(0.87); C266(0.88); C339(0.91)  LDD0542  [21]
 LDCM0226  AC11 HCT 116 C68(0.56); C166(0.84); C194(0.78); C266(1.26)  LDD0543  [21]
 LDCM0227  AC110 HCT 116 C194(0.66); C266(0.94); C339(1.09)  LDD0544  [21]
 LDCM0228  AC111 HCT 116 C194(0.57); C266(0.95); C339(0.92)  LDD0545  [21]
 LDCM0229  AC112 HCT 116 C194(0.43); C266(1.11); C339(0.96)  LDD0546  [21]
 LDCM0230  AC113 HCT 116 C68(0.73); C194(1.12); C266(1.05); C339(0.93)  LDD0547  [21]
 LDCM0231  AC114 HCT 116 C68(1.25); C194(0.83); C266(1.17); C339(0.89)  LDD0548  [21]
 LDCM0232  AC115 HCT 116 C68(0.99); C194(0.64); C266(1.42); C339(0.91)  LDD0549  [21]
 LDCM0233  AC116 HCT 116 C68(0.70); C194(0.66); C266(1.26); C339(1.08)  LDD0550  [21]
 LDCM0234  AC117 HCT 116 C68(0.82); C194(0.86); C266(1.23); C339(0.99)  LDD0551  [21]
 LDCM0235  AC118 HCT 116 C68(0.77); C194(1.01); C266(1.12); C339(1.00)  LDD0552  [21]
 LDCM0236  AC119 HCT 116 C68(0.58); C194(0.83); C266(1.19); C339(0.92)  LDD0553  [21]
 LDCM0237  AC12 HCT 116 C68(0.89); C166(0.81); C194(0.99); C266(1.13)  LDD0554  [21]
 LDCM0238  AC120 HCT 116 C68(1.20); C194(0.80); C266(0.99); C339(1.06)  LDD0555  [21]
 LDCM0239  AC121 HCT 116 C68(0.63); C194(1.32); C266(1.12); C339(0.80)  LDD0556  [21]
 LDCM0240  AC122 HCT 116 C68(0.86); C194(0.91); C266(1.21); C339(0.82)  LDD0557  [21]
 LDCM0241  AC123 HCT 116 C68(1.08); C194(1.28); C266(1.03); C339(0.82)  LDD0558  [21]
 LDCM0242  AC124 HCT 116 C68(0.76); C194(1.21); C266(0.99); C339(0.92)  LDD0559  [21]
 LDCM0243  AC125 HCT 116 C68(1.10); C194(0.99); C266(1.17); C339(1.06)  LDD0560  [21]
 LDCM0244  AC126 HCT 116 C68(0.94); C194(0.85); C266(1.25); C339(0.88)  LDD0561  [21]
 LDCM0245  AC127 HCT 116 C68(1.02); C194(0.91); C266(1.32); C339(1.10)  LDD0562  [21]
 LDCM0246  AC128 HCT 116 C68(0.64); C194(1.18); C266(1.30); C339(0.95)  LDD0563  [21]
 LDCM0247  AC129 HCT 116 C68(3.00); C194(1.57); C266(0.96); C339(1.06)  LDD0564  [21]
 LDCM0249  AC130 HCT 116 C68(0.92); C194(0.99); C266(1.22); C339(1.54)  LDD0566  [21]
 LDCM0250  AC131 HCT 116 C68(1.42); C194(1.31); C266(0.90); C339(1.41)  LDD0567  [21]
 LDCM0251  AC132 HCT 116 C68(0.82); C194(1.28); C266(1.07); C339(1.24)  LDD0568  [21]
 LDCM0252  AC133 HCT 116 C68(0.68); C194(1.02); C266(1.22); C339(1.12)  LDD0569  [21]
 LDCM0253  AC134 HCT 116 C68(0.59); C194(0.78); C266(1.29); C339(1.55)  LDD0570  [21]
 LDCM0254  AC135 HCT 116 C68(0.46); C194(0.89); C266(1.23); C339(1.28)  LDD0571  [21]
 LDCM0255  AC136 HCT 116 C68(0.40); C194(0.90); C266(1.13); C339(1.45)  LDD0572  [21]
 LDCM0256  AC137 HCT 116 C68(0.62); C194(1.18); C266(1.01); C339(1.22)  LDD0573  [21]
 LDCM0257  AC138 HCT 116 C68(0.40); C194(0.78); C266(1.27); C339(0.96)  LDD0574  [21]
 LDCM0258  AC139 HCT 116 C68(0.66); C194(0.84); C266(1.23); C339(1.00)  LDD0575  [21]
 LDCM0259  AC14 HCT 116 C68(0.45); C166(1.05); C194(0.92); C266(1.21)  LDD0576  [21]
 LDCM0260  AC140 HCT 116 C68(0.41); C194(0.76); C266(1.35); C339(1.16)  LDD0577  [21]
 LDCM0261  AC141 HCT 116 C68(0.54); C194(0.80); C266(1.31); C339(1.42)  LDD0578  [21]
 LDCM0262  AC142 HCT 116 C68(0.65); C194(1.42); C266(1.08); C339(1.16)  LDD0579  [21]
 LDCM0263  AC143 HCT 116 C68(0.73); C194(0.94); C266(1.15); C339(1.14)  LDD0580  [21]
 LDCM0264  AC144 HCT 116 C194(0.76); C68(0.83); C339(1.23); C266(1.38)  LDD0581  [21]
 LDCM0265  AC145 HCT 116 C68(0.93); C339(1.07); C194(1.07); C266(1.19)  LDD0582  [21]
 LDCM0266  AC146 HCT 116 C68(0.63); C194(0.82); C266(1.28); C339(1.39)  LDD0583  [21]
 LDCM0267  AC147 HCT 116 C68(0.70); C194(0.72); C266(1.43); C339(1.60)  LDD0584  [21]
 LDCM0268  AC148 HCT 116 C68(0.57); C194(0.79); C339(1.15); C266(1.76)  LDD0585  [21]
 LDCM0269  AC149 HCT 116 C194(0.50); C68(0.54); C339(1.29); C266(1.45)  LDD0586  [21]
 LDCM0270  AC15 HCT 116 C68(0.62); C194(0.80); C339(1.08); C266(1.22)  LDD0587  [21]
 LDCM0271  AC150 HCT 116 C68(0.60); C194(0.89); C266(1.08); C339(1.56)  LDD0588  [21]
 LDCM0272  AC151 HCT 116 C194(0.74); C68(1.12); C266(1.15); C339(1.21)  LDD0589  [21]
 LDCM0273  AC152 HCT 116 C194(0.77); C68(0.86); C266(1.21); C339(1.41)  LDD0590  [21]
 LDCM0274  AC153 HCT 116 C194(0.62); C68(0.78); C339(1.50); C266(1.94)  LDD0591  [21]
 LDCM0621  AC154 HCT 116 C68(0.77); C194(0.92); C266(1.27); C339(1.34)  LDD2158  [21]
 LDCM0622  AC155 HCT 116 C68(1.03); C194(0.76); C266(1.32); C339(1.58)  LDD2159  [21]
 LDCM0623  AC156 HCT 116 C68(1.84); C194(1.01); C266(1.03); C339(1.39)  LDD2160  [21]
 LDCM0624  AC157 HCT 116 C68(1.86); C194(1.21); C266(1.01); C339(1.41)  LDD2161  [21]
 LDCM0276  AC17 HCT 116 C194(0.94); C266(1.02); C339(1.05); C68(1.93)  LDD0593  [21]
 LDCM0277  AC18 HCT 116 C68(0.62); C194(0.75); C266(1.25); C339(1.46)  LDD0594  [21]
 LDCM0278  AC19 HCT 116 C194(0.90); C266(1.12); C339(1.15); C68(1.79)  LDD0595  [21]
 LDCM0279  AC2 HCT 116 C68(0.68); C194(0.89); C339(0.96); C266(1.09)  LDD0596  [21]
 LDCM0280  AC20 HCT 116 C194(0.95); C266(1.02); C339(1.18); C68(1.93)  LDD0597  [21]
 LDCM0281  AC21 HCT 116 C194(0.93); C266(1.06); C339(1.20); C68(1.48)  LDD0598  [21]
 LDCM0282  AC22 HCT 116 C68(0.97); C266(1.00); C194(1.08); C339(1.16)  LDD0599  [21]
 LDCM0283  AC23 HCT 116 C68(0.86); C266(0.94); C194(1.00); C339(1.20)  LDD0600  [21]
 LDCM0284  AC24 HCT 116 C266(0.99); C339(1.13); C194(1.15); C68(2.48)  LDD0601  [21]
 LDCM0285  AC25 HCT 116 C194(0.86); C166(0.97); C339(0.98); C266(1.12)  LDD0602  [21]
 LDCM0286  AC26 HCT 116 C194(0.59); C68(0.80); C166(1.11); C339(1.25)  LDD0603  [21]
 LDCM0287  AC27 HCT 116 C194(0.56); C166(1.08); C68(1.09); C339(1.25)  LDD0604  [21]
 LDCM0288  AC28 HCT 116 C194(0.58); C166(0.89); C339(1.03); C68(1.17)  LDD0605  [21]
 LDCM0289  AC29 HCT 116 C194(0.56); C166(0.86); C339(1.09); C266(1.34)  LDD0606  [21]
 LDCM0290  AC3 HCT 116 C68(0.67); C194(1.04); C266(1.08); C339(1.22)  LDD0607  [21]
 LDCM0291  AC30 HCT 116 C194(0.46); C339(0.93); C166(0.98); C68(1.05)  LDD0608  [21]
 LDCM0292  AC31 HCT 116 C194(0.63); C166(1.09); C339(1.23); C68(1.32)  LDD0609  [21]
 LDCM0293  AC32 HCT 116 C194(0.38); C68(0.64); C166(1.11); C339(1.25)  LDD0610  [21]
 LDCM0294  AC33 HCT 116 C194(0.43); C339(0.96); C166(1.01); C68(1.03)  LDD0611  [21]
 LDCM0295  AC34 HCT 116 C194(0.39); C166(0.86); C68(1.22); C339(1.32)  LDD0612  [21]
 LDCM0296  AC35 HCT 116 C68(0.54); C266(0.75); C339(0.86); C194(1.50)  LDD0613  [21]
 LDCM0297  AC36 HCT 116 C68(0.48); C339(0.79); C266(0.85); C194(1.27)  LDD0614  [21]
 LDCM0298  AC37 HCT 116 C68(0.72); C266(0.86); C339(0.91); C194(1.35)  LDD0615  [21]
 LDCM0299  AC38 HCT 116 C68(0.56); C266(0.92); C339(0.92); C194(1.09)  LDD0616  [21]
 LDCM0300  AC39 HCT 116 C68(0.43); C339(0.80); C194(0.99); C266(1.01)  LDD0617  [21]
 LDCM0301  AC4 HCT 116 C68(0.64); C194(1.07); C339(1.12); C266(1.15)  LDD0618  [21]
 LDCM0302  AC40 HCT 116 C68(0.52); C194(0.99); C339(0.99); C266(1.09)  LDD0619  [21]
 LDCM0303  AC41 HCT 116 C68(0.38); C339(0.87); C266(0.94); C194(1.03)  LDD0620  [21]
 LDCM0304  AC42 HCT 116 C68(0.51); C194(0.97); C266(1.00); C339(1.12)  LDD0621  [21]
 LDCM0305  AC43 HCT 116 C68(0.49); C194(0.87); C339(0.88); C266(1.05)  LDD0622  [21]
 LDCM0306  AC44 HCT 116 C68(0.43); C339(0.94); C266(1.01); C194(1.16)  LDD0623  [21]
 LDCM0307  AC45 HCT 116 C68(0.43); C339(0.90); C194(0.95); C266(1.17)  LDD0624  [21]
 LDCM0308  AC46 HCT 116 C194(0.89); C339(1.05); C266(1.17); C68(1.26)  LDD0625  [21]
 LDCM0309  AC47 HCT 116 C68(0.74); C194(0.90); C339(0.98); C266(1.19)  LDD0626  [21]
 LDCM0310  AC48 HCT 116 C68(0.59); C339(0.79); C194(0.93); C266(1.25)  LDD0627  [21]
 LDCM0311  AC49 HCT 116 C194(0.58); C68(0.84); C339(1.04); C266(1.60)  LDD0628  [21]
 LDCM0312  AC5 HCT 116 C68(0.38); C339(1.02); C194(1.05); C266(1.14)  LDD0629  [21]
 LDCM0313  AC50 HCT 116 C194(0.62); C68(0.85); C339(1.06); C266(1.64)  LDD0630  [21]
 LDCM0314  AC51 HCT 116 C339(0.94); C266(1.03); C68(1.19); C194(1.44)  LDD0631  [21]
 LDCM0315  AC52 HCT 116 C194(0.88); C68(0.91); C339(1.14); C266(1.16)  LDD0632  [21]
 LDCM0316  AC53 HCT 116 C194(0.74); C68(1.01); C339(1.12); C266(1.28)  LDD0633  [21]
 LDCM0317  AC54 HCT 116 C68(0.84); C194(0.85); C339(1.07); C266(1.29)  LDD0634  [21]
 LDCM0318  AC55 HCT 116 C194(0.70); C68(0.84); C339(0.92); C266(1.66)  LDD0635  [21]
 LDCM0319  AC56 HCT 116 C194(0.51); C68(0.83); C339(0.93); C266(2.34)  LDD0636  [21]
 LDCM0320  AC57 HCT 116 C68(0.73); C194(0.81); C339(1.20); C266(1.46)  LDD0637  [21]
 LDCM0321  AC58 HCT 116 C194(0.69); C68(0.81); C339(1.44); C266(1.57)  LDD0638  [21]
 LDCM0322  AC59 HCT 116 C194(0.68); C68(0.78); C339(1.53); C266(1.58)  LDD0639  [21]
 LDCM0323  AC6 HCT 116 C68(0.60); C194(0.62); C339(0.99); C166(1.06)  LDD0640  [21]
 LDCM0324  AC60 HCT 116 C194(0.74); C68(0.87); C339(1.25); C266(1.47)  LDD0641  [21]
 LDCM0325  AC61 HCT 116 C68(0.62); C194(0.70); C339(1.07); C266(1.42)  LDD0642  [21]
 LDCM0326  AC62 HCT 116 C68(0.53); C194(0.69); C339(1.67); C266(1.73)  LDD0643  [21]
 LDCM0327  AC63 HCT 116 C68(0.78); C194(0.90); C266(1.46); C339(1.54)  LDD0644  [21]
 LDCM0328  AC64 HCT 116 C68(0.77); C194(0.98); C339(1.16); C266(1.65)  LDD0645  [21]
 LDCM0329  AC65 HCT 116 C194(0.58); C68(0.73); C339(1.50); C266(1.64)  LDD0646  [21]
 LDCM0330  AC66 HCT 116 C68(0.71); C194(0.78); C266(1.49); C339(1.55)  LDD0647  [21]
 LDCM0331  AC67 HCT 116 C68(0.36); C194(0.51); C339(1.08); C266(1.74)  LDD0648  [21]
 LDCM0332  AC68 HCT 116 C68(0.43); C194(0.84); C339(0.92); C266(1.18)  LDD0649  [21]
 LDCM0333  AC69 HCT 116 C68(0.41); C194(0.78); C339(0.81); C266(1.10)  LDD0650  [21]
 LDCM0334  AC7 HCT 116 C68(0.65); C194(0.79); C339(0.87); C166(0.87)  LDD0651  [21]
 LDCM0335  AC70 HCT 116 C68(0.32); C194(0.64); C339(0.86); C266(1.11)  LDD0652  [21]
 LDCM0336  AC71 HCT 116 C68(0.40); C339(0.86); C266(1.00); C194(1.29)  LDD0653  [21]
 LDCM0337  AC72 HCT 116 C194(0.77); C339(0.82); C68(1.00); C266(1.14)  LDD0654  [21]
 LDCM0338  AC73 HCT 116 C68(0.48); C194(0.51); C339(0.63); C266(1.46)  LDD0655  [21]
 LDCM0339  AC74 HCT 116 C68(0.33); C194(0.71); C339(0.86); C266(1.38)  LDD0656  [21]
 LDCM0340  AC75 HCT 116 C68(0.39); C194(0.59); C339(0.96); C266(1.63)  LDD0657  [21]
 LDCM0341  AC76 HCT 116 C68(0.49); C339(0.81); C194(0.82); C266(1.17)  LDD0658  [21]
 LDCM0342  AC77 HCT 116 C68(0.43); C194(0.66); C339(0.81); C266(1.29)  LDD0659  [21]
 LDCM0343  AC78 HCT 116 C68(0.52); C194(0.89); C339(1.04); C266(1.07)  LDD0660  [21]
 LDCM0344  AC79 HCT 116 C68(0.37); C194(0.83); C339(0.89); C266(1.09)  LDD0661  [21]
 LDCM0345  AC8 HCT 116 C194(0.66); C166(0.83); C68(0.98); C339(1.06)  LDD0662  [21]
 LDCM0346  AC80 HCT 116 C68(0.50); C194(0.84); C339(1.07); C266(1.12)  LDD0663  [21]
 LDCM0347  AC81 HCT 116 C68(0.59); C339(0.73); C266(0.91); C194(1.16)  LDD0664  [21]
 LDCM0348  AC82 HCT 116 C68(0.28); C194(0.61); C339(1.14); C266(1.55)  LDD0665  [21]
 LDCM0349  AC83 HCT 116 C194(0.37); C339(1.05); C266(1.48)  LDD0666  [21]
 LDCM0350  AC84 HCT 116 C194(0.38); C339(1.22); C266(1.33)  LDD0667  [21]
 LDCM0351  AC85 HCT 116 C194(0.46); C339(1.10); C266(1.18)  LDD0668  [21]
 LDCM0352  AC86 HCT 116 C194(0.51); C339(0.99); C266(1.19)  LDD0669  [21]
 LDCM0353  AC87 HCT 116 C194(0.87); C266(0.98); C339(1.14)  LDD0670  [21]
 LDCM0354  AC88 HCT 116 C194(0.60); C339(1.03); C266(1.17)  LDD0671  [21]
 LDCM0355  AC89 HCT 116 C194(0.44); C266(1.29); C339(1.45)  LDD0672  [21]
 LDCM0357  AC90 HCT 116 C339(0.98); C266(1.02); C194(1.46)  LDD0674  [21]
 LDCM0358  AC91 HCT 116 C194(0.46); C339(1.08); C266(1.49)  LDD0675  [21]
 LDCM0359  AC92 HCT 116 C194(0.43); C339(1.16); C266(1.51)  LDD0676  [21]
 LDCM0360  AC93 HCT 116 C194(0.53); C339(0.94); C266(1.12)  LDD0677  [21]
 LDCM0361  AC94 HCT 116 C194(0.79); C266(1.03); C339(1.12)  LDD0678  [21]
 LDCM0362  AC95 HCT 116 C194(0.77); C339(0.85); C266(1.11)  LDD0679  [21]
 LDCM0363  AC96 HCT 116 C194(0.60); C266(1.24); C339(1.24)  LDD0680  [21]
 LDCM0364  AC97 HCT 116 C194(0.35); C339(1.06); C266(1.29)  LDD0681  [21]
 LDCM0365  AC98 HCT 116 C194(0.34); C339(0.92); C266(1.52)  LDD0682  [21]
 LDCM0366  AC99 HCT 116 C194(0.71); C266(0.96); C339(1.00)  LDD0683  [21]
 LDCM0545  Acetamide MDA-MB-231 C266(0.93); C210(0.88)  LDD2138  [44]
 LDCM0520  AKOS000195272 MDA-MB-231 C266(0.73)  LDD2113  [44]
 LDCM0248  AKOS034007472 HCT 116 C68(0.82); C166(1.16); C194(1.04); C266(1.06)  LDD0565  [21]
 LDCM0356  AKOS034007680 HCT 116 C68(0.59); C194(0.87); C166(0.91); C339(1.05)  LDD0673  [21]
 LDCM0275  AKOS034007705 HCT 116 C194(0.52); C68(0.64); C166(0.87); C339(1.08)  LDD0592  [21]
 LDCM0156  Aniline NCI-H1299 14.02  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C266(1.10); C339(0.94)  LDD2171  [21]
 LDCM0498  BS-3668 MDA-MB-231 C266(1.16); C210(0.52)  LDD2091  [44]
 LDCM0630  CCW28-3 231MFP C266(1.39); C339(1.38); C68(1.26)  LDD2214  [45]
 LDCM0108  Chloroacetamide HeLa C266(0.00); C194(0.00); H37(0.00); H39(0.00)  LDD0222  [37]
 LDCM0632  CL-Sc Hep-G2 C266(20.00); C194(0.96)  LDD2227  [30]
 LDCM0367  CL1 HCT 116 C266(0.93); C339(1.12); C194(1.21); C68(1.82)  LDD0684  [21]
 LDCM0368  CL10 HCT 116 C194(0.57); C68(0.60); C339(1.00); C266(1.53)  LDD0685  [21]
 LDCM0369  CL100 HCT 116 C68(0.65); C194(0.94); C339(0.95); C266(1.17)  LDD0686  [21]
 LDCM0370  CL101 HCT 116 C68(0.56); C194(0.75); C339(1.18); C166(1.20)  LDD0687  [21]
 LDCM0371  CL102 HCT 116 C68(0.63); C194(0.98); C339(1.00); C266(1.08)  LDD0688  [21]
 LDCM0372  CL103 HCT 116 C68(1.05); C266(1.05); C339(1.05); C194(1.07)  LDD0689  [21]
 LDCM0373  CL104 HCT 116 C194(0.90); C339(1.04); C266(1.06); C68(1.34)  LDD0690  [21]
 LDCM0374  CL105 HCT 116 C68(0.75); C194(0.83); C266(1.21); C339(1.22)  LDD0691  [21]
 LDCM0375  CL106 HCT 116 C68(0.71); C194(0.82); C339(1.21); C266(1.42)  LDD0692  [21]
 LDCM0376  CL107 HCT 116 C68(0.67); C194(0.75); C339(1.15); C266(1.34)  LDD0693  [21]
 LDCM0377  CL108 HCT 116 C194(0.70); C68(0.85); C339(1.35); C266(1.40)  LDD0694  [21]
 LDCM0378  CL109 HCT 116 C194(0.67); C339(1.06); C266(1.19); C68(1.91)  LDD0695  [21]
 LDCM0379  CL11 HCT 116 C68(0.63); C194(0.66); C339(1.04); C266(1.55)  LDD0696  [21]
 LDCM0380  CL110 HCT 116 C194(0.69); C68(0.81); C266(1.25); C339(1.28)  LDD0697  [21]
 LDCM0381  CL111 HCT 116 C194(0.63); C339(1.07); C266(1.10); C68(1.28)  LDD0698  [21]
 LDCM0382  CL112 HCT 116 C68(0.61); C194(0.90); C339(0.92); C166(0.95)  LDD0699  [21]
 LDCM0383  CL113 HCT 116 C194(0.45); C68(0.91); C339(1.00); C166(1.01)  LDD0700  [21]
 LDCM0384  CL114 HCT 116 C194(0.58); C339(0.89); C166(1.09); C68(1.14)  LDD0701  [21]
 LDCM0385  CL115 HCT 116 C194(0.50); C339(0.96); C68(1.03); C166(1.04)  LDD0702  [21]
 LDCM0386  CL116 HCT 116 C194(0.54); C68(0.62); C166(1.05); C339(1.15)  LDD0703  [21]
 LDCM0387  CL117 HCT 116 C68(0.42); C194(0.77); C339(0.86); C266(1.65)  LDD0704  [21]
 LDCM0388  CL118 HCT 116 C68(0.49); C194(0.94); C339(1.01); C266(1.02)  LDD0705  [21]
 LDCM0389  CL119 HCT 116 C339(0.83); C194(0.86); C266(1.11); C68(1.11)  LDD0706  [21]
 LDCM0390  CL12 HCT 116 C194(0.58); C68(0.64); C339(1.19); C266(1.73)  LDD0707  [21]
 LDCM0391  CL120 HCT 116 C68(0.55); C339(0.78); C266(0.99); C194(1.06)  LDD0708  [21]
 LDCM0392  CL121 HCT 116 C194(0.73); C68(0.89); C339(0.92); C266(1.46)  LDD0709  [21]
 LDCM0393  CL122 HCT 116 C68(0.68); C194(0.71); C339(1.04); C266(1.17)  LDD0710  [21]
 LDCM0394  CL123 HCT 116 C194(0.69); C339(0.92); C68(1.09); C266(1.29)  LDD0711  [21]
 LDCM0395  CL124 HCT 116 C194(0.58); C68(0.98); C339(1.06); C266(1.51)  LDD0712  [21]
 LDCM0396  CL125 HCT 116 C68(0.91); C194(0.92); C339(1.03); C266(1.11)  LDD0713  [21]
 LDCM0397  CL126 HCT 116 C194(0.79); C68(1.01); C266(1.03); C339(1.18)  LDD0714  [21]
 LDCM0398  CL127 HCT 116 C68(0.65); C194(0.77); C266(1.11); C339(1.23)  LDD0715  [21]
 LDCM0399  CL128 HCT 116 C194(0.72); C68(0.86); C339(1.23); C266(1.54)  LDD0716  [21]
 LDCM0400  CL13 HCT 116 C194(0.68); C68(0.83); C339(1.08); C266(1.28)  LDD0717  [21]
 LDCM0401  CL14 HCT 116 C194(0.88); C68(0.91); C266(1.07); C339(1.10)  LDD0718  [21]
 LDCM0402  CL15 HCT 116 C68(0.62); C194(0.71); C339(1.13); C266(1.37)  LDD0719  [21]
 LDCM0403  CL16 HCT 116 C194(0.64); C68(0.88); C166(1.14); C339(1.18)  LDD0720  [21]
 LDCM0404  CL17 HCT 116 C194(0.60); C68(0.89); C266(1.14); C166(1.23)  LDD0721  [21]
 LDCM0405  CL18 HCT 116 C194(0.79); C68(0.96); C339(1.31); C266(1.34)  LDD0722  [21]
 LDCM0406  CL19 HCT 116 C194(0.71); C68(0.73); C266(1.20); C339(1.21)  LDD0723  [21]
 LDCM0407  CL2 HCT 116 C339(0.92); C266(0.97); C194(1.17); C68(1.24)  LDD0724  [21]
 LDCM0408  CL20 HCT 116 C194(0.53); C68(0.93); C166(1.19); C339(1.58)  LDD0725  [21]
 LDCM0409  CL21 HCT 116 C68(0.43); C194(0.57); C166(1.26); C339(1.29)  LDD0726  [21]
 LDCM0410  CL22 HCT 116 C194(0.58); C68(0.85); C339(1.20); C166(1.56)  LDD0727  [21]
 LDCM0411  CL23 HCT 116 C194(0.60); C68(1.12); C166(1.16); C266(1.31)  LDD0728  [21]
 LDCM0412  CL24 HCT 116 C194(0.48); C68(1.10); C166(1.30); C339(1.33)  LDD0729  [21]
 LDCM0413  CL25 HCT 116 C68(0.58); C166(1.33); C194(0.58); C266(1.69)  LDD0730  [21]
 LDCM0414  CL26 HCT 116 C68(0.86); C166(1.01); C194(0.58); C266(1.34)  LDD0731  [21]
 LDCM0415  CL27 HCT 116 C68(0.75); C166(1.09); C194(0.65); C266(1.36)  LDD0732  [21]
 LDCM0416  CL28 HCT 116 C68(0.97); C166(1.38); C194(0.43); C266(1.56)  LDD0733  [21]
 LDCM0417  CL29 HCT 116 C68(0.67); C166(1.21); C194(0.48); C266(1.50)  LDD0734  [21]
 LDCM0418  CL3 HCT 116 C68(0.90); C194(1.04); C266(0.99); C339(0.99)  LDD0735  [21]
 LDCM0419  CL30 HCT 116 C68(1.93); C166(1.14); C194(0.73); C266(1.21)  LDD0736  [21]
 LDCM0420  CL31 HCT 116 C68(1.14); C166(0.72); C194(1.03); C266(1.13)  LDD0737  [21]
 LDCM0421  CL32 HCT 116 C68(0.58); C166(0.88); C194(0.63); C266(1.19)  LDD0738  [21]
 LDCM0422  CL33 HCT 116 C68(1.74); C166(0.57); C194(0.46); C266(1.16)  LDD0739  [21]
 LDCM0423  CL34 HCT 116 C68(0.75); C166(0.37); C194(0.40); C266(1.46)  LDD0740  [21]
 LDCM0424  CL35 HCT 116 C68(1.10); C166(0.46); C194(0.42); C266(1.53)  LDD0741  [21]
 LDCM0425  CL36 HCT 116 C68(1.20); C166(0.48); C194(0.51); C266(1.43)  LDD0742  [21]
 LDCM0426  CL37 HCT 116 C68(1.25); C166(0.45); C194(0.48); C266(1.65)  LDD0743  [21]
 LDCM0428  CL39 HCT 116 C68(0.87); C166(0.41); C194(0.52); C266(1.53)  LDD0745  [21]
 LDCM0429  CL4 HCT 116 C68(0.85); C194(0.90); C266(1.00); C339(1.00)  LDD0746  [21]
 LDCM0430  CL40 HCT 116 C68(0.69); C166(0.44); C194(0.62); C266(1.49)  LDD0747  [21]
 LDCM0431  CL41 HCT 116 C68(0.98); C166(0.62); C194(0.55); C266(1.26)  LDD0748  [21]
 LDCM0432  CL42 HCT 116 C68(0.71); C166(0.32); C194(0.42); C266(2.79)  LDD0749  [21]
 LDCM0433  CL43 HCT 116 C68(1.34); C166(0.40); C194(0.48); C266(1.78)  LDD0750  [21]
 LDCM0434  CL44 HCT 116 C68(1.05); C166(0.37); C194(0.49); C266(1.51)  LDD0751  [21]
 LDCM0435  CL45 HCT 116 C68(1.19); C166(0.35); C194(0.50); C266(1.68)  LDD0752  [21]
 LDCM0436  CL46 HCT 116 C194(1.26); C266(0.91); C339(1.00)  LDD0753  [21]
 LDCM0437  CL47 HCT 116 C194(1.26); C266(0.83); C339(0.95)  LDD0754  [21]
 LDCM0438  CL48 HCT 116 C194(1.39); C266(0.82); C339(1.08)  LDD0755  [21]
 LDCM0439  CL49 HCT 116 C194(1.15); C266(0.89); C339(1.20)  LDD0756  [21]
 LDCM0440  CL5 HCT 116 C68(1.16); C194(0.97); C266(1.08); C339(1.02)  LDD0757  [21]
 LDCM0441  CL50 HCT 116 C194(1.22); C266(0.87); C339(1.14)  LDD0758  [21]
 LDCM0442  CL51 HCT 116 C194(1.28); C266(0.96); C339(1.19)  LDD0759  [21]
 LDCM0443  CL52 HCT 116 C194(1.01); C266(0.98); C339(0.98)  LDD0760  [21]
 LDCM0444  CL53 HCT 116 C194(1.17); C266(0.86); C339(1.06)  LDD0761  [21]
 LDCM0445  CL54 HCT 116 C194(1.20); C266(0.90); C339(1.04)  LDD0762  [21]
 LDCM0446  CL55 HCT 116 C194(1.42); C266(0.91); C339(1.03)  LDD0763  [21]
 LDCM0447  CL56 HCT 116 C194(1.11); C266(0.99); C339(0.98)  LDD0764  [21]
 LDCM0448  CL57 HCT 116 C194(1.27); C266(0.95); C339(1.11)  LDD0765  [21]
 LDCM0449  CL58 HCT 116 C194(1.17); C266(0.89); C339(1.14)  LDD0766  [21]
 LDCM0450  CL59 HCT 116 C194(1.18); C266(0.89); C339(1.11)  LDD0767  [21]
 LDCM0451  CL6 HCT 116 C68(0.77); C194(0.73); C266(1.26); C339(0.85)  LDD0768  [21]
 LDCM0452  CL60 HCT 116 C194(1.13); C266(0.88); C339(1.18)  LDD0769  [21]
 LDCM0453  CL61 HCT 116 C194(0.86); C266(1.05); C339(0.95)  LDD0770  [21]
 LDCM0454  CL62 HCT 116 C194(0.79); C266(1.08); C339(0.88)  LDD0771  [21]
 LDCM0455  CL63 HCT 116 C194(0.73); C266(1.28); C339(0.74)  LDD0772  [21]
 LDCM0456  CL64 HCT 116 C194(0.67); C266(1.28); C339(0.97)  LDD0773  [21]
 LDCM0457  CL65 HCT 116 C194(0.89); C266(1.06); C339(0.98)  LDD0774  [21]
 LDCM0458  CL66 HCT 116 C194(0.61); C266(1.52); C339(0.86)  LDD0775  [21]
 LDCM0459  CL67 HCT 116 C194(0.72); C266(1.27); C339(1.04)  LDD0776  [21]
 LDCM0460  CL68 HCT 116 C194(0.63); C266(1.21); C339(1.05)  LDD0777  [21]
 LDCM0461  CL69 HCT 116 C194(0.85); C266(1.10); C339(0.91)  LDD0778  [21]
 LDCM0462  CL7 HCT 116 C68(0.72); C194(0.68); C266(1.38); C339(1.11)  LDD0779  [21]
 LDCM0463  CL70 HCT 116 C194(0.67); C266(1.17); C339(0.79)  LDD0780  [21]
 LDCM0464  CL71 HCT 116 C194(0.60); C266(1.18); C339(0.97)  LDD0781  [21]
 LDCM0465  CL72 HCT 116 C194(0.73); C266(1.07); C339(0.91)  LDD0782  [21]
 LDCM0466  CL73 HCT 116 C194(0.63); C266(1.19); C339(1.62)  LDD0783  [21]
 LDCM0467  CL74 HCT 116 C194(0.64); C266(1.29); C339(1.40)  LDD0784  [21]
 LDCM0469  CL76 HCT 116 C68(0.67); C166(1.26); C194(0.86); C266(1.17)  LDD0786  [21]
 LDCM0470  CL77 HCT 116 C68(20.00); C166(2.36); C194(0.79); C266(1.00)  LDD0787  [21]
 LDCM0471  CL78 HCT 116 C68(0.67); C166(0.98); C194(0.73); C266(1.20)  LDD0788  [21]
 LDCM0472  CL79 HCT 116 C68(1.06); C166(1.36); C194(0.63); C266(1.30)  LDD0789  [21]
 LDCM0473  CL8 HCT 116 C68(0.82); C194(0.55); C266(1.77); C339(1.12)  LDD0790  [21]
 LDCM0474  CL80 HCT 116 C68(1.21); C166(1.48); C194(1.01); C266(1.02)  LDD0791  [21]
 LDCM0475  CL81 HCT 116 C68(0.90); C166(1.45); C194(0.88); C266(1.10)  LDD0792  [21]
 LDCM0476  CL82 HCT 116 C68(0.82); C166(1.46); C194(0.95); C266(1.73)  LDD0793  [21]
 LDCM0477  CL83 HCT 116 C68(0.68); C166(1.71); C194(0.92); C266(1.41)  LDD0794  [21]
 LDCM0478  CL84 HCT 116 C68(0.77); C166(1.99); C194(0.68); C266(1.99)  LDD0795  [21]
 LDCM0479  CL85 HCT 116 C68(0.95); C166(1.19); C194(0.72); C266(1.20)  LDD0796  [21]
 LDCM0480  CL86 HCT 116 C68(0.97); C166(1.03); C194(0.91); C266(1.05)  LDD0797  [21]
 LDCM0481  CL87 HCT 116 C68(0.86); C166(1.40); C194(1.07); C266(1.18)  LDD0798  [21]
 LDCM0482  CL88 HCT 116 C68(0.70); C166(1.42); C194(0.97); C266(1.44)  LDD0799  [21]
 LDCM0483  CL89 HCT 116 C68(0.68); C166(1.90); C194(0.71); C266(1.99)  LDD0800  [21]
 LDCM0484  CL9 HCT 116 C68(1.36); C194(0.71); C266(1.24); C339(1.06)  LDD0801  [21]
 LDCM0485  CL90 HCT 116 C68(1.68); C166(1.48); C194(1.26); C266(0.89)  LDD0802  [21]
 LDCM0486  CL91 HCT 116 C68(0.62); C194(0.87); C266(1.17); C339(0.82)  LDD0803  [21]
 LDCM0487  CL92 HCT 116 C68(0.58); C194(1.05); C266(1.01); C339(0.88)  LDD0804  [21]
 LDCM0488  CL93 HCT 116 C68(0.88); C194(1.14); C266(1.07); C339(0.95)  LDD0805  [21]
 LDCM0489  CL94 HCT 116 C68(0.57); C194(0.93); C266(1.13); C339(0.81)  LDD0806  [21]
 LDCM0490  CL95 HCT 116 C68(0.54); C194(0.82); C266(1.18); C339(0.79)  LDD0807  [21]
 LDCM0491  CL96 HCT 116 C68(0.54); C194(0.89); C266(1.17); C339(0.85)  LDD0808  [21]
 LDCM0492  CL97 HCT 116 C68(0.89); C194(0.74); C266(1.12); C339(0.89)  LDD0809  [21]
 LDCM0493  CL98 HCT 116 C68(0.69); C194(0.83); C266(1.19); C339(0.87)  LDD0810  [21]
 LDCM0494  CL99 HCT 116 C68(0.71); C194(0.90); C266(1.16); C339(0.90)  LDD0811  [21]
 LDCM0634  CY-0357 Hep-G2 C266(0.79); C266(0.79)  LDD2228  [30]
 LDCM0495  E2913 HEK-293T C266(0.93); C194(0.97); C339(0.99); C68(1.02)  LDD1698  [46]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C339(1.01); C266(0.95)  LDD1702  [44]
 LDCM0031  Epigallocatechin gallate HEK-293T 6.09  LDD0183  [15]
 LDCM0175  Ethacrynic acid HeLa C68(2.54); C266(0.90)  LDD2210  [17]
 LDCM0625  F8 Ramos C210(0.59); C194(0.71); C266(1.38)  LDD2187  [47]
 LDCM0572  Fragment10 Ramos C210(1.68); C194(0.54); C266(0.71)  LDD2189  [47]
 LDCM0573  Fragment11 Ramos C210(0.01); C194(0.00)  LDD2190  [47]
 LDCM0574  Fragment12 Ramos C210(1.58); C194(0.65); C266(0.75)  LDD2191  [47]
 LDCM0575  Fragment13 Ramos C210(0.93); C194(1.05); C266(0.78)  LDD2192  [47]
 LDCM0576  Fragment14 Ramos C210(1.32); C194(0.53); C266(0.78)  LDD2193  [47]
 LDCM0579  Fragment20 Ramos C210(1.70); C194(0.73); C266(0.47)  LDD2194  [47]
 LDCM0580  Fragment21 Ramos C210(0.87); C194(0.57); C266(0.76)  LDD2195  [47]
 LDCM0582  Fragment23 Ramos C210(1.13); C194(0.99); C266(1.27)  LDD2196  [47]
 LDCM0578  Fragment27 Ramos C210(0.77); C194(0.86); C266(0.80)  LDD2197  [47]
 LDCM0586  Fragment28 Ramos C210(1.74); C194(1.37); C266(0.57)  LDD2198  [47]
 LDCM0588  Fragment30 Ramos C210(0.76); C194(0.73); C266(1.02)  LDD2199  [47]
 LDCM0589  Fragment31 Ramos C210(1.12); C194(0.96); C266(0.92)  LDD2200  [47]
 LDCM0590  Fragment32 Ramos C210(0.99); C194(0.52); C266(1.11)  LDD2201  [47]
 LDCM0468  Fragment33 HCT 116 C194(0.66); C266(1.20); C339(0.89)  LDD0785  [21]
 LDCM0596  Fragment38 Ramos C210(1.26); C194(0.55); C266(0.67)  LDD2203  [47]
 LDCM0566  Fragment4 Ramos C210(1.03); C194(0.60); C266(0.94)  LDD2184  [47]
 LDCM0427  Fragment51 HCT 116 C68(0.71); C166(0.43); C194(0.46); C266(2.52)  LDD0744  [21]
 LDCM0610  Fragment52 Ramos C210(1.03); C194(0.70); C266(0.95)  LDD2204  [47]
 LDCM0614  Fragment56 Ramos C210(1.18); C194(0.79); C266(1.13)  LDD2205  [47]
 LDCM0569  Fragment7 Ramos C210(2.97); C194(0.41); C266(0.58)  LDD2186  [47]
 LDCM0571  Fragment9 Ramos C210(2.81); C194(0.80); C266(0.65)  LDD2188  [47]
 LDCM0116  HHS-0101 DM93 Y145(0.91)  LDD0264  [19]
 LDCM0117  HHS-0201 DM93 Y145(0.79)  LDD0265  [19]
 LDCM0118  HHS-0301 DM93 Y145(0.92)  LDD0266  [19]
 LDCM0119  HHS-0401 DM93 Y145(0.98)  LDD0267  [19]
 LDCM0120  HHS-0701 DM93 Y145(0.80)  LDD0268  [19]
 LDCM0107  IAA HeLa H425(0.00); C194(0.00); H37(0.00); H39(0.00)  LDD0221  [37]
 LDCM0123  JWB131 DM93 Y145(0.86); Y24(1.02); Y416(0.96)  LDD0285  [18]
 LDCM0124  JWB142 DM93 Y145(0.43); Y24(0.25); Y416(0.80)  LDD0286  [18]
 LDCM0125  JWB146 DM93 Y145(1.59); Y24(1.23); Y416(1.15)  LDD0287  [18]
 LDCM0126  JWB150 DM93 Y145(3.39); Y24(2.54); Y416(5.39)  LDD0288  [18]
 LDCM0127  JWB152 DM93 Y145(1.60); Y24(2.11); Y416(3.75)  LDD0289  [18]
 LDCM0128  JWB198 DM93 Y145(1.06); Y24(0.23); Y416(1.78)  LDD0290  [18]
 LDCM0129  JWB202 DM93 Y145(0.39); Y24(0.63); Y416(0.93)  LDD0291  [18]
 LDCM0130  JWB211 DM93 Y145(0.82); Y24(0.66); Y416(0.94)  LDD0292  [18]
 LDCM0179  JZ128 PC-3 C194(0.00); C210(0.00); C266(0.00)  LDD0462  [14]
 LDCM0022  KB02 HCT 116 C194(1.62); C266(1.20)  LDD0080  [21]
 LDCM0023  KB03 HCT 116 C194(2.08); C266(1.01)  LDD0081  [21]
 LDCM0024  KB05 HCT 116 C194(1.76); C266(1.09)  LDD0082  [21]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C266(1.02); C210(0.80)  LDD2102  [44]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C266(0.93); C210(0.65)  LDD2121  [44]
 LDCM0109  NEM HeLa H39(0.00); H37(0.00); H425(0.00); C194(0.00)  LDD0223  [37]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C266(1.15); C210(1.07)  LDD2089  [44]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C266(1.02); C210(8.70)  LDD2090  [44]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C266(1.02); C210(2.32)  LDD2092  [44]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C266(0.32); C210(0.02)  LDD2096  [44]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C266(1.48); C210(4.35)  LDD2098  [44]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C266(1.17)  LDD2099  [44]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C266(0.87); C210(0.75)  LDD2100  [44]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C266(0.82); C210(0.91)  LDD2104  [44]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C266(1.35)  LDD2105  [44]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C266(0.63); C210(0.24)  LDD2106  [44]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C266(1.04); C210(0.63)  LDD2107  [44]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C266(0.98); C210(0.17)  LDD2108  [44]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C266(1.10); C210(1.18)  LDD2109  [44]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C266(1.13)  LDD2110  [44]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C266(1.20)  LDD2111  [44]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C266(0.63)  LDD2114  [44]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C266(0.56); C210(0.07)  LDD2116  [44]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C266(0.52); C210(0.04)  LDD2118  [44]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C266(2.06)  LDD2119  [44]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C266(0.68); C210(0.97)  LDD2120  [44]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C266(0.63); C210(0.05)  LDD2122  [44]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C266(1.30)  LDD2123  [44]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C266(0.74); C210(0.04)  LDD2124  [44]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C266(1.05)  LDD2125  [44]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C266(0.40); C210(0.04)  LDD2126  [44]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C266(1.05)  LDD2127  [44]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C266(0.30); C210(0.38)  LDD2128  [44]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C266(1.38)  LDD2129  [44]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C266(0.63)  LDD2134  [44]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C266(1.83)  LDD2135  [44]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C266(1.38)  LDD2136  [44]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C266(1.21); C210(0.61)  LDD2137  [44]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C266(1.16); C210(0.47)  LDD2140  [44]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C266(1.07); C210(0.36)  LDD2141  [44]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C266(1.21); C210(0.27)  LDD2143  [44]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C210(0.92)  LDD2147  [44]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C266(0.64)  LDD2148  [44]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C266(0.40); C210(0.06)  LDD2149  [44]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C266(0.61); C210(0.26)  LDD2150  [44]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C266(0.61); C210(0.06)  LDD2151  [44]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C266(1.03)  LDD2153  [44]
 LDCM0627  NUDT7-COV-1 HEK-293T C68(1.91); C266(0.85); C266(0.80)  LDD2206  [48]
 LDCM0628  OTUB2-COV-1 HEK-293T C68(0.92); C210(0.80); C266(0.72); C194(0.70)  LDD2207  [48]
 LDCM0131  RA190 MM1.R C194(1.17); C68(1.15); C266(1.07)  LDD0304  [49]
 LDCM0021  THZ1 HeLa S3 C194(1.13); C68(1.11); C266(1.08); C210(1.00)  LDD0460  [14]
 LDCM0111  W14 Hep-G2 S33(0.65)  LDD0238  [38]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
E3 ubiquitin-protein ligase TRIM63 (TRIM63) . Q969Q1
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Elongation factor 1-beta (EEF1B2) EF-1-beta/EF-1-delta family P24534
Elongation factor 1-delta (EEF1D) EF-1-beta/EF-1-delta family P29692
Putative elongation factor 1-delta-like protein (EEF1DP3) EF-1-beta/EF-1-delta family Q658K8
Keratin, type I cytoskeletal 17 (KRT17) Intermediate filament family Q04695
Kelch-like protein 18 (KLHL18) . O94889
Plasminogen receptor (KT) (PLGRKT) . Q9HBL7
RNA-binding protein 6 (RBM6) . P78332

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
10 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
11 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
12 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
13 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
14 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
15 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
16 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
17 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
18 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
19 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
22 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
23 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
24 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
25 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
26 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
27 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
28 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD025652
43 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
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Mass spectrometry data entry: PXD039908 , PXD029761
45 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
47 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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